On October 12, 2021 Biognosys, a leader in next-generation proteomics solutions for drug discovery and development, reported that it is supporting Cancer Scout as Proteomics provider (Press release, Biognosys, OCT 12, 2021, View Source [SID1234591113]).

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Cancer Scout is a large-scale joint research project led by University Medical Center Göttingen and Siemens Healthineers. The project received funding of EUR 10 million by the German Federal Ministry of Education and Research (BMBF)1.

The objective of Cancer Scout is to provide a new Artificial Intelligence tool for precision medicine in the fight against cancer. The research project will analyze and combine genomics, proteomics, and pathology data through Artificial Intelligence to generate a "digital biopsy" of molecular changes in tumors. Identifying these molecular changes can support early and accurate cancer diagnosis and predict personalized therapies for a patient’s tumor.

Oliver Rinner, PhD, CEO and founder of Biognosys states: "We are excited to be part of this visionary multi-omics research project and contribute to the development of more personalized clinical diagnostics and therapies for cancer with our proteomics solutions."

Biognosys was selected as the provider for the Proteomics data analysis in Cancer Scout, based on its unique technologies and workflows for large-scale proteomics, comprehensive quality standards for clinical research, and extensive expertise in precision oncology.

Biognosys’ discovery proteomics platform utilizes proprietary, patented Hyper Reaction Monitoring (HRM) mass spectrometry technology to quantify complete proteomes with unmatched precision, depth, and reproducibility. This solution can be applied with high throughput in large-scale studies involving thousands of samples from a broad range of clinical sample types.

Professor Philipp Ströbel, Director of Pathology at the University Hospital Göttingen, comments: "Combining digital pathology with proteomics and other omics data is essential to identify the full spectrum of molecular changes in tumors and enable truly personalized cancer care."

Christian Wolfrum, Head of New Business Development and Planning at Siemens Healthineers, adds: "We are excited to work with Biognosys to generate novel scientific insights in Cancer Scout and translate these into personalized cancer care solutions for clinical practice."

On October 12, 2021 Myovant Sciences (NYSE: MYOV), a healthcare company focused on redefining care for women and for men, reported it will host a webcast and conference call to discuss corporate updates and financial results for its second fiscal quarter 2021, ended September 30, 2021 (Press release, Myovant Sciences, OCT 12, 2021, https://investors.myovant.com/news-releases/news-release-details/myovant-sciences-host-second-fiscal-quarter-2021-earnings [SID1234591112]). The webcast and conference call will be held at 8:30 a.m. Eastern Time / 5:30 a.m. Pacific Time on October 26, 2021.

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Investors and the general public may access a live webcast of the call by visiting the investor relations page of Myovant’s website at investors.myovant.com. Institutional investors and analysts may also participate in the conference call by dialing 1-800-532-3746 in the U.S. or +1-470-495-9166 from outside the U.S.

A replay of the webcast, along with the earnings press release and presentation materials, will be archived on Myovant’s investor relations website.

On October 12, 2021 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, reported it has triggered the first development milestone payment under its global licensing agreement with Bristol Myers Squibb for AGEN1777, an Fc-enhanced bispecific anti-TIGIT antibody (Press release, Agenus, OCT 12, 2021, View Source [SID1234591111]). Agenus will receive a $20 million cash payment with the dosing of the first patient.

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"AGEN1777 represents Agenus’ latest innovation to activate the immune system against cancer and combat therapeutic resistance, as well as our fifth pharmaceutical collaboration to reach clinical development," said Steven O’Day, MD, Chief Medical Officer of Agenus. "With AGEN1777’s unique mechanism of action and Bristol Myers Squibb’s immuno-oncology expertise, our goal is to efficiently evaluate AGEN1777’s benefit in difficult to treat tumors."

This Phase 1 dose escalation study is designed to evaluate the safety, tolerability, and preliminary clinical activity of AGEN1777 as a single agent and in combination with a PD-1 inhibitor in patients with advanced solid tumors. The first patient was treated at Providence Cancer Institute by Dr. Rachel Sanborn. The trial will follow a standard dose-escalation design and will be used to establish the recommended Phase 2 dose (RP2D).

Bristol Myers Squibb intends to advance the research and development of AGEN1777 in immuno-oncology for high priority tumor indications including non-small cell lung cancer.

The global license agreement with Bristol Myers Squibb included a $200 million upfront payment paid in July 2021, and up to $1.36 billion in development, regulatory and commercial milestones in addition to tiered double-digit royalties on net product sales. Bristol Myers Squibb is solely responsible for the development and commercialization of AGEN1777 and its related products worldwide. Agenus retains options to conduct clinical studies under the development plan, to conduct combination studies with certain other Agenus pipeline assets, to co-fund global development for increased US royalties, and to co-promote AGEN1777 in the US upon commercialization.

About AGEN1777
AGEN1777 is a potentially first-in-class bispecific anti-TIGIT antibody engineered with an enhanced Fc region for high binding affinity and improved T and NK cell activation.

On October 12, 2021 Sapience Therapeutics, Inc., a biotechnology company focused on the discovery and development of peptide therapeutics to address difficult to treat oncology indications, reported that it was awarded a Small Business Innovative Research (SBIR) grant from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to establish proof-of-concept for the use of its second clinical candidate, ST316, to treat Wnt/β-catenin-dependent breast cancer (Press release, Sapience Therapeutics, OCT 12, 2021, View Source [SID1234591110]).

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"The Wnt pathway has remained out of reach for traditional pharmaceutical approaches, and novel modalities like ST316 are urgently needed to provide new therapeutic options for cancer patients," said Jim Rotolo, Ph.D., VP, Translational Pharmacology and Head of Research of Sapience Therapeutics. "This grant from the NCI/NIH allows us to further characterize the in vitro activity and in vivo safety and activity of ST316, which will enable us to accelerate the advancement of this program toward the clinic."

Sapience CEO and President, Dr. Barry Kappel added, "With our ST316 program, we are addressing one of the most desired undruggable targets in cancer. ST316 was designed to disrupt the pathologic aspects of Wnt/β-catenin while leaving the physiologic activities of this important pathway intact, and we appreciate the NCI/NIH support of additional preclinical work to allow us to explore its full potential."

This grant was supported by the National Cancer Institute of the National Institutes of Health under Award Number R43CA265503. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About ST316
β-catenin is a critical member of the canonical Wnt signaling pathway, a well-known development stage pathway that has been considered an "undruggable" cancer target, as small molecules have proven ineffective or toxic. Wnt/β-catenin signaling drives cancer initiation and contributes to tumor growth, angiogenesis and metastasis. ST316 exerts its activity through disruption of the BCL9/β-Catenin interaction to suppress transcription of Wnt target genes regulating proliferation, migration, invasion, and the metastatic potential of tumor cells. Sapience anticipates advancing ST316 into IND-enabling studies in 2021 and initiating clinical studies in late 2022.

On October 12, 2021 Kaleido Biosciences, Inc. (Nasdaq: KLDO), a clinical-stage biotech company with a differentiated, small-molecule approach to treating inflammatory conditions and diseases by selectively targeting the resident microbiome to restore gut-immune homeostasis, reported that CEO Dan Menichella will present a company overview at the Jefferies Virtual Next Generation IBD Therapeutics Summit at 1:45PM ET on Tuesday, October 19 (Press release, Kaleido Biosciences, OCT 12, 2021, View Source [SID1234591108]).

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The webcast of the presentation will be made available in the Investors & Media section of Kaleido’s website at View Source An archived replay will be available for 30 days following the event.