On October 11, 2021 GSK reported proposals for a major new UK-based headquarters and global campus for the new Consumer Healthcare company following separation in 2022, and its long-term plan for the future headquarters of GSK (Press release, GlaxoSmithKline, OCT 11, 2021, View Source [SID1234591097]).

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New Consumer Healthcare company headquarters to be based in Weybridge, UK
The proposals announced today form part of GSK’s ongoing work to prepare for the separation of the Group into two leading UK-based companies next year – new GSK, a global pharmaceuticals and vaccines company with an R&D approach focused on the science of the immune system, human genetics and advanced technologies, and a world leading Consumer Healthcare company with annual sales of more than £10 billion, including nine global power brands holding category leadership positions.

Under the proposals announced today the new Consumer Healthcare company will build a new campus in Weybridge, UK. This campus will house the global headquarters for the new Consumer Healthcare business, including an innovation centre (made up of R&D laboratories and the Consumer Healthcare Shopper Science lab) and the company’s global support function teams based in the UK. It will be home to around 1,400 employees.

The new Consumer Healthcare company will open its new headquarters at the end of 2024, subject to consultation and planning approvals. Whilst the development of the campus is ongoing, and at the point of separation of the two companies – expected in mid-2022 – Consumer Healthcare teams will leave GSK House in Brentford and will move to a temporary headquarters in Weybridge, at a site close to but separate from the company’s existing facilities in the area.

Brian McNamara, CEO Designate, GSK Consumer Healthcare said: "This investment in a new cutting-edge campus in the UK will bring together our first-in-class teams as we drive towards our ambitions as the world’s leading consumer healthcare company. Today’s announcement is an important step as we prepare for separation, marking an exciting new beginning for New Consumer Healthcare."

GSK to move to new UK headquarters after separation
Following separation, GSK will move to a new UK headquarters. The company will identify an appropriate site that meets the needs of the new organisation, with the search based in the same area as GSK’s current headquarters, maintaining access to the UK’s world-leading science and innovation hubs; GSK will provide a further update on its new headquarters in mid-2022, and expects to remain at the company’s current headquarters, at GSK House in Brentford, until at least the end of 2023.

On October 11, 2021 Outcomes4Me Inc., developer of a leading free mobile app and platform to navigate cancer treatment and care, reported that it has partnered with Invitae Corporation (NYSE: NVTA), a leading medical genetics company, to expand education and access to genetic testing to breast cancer patients and survivors (Press release, Invitae, OCT 11, 2021, View Source [SID1234591089]). The collaboration leverages the strengths of Invitae, which supplies clinical grade genetic testing, and Outcomes4Me’s 360-degree, validated and evidence-based cancer support and treatment options via its free and easy-to-use app. Initially and currently available in the United States, patients can now receive genetic counseling through Invitae’s partnership with Genome Medical, get testing, and upload their results within the Outcomes4Me app.

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There is a misconception that genetic testing is only useful as a preventative tool prior to a cancer diagnosis. According to Outcomes4Me patient data, almost half of users (46 percent) who qualified for testing (based on NCCN Guidelines) did not receive testing or did not know if they had received testing. However, genetic testing can provide insights that can help inform and refine precision therapy use and clinical treatment trial enrollment. In addition, genetic testing results can be used to help prevent recurrence and reduce incidence of other inherited cancers.

A cancer diagnosis is often overwhelming for patients and their families. Outcomes4Me demystifies cancer by providing the most up-to-date and validated research, support, and treatment options, all grounded in science and data and curated according to the patient’s specific diagnosis. Outcomes4Me partners with the researchers, doctors, and academics that set the rigorous standards of cancer care for all treatment providers, including the National Comprehensive Care Network (NCCN), Vanderbilt-Ingram Cancer Center (VICC) and Massachusetts General Hospital (MGH). The collaboration with Invitae expands access to genetic testing, a vitally important tool in the patient’s cancer care arsenal.

"Outcomes4Me is an indispensable platform for patients with breast cancer, giving them the personalized knowledge and access to timely new trials and targeted therapies that could lead to better health outcomes," said Ed Esplin, M.D., Ph.D., FACMG, FACP, Clinical Geneticist at Invitae. "By providing access to our comprehensive genetic testing and counseling services, Outcomes4Me is adding a valuable resource that will empower patients to advance their knowledge, understanding, and therefore, self-advocacy during treatment and survivorship."

Unlike popular direct-to-consumer genetic testing services, which test for a few specific genetic variants for certain genes, Invitae provides state-of-the-art clinical grade next-generation sequencing-based (NGS) genetic testing that comprehensively analyses more than 80 genes, including all known mutations of the important BRCA1/BRCA2 genes. This comprehensive approach, combined with associated genetic counseling, not only provides insights for cancer patients, but also for family members who may be at risk.

"Our collaboration with Invitae reinforces Outcomes4Me’s mission to give patients back control," said Maya R. Said, Sc. D., Founder and CEO of Outcomes4Me. "Because of this work with Invitae, our valued community now has rare direct access to a much-needed testing service. Outcomes4Me will proudly continue to democratize the best in cancer treatment, research, and support by removing barriers and bias in information flow."

On October 11, 2021 Sirtex Medical ("Sirtex"), a leading manufacturer of targeted liver cancer therapies, reported that the first procedure of selective internal radiation therapy (SIRT) using SIR-Spheres Y-90 resin microspheres in China was successfully performed for a patient with hepatocellular carcinoma (HCC) on Sept. 28, 2021 (Press release, Sirtex Medical, OCT 11, 2021, View Source [SID1234591087]). The milestone was reached with the support of Sirtex shareholder China Grand Pharmaceutical and Healthcare Holdings Limited.

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"This achievement marks a major step forward in our global growth as a company and in our mission to bring effective treatments to patients with cancer," said Kevin R. Smith, Chief Executive Officer of Sirtex. "We are especially excited to advance our efforts in China, given the sizable numbers of colorectal and liver cancer cases in recent years. We thank everyone involved in this accomplishment and look forward to the promising future of SIR-Spheres in China and around the world."

The procedure was performed by Dr. Jiahong Dong and his team at Boao Super Hospital in the Hainan Province. Dr. Jiahong is a world-renowned specialist in hepatobiliary pancreatic surgery and liver transplantation and was elected Academician of Chinese Academy of Engineering in 2017.

There are 400,000 new cases of liver cancer in China each year, accounting for more than half of all new cases of liver cancer worldwide. "The successful implementation of the first licensed access to the resin microsphere in the clinical treatment of liver cancer means that China’s liver cancer patients can receive international advanced selective in vivo radiation therapy," said Dr. Jiahong Dong in a press conference held yesterday. "This is a landmark and milestone in the history."

Hainan’s first try, first pilot policy allows global new technologies, new ideas and new products to be implemented through Hainan Hope City. The project of the introduction of SIR-Spheres Y-90 resin microspheres will benefit Chinese patients in China.

In November 2020, the National Medical Products Administration (NMPA) of the People’s Republic of China accepted the Sirtex new drug application (NDA) of SIR-Spheres Y-90 resin microspheres for the treatment of colorectal cancer liver metastases.

On October 11, 2021 The Twist Alliance Pan-Cancer Methylation Panel (Pan-Cancer Panel), a solution for pan-cancer study including DNA methylation library preparation and targeted enrichment for next-generation sequencing (NGS),reported that it was launched globally on September 24th (US time) (Press release, Twist Bioscience, OCT 11, 2021, View Source;a-strategic-collaboration-between-anchordx-and-twist-bioscience-for-pan-cancer-liquid-biopsy-301396510.html [SID1234591086]). The Pan-Cancer Panel was developed over a two-year period by AnchorDx in collaboration with Twist Bioscience (NASDAQ: TWST).

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The Pan-Cancer Panel, coupled the DNA methylation markers that were discovered, curated and validated by AnchorDx from many large-scale clinical studies, with the superior panel design, high-quality DNA synthesis platform and the strict quality control process developed by Twist Bioscience, ensures robust and high-performance output for large-scale screening of patient samples. The panel covers 47 disease entities from The Cancer Genome Atlas (TCGA) and 31 cancer types, such as lung, breast and colorectal cancers, each is represented by ~1000 informative genomic regions.

"DNA methylation has become an increasingly important biomarker for early cancer detection. The identification of methylation by sequencing has been challenging due to low sensitivity and efficiency and high cost. We developed a unique target enrichment-based approach to make methylation detection significantly better," said Emily Leproust, Ph.D., CEO and Co-founder of Twist Bioscience. "Collaborating with AnchorDx, a leading early cancer detection company, to develop the pan-cancer methylation panel leverages AnchorDx’s expertise in the cancer diagnostics field and enables wider access of the product and platform. We are pleased to bring the Twist Pan-Cancer Methylation Panel to the scientific community."

"The Twist Alliance Pan-Cancer Methylation Panel is a high-performance and cost-effective solution for comprehensive DNA methylation analysis. It shall facilitate basic cancer research and diagnostics development. With the launch of this product, we hope to make our due contribution to the global cancer screening efforts, and look forward to future collaborations with either academics or industries to develop more impactful clinical products." said Dr. Jian-Bing Fan, CEO and Founder of AnchorDx.

AnchorDx and Twist Bioscience signed an agreement to co-market the Twist Alliance Pan-Cancer Methylation Panel globally.

On October 11, 2021 Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, reported that it will release its financial results for the third quarter 2021 before the market opens on Wednesday, October 27, 2021, and will hold a conference call on the same day at 8:30 a.m. EDT (Press release, Thermo Fisher Scientific, OCT 11, 2021, View Source [SID1234591085]).

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During the call, the company will discuss its financial performance, as well as future expectations. To listen, call (833) 714-0931 within the U.S. or (778) 560-2662 outside the U.S. The conference ID is 6971977. You may also listen to the call live on the "Investors" section of our website, www.thermofisher.com. The earnings press release and related information can be found in that section of our website under "Financial Results." A replay of the call will be available under "Webcasts and Presentations" through Friday, November 12, 2021.