On October 7, 2021 Plexium Inc., (Plexium), a biotech company focused on discovering and developing protein degrading therapeutics directed towards historically challenging drug targets, reported that company management will present and host one-on-one meetings at the Solebury Trout/BMO Fall Private Company Showcase 2021 (Press release, Plexium, OCT 7, 2021, View Source [SID1234591009]). The company will present on Thursday, October 14th, 2021 at 9:40 am ET.

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On October 7, 2021 Servier, a global independent pharmaceutical Group, and Guangdong Maijinjia Biotechnologies (MJJ Biotech), owner of a proprietary Technology platform, acquired from Ranger Biotechnologies (Ranger), which uses short highly modified oligonucleotides (Blockmirs) to upregulate protein expression, reported that they have entered into a Collaboration and Exclusive License Option Agreement to develop a novel therapy for treating rare neurodegenerative diseases (Press release, Servier, OCT 7, 2021, View Source;utm_medium=rss&utm_campaign=neurodegenerative-diseases-servier-enter-into-a-new-research-collaboration [SID1234591007]).

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Under the collaboration agreement, the Blockmir Technology provided by MJJ Biotech will be used to develop antisense oligonucleotides (ASOs) that specifically block selected miRNA binding sites on the mRNA of a non-disclosed target to upregulate its protein level. This innovative strategy could provide a new therapeutic solution for incurable rare neurological diseases.

Upon selection of active Blockmir candidates for IND qualification done with the collaboration of Ranger, Servier has the option to license, develop and commercialize novel therapeutic products based on this technology. MJJ Biotech will receive up to 35 million euros for option fee, and in development and regulatory as well as first commercial sale milestone payments. Specific financial terms are not disclosed.

"This collaboration is a unique opportunity to partner with an experienced and recognized player in the field of antisense oligonucleotide Blockmirs to help us design and optimize ASOs by gaining access to models, technology, and experience that complements our own capabilities in order to provide patients suffering from neurodegenerative diseases with innovative therapeutic solutions", stated Johannes Krupp, Research Program Director Neurology, at Servier.

"We are very pleased to enter into this partnership with Servier and see it as an important validation of the progress that has been made by MJJ Biotech since its founding in 2019. Servier is a major pharmaceutical company with immense experience in neurodegenerative disease and we will surely benefit from this collaboration in multiple ways. We are also confident that the collaboration will prove valuable to Servier and provide new avenues for treatment of rare neurodegenerative disease", stated Thorleif Møller, Chief Scientific Officer at MJJ Biotech.

Servier has been involved in neuroscience for several decades and focuses its research on neurodegenerative diseases. Servier is particularly interested in targeted movement disorders, such as Parkinson’s disease, amyotrophic lateral sclerosis and spinocerebellar ataxias, many of which are characterized by the abnormal accumulation of certain proteins.

On October 7, 2021 Amgen (NASDAQ: AMGN) and Neumora Therapeutics, Inc. (Neumora), a clinical-stage biopharmaceutical company pioneering precision medicines for brain diseases, reported a strategic collaboration to advance neuroscience discovery, development and commercialization (Press release, Amgen, OCT 7, 2021, View Source [SID1234590983]). The companies will collaborate on programs by applying Neumora’s proprietary precision neuroscience platform to insights generated by Amgen’s deCODE genetics and human data research capabilities. In addition, Neumora has received a $100 million equity investment from Amgen and acquired exclusive global rights to develop and commercialize Amgen programs targeting casein kinase 1 delta and glucocerebrosidase for neurodegenerative diseases.

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Neumora leverages proprietary multimodal capabilities and technologies to integrate advanced computational data science with R&D to increase the probability of success of drug development in brain diseases. Neumora’s precision neuroscience platform focuses on the creation of Data Biopsy Signatures to deconvolve the complex systems that drive brain diseases and connect the signatures to clinically meaningful measures to inform the development of therapeutics for an enriched patient population, or Precision Phenotypes.

Amgen’s deCODE genetics subsidiary is a global leader in analyzing and understanding human health and disease and has been at the forefront of the analysis of human data to enhance drug discovery and development. By leveraging these platform technologies and the complementary capabilities of both companies, the collaboration aims to discover unique and unprecedented insights into brain diseases across neuropsychiatric and neurodegenerative diseases, including schizophrenia and amyotrophic lateral sclerosis (ALS), ultimately leading to effective therapeutics targeted at patients most likely to respond to treatment.

"Our collaboration with Neumora leverages both our unique capabilities from deCODE and Neumora’s focus and expertise in brain diseases to discover and develop potentially best-in-class precision therapies," said David M. Reese, M.D., executive vice president of Research and Development at Amgen. "Although Amgen is not currently engaged in neuroscience research and early development internally, this approach addresses our commitment to remain engaged in neuroscience through external collaborations, and we are excited to work with Neumora to propel R&D for brain diseases into the future and advance promising new medicines."

"This partnership with Amgen underscores the vast potential of precision drug development for brain diseases; insights generated by deCODE will further enhance Neumora’s data-driven precision medicine approach," said Paul L. Berns, co-founder, chairman and chief executive officer at Neumora. "We are also excited to expand our pipeline with potential best-in-class programs targeting casein kinase 1 delta and glucocerebrosidase for neurodegenerative diseases. Neumora is poised to become a pioneer in precision drug development for brain diseases and we look forward to working with Amgen to advance promising new medicines for patients in need of better treatment options."

About deCODE Genetics
Based in Reykjavik, Iceland, deCODE is a global leader in analyzing and understanding the human genome. Using its unique expertise in human genetics combined with growing expertise in transcriptomics and population proteomics and vast amount of phenotypic data, deCODE has discovered risk factors for dozens of common diseases and provided key insights into their pathogenesis. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE is a wholly-owned subsidiary of Amgen.

On October 7, 2021 NorthStar Medical Radioisotopes, LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic applications and medical imaging, reported the launch of its newly redesigned corporate website (Press release, NorthStar Medical Radiostopes, OCT 7, 2021, View Source [SID1234590982]). The new site includes increased functionality and a number of enhancements. Expanded content includes latest product information, updates on NorthStar’s significant campus expansion, its growing partnerships and dynamic pipeline in therapeutic and SPECT radiopharmaceuticals, and the latest in career opportunities as the Company continues to grow and expand. NorthStar welcomes visitors to its new site at: www.northstarnm.com.

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"We are very pleased to launch the new NorthStar corporate website that reflects our excitement and enthusiasm in working to provide global solutions for reliable medical radioisotope supply for patient health," said Stephen Merrick, President and Chief Executive Officer of NorthStar Medical Radioisotopes. "We redesigned the website to provide details on NorthStar’s progress and expansion, our talented and experienced management team and employee base, our robust plans for the future and our commitment to patient health. This is an exciting time for NorthStar that warrants amplified communication and updates to our audiences. We believe there is no better way to share this information than with a highly relevant website that consistently provides streamlined, timely content."

On October 7, 2021 Kyowa Kirin Co., Ltd. (TSE:4151, President and CEO: Masashi Miyamoto, "Kyowa Kirin") reported the discontinuation for developing KHK2375 (generic name: entinostat) (Press release, Kyowa Hakko Kirin, OCT 7, 2021, View Source [SID1234590979]).

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KHK2375 is a Class I selective histone deacetylase (HDAC) inhibitor, which was discovered by Syndax Pharmaceuticals Inc. Kyowa Kirin signed a license agreement with Syndax Pharmaceuticals Inc. for the exclusive rights to the development and commercialization of KHK2375 in Japan and Korea in 2014.

Under the license agreement, Kyowa Kirin developed KHK2375 for indications of breast cancer in its territory. However, concerning the situation carefully, Kyowa Kirin discontinued KHK2375 development project.

Yoshifumi Torii, Ph.D., Executive Officer, Vice President, Head of R&D Division of Kyowa Kirin commented, "We are disappointed in this decision, as it was expected to have novel possibilities in breast cancer treatment, especially in endocrine therapy. We would like to express our appreciation to all the patients and investigators who contributed to the clinical studies and our development and continue to push forward to deliver therapies that meet unmet medical needs in oncology."

The Kyowa Kirin Group companies strive to contribute to the health and well-being of people around the world by creating new value through the pursuit of advances in life sciences and technologies.