On October 6, 2021 OncoResponse, a clinical-stage biotech company advancing immunotherapies derived from the immune systems of elite cancer responders, reported that it will present three abstracts at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 36th Annual Meeting being held in Washington D.C. and virtually November 10-14, 2021 (Press release, OncoResponse, OCT 6, 2021, View Source [SID1234590874]).

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"We are pleased to be highlighting several preclinical findings at the SITC (Free SITC Whitepaper) conference demonstrating the application of our propriety immunotherapy platform we are utilizing to discover and develop therapeutic antibodies that modulate the tumor microenvironment. This includes preclinical findings for our lead therapeutic candidate, OR2805, which has entered clinical development," said Clifford Stocks, Chief Executive Officer of OncoResponse.

Details of the poster presentations are as follows:

Title: Development of OR2805, an anti-CD163 antibody derived from an elite responder to checkpoint inhibitor therapy that relieves immunosuppression caused by M2c macrophages

Poster/Abstract Number: 271
Date/Time: Friday, November 12, 7:00 a.m. to 8:30 p.m. ET

Title: Preclinical characterization of humanized anti-Siglec-15 antibodies that rescue T cells from macrophage-mediated immune suppression

Poster/Abstract Number: 262
Date/Time: Saturday, November 13, 2021, 7:00 a.m. – 8:30 p.m. EST

Title: Discovery and preclinical characterization of anti-LILRB2 antibodies that rescue T cells from macrophage-mediated immune suppression

Poster/Abstract Number: 276
Date/Time: Saturday, November 13, 2021, 7:00 a.m. – 8:30 p.m. EST

Poster presentations will be accessible in person and virtually. Onsite posters will be displayed in the SITC (Free SITC Whitepaper) Poster Hall located in Hall E of the convention center. ePosters will be available for SITC (Free SITC Whitepaper) attendees on Nov. 12 at 7 am ET and can be accessed on the SITC (Free SITC Whitepaper) virtual meeting site.

About OR2805

OR2805 is a fully human antibody discovered using B cells derived from an elite responder to checkpoint inhibitor (CPI) therapy. This antibody binds to CD163 which is highly expressed on tumor associated macrophages (TAMs) that create an immunosuppressive tumor microenvironment and inhibit anti-tumor T-cell responses. High frequency of CD163-expressing TAMs generally predicts an unfavorable prognosis in solid tumors. OR2805 is designed to improve anti-tumor T-cell responses, by reversing the immunosuppression of TAMs, as a therapeutic strategy for monotherapy and in combination with CPI.

On October 6, 2021 Dialectic Therapeutics, Inc. (Dialectic), a Texas-based clinical stage biotechnology company focused on creating innovative new technologies to treat cancer, reported the dosing of the first patient in a first-in-human, dose escalation Phase 1 trial evaluating DT2216, the first generation compound built using its proprietary and novel Antiapoptotic Protein Targeted Degradation (APTaD) technology, in patients with relapsed or refractory solid tumor and hematologic malignancies (Press release, Dialectic Therapeutics, OCT 6, 2021, View Source [SID1234590873]).

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"Advancing our first generation APTaD DT2216 into the clinic is the culmination of a tremendous amount foundational research conducted by our scientific team supported by extensive preclinical studies. This also marks the first time a protein degrader targeting the antiapoptotic BCL family of proteins has been administered in humans. We believe DT2216 has the potential to be a first-in-class anticancer agent targeting BCL-XL, the most commonly over-expressed antiapoptotic protein in cancer, as a single agent and in combination with chemotherapy regimens and other therapeutics. We look forward to learning more about the safety, tolerability and anti-tumor activity of DT2216 in this trial and presenting future data" said Dr. David Genecov, Dialectic’s President and Chief Executive Officer. "With DT2216 in the clinic, we look forward to leveraging our novel APTaD technology platform to advance the next generations of our degrader compounds."

The multicenter Phase 1 clinical trial is designed as an open-label, first-in-human, dose escalation study in patients with histologically or cytologically confirmed advanced or metastatic solid tumors and hematologic malignancies who are no longer responsive to approved or accepted standard-of-care interventions. The Phase 1 trial is anticipated to enroll between 20-40 patients that will receive a single intravenous (IV) infusion of DT2216 twice weekly for at least 4 weeks, with each cycle consisting of 28 days.

Renowned cancer centers participating in the trial include Mays Cancer Center at UT Health San Antonio, Mary Crowley Cancer Research in Dallas, Texas and The Lurie Cancer Center at Northwestern University in Chicago, Illinois. Additional information about the clinical trial is available at ClinicalTrials.gov (NCT04886622).

About DT2216 and the APTaD Technology Platform
In preclinical studies supported through a Seed Award from the Cancer Prevention & Research Institute of Texas (CPRIT), DT2216 selectively induces the degradation of B-cell lymphoma extra-large, or BCL-XL, in cancer cells and either stimulates the return of cellular apoptosis or sensitizes the cells to be more susceptible to chemotherapy, and thus cellular destruction. DT2216 has been shown to be effective in various hematologic and solid tumors as a single agent and in combination with chemotherapy. Further, these preclinical studies show cancer cells are less likely to develop resistance to DT2216 compared to other chemotherapy drugs. DT2216 accomplishes this with very little toxicity, particularly to platelets.

As with BCL-XL, there are many other significant proteins associated with cancer that cannot be targeted with current therapies. Our proprietary APTaD technology platform is a novel approach that can be applied to the broader BCL family and other protein targets. Our current research and preclinical efforts are focused on developing next generation APTaD candidates to address this high unmet need.

On October 6, 2021 Citius Pharmaceuticals, Inc. ("Citius" or the "Company") (Nasdaq: CTXR), a late-stage biopharmaceutical company dedicated to the development and commercialization of first-in-class critical care products with a focus on oncology, anti-infective products in adjunct cancer care, unique prescription products, and stem cell therapies, reported that it will present at two investor conferences during the month of October 2021 (Press release, Citius Pharmaceuticals, OCT 6, 2021, View Source [SID1234590872]).

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EVENT: Benzinga Rising Stars: Catalytic Small Cap Growth Conference
DATE: Thursday, October 7, 2021
Citius Executive Chairman Leonard Mazur will present at 9:05 a.m. ET. His presentation will be available for viewing on Benzinga’s live stream channel.

EVENT: Dawson James Securities 6th Annual Small Cap Growth Conference
DATE: Thursday, October 21, 2021
Citius Executive Chairman Leonard Mazur will present at 8:55 a.m. ET in Track 1 and will be available for 1-on-1 meetings with registered conference attendees. The conference will be held October 20-21 at the Wyndham Grand Jupiter at Harbourside Place in Jupiter, Florida. A webcast of the presentation will be available on the Events page of the Citius Investors website.

At the conferences, Mr. Mazur will discuss the Company’s growing pipeline of therapies targeting unmet medical needs consisting of two late-stage assets completing Phase 3 trials, three potential first-and-only prescription treatments in their indications, and a next-generation stem cell therapy program.

On October 6, 2021 Theseus Pharmaceuticals, Inc. ("Theseus"), a biopharmaceutical company focused on improving the lives of cancer patients through the discovery, development and commercialization of transformative targeted therapies, reported the pricing of its initial public offering of 10,000,200 shares of its common stock at a price to the public of $16.00 per share (Press release, Theseus Pharmaceuticals, OCT 6, 2021, View Source [SID1234590871]). All of the shares are being offered by Theseus. The gross proceeds to Theseus from the offering, before deducting underwriting discounts, commissions and other offering expenses payable by Theseus, are expected to be $160 million. In addition, Theseus has granted the underwriters a 30-day option to purchase up to an additional 1,500,030 shares of common stock from Theseus at the initial public offering price less underwriting discounts and commissions.

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Theseus’s common stock is expected to begin trading on The Nasdaq Global Select Market under the ticker symbol "THRX" on October 7, 2021. The offering is expected to close on or about October 12, 2021, subject to the satisfaction of customary closing conditions.

Jefferies, SVB Leerink and Cantor are acting as joint book-running managers for the offering. Wedbush PacGrow is acting as lead manager.

A registration statement relating to the securities being sold in the offering was declared effective by the Securities and Exchange Commission ("SEC") on October 6, 2021. The offering is being made only by means of a written prospectus. Copies of these documents can be accessed by visiting the SEC website at View Source Alternatively, copies of the final prospectus relating to the offering can be obtained, when available, from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by telephone at (877) 821-7388, or by email at [email protected]; SVB Leerink LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; Cantor Fitzgerald & Co., Attention Capital Markets, 499 Park Avenue, 4th Floor, New York, NY 10022, or by e-mail at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On October 6, 2021 Veracyte, Inc. (Nasdaq: VCYT) reported that four abstracts highlighting the clinical impact of the company’s genomic diagnostic tests for lung cancer and interstitial lung disease (ILD) will be presented at the American College of Chest Physicians (CHEST) Annual Meeting 2021, being held virtually October 17-20, 2021 (Press release, Veracyte, OCT 6, 2021, View Source [SID1234590870]).

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The abstracts include new data from an expanded clinical validation study which demonstrate the ability of Veracyte’s Percepta Nasal Swab test to determine cancer risk in patients with lung nodules found on CT scans – across lung nodule sizes, lung cancer stages and patients’ prior-cancer status. Veracyte developed the novel noninvasive test to help physicians more accurately, quickly and confidently determine which patients can be safely directed to routine monitoring and which should proceed to further diagnostic work-up and treatment as needed.

"The Percepta Nasal Swab is a key component of Veracyte’s lung cancer portfolio and expands our ability to answer clinical questions across the patient journey in lung cancer," said Marc Stapley, Veracyte’s chief executive officer. "Collectively, the new data that will be presented at this year’s CHEST meeting demonstrate the power of our cutting-edge genomic science and technology to help physicians and patients make better, faster and more confident care decisions in serious lung diseases."

Additional abstracts to be presented at the CHEST meeting provide further evidence that Veracyte’s Percepta and Envisia classifiers deliver valuable genomic information that helps guide patient care in lung cancer and ILDs (including idiopathic pulmonary fibrosis), respectively.

Following are details of the four abstracts:

Date/Time:

Sunday, October 17, 9:15 a.m.-10:20 a.m. CT

Title:

A Nasal Clinical-Genomic Classifier for Assessing Risk of Malignancy in Lung Nodules Demonstrates Accurate Performance Independent of Nodule Size or Cancer Stage

Abstract #:

39959 (oral presentation)

Presenter:

Carla R. Lamb, M.D., Lahey Hospital & Medical Center

Date/Time:

Sunday, October 17, 9:15 a.m.-10:20 a.m. CT

Title:

Impact of Percepta Bronchial Genomic Classifier on Lung Nodule Management at an Academic Medical Center

Abstract #:

39994 (oral presentation)

Presenter:

Harpreet Singh, M.D., Medical College of Wisconsin

Date/Time:

Monday, October 18, 12:15 p.m.-1:20 p.m. CT

Title:

The Impact of the Envisia Genomic Classifier in the Diagnosis and Management of Patients with Interstitial Lung Disease

Abstract #:

40063 (oral presentation)

Presenter:

Joseph Lasky, M.D., Tulane University Medical School

Date/Time:

On-Demand October 17-21

Title:

Role of Next Generation Sequencing with Percepta Brushing in Reclassifying Lung Nodule Risk After Non-Diagnostic Bronchoscopy

Abstract #:

36774 (poster)

Presenter:

Abhijit Raval, M.D., AnMed Health Medical Center