Repare Therapeutics Announces Closing of Upsized Offering of Common Shares and Full Exercise of Underwriters’ Option to Purchase Additional Shares

On November 2, 2021 Repare Therapeutics Inc. (Nasdaq: RPTX), a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics, reported the closing on November 1, 2021 of its upsized underwritten public offering of 4,600,000 common shares at a public offering price of $22.00 per share, which included the exercise in full by the underwriters of their option to purchase up to 600,000 additional shares (Press release, Repare Therapeutics, NOV 2, 2021, View Source [SID1234594155]). All common shares were sold by Repare. The total gross proceeds for the offering were approximately $101.2 million, before deducting underwriting commissions and offering expenses payable by Repare.

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Morgan Stanley, Goldman Sachs & Co. LLC, Cowen and Piper Sandler acted as joint book-running managers for the offering.

The securities described above were offered pursuant to an automatically effective shelf registration statement that was previously filed with the U.S. Securities and Exchange Commission (SEC) on July 2, 2021. The offering was made only by means of a prospectus supplement and the accompanying prospectus which forms a part of the effective shelf registration statement.

Copies of the final prospectus supplement related to the offering and the accompanying prospectus may be obtained by visiting the SEC’s website located at www.sec.gov or by contacting: Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014; Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone: 1-866-471-2526 or by emailing [email protected]; Cowen and Company, LLC c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY, 11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926; or Piper Sandler & Co., Attn: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, Minnesota 55402, by telephone at 800-747-3924 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Arcus Biosciences to Report Third Quarter 2021 Financial Results & Recent Corporate Highlights

On November 2, 2021 Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecule and combination medicines for people with cancer, reported that the company will report its financial results and a corporate update for the third quarter ended September 30, 2021 after the market closes on Monday, November 8, 2021 (Press release, Arcus Biosciences, NOV 2, 2021, View Source [SID1234594154]).

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Gossamer Bio to Announce Third Quarter 2021 Financial Results and Host Conference Call and Webcast on November 8, 2021

On November 2, 2021 Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, reported that it will report its third quarter 2021 financial results on Monday, November 8, 2021 (Press release, Gossamer Bio, NOV 2, 2021, View Source [SID1234594153]).

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In connection with the earnings release, Gossamer’s management team will host a live conference call and webcast at 4:15 p.m. ET on Monday, November 8, 2021, to discuss the Company’s financial results and provide a corporate update.

A replay of the audio webcast will be available for 30 days on the Investors section of the Company’s website, www.gossamerbio.com.

Scholar Rock to Present at Upcoming Healthcare Conferences

On November 2, 2021 Scholar Rock (NASDAQ: SRRK), a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, reported that management will participate in the following upcoming investor conferences (Press release, Scholar Rock, NOV 2, 2021, View Source [SID1234594151]):

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Credit Suisse 30th Annual Virtual Healthcare Conference on Tuesday, November 9th, 2021 at 8:50 a.m. ET.
Cowen 5th Annual IO Next Virtual Summit on Monday, November 15th, 2021 at 8:15 a.m. ET.
12th Annual Jefferies Global Healthcare Conference in London on Wednesday, November 17th, 2021 at 5:00 p.m. GMT (11:00 a.m. ET).
33rd Annual Piper Sandler Virtual Healthcare Conference on November 30th-December 2nd, 2021. The webcast will be available beginning at 10:00 a.m. ET on November 22.
A live webcast of presentations at the Credit Suisse, Cowen and Jefferies conferences may be accessed by visiting the Investors & Media section of the Scholar Rock website at View Source All these webcasts will be archived and available on the Company’s website for approximately 90 days following the presentation.

BostonGene Announces Publication in Cancer Research

On November 2, 2021 BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients reported a new publication in the peer-reviewed scientific journal Cancer Research, a journal of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) (Press release, BostonGene, NOV 2, 2021, View Source [SID1234594150]). The study, performed in collaboration with Weill Cornell Medicine and titled "Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas," details the role of oncogenic heat shock protein 90 (HSP90) to support metabolic pathways in B-cell lymphoma cells and in patients with diffuse large B-cell lymphoma (DLBCL).

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This study evaluated the role of oncogenic HSP90 in regulating cytosolic metabolic pathways in proliferating B-cell lymphoma cells. Oncogenic HSP90 was shown to facilitate the organization of metabolic enzymes into non-membrane-bound functional compartments. BostonGene’s analysis enabled reconstructing the microenvironment in lymphoma expressing a double hit signature, an indicator of aggressive lymphoma with high MYC activity. This analysis showed that alterations to the MYC metabolic program affected immune infiltration, providing insights into improving lymphoma immunity via MYC. It was also observed, under experimental conditions, which conserved cellular proteostasis, oncogenic HSP90 coordinated and sustained multiple metabolic pathways required for energy production and maintenance of cellular biomass as well as for secretion of extracellular metabolites.

"The goal of the study was to further understand metabolic regulation of cellular proteostasis in patients with DLBCL," said Leandro Cerchietti, M.D., Associate Professor of Medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. "The encouraging results of this research study demonstrate oncogenic HSP90 is tightly linked to the preservation of cellular biomass providing a novel mechanism of activity for HSP90 inhibitors."

"These findings underscore the pivotal role of oncogenic HSP90 in the regulation of metabolic pathways in lymphoma, revealing a potential therapeutic vulnerability in B-cell lymphoma," said Nathan Fowler, MD, Chief Medical Officer at BostonGene. "We are pleased to support Weill Cornell Medicine in their research efforts to find optimal therapeutic treatments for patients with DLBCL."