SCYNEXIS Reports the Exercise of Warrants Totalling $7.9 Million

On December 3, 2021 SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology company pioneering innovative medicines to overcome and prevent difficult-to-treat and drug-resistant infections, reported the exercise of warrants to purchase 1.2 million shares of SCYNEXIS common stock by Federated Hermes Kaufmann Small Cap Fund and Dafna Lifescience LP for which SCYNEXIS accepted a reduced exercise price (Press release, Scynexis, DEC 3, 2021, View Source [SID1234596435]). Proceeds to SCYNEXIS are approximately $7.9 million. The exercised warrants were issued in SCYNEXIS’s December 2019 financing. The remaining warrants issued in the December 2019 financing covering approximately 3.2 million shares of common stock expired unexercised on December 2, 2021.

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"We believe the exercise of warrants by two of our largest stockholders provides a significant sign of confidence in the future of SCYNEXIS, after a year that included the approval and launch of our first U.S. commercial product and continued progress in our clinical development programs to treat serious fungal infections in the hospital setting," said Marco Taglietti, M.D., President and Chief Executive Officer of SCYNEXIS. "This additional cash influx strengthens our balance sheet and supports our important mission."

Lupin and Biomm Enter into a Distribution and Marketing Agreement for Pegfilgrastim in Brazil

On December 3, 2021 Global pharma major, Lupin Limited (Lupin) reported that they have entered into an exclusive distribution and marketing agreement with Biomm SA in Brazil (Press release, Lupin, DEC 3, 2021, View Source [SID1234596434]). Under the terms of agreement, Biomm will distribute and market biosimilar Pegfilgrastim in Brazil.

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Lupin had earlier received the U.S. FDA acceptance of the Biologics License Application (BLA) for its proposed biosimilar to Neulasta (pegfilgrastim) through a filing using the 351(k) pathway.

Pegfilgrastim is indicated to reduce the duration of neutropenia and the incidence of febrile neutropenia in patients receiving chemotherapy.

Aqilion strengthens the company’s pipeline through the acquisition of a phase-1 ready anti-inflammatory program from LEO Pharma

On December 3, 2021 AQILION AB (publ) reported that it has strengthened its pipeline with an innovative development program in the field of chronic inflammation (Press release, Aqilion, DEC 3, 2021, View Source [SID1234596433]). With this acquisition, Aqilion is taking over all rights to the program, now under the name Regulus, from LEO Pharma. The project is ready for clinical trials and Aqilion plans to begin clinical development in 2022.

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Aqilion has acquired all rights to Regulus from LEO Pharma, who developed the project from early internal discovery research. Under the terms of the agreement, Aqilion will make an upfront payment that is a combination of cash and equity and LEO Pharma will become a shareholder of Aqilion. Furthermore, Aqilion will make additional payments from either product sales or through out-licensing revenues.

Regulus is a novel next-generation selective JAK1 inhibitor previously developed as LEO 142397, now AQ280. Drugs with a similar mechanism of action have shown clinical efficacy in autoimmune and inflammatory diseases. Aqilion will initially investigate AQ280 as a potential therapy for eosinophilic esophagitis (EoE), an inflammatory disease of the esophagus. To date, no drugs with the same mechanism of action have been developed for EoE and there is a high unmet medical need. Aqilion will conduct the Regulus project in-house with the aim of starting a Phase 1 safety study in healthy volunteers in 2022, followed by a Phase 2a study in patients.

"It is both gratifying and inspiring for us at Aqilion to be able to expand our chronic inflammation pipeline with such an innovative, high quality and exciting program as Regulus. Expanding our pipeline with a project in early clinical development has been a priority and we now look forward to advancing Regulus, while benefiting from synergies with our pipeline of preclinical projects," says Sarah Fredriksson, CEO of Aqilion.

"We are always excited to see our R&D operations bring forward new compounds that has the potential to help patients in any indication. In this case EoE where Aqilion is the right partner to pursue the potential of LEO 142397 – now Regulus. LEO Pharma will continue our dedication to bringing forward new innovative treatments that are either first or best in class and changing the standards of care within medical dermatology," says Thorsten Thormann, VP Research and Early Development in LEO Pharma.

About eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a rare chronic disease involving inflammation of the esophageal mucosa; its main symptom is swallowing difficulties. EoE is a relatively new diagnosis that is increasing in incidence. The disease, which has a progressive course, is also known as "allergic esophagitis" and is thought to be triggered by food allergens. Both children and adults can be affected and the diagnosis is most common in children in their teens and in adults aged 30-50. The condition is more common in men.

Chemomab Therapeutics Names David M. Weiner, MD as Interim Chief Medical Officer

On December 3, 2021 Chemomab Therapeutics Ltd. (NASDAQ: CMMB), (Chemomab) a clinical-stage biotech company focused on the discovery and development of innovative therapeutics for fibrotic and inflammatory diseases with high unmet need, reported that David M. Weiner, MD has been named Interim Chief Medical Officer, effective immediately (Press release, Chemomab, DEC 3, 2021, View Source,-MD-as-Interim-Chief-Medical-Officer [SID1234596432]). This position will be in a part-time capacity. Dr. Weiner is replacing Dr. Arnon Aharon, who has resigned. Dr. Aharon intends to continue at Chemomab for the next 60 days and as a senior medical advisor thereafter to ensure a seamless transition.

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Dr. Weiner, who is based in the U.S., has more than 25 years of experience in the discovery and clinical development of novel therapeutics and has held senior executive roles at private and public biotechnology companies.

"We believe that Dr. Weiner is a terrific addition to the Chemomab team, bringing us decades of successful industry experience in managing clinical programs in a variety of therapeutic areas," said Dale Pfost, PhD, Chief Executive Officer of Chemomab. "His keen intellect and broad expertise should serve us well as we advance our current clinical programs for CM-101, establish a growing clinical and business presence in the U.S. and potentially expand our drug development activities to include additional therapeutic indications and assets."

Dr. Pfost continued, "We want to thank Dr. Aharon for his many contributions to Chemomab. He has done an excellent job of creating the foundation for our current clinical development efforts and in progressing three discrete clinical programs to Phase 2 trials in a timely and effective way. We wish him well in his future endeavors."

Dr. Weiner most recently served as Chief Executive Officer of Amathus Therapeutics. Previously he was Chief Medical Officer at Lumos Pharma and at aTyr Pharma and, prior to that, he was the Chief Medical Officer and interim Chief Executive Officer of Proteostasis Therapeutics. Dr. Weiner held key development roles over a five-year period at EMD/Merck Serono and spent almost a decade serving in discovery research and clinical development roles of increasing responsibility at Acadia Pharmaceuticals.

"I have been impressed by the commitment to R&D excellence and substantial scientific accomplishments achieved to date by the Chemomab team," noted Dr. Weiner. "As a small startup they characterized and elucidated a completely novel target with promising potential in fibrotic and inflammatory diseases and then developed CM-101─a neutralizing antibody ‘pipeline in a product’ that is advancing in clinical trials for two rare diseases with high unmet need. I look forward to continuing to assess the potential of CM-101, while also working with the executive team as we seek to broaden our R&D activities to potentially include additional indications and clinical candidates."

Dr. Weiner received a BA degree cum laude with highest honors in research from Brandeis University and an MD degree from the School of Medicine and Biomedical Sciences, State University of New York at Buffalo. He has been a director at a number of biotechnology companies and is currently on the Board of Directors of AxoSim. Dr. Weiner serves as a consultant and scientific and clinical advisory board member to a diverse group of biotechnology companies and foundations.

Immuno-oncology: Servier and Aqemia cooperate on AI and quantum physics-driven drug discovery

On December 3, 2021 Servier and the pharmatech Aqemia reported that they have entered into a collaboration agreement to accelerate the discovery of small molecule therapeutic drug candidates in immuno-oncology (Press release, Servier, DEC 3, 2021, View Source;utm_medium=rss&utm_campaign=immuno-oncologie-servier-et-aqemia-cooperent-pour-la-decouverte-de-medicaments-a-laide-de-lia [SID1234596431]).

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This collaboration will use Aqemia’s technology based on artificial intelligence and quantum physics. Aqemia will take responsibility for the AI-based design to deliver optimized molecules that fulfill several small molecule design goals. Unlike most AI-based technologies that need experimental data to train their algorithms prior to starting the design, Aqemia will tackle the project from the earliest stage of the drug discovery by generating its own data with quantum and statistical physics-based calculations.

Olivier Nosjean, Head of Open Innovation and Scientific Affairs at Servier R&D: "This collaboration with Aqemia is a concrete example of Servier working side by side with a start-up to create value for both parties, working jointly to accelerate therapeutic innovation for patients. This collaboration is the result of the Start-up @ Servier program, where an initial phase of joint work allows us to carry out a key study or pilot application of a technology, before entering into a classic collaboration. This is our first application of this Start-up @ Servier model, and we are very happy to see it take shape with Aqemia, which is such a promising collaboration."