Corvus Pharmaceuticals Announces Participation in Upcoming Investor Conferences

On September 7, 2021 Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, reported that the Company’s management will participate in two upcoming investor conferences in September (Press release, Corvus Pharmaceuticals, SEP 7, 2021, View Source [SID1234587295]):

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The first conference is the H.C. Wainwright Annual Global Investment Conference, which is taking place September 13-15, 2021. The Company will conduct one-on-one meetings with investors at this conference and a pre-recorded corporate overview presentation by Richard A. Miller, M.D., president and chief executive officer of Corvus, will be available to play on-demand starting at 7:00 am ET on September 13. Attendees can register to view the webcast here.

The second conference is the Cantor Virtual Global Healthcare Conference, which is taking place September 27-30, 2021. The Company will conduct one-on-one meetings with investors at this conference and a virtual corporate overview presentation will be conducted by Dr. Miller at 3:20-3:50 pm ET on September 29. Attendees can register for the virtual presentation here.
Attendees can also access the webcast of the presentations noted above via the investor relations section of the Corvus website and replays will be available for 90 days following the events.

Alpine Immune Sciences Announces Participation in September Investor Conferences

On September 7, 2021 Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune/inflammatory diseases, reported that members of its management team will present at the following investor conferences in September 2021 (Press release, Alpine Immune Sciences, SEP 7, 2021, View Source [SID1234587294]):

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H.C. Wainwright 23rd Annual Global Investment Conference
Date: Monday, September 13, 2021
Time: Available on demand beginning 7:00 a.m. ET/4:00 a.m. PT
Event: Company Presentation

Oppenheimer Fall Healthcare Summit
Date: Monday, September 20, 2021
Time: 2:55 p.m. ET/11:55 a.m. PT
Event: Fireside Chat

Cantor Global Healthcare Conference
Date: Wednesday, September 29, 2021
Time: 2:00 p.m. ET/11:00 a.m. PT
Event: Company Presentation

Webcasts of the H.C. Wainwright, Oppenheimer, and Cantor presentations will be available online in the investor relations section of the company’s website at View Source A replay of the presentations will be available on the company website for 90 days following the webcast.

Seven and Eight Biopharmaceuticals Inc. Announces the First Patient Treated in a Phase 2 Clinical Trial of the TLR 7/8 dual agonist BDB001 in anti-PD-1 / anti-PD-L1 Refractory Solid Tumors

On September 7, 2021 Seven and Eight Biopharmaceuticals Inc., a clinical stage biotechnology company focused on developing proprietary novel immuno-oncology therapies to activate the immune system against cancer, reported that the first patient has been treated in a Phase 2 clinical trial evaluating BDB001 in advanced solid tumors at The University of Texas MD Anderson Cancer Center in Houston, TX (Press release, Seven and Eight Biopharmaceuticals, SEP 7, 2021, View Source [SID1234587293]).

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BDB001 is an intravenously administered Toll-Like Receptor 7 and 8 (TLR 7/8) dual agonist specifically designed to enhance immune activation against cancer. BDB001 has shown to be well tolerated as monotherapy and in combination with an anti-PD-1 mAb, with responses seen in multiple advanced solid tumor types (SITC, 20201; ASCO (Free ASCO Whitepaper), 20212).

BDB001-201 (NCT04819373) is an open-label, multi-arm Phase 2 clinical trial evaluating the efficacy, safety and tolerability of BDB001 in patients with advanced solid tumors that have progressed on anti-PD-1 or anti-PD-L1 mAb treatment.

"There is significant unmet need for effective treatment options for patients with anti-PD-1 / anti-PD-L1 refractory tumors," said Dr. Robert H.I. Andtbacka, Chief Medical Officer, Seven and Eight Biopharma. "In our BDB001 Phase 1 clinical trial there was evidence of response in these tumors. We are excited to further explore the role of BDB001 in anti-PD-1 / anti-PD-L1 refractory tumors in a Phase 2 setting."

"As an intravenously administered TLR 7/8 agonist, BDB001 has the potential to become a cornerstone of cancer immunotherapy. This Phase 2 program is an important milestone in our mission at Seven and Eight Biopharma, to develop novel treatments for cancer that expand immuno-oncology beyond PD-1, PD-L1, and CTLA-4." said Dr. Walter Lau, Chief Executive Officer, Seven and Eight Biopharma.

Other Events

On September 7, 2021 Provectus Biopharmaceuticals, Inc. (the "Company") reported to disclose the composition of its fully diluted shares of common stock, par value $.001 per share ("Common Stock"), outstanding as of the date hereof in comparison to its fully diluted shares of Common Stock outstanding in 2017 (Press release, 8-K, Provectus Biopharmaceuticals, SEP 7, 2021, View Source [SID1234587292]). The number of authorized shares of preferred stock and Common Stock of the Company are 25,000,000 and 1,000,000,000, respectively.

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2017 Fully Diluted Shares of Common Stock Outstanding

The Company reported on its Form 10-K for the calendar year ending December 31, 2016, filed with the U.S. Securities and Exchange Commission (the "SEC") on March 31, 2017, that certain equity securities were outstanding:

●364,773,297 shares of Common Stock, as of March 10, 2017,
●48,938,841 privately-held warrants to purchase Common Stock with exercise prices ranging from $0.85 to $3.00 ("Private Warrants"). These warrants were issued by the Company in conjunction with historical private placements and to Company consultants and advisors,
●28,482,344 publicly-traded warrants to purchase Common Stock with an exercise price of $0.85 ("Listed Warrants"). These warrants were issued by the Company in conjunction with a public offering that closed on June 24, 2015, and a registered exchange offer that expired on March 28, 2016,
●8,600 shares of the Company’s Series B Convertible Preferred Stock, par value $.001 per share ("Series B Preferred Stock"), and 112,570,356 warrants to purchase Common Stock with an exercise price of $0.0533 ("Ratchet Warrants"), both issued by the Company in conjunction with a public offering of equity securities that closed on August 30, 2016, and
●3,500,000 options to purchase Common Stock with strike prices ranging from $0.67 to $1.50 ("Stock Options"), issued by the Company-to-Company employees.

The warrants, options, and preferred stock described above were approved by the then-board of directors of the Company. The Company’s fully diluted shares of Common Stock outstanding in 2017 was 563,911,848 on an as converted basis.

2021 Fully Diluted Shares of Common Stock Outstanding

All Private Warrants attributed to historical private placements expired by October 31, 2020. All Listed Warrants expired on June 23, 2020.

The Company reported on its Form 10-K for the calendar year ending December 31, 2020, filed with the SEC on March 2, 2021, that certain equity securities were outstanding:

● 403,557,037 shares of Common Stock, as of February 28, 2021,
● 487,500 privately-held warrants with exercise prices ranging from $0.29 to $2.00,
● 100 shares of Series B Preferred Stock and 86,776,664 Ratchet Warrants, and
● 4,800,000 Stock Options with strike prices ranging from $0.12 to $1.04, issued to Company employees and consultants.

On June 20, 2021, all outstanding convertible promissory notes, totaling $30,560,080 of principal and accrued interest, issued as part of the Company’s 2017 and 2020 Financings and described in the Company’s Form 10-Q for the period ending March 31, 2017, filed on May 10, 2017 with the SEC, and in the Company’s Form 8-K, filed with the SEC on January 7, 2020, respectively, automatically converted into 12,373,247 shares of Series D Convertible Preferred Stock, par value $.001 per share (the "Series D Preferred Stock"), and 9,440,594 shares of Series D-1 Convertible Preferred Stock, par value $.001 per share (the "Series D-1 Preferred Stock"), which collectively are convertible into a total of 106,779,187 shares of Common Stock. For a description of the Series D Preferred Stock and Series D-1 Preferred Stock, see the Company’s Form 10-Q for the period ending June 30, 2021, filed with the SEC on August 12, 2021.

All remaining Series B Preferred Stock was converted into Common Stock on August 25, 2021. All Ratchet Warrants were exercised or expired by August 30, 2021; 13,352,966 were exercised between January 1 and August 30, 2021, and 68,723,698 expired on August 30, 2021.

The Company’s fully diluted shares of Common Stock outstanding as of September 7, 2021 is 528,667,356 on an as converted basis, which consists of 416,575,669 shares of Common Stock outstanding, 512,500 shares of Common Stock issuable upon exercise of warrants, 4,800,000 shares of Common Stock issuable upon exercise of options, and 106,779,187 shares of Common Stock issuable upon conversion of the Series D Preferred Stock and Series D-1 Preferred Stock.

Innate Pharma Announces Conference Call and Webcast for First Half 2021 Business Update

On September 7, 2021 Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) ("Innate" or the "Company"), reported that the Company will hold a conference call on Wednesday, September 15, 2021, at 2 p.m. CEST / 8 a.m. EDT, to give an update on business progress during the first half of 2021 (Press release, Innate Pharma, SEP 7, 2021, View Source [SID1234587291]).

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Participating in the call will be Innate’s Chief Executive Officer Mondher Mahjoubi, MD, Chief Medical Officer Joyson Karakunnel, MD, MSc, FACP, and Chief Financial Officer Frédéric Lombard, MBA.

Details for the Virtual Event

The live webcast will be available at the following link:

View Source

Participants may also join via telephone to ask questions by registering in advance of the event at View Source Upon registration, participants will be provided with dial-in numbers, a direct event passcode and a unique registrant ID that they may use 10 minutes prior to the event start to access the call. Call reminders will also be sent to registered participants via e-mail the day prior to the event.

This information can also be found on the Investors section of the Innate Pharma website, www.innate-pharma.com. A replay of the webcast will be available on the Company website for 90 days following the event.