On June 17, 2021 Seelos Therapeutics reported ACKNOWLEDGMENT AND TERMINATION AGREEMENT (this "Agreement") made and entered into as of June 14, 2021, by and between Seelos Therapeutics, Inc., a Nevada corporation (the "Company"), and Lind Global Asset Management II, LLC, a Delaware limited liability company ("Lind" and, together with the Company, the "Parties")(Press release, Apricus Biosciences, JUN 17, 2021, View Source [SID1234584103]).

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On June 17, 2021 Apollo Therapeutics, a unique collaboration between three leading universities (University College London, Imperial College and University of Cambridge) and three global pharmaceutical companies (AstraZeneca, GlaxoSmithKline and Johnson & Johnson) set up in 2016 has received £100m in investment to further develop and translate early-stage science into clinical development for patient benefit(Press release, UCLB, JUN 17, 2021, View Source [SID1234584101]).

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In order to translate research in the most time and capital efficient way possible, Apollo Therapeutics has been set up as a portfolio-based biopharmaceutical company and has completed a £100m Series A financing deal. The financing was led by Patient Square Capital, with participation from additional investors including UCL Technology Fund, Rock Springs Capital and Reimagined Ventures. Proceeds from the investment will support rapid advancement of the pipeline with over 15 therapeutic programs currently in development across oncology, major inflammatory disorders and rare disease. Apollo will continue to collaborate with UCL, University of Cambridge and Imperial College to source new projects for further development.

Apollo is grounded in research from UCL, Imperial College and University of Cambridge. The collaboration between the three universities and three pharmaceutical companies – AstraZeneca, GlaxoSmithKline and Johnson & Johnson is unique and is a capital efficient innovative way to ensure more research can be translated and commercialised at scale.

The three British universities are in the top 10 universities in the world and are at the forefront of developing basic and translational research including oncology, major inflammatory disorders and rare disease, that provides opportunities for drug discovery.

Apollo also secured its first out-licensing deal last summer from technology developed at UCL with Axovia, a company backed by Deerfield, another U.S. healthcare investment firm and with support from UCL Technology Fund.

On June 17, 2021 Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors, reported that the ONCOS-102 and durvalumab trial in patients with advanced peritoneal malignancies has completed enrollment in the colorectal cancer cohort(Press release, Targovax, JUN 17, 2021, View Source [SID1234584100]).

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This phase 1/2 trial investigates the safety, biologic and anti-tumor activity of ONCOS-102 in combination with Imfinzi (durvalumab, anti-PD-L1) in patients with advanced peritoneal malignancies who have failed prior standard chemotherapy and have histologically confirmed platinum-resistant or refractory epithelial ovarian or colorectal cancer.

In October 2020, the pre-defined disease control efficacy threshold in part 1 in the colorectal cancer cohort was met, and this expansion cohort was opened for recruitment of the part 2 patients. The clinical and immune activation data are expected to be available first half of 2022.

Dr. Magnus Jäderberg, Chief Medical Officer of Targovax, said: "We are very pleased to see that recruitment is completed into this trial. This population of metastatic CRC who have failed prior therapy with peritoneal metastases is a large patient group with no effective available treatment. We look forward to seeing the clinical and immune activation data from this novel combination of immunotherapies and hope that it can deliver benefit to the patients."

The trial is a collaboration between Targovax, AstraZeneca (LSE/STO/Nasdaq: AZN), Cancer Research Institute (CRI) and Ludwig Cancer Research.

On June 17, 2021 Synlogic, Inc. (Nasdaq: SYBX), a clinical stage company bringing the transformative potential of synthetic biology to medicine, reported that it has entered into a research collaboration agreement with Roche for the discovery of a novel Synthetic Biotic medicine for the treatment of inflammatory bowel disease (IBD)(Press release, Synlogic, JUN 17, 2021, View Source [SID1234584099]). Under the terms of the agreement, Synlogic and Roche will collaborate to develop a Synthetic Biotic medicine addressing an undisclosed novel target in IBD.

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"Our mission is to develop Synthetic Biotic medicines that benefit patients in meaningful ways," said David Hava, Ph.D., Synlogic’s Chief Scientific Officer. "We are excited to expand our efforts in inflammation, working to address the unmet needs of patients with inflammatory bowel disease."

"We are excited to work with Synlogic and explore the potential of a new modality for the treatment of IBD," said James Sabry, Global Head, Roche Pharma Partnering. "Synlogic and Roche share a commitment to advancing innovative science and delivering transformative medicines to patients living with inflammatory disease."

At the conclusion of the research period, Roche will have the exclusive option to enter a licensing and collaboration agreement for further development and commercialization of the program.

Learn more about Synlogic’s programs and pipeline by visiting View Source

On June 17, 2021 Redx Pharma plc (AIM: REDX),the drug discovery and development company focused on cancer and fibrosis, reported that a milestone payment from AstraZeneca (NASDAQ: AZN) has been triggered as a result of progress in the development of RXC006,a preclinical porcupine inhibitor, targeting fibrotic diseases including idiopathic pulmonary fibrosis (IPF)(Press release, Redx Pharma, JUN 17, 2021, View Source [SID1234584098]).

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The milestone payment of$4 million has been triggered under the terms of the out licensing agreement announced on4 August 2020 and forms part of the previously announced $17 million in early payments between deal signature and the successful commencement of the first clinical trial.

Under this agreement, in addition to the $17 million in early payments, Redx may receive up to a further$360 million in development and commercial milestone payments throughout the course of the programme. The Company is also eligible to receive tiered royalties of mid-single digit percentages, based on any future net sales.

Porcupine inhibition is a novel anti-fibrotic approach that suppresses Wnt ligand secretion from pro-fibrotic cells. Wnt ligands are known to be strong drivers of fibrotic mechanisms and are highly expressed in diseases such as IPF. Wnt ligands regulate multiple aspects of disease biology so porcupine inhibition presents a potentially powerful anti-fibrotic approach. AstraZeneca is taking RXC006 forward into clinical development, targeting fibrotic diseases including IPF and anticipates entering clinical development in 2021.

Redx continues to execute on its strategy, progressing its lead oncology and fibrosis programmes. These include the oral porcupine inhibitor, RXC004, targeting Wnt-driven tumours, which is in an ongoing Phase 1 clinical trial in oncology patients, and the oral ROCK2 inhibitor, RXC007, which targets fibrosis, where first in human studies commenced in June 2021.

Lisa Anson, Chief Executive Officer of Redx Pharma commented: "We are extremely pleased that AstraZeneca are progressing RXC006 and the successful achievement of this milestone payment highlights, once again, Redx’s ability to generate molecules that have significant potential as novel medicines for unmet medical needs. We look forward to AstraZeneca progressing RXC006 into clinical trials and potentially delivering to patients who need new treatment options.