On April 28, 2021 NuCana plc (NASDAQ: NCNA) reported that Hugh Griffith, Chief Executive Officer, and Don Munoz, Chief Financial Officer, will host one-on-one meetings at the 7th Annual Truist Securities Life Sciences Summit being held virtually from May 4 to May 5, 2021 (Press release, Nucana BioPharmaceuticals, APR 28, 2021, View Source [SID1234584206]).

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Event: 7th Annual Truist Securities Life Sciences Summit
Date: May 4 to May 5, 2021

On April 28, 2021 Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with cancer reported that it will host a conference call on May 12, 2021 at 4:30 PM Eastern Time to discuss results for its first quarter ended March 31, 2020 (Press release, Panbela Therapeutics, APR 28, 2021, View Source [SID1234583758]).

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Conference Call Information

About SBP-101

SBP-101 is a proprietary polyamine analogue designed to induce polyamine metabolic inhibition (PMI) by exploiting an observed high affinity of the compound for pancreatic ductal adenocarcinoma and other tumors. The molecule has shown signals of tumor growth inhibition in clinical studies of US and Australian metastatic pancreatic cancer patients, suggesting potential complementary activity with an existing FDA-approved standard chemotherapy regimen. In data evaluated from clinical studies to date, SBP-101 has not shown exacerbation of bone marrow suppression or peripheral neuropathy, which can be chemotherapy-related adverse events. Recently observed serious visual adverse events are being evaluated and patients with a history of retinopathy or at risk of retinal detachment are excluded from SBP-101 studies. The safety data and PMI profile observed in the current Panbela sponsored clinical trial generally provides support for continued evaluation of SBP-101 in a randomized clinical trial. For more information, please visit View Source .

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On April 28, 2021 Race Oncology Limited ("Race") reported that it has entered into a collaborative preclinical research program with The University of Newcastle to investigate the heart safety Bisantrene offers over current anthracycline therapeutics (Press release, Race Oncology, APR 28, 2021, View Source [SID1234579463]). Eminent cardiotoxicity researchers, Associate Professors Aaron Sverdlov and Doan Ngo of the University of Newcastle, will lead the project.

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While Bisantrene’s heart safety has been demonstrated in more than 40 clinical trials, exactly how it avoids causing cardiotoxicity is unknown. Advances in molecular biology since the 1980s now allow the underlying mechanism of action to be determined. The aim of this project is to explore Bisantrene’s low cardiotoxicity at the molecular level. Bisantrene has recently been identified as a targeted inhibitor of the Fatso/Fat mass and obesity-associated protein (FTO)1. The possible role of FTO inhibition in Bisantrene’s lack of cardiotoxicity will be a primary focus of this research project.

Pillar 2 of Race’s Three Pillar strategy (ASX Announcement: 30 Nov 2020) is focused on the potential for Bisantrene to act as an anthracycline replacement, which are commonly used in the treatment of breast cancer. Anthracyclines are a class of chemotherapeutics known to be effective, but also cardiotoxic. The results of this study will support Phase IIb human trials of a Bisantrene in anthracycline naïve breast cancer patients. These trials are currently being explored for feasibility in Europe, with a potential for initiation in 2022.

"This is an exciting development for Race and we are looking forward to collaborating with Assistant Professors Sverdlov and Ngo on this important project. Understanding how Bisantrene works at a molecular level to avoid damage to the heart will aid all our clinical plans."

Chief Scientific Officer, Dr Daniel Tillett
This preclinical study is to start immediately with result to be reported over the coming 12 months.

About Associate Professors Aaron Sverdlov and Doan Ngo
Associate Professors Sverdlov and Ngo lead the dedicated Australian-first, bench-to- bedside "Cancer and the Heart" clinical and research program at University of Newcastle, Hunter Medical Research Institute, Hunter New England Local Health District and Calvary Mater Newcastle Hospitals. This program incorporates basic mechanistic discovery studies looking at mechanisms of cardiotoxicity, drug discovery studies, translational human research, clinical research and clinical inpatient and outpatient service delivery.

In recognition of this important initiative, A/Prof Aaron Sverdlov was awarded the 2018 Ministerial Award for Rising Stars in Cardiovascular Research. A/Prof Doan Ngo, a co- lead of the program was awarded NSW Health EMC Fellowship in Cardio-Oncology (2018-2021) and the highly prestigious National Heart Foundation Future Leader Fellowship (2021-2025) for the cardio-oncology program of work.

Both A/Profs Aaron Sverdlov and Doan Ngo have been invited to establish and co-chair the National Cardio-Oncology Working Group under the auspices of the Australian Cardiovascular Alliance (ACvA). The aim of the group is to coordinate clinical and research activities in the field of Cardio-Oncology in Australia and act as a scientific and advocacy body to improve the quality of cardiovascular care for our cancer patients.

Associate Professor Sverdlov has over 50 peer-reviewed publications and 4 book chapters (including chapters on Oxidative Stress in Heart Failure in the textbook "Heart Failure: A Companion to Braunwald’s Heart Disease") with over 1100 citations and has had more than 80 presentations at international and national meetings. He received over 30 competitive grants, with >20 in the last 5 years (total >$2.5M AUD).

Associate Professor Ngo is an academic pharmacist and a successful basic and translational scientist with multiple important contributions in the cardiovascular and metabolic field. She has more than 55 publications, of which more than 40 were published in the last 5 years

On April 28, 2021 OmniSeq, an innovator in next generation sequencing in oncology, reported the New York State Department of Health’s Clinical Laboratory Evaluation Program has approved the OmniSeq INSIGHTSM test (Press release, OmniSeq, APR 28, 2021, View Source,the%20OmniSeq%20INSIGHTSM%20test.&text=OmniSeq%20INSIGHT%20is%20a%20tissue%2Dbased%2C%20next%20generation%20sequencing%20test. [SID1234579250]). The test detects genomic variants, genomic signatures, and immune gene expression, providing physicians with clinically actionable evidence to inform therapeutic treatment decisions and identify potential clinical trial options for patients with late-stage solid tumor cancers.

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The test will be commercially available to U.S.-based clinicians exclusively through Labcorp and globally to biopharmaceutical companies through Labcorp Drug Development. Throughout Canada, the test will be available through Dynacare, a Labcorp company.

"The launch of OmniSeq INSIGHT represents the continued evolution of our commitment to innovation and to the delivery of the most advanced, comprehensive solid tumor profiling assay," said Margot Schoenborn, Chief Executive Officer, OmniSeq. "It is designed to detect and characterize the genomic and immune features of patients’ cancer tumors to quickly guide more precise, individualized treatment decisions for patients to ensure they receive the best personalized medicine options available."

OmniSeq INSIGHT is a tissue-based, next generation sequencing test. It has been clinically and analytically validated for all solid tumors, interrogating gene alterations that are targets identified for therapy. Completely unique to the test is the integration of immune expression profiling, which detects genes involved in the anti-cancer immune response and tumor-immune mechanisms including low-expressing genes involved in inflammatory signaling. The combined profiling of molecular and immune genes delivers an unparalleled and powerful new tool to help physicians more effectively select personalized therapies and immunotherapies, as well as match patients to clinical trials based on multi-immune marker analyses.

OmniSeq INSIGHT delivers the distinct advantage of leveraging three technologies to better inform physicians in selecting the most appropriate therapies or clinical trials for their patients. DNA sequencing is used to detect base substitutions, insertions, deletions, copy number alterations, tumor mutational burden and microsatellite instability. RNA sequencing is employed for detection of known and novel gene arrangements in order to maximize detection of fusion events and gene expression profiling; this also provides differentiating insight into critical tumor-immune interactions. Additionally, PD-L1 expression is measured by immunohistochemistry using FDA-approved assays based on the tumor type tested.

OmniSeq INSIGHT can be used in both diagnostic and drug development settings. It is actively integrated into numerous drug development programs and can be configured as an effective discovery tool, screening tool or clinical trial assay and can drive companion diagnostics development and commercialization initiatives. OmniSeq INSIGHT is offered to global biopharmaceutical customers directly and through Labcorp Drug Development, which collectively have an extensive track record in validating assays across key regulatory standards, including CLIA, CLEP, CE-IVD and FDA under an ISO 13485 quality management system for medical devices.