On April 28, 2021 iCo Therapeutics Inc. ("iCo" or the "Company") (TSXV: iCo) (OTCQB: iCoTF) reported that it has closed its previously announced private placement (the "Financing") in connection with its proposed business combination with Satellos Bioscience Inc. ("Satellos") by way of a plan of arrangement (the "Arrangement") in accordance with Section 192 of the Canada Business Corporations Act (Press release, iCo Therapeutics, APR 28, 2021, View Source [SID1234578569]). The completion of the Arrangement will result in the reverse takeover of the Company as defined in the policies of the TSX Venture Exchange ("TSXV") and the resulting entity will continue to operate in the life sciences industry under the name "Satellos Bioscience Inc." (the "Resulting Issuer").

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Pursuant to the Financing, the Company issued 85,294,117 subscription receipts (the "Subscription Receipts") at a price of $0.085 per Subscription Receipt for aggregate gross proceeds of approximately C$7.25 million. Each Subscription Receipt will entitle the holder thereof to receive, upon satisfaction of certain escrow release conditions, including without limitation, the completion of the Arrangement, and without payment of additional consideration, one common share of the Resulting Issuer (a "Resulting Issuer Share"). The proceeds from the Financing have been placed in escrow and, upon satisfaction of the escrow release conditions, will be used for research, development, and general corporate expenses of the Resulting Issuer.

The Resulting Issuer Shares issued in connection with the Financing will be subject to a hold period expiring 4 months and one day from the date of issuance in accordance with applicable Canadian securities laws. Additionally, in connection with the Financing, certain Resulting Issuer Shares issued to former shareholders of Satellos pursuant to the Arrangement will be subject to a lock-up agreement.

The Financing was led by Bloom Burton Securities Inc. and includes Richardson Wealth Ltd.

On April 27, 2021 CellCentric reported that P300/CBP is an emerging target offering a new path to treat specific cancers (Press release, CellCentric, APR 27, 2021, View Source [SID1234584831]). CCS1477, developed by CellCentric, is a small molecule inhibitor of the twin regulator proteins, and formulated as an oral capsule. CCS1477, a first-in-class compound is in parallel strands of clinical trials to treat endocrine resistant prostate cancer, haematological malignancies and targeted tumours (with particular mutations or molecular drivers). These are all significant clinical unmet needs. Following Phase 1b dose escalation and schedule setting conducted at 16 centres in the UK, CellCentric’s clinical programme is expanding into the US, with the FDA opening an IND for CCS1477 for solid tumours.
CCS1477 is novel drug to treat specific cancers. It is a highly specific inhibitor of the common bromodomain of twin acetyltransferases and gene co-activators p300 and CBP. The compound and target pathway was presented at AACR (Free AACR Whitepaper) 2019 as a New Drug on the Horizon, and a summary of pre-clinical and translational data published in Cancer Discovery in January 2021:

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Inhibiting p300/CBP impacts the transcription of Myc, a well characterised driver of cancer tumours. It also down regulates both the androgen receptor and its variants, known to be important in the progression of late stage, drug resistant, prostate cancer. P300/CBP inhibition also impacts IRF4, which is important in certain haematological malignancies. CellCentric has initiated clinical trials evaluating CCS1477 as a monotherapy, and in combination with standard of care agents. For prostate cancer, this includes abiraterone and enzalutamide. For haematological malignancies, this will include pomalidomide and azacytidine.

Clinical trials of CCS1477 were initiated originally at The Royal Marsden NHS Foundation Trust, London and The Christie NHS Foundation Trust, Manchester. 16 centres are now active in the UK. The expansion to the US builds on the continued progress that was made despite the challenges of the Covid pandemic, with dose and schedules being finalised across different indications. CellCentric has collaborated with multiple research and clinical centres in the US, including Thomas Jefferson University/Sidney Kimmel Cancer Centre, Philadelphia; Columbia University, New York; and The Mayo Clinic, Phoenix.

CEO, Dr Will West, commented ‘Running clinical trials over the last year has obviously not been easy. The team has done an incredible job in building capacity and delivery over the last 12 months. Expanding now into the US is a key step, building on the strong operational platform already created.’

On April 27, 2021 Concert Pharmaceuticals, Inc. (NASDAQ: CNCE) reported that it will report its financial results for the first quarter of 2021, on Tuesday, May 4, 2021, before the U.S. financial markets open (Press release, Concert Pharmaceuticals, APR 27, 2021, View Source [SID1234584683]). The Company will host a conference call and webcast at 8:30 a.m. ET to discuss its first quarter 2021 financial results and provide a business update. Individuals interested in participating in the call should dial (855) 354-1855 (U.S. and Canada) or (484) 365-2865 (International).

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A live webcast of the conference call may be accessed in the Investors section of the Company’s website at www.concertpharma.com. Please log on to the Concert website approximately 15 minutes prior to the scheduled webcast to ensure adequate time for any software downloads that may be required. A replay of the webcast will be available on Concert’s website for three months.

On April 27, 2021 Instil Bio, Inc. ("Instil") (Nasdaq: TIL) reported that it received orphan drug designation (ODD) from the U.S. Food and Drug Administration (FDA) for the treatment of melanoma stages IIB to IV with its ITIL-168 TIL therapy (Press release, Instil Bio, APR 27, 2021, View Source [SID1234583993]).

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"The Orphan Drug Designation incentivizes biotech companies to develop new therapies that are important for patients. We are pleased to advance development of ITIL-168 for the treatment of melanoma stages IIB to IV with this designation," said Bronson Crouch, Chief Executive Officer of Instil.
Orphan Drug Designation confers potential benefits to sponsors, including tax credits for qualified clinical testing, waiver of BLA user fees, and eligibility of market exclusivity for 7 years upon marketing approval.

About ITIL-168

ITIL-168 is an investigational, autologous cell therapy made from tumor infiltrating lymphocytes, or TILs. ITIL-168 is manufactured with Instil’s proprietary, optimized, and scalable manufacturing process, which has been designed to capture and preserve the maximum diversity of each patient’s TILs; the manufacturing process also offers significant scheduling flexibility for patients and physicians at the time of both tumor resection and TIL treatment. Instil plans to investigate ITIL-168 in a global phase 2 trial in advanced melanoma in 2021 and additional solid tumor indications in Phase 1 clinical trials beginning in 2022.

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