Corporate Presentation

On April 12, 2021 Pieris Pharmaceuticals Presented the Corporate Presentation (Presentation, Pieris Pharmaceuticals, APR 12, 2021, View Source [SID1234577901]).

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Y-mAbs Announces GPA33-SADA Data Presented at AACR

On April 12, 2021 Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, reported that Dr. Sebastian Chung from Memorial Sloan Kettering Cancer Center ("MSK") presented a virtual poster discussing the SADA technology platform for pre-targeted radioimmunotherapy against GPA33 in a xenograft model of colorectal peritoneal carcinomatosis at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) ("AACR") Annual Meeting on April 10, 2021 (Press release, Y-mAbs Therapeutics, APR 12, 2021, View Source [SID1234577900]).

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The SADA technology utilizes a pre-targeted payload delivery method where antibody constructs assemble in tetramers and bind to the tumor target. Unbound constructs predictably disassemble into smaller antibody fragments and are excreted through the kidneys within hours after administration. In a second infusion, a radioactive payload binds to the antibody constructs to radiate the tumor. Y-mAbs expects to submit its first IND for a SADA construct targeting GD2 in the fourth quarter of 2021.

The GPA33-SADA construct was created using the SADA technology, which was licensed by the Company from MSK and Massachusetts Institute of Technology ("MIT") in April 2020. In a xenograft model of colorectal peritoneal carcinomatosis, GPA33-SADA showed a favorable tumor to blood ratio radioactivity uptake of 122 measured 24 hours after injection. GPA33 is expressed on 95% of all colorectal cancers. An IND for the GPA33-SADA is targeted for next year.

Researchers at MSK developed GPA33-SADA, which is exclusively licensed by MSK and MIT to Y-mAbs. As a result of this licensing arrangement, both MSK and MIT have institutional financial interests related to the compound and Y-mAbs.

Aptus Clinical announces the first patient has been dosed in the Artelo Biosciences’ CAReS Phase 1b/2a study in cancer anorexia

On April 12, 2021 Aptus Clinical, as the full service CRO provider for the Phase 1b/2a Cancer Appetite Recovery Study (CAReS), reported that it has assisted Artelo Biosciences in the planning and running of this important study which investigates the potential for ART27.13 (a peripherally synthetic cannabinoid agonist), to alleviate anorexia associated with cancer, a condition with significant unmet need and no licensed treatments (Press release, Aptus Clinical, APR 12, 2021, View Source [SID1234577899]).

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Steve McConchie, CEO at Aptus Clinical said ‘The CAReS study is an important investigation in cancer anorexia, and we are delighted that the partnership we have developed with Artelo has achieved the important milestone of first patient recruited and dosed. We are excited to be working with Artelo in assessing whether ART27.13 can make a difference to patients who are suffering from this distressing condition and improve their quality of life.

Gregory D. Gorgas, President and CEO of Artelo Biosciences commented "Artelo are excited to be starting the CAReS trial investigating ART27.13 in patients who currently have no licensed options to alleviate the devastating condition of cancer-associated anorexia. ART27.13 has already demonstrated significant weight gain potential in patients with chronic back pain who were otherwise healthy, and we look forward to seeing the results when translated into anorexic cancer patients who have suffered significant weight loss."

Advaxis, Inc. Announces $20 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

On April 12, 2021 Advaxis, Inc. (Nasdaq: ADXS) (the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of immunotherapy products, reported it has entered into definitive agreements with two healthcare-focused, institutional investors for the purchase of (i) 17,577,400 shares of common stock , (ii) 7,671,937 pre-funded warrants (the "Pre-Funded Warrants") to purchase 7,671,937 shares of common stock and (iii) registered common share purchase warrants to purchase 11,244,135 shares of common stock (Press release, Advaxis, APR 12, 2021, View Source [SID1234577897]). The Company has also agreed to issue to the investors, in a concurrent private placement, unregistered common share purchase warrants to purchase 14,005,202 shares of the Company’s common stock. Each share of common stock and accompanying common share purchase warrant are being sold together at a combined offering price of $0.7921, and each Pre-funded Warrant and accompanying common warrant are being sold together at a combined offering price of $0.7911, pursuant to a registered direct offering, priced at-the-market under Nasdaq rules. The Pre-Funded Warrants are immediately exercisable, at an exercise price of $0.001, and may be exercised at any time until all of the Pre-Funded Warrants are exercised in full. The registered common share purchase warrants will have an exercise price of $0.70 per share, will be immediately exercisable, and will expire five (5) years from the date of issuance. The unregistered common share purchase warrants will have an exercise price of $0.70 per share, will be exercisable fourteen days after the Company increases its authorized share capital, and will expire five (5) years from their initial exercise date (collectively, the "Offering").

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The Company plans to use the net proceeds from the offering to fund its continued research and development initiatives in connection with expanding its product pipeline including, but not limited to, investment in its ADXS-HOT program and for general corporate purposes. The Company may also use a portion of the net proceeds to acquire or invest in other businesses, products and technologies.

A.G.P./Alliance Global Partners is acting as sole placement agent for the Offering.

The Offering is being made pursuant to an effective shelf registration statement on Form S-3 (File No. 333-226988) previously filed with the U.S. Securities and Exchange Commission (the "SEC"), and an additional registration statement on Form S-3 filed pursuant to Rule 462(b) under the Securities Act, which became effective upon filing on August 30, 2018. A prospectus supplement describing the terms of the proposed offering will be filed with the SEC and will be available on the SEC’s website located at www.sec.gov. Electronic copies of the prospectus supplement may be obtained, when available, from A.G.P./Alliance Global Partners, 590 Madison Avenue, 28th Floor, New York, NY 10022 or via telephone at 212-624-2060 or email: [email protected]. Before investing in this offering, interested parties should read in their entirety the prospectus supplement and the accompanying prospectus and the other documents that the Company has filed with the SEC that are incorporated by reference in such prospectus supplement and the accompanying prospectus, which provide more information about the Company and such offering. Copies of the Supplement, the Base Shelf Prospectus and the Registration Statement may also be obtained from A.G.P./Alliance Global Partners, 590 Madison Avenue, 28th Floor, New York, NY 10022 or via telephone at 212-624-2060 or email: [email protected].

No securities regulatory authority has either approved or disapproved of the contents of this press release. This press release is for information purposes only and shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Kineta Presents New Preclinical Data on its Lead VISTA Antagonist Antibody at the AACR Annual Meeting 2021

On April 12, 2021 Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, reported the presentation of new preclinical data on its VISTA antagonist antibody at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021 (Press release, Kineta, APR 12, 2021, View Source;utm_medium=rss&utm_campaign=kineta-presents-new-preclinical-data-on-its-lead-vista-antagonist-antibody-at-the-aacr-annual-meeting-2021 [SID1234577896]). Thierry Guillaudeux, PhD, Senior Vice President Immuno-oncology at Kineta, presented a poster detailing new preclinical data on the company’s lead anti-VISTA antibody.

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Key results with Kineta’s anti-VISTA lead antibody include the following:

Highly specific VISTA binding
Activates monocytes and this activation is NK cell dependent
Reverses MDSC suppression of T cells
Induces strong anti-tumor response as a single agent or in combo-therapies with anti-PD1 in different hard to treat tumor models
"Our lead anti-VISTA antibody has demonstrated exceptional preclinical performance which will enable Kineta to develop a differentiated immunotherapy with a new mechanism of action compared to the current T cell focus immunotherapies" said Shawn Iadonato, PhD, Chief Executive Officer at Kineta. "We are excited to advance IND enabling studies and enter the clinic in early 2022."

VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate antitumor immune function. Blocking VISTA activates an immune cell cascade that increases T cell effector functions to drive an efficient anti-tumor response. Preclinical studies have demonstrated single agent anti-VISTA activity but also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the efficacy of those checkpoint inhibitors.

Presentation Details:

Title: A fully human anti-vista antibody as a promising therapy against poorly immunogenic tumors
Session Type: E-Poster Session
Session Title: Immune Checkpoints
Poster Number: 1637
Presenter: Thierry Guillaudeux, PhD

Click on the link below to take you to the Kineta website where you can view the presentation:

VISTA Publications – Kineta VISTA Presentation at AACR (Free AACR Whitepaper)