On April 6, 2021 Leidos (NYSE: LDOS), a FORTUNE 500 science and technology leader, has scheduled a conference call for Tuesday, May 4, 2021, at 8 a.m. (ET) reported its first quarter financial results for the period ending April 2, 2021 (Press release, Leidos, APR 6, 2021, View Source [SID1234577605]). The company plans to issue its quarterly earnings press release before the conference call on May 4, 2021.

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The details for the earnings conference call follow:

Replay:

A telephone playback of the first quarter earnings conference call is scheduled to be available beginning at 11:30 a.m. (ET) on May 4, 2021, through 11:59 p.m. (ET) on May 11, 2021. The replay will be accessible by calling 877-660-6853 (International callers: +1-201-612-7415), and entering conference ID 13718327.

An archived version of the webcast will be available on the Leidos Investor Relations website at View Source

On April 6, 2021 Bio-Techne Corporation (NASDAQ: TECH) reported that management will host a conference call and webcast on Thursday, May 6, 2021, at 8:00 a.m. CDT to review third quarter 2021 financial results (Press release, Bio-Techne, APR 6, 2021, https://investors.bio-techne.com/news/detail/243/bio-techne-to-host-conference-call-on-may-6-2021-to-announce-third-quarter-2021-financial-results [SID1234577604]).

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Access to the discussion may be obtained as follows:

A recorded rebroadcast will be available for interested parties unable to participate in the live conference call by dialing 1-844-512-2921 or 1-412-317-6671 (for international callers) and referencing Conference ID 13718437.

The replay will be available from 11:00 a.m. CDT on Thursday, May 6, 2021 until 11:00 p.m. CDT on Sunday, June 6, 2021.

On April 6, 2021 ORPHELIA Pharma and Biocodex reported the execution of an exclusive distribution and marketing agreement for Kigabeq (vigabatrin) for most of the European Union territory, including France (Press release, ORPHELIA Pharma, APR 6, 2021, View Source [SID1234577603]).

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Kigabeq, the first pediatric form of vigabatrin developed by ORPHELIA Pharma, is notably indicated in the treatment of infantile spasms (West syndrome). Kigabeq is approved in Europe, where this medicine, intended exclusively for children, benefits from a centralized marketing authorization (Pediatric Use Marketing authorization, PUMA).

"We are very pleased to release this collaboration agreement with Biocodex", says Hugues BIENAYME, Founder and CEO of ORPHELIA Pharma, "With their long-standing experience in the field of pediatric epilepsy, Biocodex is certainly the best partner for Kigabeq distribution in Europe".

"With Kigabeq, the only pediatric presentation of vigabatrin, Biocodex is expanding its portfolio of drugs intended for rare and serious pathologies in children" adds Nicolas Coudurier, CEO of Biocodex, " Kigabeq and Diacomit (stiripentol, developed and marketed by Biocodex) are two drugs which address unmet medical needs for young patients affected by severe and resistant to treatment epilepsies".

"Our objective is to make Kigabeq available to all European clinicians, so that children affected by West syndrome can benefit." concludes Gilles ALBERICI, President of ORPHELIA Pharma, "Thanks to this agreement with Biocodex, Kigabeq will soon be prescribed in most of the European territory."

About Kigabeq

Kigabeq is the first pediatric formulation of vigabatrin, an essential anti-epileptic drug. Presented as soluble and scored tablets of 100 mg and 500 mg for oral or nasogastric administration, Kigabeq is notably indicated for the treatment of infantile spasms (West syndrome), an extremely serious epileptic encephalopathy of the infant. Kigabeq was developed exclusively for children and has been granted European Pediatric Marketing Authorization (PUMA).

About infantile spasms

West syndrome, or infantile spasms, is an extremely serious epileptic encephalopathy in infants that combines epileptic spasms, psychomotor deterioration and a hypsarrhythmic type electroencephalogram. It is a rare disease, with an estimated incidence of 5 per 10,000 births. It can occur in an infant with previously normal development or with a pre-existing delay; in all cases, infantile spasms severely hamper the psychomotor development. Pharmacological treatment should be started quickly to allow the spasms to stop and to improve the prognosis.

On April 6, 2021 Genmab reported the initiation of a share buy-back program to mitigate dilution from warrant exercises and to honor our commitments under our Restricted Stock Units program (Press release, Genmab, APR 6, 2021, View Source [SID1234577602]).

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The share buy-back program is expected to be completed no later than June 30, 2021 and comprises up to 200,000 shares.

The following transactions were executed under the program from March 29, 2021 to March 31, 2021:

Details of each transaction are included as an appendix to this announcement.

Following these transactions, Genmab holds 202,977 shares as treasury shares, corresponding to 0.31% of the total share capital and voting rights.

The share buy-back program is undertaken in accordance with Regulation (EU) No. 596/2014 (‘MAR’) and the Commission Delegated Regulation (EU) 2016/1052, also referred to as the "Safe Harbour Regulation." Further details on the terms of the share buy-back program can be found in our company announcement no. 11 dated February 23, 2021.

On April 6, 2021 Volastra Therapeutics, a biotechnology company developing novel therapies for the prevention and treatment of metastatic cancer, reported the extension of its original $12 million seed round to a total of $44 million (Press release, Volastra Therapeutics, APR 6, 2021, View Source [SID1234577601]). New investors Vida Ventures and Catalio Capital Management joined a syndicate that includes Polaris Partners, Droia Ventures, ARCH Venture Partners and Quark Venture.

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The funding supports the further build-out of Volastra’s technology platform, which exploits unique insights into chromosomal instability (CIN) to rapidly identify and validate novel targets to block metastasis. In the U.S. alone, more than 350,000 people a year are diagnosed with metastatic cancer. Less than a third respond to targeted or immuno-therapies, making metastasis one of the most pressing unsolved challenges in cancer.

"The support of our new and existing investors reflects the increasing interest around CIN as a core driver in cancer biology," said Charles Hugh-Jones, M.D., Volastra’s Chief Executive Officer. "This latest financing places us in a position of strength to advance our bold vision to change the treatment paradigm for patients with metastatic cancers."

"Our initial investment in Volastra reflected our excitement about the potential of this novel approach to address an unmet need in oncology," said Amy Schulman, Volastra Director and Managing Partner, Polaris. "With this seed extension, we are delighted to expand our syndicate with Vida Ventures and Catalio Capital Management, who share our commitment to identifying and funding innovation that has the potential to have a meaningful impact for patients."

Volastra’s scientific founders were the first to identify CIN as a key driver of metastatic cancer. The company is developing proprietary computational and experimental approaches to understand CIN biology and drive drug discovery. Among Volastra’s tools is a proprietary technology suite to bulk-measure and exploit vulnerabilities in chromosomally unstable cancer cells.

"Volastra’s approach is focused on defining and treating the biology of metastasis," said Lewis Cantley, Ph.D., Professor of Cancer Biology in Medicine and Meyer Director of the Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College. "In just over a year, the Volastra team has shepherded this science into the next stage of development, building technologies to identify CIN at scale and developing novel compounds to block metastasis. By leveraging these unique insights into CIN, we are one step closer to unlocking new therapeutic options for some of the toughest-to-treat solid tumors."

Volastra recently announced a partnership with Dewpoint Therapeutics to discover novel molecules capable of blocking immuno-suppressive signaling in CIN-high tumors. In addition, Volastra announced a collaboration with Microsoft to develop proprietary artificial intelligence algorithms to detect and predict metastatic potential in human tissue samples