On November 22, 2021 Infinity Pharmaceuticals, Inc. (NASDAQ: INFI), a clinical-stage biotechnology company developing eganelisib, a potentially first-in-class, oral, immuno-oncology macrophage reprogramming therapeutic which addresses a fundamental biologic mechanism of immune suppression in cancer, reported that Adelene Perkins, Chief Executive Officer, will present at the upcoming Piper Sandler 33rd Annual Virtual Healthcare Conference (Press release, Infinity Pharmaceuticals, NOV 22, 2021, View Source [SID1234595891]).

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The presentation will be a fireside chat with Ted Tenthoff, Piper’s Senior Biotech Analyst, which will be available on the Company’s website beginning November 22nd. Management will also be available for 1-on-1 meetings with investors during the conference which will take place November 29th through December 2nd.

Presentation details can be found below:

33rd Annual Virtual Healthcare Conference
Format: Presentation and 1-on-1 meetings
Date and Time: Presentation available starting Monday, November 22nd at 10:00am ET; 1-on-1 meetings November 29th – December 2nd
The presentations and archived webcasts can be accessed in the Investors/Media section of Infinity’s website at www.infi.com and will be available on Infinity’s website for 30 days following the event.

On November 22, 2021 Perrigo Company plc (NYSE; TASE: PRGO), a leading provider of Consumer Self-Care Products, reported that it is taking steps to voluntarily delist the Company’s ordinary shares from trading on the Tel Aviv Stock Exchange (TASE) (Press release, Perrigo Company, NOV 22, 2021, View Source [SID1234595890]). Perrigo is delisting its shares from the TASE after divesting its Israeli-based operations earlier this year. As such, Perrigo has requested that the TASE immediately initiate the process to delist the Company’s ordinary shares.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Under Israeli law, the delisting of Perrigo’s ordinary shares from the TASE is expected to become effective three months after the date of the Company’s request to the TASE to delist the Company’s ordinary shares, which occurred on November 22, 2021. Perrigo ordinary shares will continue to be listed on the New York Stock Exchange (NYSE), and all of its ordinary shares now traded on the TASE are expected to be transferred to the NYSE where they can continue to be traded.

Perrigo CEO and President Murray S. Kessler commented, "Perrigo has undergone a significant transformation over the past three years. Part of this transformation included the divestiture of our Israeli-based assets earlier this year and we believe now is the appropriate time to delist."

On November 22, 2021 CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, reported that the U.S. Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation to CTX110, its wholly-owned allogeneic CAR-T cell therapy targeting CD19+ B-cell malignancies (Press release, CRISPR Therapeutics, NOV 22, 2021, View Source [SID1234595889]).

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"This RMAT designation is based on the encouraging clinical data we have presented thus far, and it is an important milestone that recognizes the transformative potential of CTX110 for the treatment of hematological malignancies," said Samarth Kulkarni, Ph.D., Chief Executive Officer of CRISPR Therapeutics. "We look forward to working closely with the FDA as we continue our efforts to bring this important new therapeutic modality to patients."

Established under the 21st Century Cures Act, RMAT designation is a dedicated program designed to expedite the drug development and review processes for promising pipeline products, including genetic therapies. A regenerative medicine therapy is eligible for RMAT designation if it is intended to treat, modify, reverse or cure a serious or life-threatening disease or condition, and preliminary clinical evidence indicates that the drug or therapy has the potential to address unmet medical needs for such disease or condition. Similar to Breakthrough Therapy designation, RMAT designation provides the benefits of intensive FDA guidance on efficient drug development, including the ability for early interactions with FDA to discuss surrogate or intermediate endpoints, potential ways to support accelerated approval and satisfy post-approval requirements, potential priority review of the biologics license application (BLA) and other opportunities to expedite development and review.

About CTX110
CTX110, a wholly owned program of CRISPR Therapeutics, is a healthy donor-derived gene-edited allogeneic CAR-T investigational therapy targeting Cluster of Differentiation 19, or CD19. CTX110 is being investigated in the ongoing CARBON trial.

About CARBON
The ongoing Phase 1 single-arm, multi-center, open label clinical trial, CARBON, is designed to assess the safety and efficacy of several dose levels of CTX110 for the treatment of relapsed or refractory B-cell malignancies.

On November 22, 2021 Akoya Biosciences, Inc. (Nasdaq: AKYA) ("Akoya"), The Spatial Biology Company, reported that it will host an inaugural Spatial Day on December 15, 2021 at 12 p.m. ET. The program will feature Akoya speakers and experts at the forefront of this new field who will discuss how spatial biology is uniquely positioned to address challenges in discovery, translational and clinical research, where the field is headed, and Akoya’s vision for the future (Press release, Akoya Biosciences, NOV 22, 2021, View Source [SID1234595888]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Akoya is a pioneer in the rapidly emerging field of spatial phenotyping, a transformational new application that is giving unprecedented context to cell-cell interactions within tissue biology. Understanding spatial biomarker signatures within the framework of spatial phenotyping has the potential to unlock an explosion of new applications in medicine and research, such as the ability to segment patient populations based on immune interactions, development of spatial diagnostic assays, drug discovery, and design or identification of personalized therapeutic interventions. Biomarkers that predict response or resistance to drugs, based on understanding specific types and subtypes of immune cells and the ability to map their spatial distribution, are among the most advanced opportunities with spatial phenotyping.

The agenda and speakers are as follows:

Welcome & Introduction, Brian McKelligon, CEO, Akoya
Revolutionizing Our Understanding of Disease Biology, Kai Kessenbrock, PhD, Principal Investigator, Human Cell Atlas Initiative, University of California, Irvine, CA, and Robert Schreiber, PhD, Professor of Pathology, Washington University, St. Louis, MO
Q&A Roundtable, hosted by Niro Ramachandran, PhD, CBO, Akoya
Changing the Standard of Care Using Spatial Biomarkers, Carl Barrett, PhD, VP, Translational Medicine, AstraZeneca plc, and Kurt Schalper, MD, PhD, Professor of Pathology and Oncology, Yale University, New Haven, CT
Q&A Roundtable, hosted by Pascal Bamford, PhD, SVP, R&D, Akoya
The Future Direction of Akoya, Niro Ramachandran, PhD, CBO, Akoya
Closing remarks, Brian McKelligon, CEO, Akoya
Audience Q&A

On November 22, 2021 Keros Therapeutics, Inc. ("Keros") (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for patients suffering from hematological and musculoskeletal disorders with high unmet medical need, reported that Keros’ President and Chief Executive Officer Jasbir S. Seehra, Ph.D. will present at the Piper Sandler 33rd Annual Virtual Healthcare Conference (Press release, Keros Therapeutics, NOV 22, 2021, View Source [SID1234595887]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A recording of the fireside chat presentation will be available starting on Monday, November 22, 2021 at 10:00 a.m. ET., and will be archived in the Investors section of the Keros website at View Source A replay will be available for 90 days following the conclusion of the event.