On November 2, 2021 Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecule and combination medicines for people with cancer, reported that the company will report its financial results and a corporate update for the third quarter ended September 30, 2021 after the market closes on Monday, November 8, 2021 (Press release, Arcus Biosciences, NOV 2, 2021, View Source [SID1234594154]).

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On November 2, 2021 Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, reported that it will report its third quarter 2021 financial results on Monday, November 8, 2021 (Press release, Gossamer Bio, NOV 2, 2021, View Source [SID1234594153]).

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In connection with the earnings release, Gossamer’s management team will host a live conference call and webcast at 4:15 p.m. ET on Monday, November 8, 2021, to discuss the Company’s financial results and provide a corporate update.

A replay of the audio webcast will be available for 30 days on the Investors section of the Company’s website, www.gossamerbio.com.

On November 2, 2021 Scholar Rock (NASDAQ: SRRK), a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, reported that management will participate in the following upcoming investor conferences (Press release, Scholar Rock, NOV 2, 2021, View Source [SID1234594151]):

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Credit Suisse 30th Annual Virtual Healthcare Conference on Tuesday, November 9th, 2021 at 8:50 a.m. ET.
Cowen 5th Annual IO Next Virtual Summit on Monday, November 15th, 2021 at 8:15 a.m. ET.
12th Annual Jefferies Global Healthcare Conference in London on Wednesday, November 17th, 2021 at 5:00 p.m. GMT (11:00 a.m. ET).
33rd Annual Piper Sandler Virtual Healthcare Conference on November 30th-December 2nd, 2021. The webcast will be available beginning at 10:00 a.m. ET on November 22.
A live webcast of presentations at the Credit Suisse, Cowen and Jefferies conferences may be accessed by visiting the Investors & Media section of the Scholar Rock website at View Source All these webcasts will be archived and available on the Company’s website for approximately 90 days following the presentation.

On November 2, 2021 BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients reported a new publication in the peer-reviewed scientific journal Cancer Research, a journal of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) (Press release, BostonGene, NOV 2, 2021, View Source [SID1234594150]). The study, performed in collaboration with Weill Cornell Medicine and titled "Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas," details the role of oncogenic heat shock protein 90 (HSP90) to support metabolic pathways in B-cell lymphoma cells and in patients with diffuse large B-cell lymphoma (DLBCL).

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This study evaluated the role of oncogenic HSP90 in regulating cytosolic metabolic pathways in proliferating B-cell lymphoma cells. Oncogenic HSP90 was shown to facilitate the organization of metabolic enzymes into non-membrane-bound functional compartments. BostonGene’s analysis enabled reconstructing the microenvironment in lymphoma expressing a double hit signature, an indicator of aggressive lymphoma with high MYC activity. This analysis showed that alterations to the MYC metabolic program affected immune infiltration, providing insights into improving lymphoma immunity via MYC. It was also observed, under experimental conditions, which conserved cellular proteostasis, oncogenic HSP90 coordinated and sustained multiple metabolic pathways required for energy production and maintenance of cellular biomass as well as for secretion of extracellular metabolites.

"The goal of the study was to further understand metabolic regulation of cellular proteostasis in patients with DLBCL," said Leandro Cerchietti, M.D., Associate Professor of Medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. "The encouraging results of this research study demonstrate oncogenic HSP90 is tightly linked to the preservation of cellular biomass providing a novel mechanism of activity for HSP90 inhibitors."

"These findings underscore the pivotal role of oncogenic HSP90 in the regulation of metabolic pathways in lymphoma, revealing a potential therapeutic vulnerability in B-cell lymphoma," said Nathan Fowler, MD, Chief Medical Officer at BostonGene. "We are pleased to support Weill Cornell Medicine in their research efforts to find optimal therapeutic treatments for patients with DLBCL."

On November 2, 2021 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported that an article highlighting preclinical data from BT7480, a tumor-targeted immune cell agonist (TICA) targeting Nectin-4 and agonizing CD137 (4-1BB), was published in the Journal for ImmunoTherapy of Cancer (JITC) (Press release, Bicycle Therapeutics, NOV 2, 2021, View Source [SID1234594149]). The article, titled "BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist (Bicycle TICA) induces tumor localized CD137 agonism" is available online via this link.

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"CD137 is an important co-stimulatory receptor expressed on multiple components of the immune system. CD137 activation can drive anti-tumor immunity but activation outside of the tumor may give rise to toxicity. To that end, we have developed BT7480, a novel, first-in-class Nectin-4/CD137 Bicycle TICA, that activates CD137 only in the presence of Nectin-4 expressing tumor cells," said Nicholas Keen, Ph.D., Chief Scientific Officer of Bicycle Therapeutics. "The data published today in JITC describe BT7480’s ability to elicit rapid reprogramming of the tumor immune microenvironment, which leads to complete regressions and anti-tumor immunity with only intermittent drug exposure in syngeneic mouse tumor models. We believe this work supports the clinical investigation of BT7480 for the treatment of cancer, and we look forward to dosing the first patient in our Phase I/II clinical trial which we plan to commence by the end of this year."