On November 2, 2021 Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, reported that it will host a conference call and webcast on Tuesday, November 9, 2021 at 8:00 a.m. ET to report financial results for the third quarter ended September 30, 2021 and provide business updates (Press release, Mersana Therapeutics, NOV 2, 2021, https://ir.mersana.com/news-releases/news-release-details/mersana-therapeutics-host-conference-call-announcing-third-2 [SID1234594075]).

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To access the call, please dial 877-303-9226 (domestic) or 409-981-0870 (international) and provide the Conference ID 2116349. A live webcast of the presentation will be available on the Investors & Media section of the Mersana website at www.mersana.com.

On November 2, 2021 OncoSec Medical Incorporated (NASDAQ: ONCS) reported that it will host a conference call and webcast for investors and analysts on Friday, November 12 at 7:00 AM ET featuring key opinion leaders (KOLs) Matteo Carlino, MD, from Westmead and Blacktown Hospitals, Adil Daud, MD, from University of California San Francisco, Pablo Fernandez Peñas MD, PhD, FACD, from The University of Sydney, and Montaser Shaheen, MD, from the University of Arizona Cancer Center. The KOLs will discuss the clinical relevance of the updated KEYNOTE-695 data being presented in a poster at the SITC (Free SITC Whitepaper) 2021 Annual Meeting. Specifically, the KEYNOTE-695 clinical trial enrolled metastatic melanoma patients that are refractory to Immune Checkpoint Blockade, non-responders as defined by the Society of Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) recommendations.1

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Adil Daud, M.D., a Professor of Medicine at The University of California, San Francisco, Director of the Melanoma Clinical Research, remarked, "TAVO works by optimizing cellular uptake of DNA-based IL-12 in the tumor microenvironment, leading to local, sustained production of IL-12 in the tumor, where it matters. TAVO recruits and primes immune cancer-fighting cells in the tumor leading to systemic immune responses without systemic toxicity, and we look forward to the updated data at SITC (Free SITC Whitepaper) 2021 in this highly refractory patient population."

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1Kluger HM, Tawbi HA, Ascierto ML, et al. Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC (Free SITC Whitepaper) Immunotherapy Resistance Taskforce. Journal for ImmunoTherapy of Cancer 2020;8:e000398. doi:10.1136/ jitc-2019-000398

On November 2, 2021 MorphoSys AG reported Monjuvi(R) Sales for the First Nine Months and Third Quarter of 2021 and Invitation to the upcoming Conference Call on November 11, 2021 (Press release, MorphoSys, NOV 2, 2021, View Source [SID1234594073])

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MorphoSys AG (FSE: MOR; NASDAQ: MOR) today announces that revenues from product sales of Monjuvi(R) (tafasitamab-cxix) in the U.S. amount to € 18.6 million (US$ 22 million) for the third quarter of 2021 and € 46.4 million (US$ 55.5 million) for the first nine months of 2021. Monjuvi(R) is being co-commercialized by Incyte and MorphoSys in the United States.

MorphoSys will publish its full results for the first nine months and third quarter 2021 on November 10, 2021 at 10:00pm CET (4:00pm EST).

MorphoSys’ Management Board will host a conference call and webcast on November 11, 2021 at 2:00pm CET (8:00am EST) to present the first nine months and third quarter financial results 2021 and provide a further outlook for 2021.

The conference call will start with a presentation by the Management Board followed by a Q&A session.

A live webcast and slides will be made available at the Media and Investors section under Conferences on MorphoSys’ website, www.morphosys.com.

On November 2, 2021 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported that an article highlighting preclinical data from BT7480, a tumor-targeted immune cell agonist (TICA) targeting Nectin-4 and agonizing CD137 (4-1BB), was published in the Journal for ImmunoTherapy of Cancer (JITC) (Press release, Bicycle Therapeutics, NOV 2, 2021, View Source [SID1234594072]). The article, titled "BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist (Bicycle TICA) induces tumor localized CD137 agonism" is available online via this link.

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"CD137 is an important co-stimulatory receptor expressed on multiple components of the immune system. CD137 activation can drive anti-tumor immunity but activation outside of the tumor may give rise to toxicity. To that end, we have developed BT7480, a novel, first-in-class Nectin-4/CD137 Bicycle TICA, that activates CD137 only in the presence of Nectin-4 expressing tumor cells," said Nicholas Keen, Ph.D., Chief Scientific Officer of Bicycle Therapeutics. "The data published today in JITC describe BT7480’s ability to elicit rapid reprogramming of the tumor immune microenvironment, which leads to complete regressions and anti-tumor immunity with only intermittent drug exposure in syngeneic mouse tumor models. We believe this work supports the clinical investigation of BT7480 for the treatment of cancer, and we look forward to dosing the first patient in our Phase I/II clinical trial which we plan to commence by the end of this year."

On November 2, 2021 Bausch Health Companies Inc. (NYSE/TSX: BHC) ("Bausch Health" or the "Company" or "we") reported its third-quarter 2021 financial results (Press release, Bausch Health, NOV 2, 2021, View Source [SID1234594071]).

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"Our third-quarter 2021 results continue to demonstrate that our recovery from the effects of the COVID-19 pandemic remains in progress across our business segments," said Joseph C. Papa, chairman and CEO, Bausch Health. "In the third quarter, several key products grew and gained market share. Additionally, we are delivering on multiple near-term R&D catalysts that we believe will help drive future growth."

"We have remained steadfast in our commitment and have been working diligently to accelerate the strategic alternatives process that will enable us to unlock value in our three attractive businesses as soon as possible," continued Mr. Papa. "We are excited to announce that, subject to market conditions and other approvals, we expect to launch the proposed IPO of our Solta Medical business in December 2021 or January 2022, and following that, we expect to launch the Bausch + Lomb IPO approximately 30 days later, also subject to market conditions and other approvals."3

Select Company Highlights

Launched Biotrue Hydration Boost Lubricant Eye Drops in the United States
Completed divestiture of Amoun Pharmaceutical Company S.A.E. (Amoun) to Abu-Dhabi-based ADQ
Repaid debt by $1.100 billion in the third quarter of 2021 using cash on hand, cash generated from operations and in connection with the Amoun divestiture
Pipeline Advancements

Received U.S. Food and Drug Administration (FDA) approval of the New Drug Application (NDA) for XIPERE4 (triamcinolone acetonide injectable suspension), a therapy that uses the suprachoroidal space to treat patients suffering from macular edema associated with uveitis; launch is expected to occur in the first quarter of 2022
Announced statistically significant topline results from the second Phase 3 trial evaluating the investigational drug NOV035 (perfluorohexyloctane) as a first-in-class eye drop with a novel mechanism of action to treat the signs and symptoms of dry eye disease associated with Meibomian gland dysfunction; Bausch Health expects to file an NDA with the FDA in the first half of 2022
VYZULTA (latanoprostene bunod ophthalmic solution), 0.024%, received regulatory approval in Thailand
Accelerating Strategic Alternatives
The Company has continued to execute upon its plans to pursue an initial public offering (IPO) of its Solta Medical (Solta) business. In preparation for the IPO, the Company has submitted a confidential S-1 to the U.S. Securities and Exchange Commission and has made key leadership appointments. The Company expects to launch the Solta IPO in December 2021 or January 2022, subject to market conditions and regulatory, stock exchange and other approvals. In addition, the Company has continued to execute upon its previously announced plans to separate Bausch + Lomb from Bausch Pharma6 and expects to launch an IPO for Bausch + Lomb approximately 30 days after the IPO of Solta, subject to market conditions and regulatory, stock exchange and other approvals. After that, the Bausch + Lomb spinoff can occur following the expiry of customary lock-ups and receipt of applicable shareholder and other necessary approvals and the achievement of the Company’s target net leverage ratios.2

Third-Quarter 2021 Revenue Performance
Total reported revenues were $2.111 billion for the third quarter of 2021, as compared to $2.138 billion in the third quarter of 2020, a decrease of $27 million. Excluding the favorable impact of foreign exchange of $19 million and the impact of divestitures and discontinuations of $46 million, primarily due to the divestiture of Amoun, revenue was flat organically1,7, compared to the third quarter of 2020.