On October 21, 2021 Imvax, Inc., a clinical-stage biotechnology company developing personalized, whole tumor-derived immunotherapies, reported a poster presentation at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) in Washington, D.C., from November 10-14, 2021 (Press release, Imvax, OCT 21, 2021, View Source [SID1234591708]).

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The poster highlights recent preclinical data for the company’s most advanced product candidate, IGV-001. The data elucidate potential mechanisms for the observed immune-stimulating and tumor-suppressing activity of IGV-001 seen in the Phase 1 clinical study for glioblastoma.

"We’re pleased to share new insights into the mechanism of action of IGV-001, which are supportive of the clinical efficacy data we’ve previously reported," said John Furey, Chief Executive Officer. "These insights are valuable both as we prepare for a Phase 2b trial in glioblastoma and as we expand our platform to address other solid tumor types."

Details of the poster presentation are as follows:

Title: Autologous glioblastoma tumor cells and an antisense oligonucleotide against insulin-like growth factor type 1 receptor protect against tumor challenge and generate T cell anti-tumor responses
Number: P218
Timing: November 13, 2021, 7:00 a.m-8:30 p.m. EST
Presenter: Mark Exley, Ph.D., Chief Scientific Officer

On October 21, 2021 Oncodesign (ALONC – FR0011766229), a French biopharmaceutical company specialized in kinase inhibitor research and precision medicine, and TiumBio (KOSDAQ:321550), a company specializing in R&D for rare diseases, reported the signature of a research collaboration agreement on R&D of potential drug candidates for fibrosis (Press release, Oncodesign, OCT 21, 2021, View Source [SID1234591707]).

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Under this agreement, Oncodesign will be responsible for identification, chemical synthesis and optimization of Nanocyclix drug candidates and their early-stage analysis, while TiumBio will be responsible for the advanced evaluation of fibrotic efficacy of the drug candidates. This initial phase of the collaboration will be funded by TiumBio.

Also, TiumBio has secured an exclusive option to in-license global development and commercialization rights of the discovered drug candidates after their evaluation upon reaching predefined success criteria. Financial conditions for this option, which might be lifted over the next year, cannot be disclosed at this stage.

Hun-Taek Kim, CEO of TiumBio, stated: "We are delighted to work with Oncodesign to achieve our common goal of developing treatments for rare and incurable diseases. If we combine Oncodesign’s kinase inhibitor-based platform technology and our fibrosis-centered R&D experience and expertise in rare diseases, I am confident that we can develop new and innovative drugs in the fibrosis area."

Philippe Genne, CEO and founder of Oncodesign, said: "This new collaboration with TiumBio, an expert company in fibrosis in South-Korea, further expands the global reach of our unique technologies. Following earlier collaborations with international pharmaceutical companies including BMS (Bristol-Myers-Squibb), Ipsen, Sanofi, Servier and UCB, our platform technology Nanocyclix again is poised to bring solutions in a difficult area. I am thrilled to team up with TiumBio to find solutions for patients suffering from Fibrosis."

Jan Hoflack, CSO of Oncodesign, added: "This agreement is another example where an expert pharma company looking for compounds with unique and hard-to-meet criteria comes to benefit from our Nanocyclix technology platform, looking for high potency and exquisite selectivity. Upfront testing of the Nanocyclix diversity set has allowed to identify starting points satisfying TiumBio’s initial criteria and has led to this exciting collaboration."

About Fibrosis

Fibrosis occurs in most tissues of the human body, which is a phenomenon of fibrous connective tissue formation. As the disease progresses, the function of the corresponding organ is defected, which can lead to various chronic fatal disease conditions such as pulmonary and liver fibrosis. In addition, fibrosis accounts for about 45% of all cause disease mortality1, and since there are few effective treatments currently available, it is a disease area with a very high unmet medical demand from patients.

On October 21, 2021 Blueprint Medicines Corporation (NASDAQ: BPMC), reported that it will host a live conference call and webcast at 8:30 a.m. ET on Thursday, October 28, 2021 to report its third quarter 2021 financial results and provide a corporate update (Press release, Blueprint Medicines, OCT 21, 2021, View Source [SID1234591705]).

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To access the live conference call, please dial 844-200-6205 (domestic) or 929-526-1599 (international), and refer to conference ID 963004. A webcast of the call will also be available under "Events and Presentations" in the Investors & Media section of the Blueprint Medicines website at View Source The archived webcast will be available on Blueprint Medicines’ website approximately two hours after the conference call and will be available for 30 days following the call.

On October 21, 2021 argenx (Euronext & Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases and cancer, reported that it will host a conference call and audio webcast on Thursday, October 28, 2021 at 2:30 pm CET (8:30 am ET) to discuss its third quarter 2021 financial results and provide a business update (Press release, argenx, OCT 21, 2021, View Source [SID1234591700]).

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A webcast of the live call may be accessed on the Investors section of the argenx website at argenx.com/investors. A replay of the webcast will be available on the argenx website for approximately one year following the call.

On October 21, 2021 Checkmate Pharmaceuticals, Inc. (Nasdaq: CMPI) ("Checkmate"), a clinical stage biopharmaceutical company focused on developing its proprietary technology to harness the power of the immune system to combat cancer, reported a live webcast on innate immune modulators and vidutolimod (CMP-001) hosted by Jefferies on Tuesday, October 26 from 11:00am – 12:00pm ET (Press release, Checkmate Pharmaceuticals, OCT 21, 2021, View Source [SID1234591699]).

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The webcast will be moderated by Maury Raycroft, Ph.D. and feature Jason Luke, M.D., FACP and Art Krieg, M.D. in a scientific discussion of the role of innate immune modulators in cancer treatment. Dr. Luke will review the various approaches to modulate innate immunity for the treatment of cancer and the challenges experienced by the field. Dr. Krieg will discuss the unique modality and mechanism of action of vidutolimod, a biologic, advanced generation Toll-like receptor 9 (TLR9) agonist, which is in late-stage clinical trials for patients with melanoma and proof-of-concept clinical trials for patients with head and neck cancer, cutaneous squamous cell carcinoma, and Merkel cell carcinoma.

Dr. Luke is an internationally recognized clinical and translational investigator in melanoma and early drug development, particularly immuno-oncology. Dr Krieg is the Founder and Chief Scientific Officer of Checkmate Pharmaceuticals, Inc. He has published more than 250 scientific papers and is an inventor on more than 50 issued U.S. patents covering oligonucleotide technologies.

The webcast can be accessed under "Events & Presentations" in the Investors section of the Checkmate website. An archived copy of the webcast will be available on the Checkmate website for approximately 90 days after the event.