Abalos Therapeutics Completes Series A Extension Bringing Total Raised to EUR 43 Million

On October 14, 2021 Abalos Therapeutics reported an extension to its Series A funding round bringing the total raised in this round to EUR 43 million (USD 50 million) (Press release, Abalos Therapeutics, OCT 14, 2021, View Source [SID1234591247]). The extension was led by Seventure Partners with support from Coparion, Ventura BioMed Investors and Hx Bio Ventures as well as contributions from existing investors from the initial Series A round including Boehringer Ingelheim Venture Fund (BIVF), Gründerfonds Ruhr, NRW.BANK and High-Tech Gründerfonds (HTGF). The financing underscores the potential of Abalos’ differentiated immuno-virotherapy approach to generate a maximal immune response specifically targeted against a patient’s cancer and its metastases. The proceeds will enable the company to advance its first product candidate into a Phase 1/2 trial in multiple solid tumors including the expansion cohorts to demonstrate early signs of clinical efficacy as well as fund further pipeline expansion.

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"Since the closing of our initial Series A financing round, we have achieved significant progress in the development of our product candidates and built a leadership team of drug development and immuno-oncology experts that support our goal of bringing this unique therapeutic modality to cancer patients," said Dr. Marcus Kostka, CEO of Abalos Therapeutics. "We value this commitment from our new and current investors that will enable our lead arenavirus-based program to enter clinical evaluation with the goal of establishing clinical proof of concept."

"Abalos is developing a powerful new class of immuno-virotherapeutics to treat cancer. Their product candidates have the potential to treat a range of solid cancers and also to increase the effect of approved immuno-oncology drugs," said Annegret de Baey, Venture Partner at Seventure Partners.

"We are very excited to see such a distinct approach in the crowded immuno-oncology space and look forward to supporting the Abalos leadership team as they continue on the journey of developing a pipeline of candidates that could greatly improve the immune system’s ability to identify hard-to-treat tumors and elicit a long-term anti-tumor immune response," added Isabelle de Cremoux, CEO and Managing Partner at Seventure.

Abalos was launched in October 2019 to advance a technology platform that harnesses the unique features of the lymphocytic choriomeningitis virus (LCMV), which specifically targets tumor cells. Through its proprietary Fast Evolution Platform, Abalos is generating variants with optimized anti-tumoral properties to trigger a highly precise and directed immune response that can be utilized for distant metastases and enable long-term disease control.

In conjunction with the closing of the Series A financing round extension, Annegret de Baey from Seventure Partners and Sebastian Pünzeler from Coparion will join Abalos’ Supervisory Board.

Anticancer Bioscience Welcomes New Investor into Seed Financing Round Bringing Total Raised to Over $31m to Advance Synthetic Lethality Approaches to Cancer Therapy

On October 14, 2021 Anticancer Bioscience (ACB), pioneers in synthetic lethal approaches to precision oncology, reported that it had secured an additional CNY 68.4 million (~USD 10.6 million) from new Chinese investors (Press release, Anticancer Bioscience, OCT 14, 2021, View Source [SID1234591246]). The seed extension financing was led by Three Rivers Capital, who joins existing private Chinese investors. The total raised in the seed round is now over USD31 million (around CNY 200 million).

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The proceeds will be mainly used to accelerate the preclinical development of the company’s two most advanced programs, MYC-synthetic lethal and contact inhibition restoration. The funds will also be used to optimize lead compounds for polyploidy-synthetic lethal therapy and to identify additional lead compounds for the company’s contact inhibition restoration approach to combatting cancer.

ACB is applying synthetic lethal approaches to develop targeted cancer therapies. These have the potential to be much safer and more effective than current therapies. ACB has access to world-leading cancer biology expertise and drug discovery platforms that enable the company to identify novel compounds that can target both genetic and epigenetic vulnerabilities of cancer cells. ACB has bespoke chemical compound libraries and has invested in developing one of the world’s largest natural product libraries, providing a rich screening resource for potential cancer therapeutics.

Commenting on the financing, Dun Yang PhD, Founder, President, and CEO of ACB said, "This successful financing round is a further strong endorsement of our innovative approach to identifying first-in-class and best-in-class therapeutics for the treatment of cancer, using synthetic lethal strategies. It underlines our progress over the past months and will help accelerate our five drug discovery programs through optimization to candidate selection and IND enabling studies. We aim to initiate two clinical trials in 2022."

Xiaoyin Chen, Investment Director at Three Rivers Capital said: "ACB is an emerging innovative biotech with global competitiveness. We firmly believe that only revolutionary innovations in drug discovery and development can generate great clinical benefits and value. ACB utilizes its unique small molecule libraries and screening approaches, combined with its multiple proprietary platform technology based on synthetic lethality, to develop broad-spectrum anti-cancer drugs and strives to become the pioneer in developing novel and next-generation cancer therapies."

ACB will be presenting its innovative drug discovery platforms and pipeline at the LSX Inv€$tival Showcase in November.

Moderna to Report Third Quarter Financial Results on Thursday, November 4, 2021

On October 14, 2021 Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, reported that it will host a live conference call and webcast at 8:00 a.m. ET on Thursday, November 4, 2021 to report its third quarter 2021 financial results, and provide a corporate update (Press release, Moderna Therapeutics, OCT 14, 2021, View Source [SID1234591245]).

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To access the live conference call, please dial 866-922-5184 (domestic) or 409-937-8950 (international) and refer to conference ID 9177025. A webcast of the call will also be available under "Events and Presentations" in the Investors section of the Moderna website at investors.modernatx.com. The archived webcast will be available on Moderna’s website approximately two hours after the conference call and will be available for one year following the call.

4SC to present at the EORTC CL Group 20-21 Meeting

On October 14, 2021 4SC AG (4SC, FSE Prime Standard: VSC) reported that it will attend and present at the European Organisation for Research and Treatment of Cancer Conference (EORTC) Cutaneous Lymphoma Group 20-21 Meeting in Marseille, France, from 14-16 Oct 2021 (Press release, 4SC, OCT 14, 2021, View Source [SID1234591244]). The posters will be available on 4SC’s website after the conference.

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A summary of the posters is listed below.

Poster – RESMAIN study update: RESMAIN study – Evaluating resminostat for maintenance treatment of patients with advanced stage (Stage IIB‑IVB) mycosis fungoides (MF) or Sézarysyndrome (SS)
Poster – Scientific data from research exploring the mode-of-action of resminostat: Mode-of-action of HDAC inhibitor resminostat in CTCL cells

PTC Therapeutics to Host Conference Call to Discuss Third Quarter 2021 Financial Results

On October 14, 2021 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that the company will host a webcast conference call to report its third quarter 2021 financial results and provide an update on the company’s business and outlook on Thursday, Oct. 28, at 4:30 p.m. ET (Press release, PTC Therapeutics, OCT 14, 2021, https://ir.ptcbio.com/news-releases/news-release-details/ptc-therapeutics-host-conference-call-discuss-third-quarter-2021 [SID1234591241]).

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The call can be accessed by dialing (877) 303-9216 (in the United States) or (973) 935-8152 (outside of the United States) five minutes prior to the start of the call and providing the passcode 8574103. A live, listen-only webcast of the conference call can be accessed on the investor section of the PTC website at View Source A replay of the call will be available approximately two hours after completion of the call and will be archived on the company’s website for 30 days following the call.