On October 13, 2021 Biotech company Prescient Therapeutics reported that has given investors a glimpse into the progress of its next-generation CAR-T platform, OmniCAR, with data to be presented at leading cell and gene therapy conference Meeting on the Mesa (Press release, Prescient Therapeutics, OCT 13, 2021, View Source;utm_medium=rss&utm_campaign=prescient-therapeutics-showcases-pre-clinical-success-of-cancer-fighting-treatment [SID1234591146]).

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In an announcement made this morning, the Melbourne-based company revealed its OmniCAR platform continues to demonstrate several key attributes in early studies.

These attributes include the treatment’s high-potency, dose-responsiveness of cancer killing activity, and the ability for clinicians to disarm and re-arm the cells used in treatment without hindering their effectiveness.

These are important milestones in the development of Prescient’s in-house OmniCAR programs, as well as in the development of the overall platform and demonstrating novel features relevant to potential partners and collaborators.

Dr Rebecca Lim, Prescient’s Director of Scientific Affairs, is encouraged by the result, noting:

"Our most recent work conducted in collaboration with the Peter MacCallum Cancer Centre showed that OmniCAR-T cells begin antigen-directed killing of tumour cells in vitro as soon as they are armed," she said.

"The team also showed that OmniCAR-T cells could be rearmed and continue to kill tumour cells without loss of cytotoxicity."

"Excitingly, we saw for the first time the real-time ‘switchability’ of the OmniCAR system where the tumour killing ability of the OmniCAR-T cells could be redirected towards a different antigen through the addition of a different binder."

Dr Lim said the early wins were "extremely encouraging", adding that she is excited for the next round of tests.

The results will be shared in detail with the industry’s most prominent companies at the Cell & Gene Meeting on the Mesa conference, based in Carlsbad, California, US.

Prescient Therapeutics CEO Steven Yatomi-Clarke said he is excited by the opportunity to share the company’s results with the industry’s leading businesses.

"It is very pleasing to see a large body of work accomplished successfully so quickly and is a credit to the Prescient team and the incredible collaborators at Peter MacCallum Cancer Centre," he added.

"Importantly, none of these tests have even been optimised, so we have yet to see the true limits of this technology. OmniCAR is proving to be a predictable and powerful system to work with."

OmniCAR is a next-generation CAR-T platform that aims to overcome challenges that face traditional CAR-T therapies – which use genetically modified cells from a patient’s own immune system to fight cancer.

These challenges include poor dose-responsiveness (leading to unpredictable reactions in patients as the strength of their treatment is increased), an inability to redirect CAR-T cells to attack different tumours, and the need for multiple CAR-T infusions to adequately fight cancer. CEO Steven Yatomi-Clarke and Dr Rebecca Lim will be presenting a session next Tuesday at 11am (AEDT) where they will explain the OmniCAR platform and latest results in more detail. Please click here to register for the session.

Reach Markets have been engaged by PTX to help manage their investor communications.

On October 13, 2021 Roche reported that it will publish its Sales Results for the 3rd Quarter of 2021 prior to the opening of the Swiss Stock Exchange on Wednesday, October 20th, 2021 (Press release, Hoffmann-La Roche, OCT 13, 2021, View Source [SID1234591139]).

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On October 12, 2021 Theratechnologies reported that earnings call will be held on October 13, 2021 at 8:30 a.m. ET (Press release, Theratechnologies, OCT 12, 2021, View Source [SID1234596233]).

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On October 12, 2021 Kytopen reported that 2021 Cell & Gene Meeting on the Mesa, organized by the Alliance for Regenerative Medicine, was a hybrid event held in-person in Carlsbad, CA on October 12 -14th and virtually on October 19th & 20th (Press release, Kytopen, OCT 12, 2021, View Source;utm_medium=rss&utm_campaign=kytopen-presents-at-the-2021-cell-gene-meeting-on-the-mesa [SID1234594172]). Tackling the commercialization hurdles facing the cell and gene therapy sector today, this meeting covers a wide range of topics from clinical trial design to alternative payment models to scale-up and supply chain platforms for advanced therapies.

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In this year company presentation, Kytopen provided a case study of our Flowfect non-viral transfection platform for ex vivo cell therapy discovery and manufacturing. The study in CD34+ stem cells & mRNA highlights our tiered approach to optimize payload and transfection parameters while confirming the robustness of the process despite donor variability and scale up for clinical relevance. In just 6 weeks, we scaled our process to transfect 200x more CD34+ stem cells in seconds while maintaining significantly high levels of cell recovery, viability, and efficiency.

The Flowfect platform is a transformative solution that eliminates the complexity of scale up in cell engineering in one flexible scalable solution. Our goal is to reduce risk while providing maximum control and flexibility to drive higher yields, faster approvals, and better outcomes for curative cellular disease treatment.

ARM’s 2021 Meeting on the Mesa attracted more than 1,700 registrants this year, including nearly 1,200 attendees at the in-person portion of the conference in Carlsbad, CA. With an approximately 40% increase in the number of registrants from 2019 and 2020, this year’s meeting was the largest in ARM’s history. The conference featured three days of live panels and presentations, as well as additional on-demand content and nearly 3,000 virtual and in-person partnering meetings.

On October 12, 2021 Bicycle Therapeutics plc (the "Company") reported that it entered into an underwriting agreement (the "Underwriting Agreement") with Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC and SVB Leerink LLC (the "Representatives"), as representatives of the several underwriters named therein (collectively, the "Underwriters"), pursuant to which the Company agreed to issue and sell 3,240,741 American Depositary Shares ("ADSs"), each representing one of the Company’s ordinary shares, nominal value £0.01 per share, at a public offering price of $54.00 per ADS (the "Offering") (Filing, 8-K, Bicycle Therapeutics, OCT 12, 2021, View Source [SID1234591239]). The net proceeds to the Company from the Offering are expected to be approximately $163.8 million, after deducting underwriting discounts and commissions and estimated offering expenses payable by the Company. The Company also granted the Underwriters an option to purchase 486,111 additional ADSs at the public offering price.

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The Offering is being made pursuant to the Company’s registration statement on Form S-3 (File No. 333-260179), which became effective upon filing with the Securities and Exchange Commission on October 12, 2021, a base prospectus dated October 12, 2021 and the related prospectus supplement dated October 12, 2021. The Offering is expected to close on October 15, 2021, subject to customary closing conditions.

The Underwriting Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company and the Underwriters, including for liabilities under the Securities Act of 1933, as amended, other obligations of the parties and termination provisions. The representations, warranties and covenants contained in the Underwriting Agreement were made only for purposes of such agreement and as of specific dates, were solely for the benefit of the parties to such agreement and may be subject to limitations agreed upon by the contracting parties, including being qualified by confidential disclosures exchanged between the parties in connection with the execution of the Underwriting Agreement. The Company’s directors and executive officers have agreed, subject to certain exceptions, not to sell or transfer any ordinary shares (including ADSs representing ordinary shares) for 60 days, and the Company has agreed not to sell or transfer any ordinary shares (including ADSs representing ordinary shares) for 60 days, in each case, after October 12, 2021, without first obtaining the written consent of the Representatives.