AccessHope and Emory Healthcare Announce Collaboration, Extending Access to Cancer Expertise in the Southeastern United States and Beyond

On January 10, 2022 AccessHope, LLC, a company that provides cancer expertise to employers and their health care affiliates, reported a new foundational collaboration with Emory Healthcare and Winship Cancer Institute of Emory University, extending access to specialized cancer expertise to more people living with complex cancers across the United States (Press release, AccessHope, JAN 10, 2022, View Source [SID1234598600]). Emory Healthcare, along with Winship, joins AccessHope’s existing collaboration with three other National Cancer Institute (NCI)-Designated Comprehensive Cancer Centers to offer innovative support and deliver advanced, expert knowledge for employees with cancer to their health plans and their local treating oncologists.

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Cancer specialists from Winship will provide tumor type-specific expertise for AccessHope’s core services — Accountable Precision Oncology, Expert Advisory Review and Cancer Support Team — to plan members in southeastern states, including Alabama, Florida, Georgia, Mississippi, North Carolina, South Carolina and Tennessee, and across the United States.

"People deserve access to the latest cancer care knowledge, regardless of their geographic location. The ability to remotely access health information has become increasingly important for the patient experience, particularly during the COVID-19 pandemic when people’s ability or willingness to travel for cancer care may have been impacted," says Mark Stadler, chief executive officer, AccessHope.

Through an employer benefit that provides access to a broad network of oncology experts, AccessHope’s cancer support services help employees and their families navigate the complexity of a cancer diagnosis to improve quality of life and health outcomes, return to their work and lives, and reduce expenses. Medical specialists at Emory Healthcare and Winship are at the forefront of lifesaving discoveries and the latest cancer research, and they can help health plans and treating oncologists guide their patients to clinical trials, genetic/genomic testing and the newest personalized treatments, such as breakthrough medications and targeted therapies.

"We are honored to welcome Emory Healthcare and Winship into our growing family of foundational collaborators, which also includes City of Hope, Dana-Farber Cancer Institute, and Northwestern Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University," adds Stadler. "As we continue connecting plan members and their local treating oncologists with these world-renowned specialists who can review their cases, our primary goal is to share insights they can use to optimize cancer treatment plans and improve clinical outcomes."

Emory Healthcare, with 24,000 employees and 11 hospital campuses, is the most comprehensive academic health system in Georgia. System-wide, it has 2,722 licensed beds and more than 3,300 physicians practicing in more than 70 specialties, serving metro Atlanta and the state of Georgia with 250 locations.

"At Emory Healthcare, patients are at the center of everything we do, and our mission is to improve lives and provide hope," says Jonathan S. Lewin, M.D., executive vice president for health affairs of Emory University and chief executive officer of Emory Healthcare. "Through innovation and discovery, our clinicians and cancer specialists are focused on advancing medical research and progressive cancer treatments that will benefit those who are diagnosed, and we are pleased to collaborate with AccessHope to provide further access to patients in need of cancer expertise."

Winship Cancer Institute expertise available for patients with complex cancers

As Georgia’s only NCI-Designated Comprehensive Cancer Center, Winship is the epicenter of the state’s cancer research, education and care, and is ranked in the top 50 in the United States and No. 1 in Georgia for cancer care, according to U.S. News & World Report. Winship clinicians see more than 17,000 newly diagnosed patients each year. The center is poised to grow; construction is underway on a new 17-story cancer facility, the largest expansion in Winship’s history.

"Winship is proud to work with AccessHope to provide top-notch expertise to the care of patients in our region at an exciting time of new possibilities in cancer care," says Winship Executive Director Suresh S. Ramalingam, M.D. "Winship’s leading experts will work with individuals’ health plans and their local care teams to provide specialized knowledge and insights."

Research is also a key component of Winship’s mission. Investigators enrolled more than 900 participants in more than 300 clinical trials in 2020, the same year it received $80 million in research funding. Winship collaborates with professionals from around the world and with national and state agencies, including the Centers for Disease Control and Prevention, the American Cancer Society and the Georgia Research Alliance.

"Winship oncologists are seeing a recent trend of more patients coming through our doors with advanced or later-stage cancers, which likely progressed from delayed screenings or treatment during the COVID-19 pandemic," says Sagar Lonial, M.D., FACP, chief medical officer of Winship Cancer Institute of Emory University. "Through our new collaboration with AccessHope, Winship clinicians will provide valuable medical expertise for patients with complex cancers, including our multidisciplinary teams that care for head and neck, lung, prostate and breast cancers, as well as the rapidly changing field of blood cancers. Those experts can then provide recommendations to local oncologists, so individuals then receive state-of-the-art care as quickly as possible."

Increased quality of and access to health care

Emory Healthcare was named as one of the top 10 most trusted health care brands in the United States and the top health care system in Georgia in a recent survey conducted by the American Hospital Association of more than 30,000 consumers. Consumers reported that three strategies were paramount to boost trust: being transparent and clear with information, listening and being empathetic, and offering care and treatment choices to patients.

"Improving access, increasing options and expanding health literacy can go a long way in addressing critical issues in health care such as health disparities, trust in health care and health care providers, and patients proactively seeking out specialized medical care. AccessHope’s unique approach in connecting people with cancer expertise, regardless of their geographic location, was a natural fit for Emory Healthcare and Winship Cancer Institute, where patients come first," says Dane Peterson, president and chief operating officer, Emory Healthcare. "Together, Emory Healthcare and AccessHope will increase access to medical expertise, and we will further transform health and healing at home in Georgia and beyond."

In December 2021, the medical journal JCO Oncology Practice published a peer-reviewed study on how AccessHope influences lung cancer cases. Titled "A Novel Program Offering Remote, Asynchronous Subspecialist Input in Thoracic Oncology: Early Experience During a Pandemic," the study found that AccessHope’s NCI-level subspecialists provided evidence-based recommendations to influence 93% of the cases AccessHope received. Accompanying the clinical and humanistic benefits was an average of $19,000 in cost savings per plan member.

Today, AccessHope serves approximately 3.3 million plan members who have access to its cancer support services through 75 employers and collaborative relationships with Collective Health via its Premier Partner Program and with Health Transformation Alliance and Quantum Health.

Fusion Pharmaceuticals Announces Nomination of First Targeted Alpha Therapy Candidate in Collaboration with AstraZeneca to Advance into IND-Enabling Studies for Phase 1 Development

On January 10, 2022 Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, reported nomination of the first targeted alpha therapy (TAT) candidate under the Company’s collaboration agreement with AstraZeneca (LSE/STO/Nasdaq: AZN) (Press release, Fusion Pharmaceuticals, JAN 10, 2022, View Source [SID1234598589]). Both companies will jointly develop through a Phase 1 study the novel TAT which utilizes Fusion’s Fast-Clear linker technology to radiolabel an AstraZeneca-owned bispecific antibody with the alpha-emitting isotope, actinium-225.

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"Fusion is at the forefront developing a new wave of cancer therapies using alpha-emitting medical isotopes and various targeting vehicles," said John Valliant, Ph.D. "One of the pillars of our platform is to create next-generation immunoconjugates, and we are excited to be working with AstraZeneca to pursue a novel radioimmunoconjugate for oncology. We had strong alignment among our joint development committee to move this novel TAT forward into a planned Phase 1 study and we look forward to sharing more information as we approach the investigational new drug application (IND) filing."

Under the terms of the previously announced collaboration agreement, Fusion will be operationally responsible for preclinical development through first-in-human studies, while AstraZeneca will be responsible for subsequent clinical development. The companies will share costs equally through clinical development. IND enabling studies are ongoing.

Corporate Presentation

On January 10, 2022, Sutro Biopharma, Inc. (the "Company") Presented the corporate presentation (Presentation, Sutro Biopharma, JAN 10, 2022, View Source [SID1234598567]).

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ROYALTY PHARMA HIGHLIGHTS ACCOMPLISHMENTS AND PROVIDES BUSINESS UPDATE AT 40TH ANNUAL J.P. MORGAN HEALTHCARE CONFERENCE

On January 10, 2022 Royalty Pharma plc (Nasdaq: RPRX) reported an update on its business performance, including recent key accomplishments and the full-year 2021 outlook for Net cash provided by operating activities (a GAAP financial measure) and Adjusted Cash Receipts (a non- GAAP financial measure). Pablo Legorreta, Royalty Pharma’s founder and Chief Executive Officer, will discuss these updates today as part of a webcast presentation at the 40th Annual J.P. Morgan Healthcare Conference to be held virtually at 8:15 a.m. Eastern Time (Press release, Royalty Pharma , JAN 10, 2022, View Source [SID1234598566]).

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"I am very pleased with the performance of Royalty Pharma in 2021," said Pablo Legorreta. "We strengthened our longstanding leadership position, delivered impressive financial results and deployed substantial capital on new royalty transactions which will help drive future growth. Given the extraordinary pace of medical advances and our unique role at the heart of funding life science innovation, I am confident that we will deliver attractive, compounding growth in the coming years."

Strong 2021 Financial Performance

Based on preliminary unaudited fourth quarter 2021 results, Royalty Pharma expects Net cash provided by operating activities (GAAP) to be in the range of $2,010 to $2,030 million for full-year 2021. Additionally, Royalty Pharma now expects to deliver Adjusted Cash Receipts(1) (non-GAAP financial measure) for full-year 2021 at the high end of its guidance range of $2,110 to $2,130 million, which represents growth of 18% year-over-year. This strong double-digit growth in Adjusted Cash Receipts was achieved despite a significant decline in royalties from the HIV franchise, which was the company’s fourth largest royalty in 2020.

Royalty Pharma also enhanced its balance sheet in 2021 through an innovative $1.3 billion debt financing, which included its first-ever social bond.

Royalty Pharma’s preliminary unaudited fourth quarter 2021 results provided in this press release are subject to change in connection with the completion of the company’s final closing procedures, final adjustments and other developments that may arise in the course of the preparation or audit of its financial statements. Royalty Pharma’s management will host a conference call to discuss the company’s fourth quarter and full year 2021 results in the coming weeks.

Strong Capital Deployment Added Innovative Therapies, Enhancing Long-term Growth

Royalty Pharma has previously disclosed that it expects to deploy approximately $7 billion in capital on new royalty transactions over the period 2020 to 2025. Given the rapid pace of life science innovation – and the accompanying demands for capital from the biopharma industry – the company is tracking well ahead of its plan. From 2020 to 2021, Royalty Pharma has announced transactions of $5.5 billion, including $3.0 billion in 2021.

In total, through these transactions, 20 therapies have been added to Royalty Pharma’s portfolio (of which nine are either currently or projected to be blockbusters that generate annual sales of $1 billion or more based on consensus estimates). These new medicines are expected to make a significant contribution to the company’s financial performance in the coming years. In aggregate, based on consensus sales forecasts, these investments are estimated to add more than $750 million to Royalty Pharma’s annual Adjusted Cash Receipts in 2025 with potential upside from development-stage therapies.

Webcast of J.P. Morgan Healthcare Conference

Royalty Pharma will present at the 40th Annual J.P. Morgan Healthcare Conference at 8:15 a.m. ET today. The webcast will be accessible from Royalty Pharma’s "Events" page at View Source The webcast will also be archived for a minimum of thirty days.

Jazz Pharmaceuticals Announces Vision 2025 to Deliver Sustainable Growth and Enhanced Value to Drive Transformation to Innovative, Global Biopharmaceutical Leader

On January 10, 2022 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported its Vision 2025 to deliver sustainable growth and enhanced value. Vision 2025 includes the following expectations: 1) generating $5 billion in revenue in 2025; 2) approval of at least five additional novel products by the end of the decade; and 3) realizing a 5% adjusted operating margin1 improvement from 2021 to 2025, driven by operational excellence (Press release, Jazz Pharmaceuticals, JAN 10, 2022, View Source [SID1234598565]). The Company also confirmed that it expects to meet its previously announced 2021 revenue guidance range of $3.02 to $3.1 billion and its net product sales guidance for neuroscience and oncology.2

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Jazz ended 2021 demonstrating executional excellence across its business, including launching five key products in 2020 and 2021, integrating the GW Pharmaceuticals business, making progress towards its deleveraging target and initiating multiple potentially registrational clinical trials. The Company remains on track to deliver revenue diversification, with at least 65% of 2022 net product revenue from newly launched or acquired products,3 driving sustainable growth and enhanced shareholder value.

"Building on our track record of strong execution and guided by our patient-centric approach, Jazz is setting forth its Vision 2025 to deliver meaningful treatment options to patients, a great place to work for employees and significant value to shareholders," said Bruce Cozadd, chairman and chief executive officer of Jazz Pharmaceuticals. "Jazz’s leadership in sleep and rare epilepsy with Xywav and Epidiolex, respectively, coupled with promising new oncology products like Zepzelca and Rylaze, have led to the rapid transformation of our revenue base. We are further poised to enter new disease areas with serious unmet patient need and substantial market potential, including movement disorders and PTSD, with our mid-to late-stage assets nabiximols, suvecaltamide (JZP385) and JZP150. We expect our continued operational excellence to drive a five-percentage point improvement in our adjusted operating margin from 2021 to 2025, and we are confident in our ability to continue to leverage strategic capital allocation to grow our business."

Vision 2025 includes the following expectations:

Commercial: Generating $5 billion in revenue in 2025

Approximately $2.0 billion from oxybate franchise, which includes Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution in narcolepsy and idiopathic hypersomnia, Xyrem (sodium oxybate) oral solution and royalties from Xyrem authorized generics.

Approximately $2.5 billion from Epidiolex/Epidyolex (cannabidiol) and oncology franchise, including new products Zepzelca (lurbinectedin) and Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn).

Approximately $0.5 billion from additional growth opportunities, internal clinical development pipeline and future corporate development.

Pipeline: Approval of at least five additional novel products by the end of the decade

The Company’s pipeline has expanded four-fold since 2015 with 18 novel candidates currently in development. Jazz completed 11 licensing and M&A deals since 2019 alone, including five programs in clinical-stage development.

Jazz believes its pipeline is positioned to deliver at least five additional novel product approvals in areas of critical unmet patient need and significant market opportunity by the end of the decade.

Operational excellence: Driving a 5% adjusted operating margin1 improvement from 2021 to 2025

The Company is focused on disciplined investment to drive both top- and bottom-line growth and an improvement of five percentage points to its adjusted operating margin from 2021 to 2025, leveraging its global neuroscience and oncology businesses.

Strategic capital allocation will continue to be an important driver of the Company’s growth. Jazz is on track to achieve its net leverage ratio4 target of being below 3.5x by the end of 2022, which provides flexibility to continue smaller-scale corporate development as the Company delevers. In addition, Jazz will contemplate larger scale corporate development in the coming years to accelerate growth and diversification.

Presentation and Webcast

Bruce Cozadd will provide a corporate overview and discuss the Company’s Vision 2025 during the virtual presentation at the 40th Annual J.P. Morgan Healthcare Conference from 2:15 – 2:55 p.m. ET / 7:15 – 7:55 p.m. GMT on Monday, January 10, 2022.

A live audio webcast of the presentation may be accessed from the Investors section of the Jazz Pharmaceuticals website at www.jazzpharma.com. Please connect to the website prior to the start of the presentation to ensure adequate time for any software downloads that may be necessary to listen to the webcast. A replay of the webcast will be available on the website for 30 days.