On January 12, 2022 Heat Biologics, Inc. ("Heat") (NASDAQ: HTBX), a clinical-stage biopharmaceutical company focused on developing first-in-class therapies to modulate the immune system, reported promising new preclinical data regarding PTX-35 has been accepted for publication in the American Journal of Transplantation and is available at: View Source (Press release, Heat Biologics, JAN 12, 2022, View Source [SID1234598616]).

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Key Findings:

·A single dose of the preclinical version of PTX-35 (mPTX-35), was able to expand regulatory T cells (Tregs) and significantly improve disease and graft survival outcomes.
·Chemically induced pancreatic failure (a model for type-1 diabetes) could be partially reversed when mice were transplanted with beta-cell islet allografts and treated with mPTX-35.
·Disease protection in preclinical models was correlated with a significant expansion of Tregs and protection of the allograft, resulting in euglycemia and a graft survival benefit.
·Long-term surviving grafts showed a marked increase in Treg infiltration which directly correlated with mPTX-35 agonist activity.

PTX-35 is a novel, potential first-in-class antibody immunomodulator of TNFRSF25 (death receptor 3), a receptor that is preferentially expressed by antigen-experienced T cells and can be manipulated to expand regulatory T-cell subsets. PTX-35 is the Company’s first antibody-based product, currently in a Phase 1 clinical trial for the treatment of patients with solid tumors.

Dr. James Shapiro, Professor in the Department of Surgery and Clinical Islet Transplant Program at the University of Alberta, Edmonton, Canada, commented, "The study demonstrated that a single dose of PTX-35 enabled prolonged graft survival in a mouse model of pancreatic islet allotransplantation. Additionally, PTX-35 could contribute to achieving lasting immunological tolerance in organ transplantation."

Jeff Wolf, Chief Executive Officer of Heat, commented, "We are very encouraged by these results showing pronounced Treg expansion and significantly prolonged graft survival compared to control. PTX-35 has the potential to modulate immunological responses and may facilitate minimization of post-transplant immunosuppression, which supports further clinical evaluation in the context of inflammatory disease. Similar preclinical results have also been previously demonstrated for bone marrow, corneal and cardiac transplantation using these and other TNFRSF25 agonists."

Mr. Wolf further noted, "We are also making significant progress with HS-110 and expect to file for an End of Phase 2 meeting with the FDA this quarter. Our goal for this meeting is to discuss potential Phase 3 registration pathways for HS-110. Although this submission is taking longer than expected, we believe we have prepared a very comprehensive package and look forward to the FDA’s feedback."

On January 12, 2022 Denovicon reported to be participating in BIO Partnering at JPM 2022 (Press release, Denovicon Therapeutics, JAN 12, 2022, View Source [SID1234598615]). Reach out to us there, if you’re interested in learning more about our AI/machine learning/molecular modeling platform and current molecular assets.

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On January 12, 2022 Apollomics Inc. an innovative biopharmaceutical company committed to the discovery and development of mono- and combination- oncology therapies, reported that the management team will host two upcoming webcasts to accommodate participants from the U.S. and China (Press release, Apollomics, JAN 12, 2022, View Source [SID1234598613]). Co-Founder, Chairman and Chief Executive Officer, Guo-Liang Yu, PhD, will be joined by Sanjeev Redkar, PhD, Co-Founder and President, K. Peony Yu, M.D., Chief Medical Officer, and Wilson W. Cheung, CPA, Chief Financial Officer, to provide a strategic overview and an update on the Company’s pipeline programs.

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Session Dates/Times:

Session U.S. Pacific U.S. Eastern China Europe
English January 26th
11:00 a.m.

January 26th
2:00 p.m.

January 27th
3:00 a.m.

January 26th
8:00 p.m.

Chinese January 26th
7:00 p.m.

January 26th 10:00 p.m. January 27th 11:00 a.m. January 27th 4:00 a.m.
All are invited to listen to the event and view the presentation via webcast on the Apollomics website under the News/Events section: Events and Presentations. An archive of the webcast will be available for three months.

On January 11, 2022 Allogene Therapeutics, Inc., a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer and Antion Biosciences, a Swiss cell and gene engineering company, reported that they have entered into an exclusive collaboration and global license agreement for Antion’s miRNA technology (miCAR) to advance multiplex gene silencing as an additional tool to develop next generation allogeneic CAR T products (Press release, Antion Biosciences, JAN 11, 2022, View Source [SID1234629137]).

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Antion is an early-stage research company with foundational miRNA technology. In preclinical studies, Antion has demonstrated proof-of-concept for multiplex gene silencing in an allogeneic CAR T cell model. These studies demonstrated the ability of miCARTM technology to silence multiple gene targets in a single step and indicate this technology has broad application within cell and gene engineering. Allogene plans to deploy miCARTM with other technologies to develop next-generation strategies for immune evasion and other advances in allogeneic CAR T therapy.

"We believe that Antion has one of the few technology options capable of delivering multiplex gene silencing with a high degree of specificity and potency," said Rafael Amado, M.D., Executive Vice President of Research and Development and Chief Medical Officer. "We are excited to be working with Antion to explore how their miCAR technology may advance and accelerate Allogene’s research efforts aimed at creating best in class allogeneic cell therapies."

As part of this agreement, Antion will exclusively collaborate with Allogene on oncology products for a defined period. Allogene will also have exclusive worldwide rights to commercialize products incorporating Antion technology developed during the collaboration. Allogene will provide Antion an upfront cash payment and a preferred equity investment. Allogene will pay Antion developmental and commercial milestones and a single-digit royalty on any product sales. Allogene will also take a seat on Antion’s Board of Directors.

"This collaboration represents an exciting validation of the power and flexibility of our miCAR platform." said Sven Kili, M.D., Chief Executive Officer. "We are extremely enthusiastic to be working with Allogene, as the world leader in Allogeneic CAR T therapies to bring next-generation life changing therapies to patients"

On January 11, 2022 Hillstream BioPharma, Inc. (NASDAQ:HILS) ("Hillstream", the "Company"), a biotechnology company developing novel therapeutic candidates targeting ferroptosis, an emerging new anti-cancer mechanism resulting in iron mediated cell death for drug resistant and devastating cancers, reported the pricing of its initial public offering of 3,750,000 shares of the Company’s common stock at a public offering price of $4.00 per share for aggregate gross proceeds of $15,000,000 prior to deducting underwriting discounts, commissions, and other offering expenses (Press release, Hillstream Biosciences, JAN 11, 2022, View Source [SID1234628147]). In addition, the Company has granted the underwriters a 45-day option to purchase up to an additional 562,500 shares of common stock at the public offering price less discounts and commissions, to cover over-allotments.

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The shares of common stock are expected to begin trading on the Nasdaq Capital Market under the ticker symbol "HILS" on January 12, 2022. The offering is expected to close on January 14, 2022, subject to satisfaction of customary closing conditions.

The net proceeds from the initial public offering will be used to advance the Company’s product candidate HSB-1216 through pre-clinical activities, completion of Phase 1 studies and manufacturing, to advance the Company’s product candidate HSB-888 through pre-clinical activities and IND submission, as well as for general corporate and working capital purposes.

ThinkEquity is acting as sole book-running manager for the offering.

The registration statement on Form S-1 (file No. 333-259821) relating to the shares being sold in this offering has been filed with the U.S. Securities and Exchange Commission (the "SEC") and became effective on January 11, 2022. A final prospectus related to the proposed offering will be filed and made available on the SEC’s website at View Source The offering is being made only by means of a prospectus. Electronic copies of the final prospectus may be obtained, when available, from ThinkEquity, 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673 and by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.