On January 11, 2022 Shanghai Fosun Pharmaceutical (Group) Co., Ltd ("Fosun Pharma"; Stock Code: 600196.SH, 02196.HK), a leading innovation-driven international healthcare group in China and Insilico Medicine ("Insilico"), an end-to-end artificial intelligence (AI)-driven drug discovery and development company, reported that entered into a collaboration agreement to advance the discovery and development of drugs targeting a number of different targets globally through the use of AI technology (Press release, Fosun Pharma, JAN 11, 2022, https://www.prnewswire.com/news-releases/fosun-pharma-and-insilico-medicine-announce-a-strategic-ai-driven-drug-discovery-and-development-collaboration-to-jointly-advance-multiple-targets-301457569.html [SID1234605451]).

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Fosun Pharma and Insilico Medicine Announce a Strategic, AI-driven Drug Discovery and Development Collaboration
Fosun Pharma and Insilico Medicine Announce a Strategic, AI-driven Drug Discovery and Development Collaboration
This strategic collaboration includes an AI-driven drug discovery research and development (R&D) collaboration on four biological targets, as well as the co-development of Insilico’s QPCTL program. Insilico will receive a total upfront payment of $13 million for the R&D collaboration projects and the co-development of the QPCTL program, potential milestone-based payments, and share commercialization profits from the QPCTL program. In addition, Fosun Pharma will make an equity investment in Insilico.

"We are pleased to enter into strategic collaboration with Insilico. Fosun Pharma is committed to promoting innovative R&D, and is oriented towards fulfilling unmet clinical needs and improving products’ accessibility. We look forward to working with Insilico to leverage the technological and clinical development strengths of both companies, jointly improving the efficiency of innovative drug R&D, and benefiting more patients worldwide," said Yifang Wu, Chairman and CEO of Fosun Pharma.

The collaboration aims to combine Insilico’s end-to-end AI-driven drug discovery platforms and Fosun Pharma’s clinical development and commercial expertise to discover and develop a portfolio of novel therapeutics. Pursuant to the collaboration agreement, Insilico will take responsibility for delivering a preclinical candidate for the QPCTL program and advancing it to IND stage, after which, Fosun Pharma will then conduct human clinical studies and co-develop the candidate globally. In parallel, Fosun Pharma’s R&D team will nominate four therapeutic targets to be assessed by Insilico’s AI platform and R&D team, who are responsible of advancing drug candidates to IND stage.

As part of the collaboration, Fosun Pharma will secure access to Insilico’s PandaOmics and Chemistry42 platforms in order to advance Fosun Pharma’s internal AI-powered discovery and development efforts.

"In partnering with Fosun Pharma, a leading pharmaceutical company, we begin a new era of AI-powered end-to-end drug discovery and development as human-machine collaboration becoming the new normal in precision drug discovery and development. We previously demonstrated that AI can be used to discover novel targets and generate novel molecules that can be tested in humans in record time. Now, we are partnering with one of the leading scientific teams in the pharmaceutical industry to take this technology to the next level for the benefit of patients worldwide", said Alex Zhavoronkov, PhD, Founder and CEO of Insilico Medicine.

On January 11, 2022 BeyondSpring Pharmaceuticals (the "Company" or "BeyondSpring") (NASDAQ: BYSI), a global pharmaceutical company focused on the development of cancer therapeutics, reported an organizational streamlining initiative focused on prioritizing the Company’s highest value business activities, extending its cash runway and preserving long-term sustainability (Press release, BeyondSpring Pharmaceuticals, JAN 11, 2022, View Source [SID1234598612]).

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As part of the reorganization, BeyondSpring is reducing its U.S. workforce by 35%, including reassignment of certain personnel to subsidiaries, which is expected to result in cost savings that will extend the cash runway. The reorganization follows BeyondSpring’s receipt of a Complete Response Letter from the U.S. Food and Drug Administration for the New Drug Application (NDA) seeking approval of plinabulin in combination with granulocyte colony-stimulating factor for the prevention of chemotherapy-induced neutropenia (CIN) on November 30, 2021.

"The reorganization of BeyondSpring is a necessary step forward for the Company to deliver on its mission to develop innovative cancer therapies and improve clinical outcomes for patients who have high unmet medical needs globally," said Dr. Lan Huang, BeyondSpring’s co-founder, chief executive officer and chairwoman. "This reorganization will enable BeyondSpring to reduce operating expenses and extend its cash runway. We express sincere appreciation to colleagues impacted by this decision, and thank our team members for their contributions."

Going forward, BeyondSpring intends to prioritize the following clinical and regulatory activities:

Continued advancement of the regulatory process of plinabulin in CIN in China and the U.S.

NDA filing and regulatory process of non-small cell lung cancer (NSCLC) in the U.S. and China

Advancement of immune-oncology (IO) trials with plinabulin in triple combination IO therapy in various cancers.

The Company remains committed to optimizing the value of the plinabulin franchise through further clinical development in areas of unmet medical need.

On January 11, 2022 Integra LifeSciences Holdings Corporation (NASDAQ: IART), a leading global medical technology company, reported that certain unaudited preliminary fourth quarter and full-year 2021 revenue results (Press release, Integra LifeSciences, JAN 11, 2022, View Source [SID1234598611]).

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Preliminary Fourth Quarter and Full-Year 2021 Revenue Results

Fourth quarter 2021 revenue is expected to be in a range of $404 million to $406 million, representing an increase of approximately 4% on a reported basis and an increase of approximately 8% on an organic basis compared to the prior year. Revenue is in line with the outlook the Company provided in November and represents a sequential revenue improvement from the third quarter.

The Company expects full-year 2021 reported revenue to be in a range of $1,541 million to $1,543 million, representing an increase of approximately 12% on a reported basis and an increase of approximately 14% on an organic basis.

The preliminary results set forth above are unaudited and remain subject to completion of the Company’s financial closing procedures.

"I am pleased with our execution and performance during the fourth quarter, particularly amid the challenges driven by the ongoing pandemic," said Jan De Witte, Integra’s president and chief executive officer. "In my first months as CEO, I have come to appreciate Integra’s talented and resilient team, its rich history of global leadership, sound business platform and strong financial wherewithal and see significant untapped potential ahead. As 2022 gets underway, we are focused on executing on our growth priorities, specifically new product introductions, clinical research, enhancing digital capabilities and international expansion, supplemented by strategic acquisitions. We also are accelerating our ESG ambitions and have added sustainability to our strategy framework as an enabler to our success. We remain committed to achieving our 5% – 7% long-term organic growth target and are reaffirming our long-term financial aspirations."

Share Repurchase Program

The company is planning a $125 million share repurchase as a part of a previous approval by the Board of Directors, with an authorization of up to $225 million. The company may repurchase shares at the company’s discretion, subject to applicable regulatory and other legal requirements. The number of shares to be repurchased and the timing of such transactions will depend on a variety of factors, including market conditions, regulatory requirements, other corporate considerations, and could be suspended or discontinued at any time as determined by Integra management.

De Witte concluded, "Our ability to reinvest for growth and repurchase shares is a testament to our strong balance sheet and commitment to creating shareholder value. We are excited about the future of Integra as we deploy our capital in support of strong profitable growth and returns for our shareholders."

40th Annual J.P. Morgan Healthcare Conference

The Company is scheduled to present at the 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022, at 4:30 p.m. ET. A live webcast of the presentation will be available on the Investor Relations section of the company’s website at www.integralife.com.

Fourth Quarter and Full-Year 2021 Financial Results Conference Call

The Company will release fourth quarter and full-year 2021 financial results on Wednesday, February 23, 2022, before the market opens. In conjunction with the earnings release, Integra’s management team will host a conference call at 8:30 a.m. ET.

As part of this call, the Company will provide an update on first quarter and full-year 2022 expectations.

The live call is accessible by dialing (888) 394-8218 and using the passcode 701830. A simultaneous webcast of the call will be available via the Company’s website at www.integralife.com.

A live webcast of the presentation will be available on the Integra LifeSciences investor relations website at View Source

A webcast replay of the call can be accessed through the Investor Relations homepage of Integra’s website at www.integralife.com.

On January 11, 2022, Verastem, Inc. Presented the Corporate Presentation (Presentation, Verastem, JAN 11, 2022, View Source [SID1234598610]).

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On January 11, 2022 Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, reported the company has entered into a strategic research collaboration with 48 Hour Discovery Inc. (48HD) to discover novel, peptide-based radiopharmaceuticals for the treatment of various solid tumors (Press release, 48Hour Discovery, JAN 11, 2022, View Source [SID1234598609]).

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"Fusion’s versatile platform, supported by our internal research capabilities, allows us to create targeted alpha therapies (TATs) using different classes of targeting molecules, tailoring the approach based upon the disease target," said Fusion Chief Executive Officer John Valliant, Ph.D. "With our antibody, bispecific, and small molecule programs in the clinic or progressing through investigational new drug-enabling studies, we are excited to announce our work with peptides. Partnering with a global leader in peptide discovery further diversifies our capabilities and assets needed to create differentiated TATs in multiple areas of high unmet medical need."

Under the agreement, Fusion has global rights to develop and commercialize any peptides discovered under the collaboration.