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On February 11, 2022 Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company developing a new class of custom-built protein drugs known as DARPin therapeutics, reported that its Chief Executive Officer, Patrick Amstutz, Ph.D., will participate in the SVB Leerink 11th Annual Global Healthcare Conference 2022 (Press release, Molecular Partners, FEB 11, 2022, View Source [SID1234608049]). The presentation will take place on Wednesday, February 16, at 9:20 am ET.

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The webcasted presentation will be made available on the Molecular Partners website.

On February 11, 2022 Alligator reported that During the fourth quarter 2021 reached several key milestones in our pre-clinical, clinical, and partnered programs (Press release, Alligator Bioscience, FEB 11, 2022, View Source [SID1234608044]). Our priorities continue to be shaped by the rising need for cancer drug therapies that are safer and more effective."

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Significant Events: October – December 2021

First patient dosed in the Phase II clinical trial of AC101 (HLX22), out-licensed to Shanghai Henlius Biotech, Inc. and AbClon, Inc.
Proof-of-concept Phase I clinical trial was initiated to assess the safety and efficacy of mitazalimab in combination with MesoPher, an experimental dendritic cell vaccine, in patients with pancreatic cancer, led by investigators at Erasmus MC University Medical Center Rotterdam, The Netherlands.
Alligator Bioscience and Aptevo Therapeutics co-authored a poster on ALG.APV-527, presented by Aptevo at SITC (Free SITC Whitepaper) Annual Meeting 2021.
Alligator presented three posters at the SITC (Free SITC Whitepaper) Annual Meeting 2021, on Neo-X-PrimeTM, ATOR-1017, and OPTIMIZE-1.
The company successfully carried out an oversubscribed Rights Issue raising approximately SEK 257 million, before transaction costs.
The company announced a trial update and early readout for ATOR-1017, confirming biomarker, safety, and tolerability data.
FINANCIAL SUMMARY
October-December 2021

Net sales, SEK 5.2 million (-)
Operating profit/loss, SEK -36.9 million (-34.1)
Profit/loss for the period, SEK -36.8 million (-34.5)
Earnings per share before and after dilution, SEK -0.17 (-0.48)
Cash flow for the period, SEK 198.8 million (-33.2)
Cash and cash equivalents, SEK 278.1 million (103.3)
January-December 2021

Net sales, SEK 12.9 million (4.4)
Operating profit/loss, SEK -141.6 million (-144.3)
Profit/loss for the period, SEK -141.7 million (-143.3)
Earnings per share before and after dilution, SEK -0.64 (-2.01)
Cash flow for the period, SEK 174.7 million (9.4)
Cash and cash equivalents, SEK 278.1 million (103.3)
The full report is attached as PDF available on the company’s website: View Source

Conference call/webcast
Alligator will host a conference call today, February 11, 2022, at 3:30 p.m. CEST for investors, analysts and media, where CEO Søren Bregenholt and CFO Marie Svensson will present and comment on the Interim Report. The conference call will be held in English.

The conference call will be broadcast live on the web and can be accessed via the link:
Alligator Bioscience, Audiocast with teleconference, Q4, 2021 | Financial Hearings

This information is such information as Alligator Bioscience AB (publ) is obliged to make public pursuant to the Swedish Securities Markets Act. The information was submitted for publication, through the agency of the contact person set out above, at 08:00 a.m. CEST on February 11, 2022.

On February 11, 2022 Photocure ASA (PHO: OSE), The Bladder Cancer Company, reported that its partner Asieris Pharmaceuticals (SSE: 688176) has obtained the Phase III clinical trial application (CTA) approval from the National Medical Products Administration (NMPA) of China for Hexvix (Press release, PhotoCure, FEB 11, 2022, View Source [SID1234608043]).

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The study is a prospective, multicenter bridging trial aimed to investigate the additional detection rate and safety of Hexvix and blue light cystoscopy (BLC) versus white light cystoscopy in Chinese patients with non-muscle invasive bladder cancer (NMIBC, tumor types CIS, Ta, T1). The study will be led by Peking Union Medical College Hospital, Chinese Academy of Medical Sciences. Professor Li Hanzhong, Head of the Department of Surgery, Peking Union Medical College Hospital, will serve as the Principal Investigator to lead a team of top experts in the field of bladder cancer in China to carry out this study.

According to Frost & Sullivan, the number of new bladder cancer cases in China reached 86,000 in 2020, and is expected to rise to 101,000 in 2025, with a compound annual growth rate of 3.4% during the period. The total number of patients with bladder cancer in China was estimated to be higher than 600,000 in 2020. The use of BLC with Hexvix for the management of NMIBC is included in the global expert consensus guidelines.

In January 2021, Asieris Pharmaceuticals entered into a license agreement with Photocure, obtaining exclusive rights to register and commercialize Hexvix in mainland China and Taiwan. In December 2021, Hexvix was put into pilot use in the Boao Lecheng International Medical Tourism Pilot Zone in Hainan Province: the first patient in China received blue light cystoscopy with Hexvix at Hainan General Hospital.

"We are very glad that the phase Ⅲ trial of Hexvix has been approved by the NMPA" said Dr. Yong Xue, Chief Medical Officer of Asieris. "We will accelerate the clinical trial process so that doctors and patients in China will have access to this breakthrough technology as early as possible."

"This clinical registration trial is a critical step toward giving bladder cancer patients access to Hexvix in China. Hexvix is a diagnostic agent that has been proven to improve the detection, and completeness of resection of tumors, and can be an important solution in the management of disease", said Anders Neijber, Vice President Global Medical Affairs and Clinical Development at Photocure.

Read Asieris’ full media release here: View Source

Note to editors

All trademarks mentioned in this release are protected by law and are registered trademarks of Photocure ASA

This press release may contain product details and information which are not valid, or a product is not accessible, in your country. Please be aware that Photocure does not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin.

About Bladder Cancer

Bladder cancer ranks as the seventh most common cancer worldwide with 1 720 000 prevalent cases (5-year prevalence rate)1a, 573 000 new cases and more than 200 000 deaths annually in 2020.1b

Approx. 75% of all bladder cancer cases occur in men.1 It has a high recurrence rate with an average of 61% in year one and 78% over five years.2 Bladder cancer has the highest lifetime treatment costs per patient of all cancers.3

Bladder cancer is a costly, potentially progressive disease for which patients have to undergo multiple cystoscopies due to the high risk of recurrence. There is an urgent need to improve both the diagnosis and the management of bladder cancer for the benefit of patients and healthcare systems alike.

Bladder cancer is classified into two types, non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), depending on the depth of invasion in the bladder wall. NMIBC remains in the inner layer of cells lining the bladder. These cancers are the most common (75%) of all BC cases and include the subtypes Ta, carcinoma in situ (CIS) and T1 lesions. In MIBC the cancer has grown into deeper layers of the bladder wall. These cancers, including subtypes T2, T3 and T4, are more likely to spread and are harder to treat.4

1 Globocan. a) 5-year prevalence / b) incidence/mortality by population. Available at: View Source, accessed [January 2022].
2 Babjuk M, et al. Eur Urol. 2019; 76(5): 639-657
3 Sievert KD et al. World J Urol 2009;27:295–300
4 Bladder Cancer. American Cancer Society. View Source

About Hexvix/Cysview (hexaminolevulinate HCl)

Hexvix/Cysview is a drug that preferentially accumulates in cancer cells in the bladder making them glow bright pink during Blue Light Cystoscopy (BLC). BLC with Hexvix/Cysview improves the detection of tumors and leads to more complete resection, fewer residual tumors and better management decisions.

Cysview is the tradename in the U.S. and Canada, Hexvix is the tradename in all other markets. Photocure is commercializing Cysview/Hexvix directly in the U.S. and Europe, and has strategic partnerships for the commercialization of Hexvix/Cysview in China, Chile, Australia and New Zealand.

Please refer to View Source for further information on our commercial partners.

On February 11, 2022 Blueprint Medicines Corporation (NASDAQ: BPMC) reported its participation in the following upcoming investor conferences (Press release, Blueprint Medicines, FEB 11, 2022, View Source [SID1234608042]).

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SVB Leerink 11th Annual Global Healthcare Conference on Friday, February 18, 2022 at 10:40 a.m. ET.
Cowen 42nd Annual Healthcare Conference on Tuesday, March 8, 2022 at 9:10 a.m. ET.
A live webcast of each presentation will be available by visiting the Investors & Media section of Blueprint Medicines’ website at View Source A replay of the webcasts will be archived on Blueprint Medicines’ website for 30 days following each presentation.