On February 11, 2022 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company focused on the development of new solid tumor cancer therapies, reported financial results for its fiscal second quarter ended December 31, 2021 and provided a corporate update (Press release, Kintara Therapeutics, FEB 11, 2022, View Source [SID1234608019]).

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CORPORATE HIGHLIGHTS AND RECENT DEVELOPMENTS

Received notice of the U.S. Patent and Trademark Office’s issuance of United States Patent No. 11,234,955 to VAL-083 covering a method of treating brain tumors including GBM, medulloblastoma, and cancer brain tumor stem cells that has O6-methyl guanine methyltransferase (MGMT)-driven drug resistance (February).

Reported that the Global Coalition for Adaptive Research (GCAR) glioblastoma multiforme (GBM) Adaptive Global Innovative Learning Environment (AGILE) registrational Phase 2/3 clinical study (GBM AGILE Study) has screened over 1,000 patients. According to GCAR, enrollment rates for the study are 3 to 4 times greater than traditional GBM studies with active sites averaging 0.75 to 1 patient per site per month. As of January 10, 2022, there were 31 activated clinical sites in the United States and Canada in the Kintara treatment arm in this study (January).

Announced that the Luxembourg Institute of Health received a multi-year research grant to study and further understand the mechanism of action of VAL-083 (January).

Activated the first Canadian site for the VAL-083 treatment arm in the GBM AGILE Study (November).

Positioned Kintara’s management team for its next stage of development by announcing that Robert E. Hoffman, the current Chairman, succeeded Saiid Zarrabian as President and Chief Executive Officer. Mr. Hoffman will continue in the capacity as Chairman and Mr. Zarrabian has transitioned to heading up Kintara’s strategic partnerships initiative and will remain a member of its Board of Directors (November).

Continued to advance development of REM-001 for the treatment of Cutaneous Metastatic Breast Cancer (CMBC), including taking critical steps toward manufacturing sufficient quantity of drug to allow for initiation and completion of the 15-patient confirmatory study. Enrollment of first patient is expected in the second quarter of calendar 2022.

"I am pleased by the progress we have made over the past quarter, highlighted by the enrollment rates in the GCAR AGILE Study for GBM which has outperformed our expectations," commented Robert E. Hoffman, Kintara’s President and Chief Executive Officer. "Our 15-patient confirmatory study of REM-001 for cutaneous metastatic breast cancer remains on track to start enrolling patients in the second quarter of calendar year 2022."

On February 11, 2022 Coherus BioSciences, Inc. ("Coherus", Nasdaq: CHRS), reported that its fourth quarter and full year 2021 financial results will be released after market close on Thursday, February 17, 2022 (Press release, Coherus Biosciences, FEB 11, 2022, View Source [SID1234608018]). Starting at 5 p.m. ET, Coherus’ management team will host a conference call and webcast to discuss financial results and provide a general business update .

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After releasing fourth quarter and full year 2021 financial results, the Company will post them on the Coherus website at View Source

On February 11, 2022 Keros Therapeutics, Inc. ("Keros") (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for patients suffering from hematological and musculoskeletal disorders with high unmet medical need, reported that Keros’ President and Chief Executive Officer Jasbir S. Seehra, Ph.D. will present at the 11th Annual SVB Leerink Global Healthcare Conference on Friday, February 18th at 9:20 am ET (Press release, Keros Therapeutics, FEB 11, 2022, View Source [SID1234608017]).

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The fireside chat presentation will be webcast live at View Source;page=kros&url=View Source and archived in the Investors section of the Keros website at View Source A replay will be available for 90 days following the conclusion of the event.

On February 11, 2022 Replimune Group, Inc. (NASDAQ: REPL), a clinical stage biotechnology company pioneering the development of a novel class of tumor-directed oncolytic immunotherapies, reported that Philip Astley-Sparke, Chief Executive Officer of Replimune, will present in a fireside chat at the 11th Annual SVB Leerink Global Healthcare Conference being held virtually on Friday, February 18, 2022 at 8:40 AM ET (Press release, Replimune, FEB 11, 2022, View Source [SID1234608016]).

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A simultaneous webcast will be available in the Investors section of Replimune’s website at www.replimune.com. A replay will be available for approximately 90 days following the conference.

On February 11, 2022 Immunomic Therapeutics, Inc., ("ITI"), a privately-held clinical-stage biotechnology company pioneering the study of LAMP-mediated nucleic acid-based immunotherapy reported that the company will be presenting at the upcoming 2022 BIO CEO & Investor Conference being held at the Marriott Marquis in NYC on February 14-15 and virtually through the 17th (Press release, Immunomic Therapeutics, FEB 11, 2022, View Source [SID1234608012]).

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Bob Newman, ITI’s Chief Business Officer, will deliver a presentation titled, "Pioneering the Next Generation of Immunotherapies" discussing ITI’s investigational UNiversal Intracellular Targeted Expression (UNITE) platform and its application in immuno-oncology, specifically glioblastoma multiforme (GBM). ITI’s technology platform has the potential to utilize the body’s natural biochemistry to develop a broad immune response and is currently being employed in a Phase II clinical trial as a cancer immunotherapy.

Hosted annually by the Biotechnology Innovation Organization (BIO) for over 20 years, the conference is focused on emerging public and private companies, offering a meeting place for institutional investors, industry analysts, and senior biotech executives. The conference draws biotech companies looking to make the connections needed to take their products to the next phase.

Presentation details are as follows:

Who: Bob Newman, Chief Business Officer of Immunomic Therapeutics, Inc.

What: Pioneering the Next Generation of Immunotherapies

Registered attendees may access the presentation here: https://bit.ly/3HIAh9b

About UNITE

ITI’s investigational UNITE platform, or UNiversal Intracellular Targeted Expression, works by fusing pathogenic antigens with the Lysosomal Associated Membrane Protein 1 (LAMP1), an endogenous protein in humans, for immune processing. In this way, ITI’s vaccines (DNA or RNA) have the potential to utilize the body’s natural biochemistry to develop a broad immune response including antibody production, cytokine release and critical immunological memory. This approach puts UNITE technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in a Phase II clinical trial as a cancer immunotherapy. ITI is also collaborating with academic centers and biotechnology companies to study the use of UNITE in cancer types of high mortality, including cases where there are limited treatment options like glioblastoma and acute myeloid leukemia. ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. Preclinical data is currently being developed to explore whether LAMP1 nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response.