On March 24, 2022 Arcellx, Inc. (NASDAQ: ACLX), a biotechnology company reimagining cell therapy through the development of innovative immunotherapies for patients with cancer and other incurable diseases, reported business highlights and financial results for the fourth quarter and year ended December 31, 2021 (Press release, Arcellx, MAR 24, 2022, View Source [SID1234610933]).

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"Becoming a publicly traded company was an important milestone for our organization providing us with additional resources to continue advancing our novel platform for patients with cancer and other incurable diseases," said Rami Elghandour, Arcellx’s chairman and chief executive officer. "The preliminary data from our lead clinical program, CART-ddBCMA for the treatment of relapsed or refractory multiple myeloma (r/r MM), presented at the 2021 Annual Meeting of the American Society of Hematology (ASH) (Free ASH Whitepaper), demonstrated a 100% overall response rate, and continued robust long-term responses with a potentially best-in-class safety profile, in a challenging patient population. These data are indicative of our excitement to advance this program from a Phase 1 trial to a Phase 2 pivotal trial by the end of this year. Additionally, we are planning to initiate two additional Phase 1 programs utilizing our controllable and adaptable ARC-SparX technology, in r/r MM and relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome. We believe Arcellx can help patients by engineering therapies that are safer, more effective, and more broadly accessible, and we are committed to delivering on our mission."

Recent Business Highlights

Completed upsized IPO raising $142.3 million in gross proceeds. In February 2022, Arcellx completed its initial public offering selling 9,487,500 shares of its common stock, which included the exercise in full of the underwriters’ option to purchase 1,237,500 additional shares of its common stock, at a public offering price of $15.00 per share. The aggregate gross proceeds from the offering were $142.3 million, before deducting underwriting discounts and commissions and other offering expenses payable by Arcellx.

Announced pre-clinical data presentation for ACLX-002 at AACR (Free AACR Whitepaper). On March 8, 2022, Arcellx announced the upcoming presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022 of pre-clinical data for ACLX-002, a novel CD123-targeted universal CAR-T cell therapy for relapsed or refractory acute myeloid leukemia (AML). ACLX-002 can be activated in a dose dependent manner in vivo with soluble protein adapters allowing for controllability and adaptability to address intra- and inter-patient disease heterogeneity and off-target antigen expression that are often associated with serious dose-limiting adverse events in AML. Details of the presentation are as follows:

Session Category:

Immunology

Session Title:

Adoptive Cell Therapy 2

Session Date and Time:

Sunday, April 10, 2022, 1:30 PM – 5:00 PM

Location:

New Orleans Convention Center, Exhibit Halls D-H, Poster Section 37

Poster Board Number:

22

Permanent Abstract Number:

587

Expanded board of directors. In December 2021, Kavita Patel, M.D. was appointed to Arcellx’s board of directors. Dr. Patel brings a wealth of knowledge from her experience as a practitioner, a hospital administrator and as an expert and published author on healthcare policy and reform. Since 2020, Dr. Patel has served as a primary care physician at Mary’s Center in Washington DC. Since January 2011, Dr. Patel has served as a Nonresident Fellow at the Brookings Institution where she concentrates on several efforts including delivery system reforms and cost containment. From 2011 to 2018, Dr. Patel served in leadership roles at Johns Hopkins. Earlier in her career, Dr. Patel served as a director of policy for The Office of Intergovernmental Affairs and Public Engagement in The White House under President Obama and a deputy staff director to the late Senator Edward Kennedy, focusing on pandemic preparedness and health care reform. Her prior research in healthcare quality and community approaches to mental illness have earned national recognition and she has published numerous papers and book chapters on healthcare reform and health policy. Dr. Patel currently serves as a member of the board of directors for Intelligent Medicine Acquisition Corp., Select Quote, Inc., and Sigilon Therapeutics, Inc. Dr. Patel earned an M.D. from University of Texas Health Science Center, an M.S. in Health Services Research from the University of California Los Angeles and her B.A. from the University of Texas at Austin.

Fourth Quarter and Full year 2021 Financial Highlights

Cash, cash equivalents and marketable securities:

As of December 31, 2021, and December 31, 2020, Arcellx had cash and cash equivalents and marketable securities of $104.6 million and $46.6 million, respectively. In February 2022, Arcellx completed its initial public offering raising gross proceeds of $142.3 million, which resulted in net proceeds of $128.0 million, after deducting underwriting discounts and commissions and other offering expenses paid by Arcellx. Arcellx expects that the cash on hand subsequent to the IPO will fund its operations into the second half of 2023.

R&D expenses:

Research and development expenses were $13.4 million for the quarter ended December 31, 2021, compared to $6.9 million for the quarter ended December 31, 2020, an increase of $6.5 million. Research and development expenses were $46.9 million for the year ended December 31, 2021, compared to $25.1 million for the year ended December 31, 2020, an increase of $21.8 million. These increases were driven by higher costs associated with our CART-ddBCMA program, preclinical development of our other product candidates and increased headcount.

G&A expenses:

General and administrative expenses were $7.3 million for the quarter ended December 31, 2021, compared to $2.2 million for the quarter ended December 31, 2020, an increase of $5.1 million. General and administrative expenses were $18.1 million for the year ended December 31, 2021, compared to $7.0 million for the year ended December 31, 2020, an increase of $11.1 million. These increases were driven by increased headcount and professional services costs such as legal, audit services and consultants.

Net loss:

Net loss was $20.7 million and $9.1 million for the quarters ended December 31, 2021, and 2020, respectively; and $65.0 million and $32.1 million for the years ended December 31, 2021, and 2020, respectively.

On March 24, 2022 Inhibrx, Inc. (Nasdaq: INBX), a biotechnology company with four clinical programs in development and an emerging pre-clinical pipeline, reported that data from INBRX-121 and INBRX-130 will be presented at the 2022 American Association for Cancer Research (AACR) (Free AACR Whitepaper) ("AACR") Annual Meeting to be held April 8th- 13th, 2022 in New Orleans, LA (Press release, Inhibrx, MAR 24, 2022, View Source [SID1234610932]).

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"We are excited to share some of the updated preclinical data for our targeted cytokine platform and INBRX-121 that specifically expands and enhances the cytotoxic capacity of NK cells. Additionally, we will introduce our unique T-cell engager platform, CONTRA-MAB, and INBRX-130 that targets the 5T4 antigen on solid tumors," said Brendan Eckelman, Ph.D., Inhibrx Co-founder and Chief Scientific Officer. "We believe that both of these platforms are foundational to our continued efforts aimed at growing our emerging pipeline of therapeutic candidates in oncology."

Details on poster presentations are shared below:

Title: INBRX-121, a safe and efficacious molecular targeted cytokine that enhances NK cell-mediated tumor killing
Track/Session: Immunology – Immunomodulatory Agents and Interventions 2
Abstract/Poster: 3513 / 15
Lead Author: Heather Kinkead
Date & Time: April 12, 2022, 1:30-5:00 PM CDT
Location: Exhibit Halls, Poster Section 37

Title: INBRX-130, a 5T4-targeted CONTRA-MAB, is a potent CD3 bispecific antibody engineered to have minimal off-tumor activity
Track/Session: Immunology – Therapeutic Antibodies 2
Abstract/Poster: 2912 / 27
Lead Author: Katelyn M. Willis
Date & Time: April 12, 2022, 9:00 AM- 12:30 PM CDT
Location: Exhibit Halls, Poster Section 38

Posters will be available on-demand on the AACR (Free AACR Whitepaper) website for attendees (www.aacr.org) beginning at 12:00 PM CDT on April 8, 2022 until July 13, 2022. Upon release at AACR (Free AACR Whitepaper), the scientific posters will be accessible through Inhibrx’s website at View Source

About INBRX-121
Inhibrx developed a molecular targeted cytokine ("MTC") platform that combines an engineered IL-2 variant with reduced affinity for the IL-2 receptor and high affinity sdAbs to restrict IL-2 receptor signaling to cells expressing the target antigen (termed cis-signaling). Inhibrx’s MTC platform provides a novel path to overcoming the limitations of IL-2 therapy through the pinpointed delivery of IL-2 activity to target cells of interest. INBRX-121 is an MTC designed to deliver IL-2 to NK cells using an NKp46-specific sdAb as the targeting moiety. INBRX-121 drives specific NK cell expansion and enhances activation and cytotoxic capacity. Unlike T cells, tumor recognition by NK cells is independent of MHC-presented antigens and can elicit immediate cytotoxic activity. Further, many of the toxicities associated with T cell therapeutics have not been observed with NK-centric treatments. Due to its unique design, INBRX-121 has the potential to be a safe and efficacious treatment option for a broad array of cancer indications both as a monotherapy and in combination with ADCC-enabled antibodies.

About INBRX-130
Inhibrx has developed a CD3 bispecific platform, CONTRA-MAB (Constrained T Cell Redirecting and Activating Multispecific Antibody), that combines tumor-associated antigen targeting single-domain antibodies (sdAbs) with a constrained CD3-targeting VH/VL pair that has been strategically positioned and affinity engineered to minimize T cell activation and cytokine production in the absence of target antigen engagement. INBRX-130 is a CONTRA-MAB that targets trophoblast glycoprotein (TPBG; 5T4), a cell-surface protein that is upregulated across many solid tumor indications but has restricted expression on normal adult tissues. Due to the unique CONTRA-MAB design and the broad tumor biased expression of 5T4 across solid tumors, INBRX-130, has the potential to have a greater therapeutic index over other T-cell directed therapeutics in the solid tumor setting and thereby provide a significant benefit to patients in need.

On March 24, 2022 Harbour BioMed ("HBM" or the "Company"; HKEX: 02142), a global biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics focusing on oncology and immunology, reported full year 2021 annual results (Press release, Harbour BioMed, MAR 24, 2022, View Source [SID1234610931]). During the reporting period, the Company’s product development continued to make outstanding breakthroughs, unleashing the power of innovative technology platforms and globalization advantages.

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"2021 was a year of strong momentum for Harbour BioMed. The company has been making significant progress with respect to our highly differentiated pipeline products and business operations," said Jingsong Wang, Founder, Chairman and Chief Executive Officer. "Our 10 clinical trials are ongoing while two of them, Batoclimab and Tanfanercept, are in pivotal phase III trials and are progressing towards BLA (Biologics License Application) submission. We’ve seen encouraging data of the global clinical trials of HBM4003 and solid progress of multiple assets through pre-clinical development. The value of our platforms has been further validated with more than 50 leading partners around world.

Moving forward in 2022, we will continue to explore more differentiated novel therapeutics on a global basis, leveraging in-house technology platforms and strong research and development capabilities. I believe that each of our innovative products empowered by our unique platforms has the potential to benefit the patients globally, accelerating our mission to lead a healthy life with breakthrough medicines globally."

Recent Highlights:

Continued advancement across broad pipeline of core assets —

10 clinical trials are ongoing.
2 products, Batoclimab (HBM9161 for patients with myasthenia gravis) and Tanfanercept (HBM9036 for patients with dry eye disease), are in pivotal phase III trials and are progressing towards BLA submission.
Global clinical trials of HBM4003 in both monotherapy and combination therapy are also rapidly advancing at full pace, with encouraging data and promising results to date.
Multiple assets are progressing through pre-clinical development —

6 innovative and differentiated products are nearing clinical stages of development.
HBM7008 was approved for phase I clinical trial in Australia and HBM9378 was approved for phase I clinical trial in China.
HBM1020, HBM1022, HBM1007, and HBM7020 are all advancing towards clinical applications.
Another 7 INDs are approved. This portfolio of innovative and differentiated products entering the clinical stage demonstrates the value of the Company’s technology platforms.
The Company is actively exploring new scientific discoveries in novel therapeutic areas to address unmet medical needs —

Leveraging in-house technology platforms, the Company is incubating NK cell therapy, bispecific NK cell engager and developing innovative antibody drug conjugate (ADC) products.
The Company’s scientific research team strives to scale new heights in science with its strong research and development capabilities —

In the period, 65 patents were filed.
The Company also participated in multiple academic conferences, presenting scientific achievements while highlighting its strong innovation capabilities.
Further advanced its global strategy through multiple collaborations —

Entered into a research collaboration agreement with the Dana-Farber Cancer Institute of the Affiliated Hospital of Harvard Medical School.
Reached a strategic collaboration on artificial intelligence with BioMap, integrating the Company’s AI technology advantages into the Harbour Mice platform.
Further expanded an academic collaboration with the Icahn School of Medicine at Mount Sinai.
Advanced the strategic collaboration with Hualan Bio, and several assets are expected to enter the clinical stage this year.
The value of the Company’s platforms is further validated with more than 50 leading partners around the world.
Driving antibody drug development through innovation

The Company remains committed to the discovery and development of differentiated antibody therapeutics focusing on oncology and immunology. Powered by Harbour BioMed’s unique technology platforms, it has developed a differentiated portfolio and innovation engine for sustained long-term expansion and growth of its self-developed pipeline.

Harbour BioMed is at the forefront of developing next generation immuno-oncology therapeutics, including innovative immune cell engager bispecific antibodies, unique Treg depletion mechanism, and novel immune escape pathway. Cancer treatment market unfolds vast opportunities, and the Company seeks to develop oncology therapeutics that address situations where 70%-80% of patients do not respond to or are resistant to PD1/PD-L1, in its pursuit of next-generation immuno-oncology therapeutics which tap the potential value of this $100 billion market.

With the R&D advantages of HBM’s unique and highly efficient antibody discovery platforms under one organizational umbrella, the Company developed a number of first-in-class clinical and preclinical products. Among them, the bispecific antibody HBM7008 (B7H4/4-1BB) and the monoclonal antibody HBM1020 (B7H7) which represents the next generation of immune checkpoint inhibitors with significant differentiated advantages. In addition, the monoclonal antibody HBM1022 targets the Treg cell protein CCR8. CCR8 is recognized globally as a challenging target but one which is garnering increased attention in immuno-oncology. The Company’s use of mRNA immunization technology combined with its proprietary antibody platforms allow for a suite of solutions of G protein-coupled receptor (GPCR) antibody discovery. These noted products were all developed by the Company and indicative of the encouraging progress HBM has made in overcoming the challenges faced across the competitive landscape. The Company looks forward to continuing this success with promising clinical results as these and other programs move forward in their development lifecycles.

The rapid advancement of HBM’s clinical pipeline has continued into 2022, with multiple milestones reported in the first quarter. In February, the fully human monoclonal antibody HBM9378 (or SKB378) generated from the Company’s H2L2 platform was approved for an investigational new drug ("IND") clinical trial application for the treatment of moderate to severe asthma; in the same month, HBM7008 (B7H4/4-1BB), the world’s first-in-class product from the HBICE bispecific antibody platform, was officially approved by the Independent Review Board (IRB) in Australia and could potentially provide improved efficacy with better safety as compared to traditional monoclonal antibody therapies. The Company expects 4-6 products to enter the clinical stage this year and to rapidly push forward innovative products with blockbuster potential, laying a solid foundation for building a global competitive advantage.

HBM’s cutting-edge fully human antibody platforms enable unique innovation and differentiation

HBM’s antibody discovery platforms are the engine of its portfolio innovation: HBICE – a fully human bispecific antibody platform for immune cell engagers, a fully human heavy-chain-only antibody HCAb platform for monoclonal antibodies, and a fully human heavy and light chain antibody H2L2 platform with global patent protection. These robust technology platforms drive the Company to continuously advance antibody drug development while move towards more novel and challenging targets to address unmet medical needs, providing the momentum for sustained therapeutics innovation worldwide.

It is worth noting that, in the field of bispecific antibodies development, the Company’s fully human HBICE bispecific platform for immune cell engagers, the highly differentiated bispecific antibody technology platform globally, is built upon the fully human HCAb based formats for immune cell engagers, which is also a patented achievement independently developed by the Company. The HBICE platform focuses on immune cell engagers, which can flexibly generate multiple molecular structures adapting to different biological mechanisms of action and effectively solving the problem of heavy and light chain mismatch in antibody engineering. The technology platform connects tumor cells with immune cells, activates immune cells, and kills tumor cells specifically, which can improve the effectiveness of treatment and reduce the risk of cytokine storm, avoiding the toxicity risk of systemic activation. Thus, safety is significantly improved, which is conducive to creating more innovative, differentiated, and safe products.

HBM is actively strengthening globalization presence to empowering its long-term development goals

As innovation and development across the biopharmaceutical industry continues to become more global, the Company is thriving on its three global innovation research centers and four major clinical sites, which reflects the Company’s global ambition and continued investment into its R&D capabilities. By integrating R&D centers established in the US, the Netherlands and China, the Company is capable to consolidate leading global scientific and technological innovation resources. By maximizing regional innovation success, resource utilization is improved and translational clinical research results are advanced, accelerating bringing about differentiated innovative therapeutics, facilitating cooperation within the industry for the benefit of patients. At the same time, following the strategy of international research and development, HBM set up with four clinical sites in China, the US, Australia, and Europe to speed up the global development of its self-developed products.

Importantly, innovative solutions shape the global biopharmaceutical industry. The Company is jointly developing the next generation of innovative therapeutics through its proprietary technology platforms and global innovation network; an approach that has been validated by over 50 industry and academia partners with more than 10 products having entered the clinical stage. External collaborations include those with Eli Lilly, AbbVie, Pfizer, BeiGene, Innovent, Dana-Farber Hospital of Harvard Medical School, and Icahn School of Medicine of Mount Sinai Medical System in New York. Our global footprint enables the value proposition the Company’s antibody technology platforms, which can be continuously tapped into and increasing the commercial income generating potential of its R&D capabilities.

In addition, the Company previously announced that it will initiate exploration of NK cell and ADC therapeutics. The Company hopes to leverage its novel technology across these frontier therapeutic areas, expand the application of its technology platforms, and lead next drug development programs to address areas of significant unmet clinical needs.

Accelerating clinical development to unlock potential value

As of now, the Company has independently developed more than ten highly differentiated products, two of which are in pivotal clinical phase III trials and are moving towards Biologics License Application (BLA) submission – namely Batoclimab (HBM9161), which has obtained the national Breakthrough Therapeutics Designation for myasthenia gravis, and Tanfanercept (HBM9036), the first globally innovative biological drug for dry eye disease in China.

Specifically, Batoclimab is a next generation fully human monoclonal antibody that selectively binds to and inhibits the neonatal crystal fragment receptor (FcRn) and has the potential for breakthrough treatment of various autoimmune diseases. Tanfanercept is the most advanced product candidate currently being developed by the Company for the treatment of moderate-to-severe dry eye disease, which has a bright market potential in the emerging dry eye drug market in China. These two products are highly differentiated and have large potential market opportunities.

As people begin to emerge from the global pandemic, good health is even more in focus now. In the increasingly competitive biopharmaceutical market, innovation is no doubt the core commodity. Harbour BioMed has built a broad moat with its innovation engine and differentiated pipeline, leveraging its unique and robust antibody technology platforms, regional global innovation ecosystem, and accelerated clinical operations of its core products.

On March 24, 2022 Novocure (NASDAQ: NVCR) reported that Dr. David Tran, Chief of the Division of Neuro-Oncology at the McKnight Brain Institute at the University of Florida, will present updated results from his investigator-initiated phase 2 pilot 2-THE-TOP clinical trial testing the safety and preliminary efficacy of Tumor Treating Fields (TTFields) together with pembrolizumab and temozolomide for the treatment of adult patients with newly diagnosed glioblastoma (GBM) (Press release, NovoCure, MAR 24, 2022, View Source [SID1234610929]).

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These preliminary results, which are based on a median follow-up time of 16.8 months, compare outcomes for 26 patients in the ongoing 2-THE-TOP trial versus a historical, matched-control group of 26 patients from the TTFields plus temozolomide arm of the phase 3 pivotal EF-14 clinical trial. For patients in the 2-THE-TOP trial, median progression-free survival was 12.1 months, compared with 7.9 months for the matched-control patients in EF-14 (hazard ratio=0.46, p=0.033). Patients in 2-THE-TOP had a median overall survival of 25.2 months, compared with 15.9 months for the matched-control patients in EF-14 (hazard ratio=0.38, p=0.020).

Of the 15 patients in 2-THE-TOP with measurable target lesions, six (40%) achieved partial to complete response and eight (53%) had stable disease.

"These data from 2-THE-TOP are exciting and point to the potential benefit of Tumor Treating Fields together with pembrolizumab and temozolomide," said Uri Weinberg, Novocure’s Chief Science Officer. "TTFields’ ability to activate a downstream immune response, effectively turning a cold tumor hot, is a unique element of TTFields therapy."

Dr. Tran will present his data from 2-THE-TOP at the 6th Quadrennial Meeting of the World Federation of Neuro-oncology Societies (WFNOS 2022) in Seoul, South Korea on March 26, 2022. His oral presentation, which has been selected for a Best Abstract Award, will be delivered during the conference’s Top 10 Session 2 at 10:15 a.m. KST, followed by a live question-and-answer session.

In a preclinical study published in the Journal of Clinical Investigation (JCI) on Feb. 24, 2022, Dr. Tran’s research group reported that TTFields-mediated cell disruption activates the immune system, triggering an anti-tumor cell response that may be effectively used together with existing immunotherapy approaches in the treatment of solid tumors with limited systemic toxicity. These preclinical findings provided the mechanistic rationale for the 2-THE-TOP study.

"We are very encouraged by the data from Dr. Tran’s 2-THE-TOP study, and by the mechanistic insights published by his research group in JCI," said William Doyle, Novocure’s Executive Chairman. "We plan to continue exploring the potential of using Tumor Treating Fields with immunotherapies, which could shift the treatment paradigm for patients with this aggressive disease."

Dr. Tran’s oral presentation at WFNOS 2022 is one of three oral presentations at the conference highlighting research on TTFields.

Dr. Carsten Hagemann of the Department of Neurosurgery at University Hospital Würzburg will present preclinical data on TTFields as a novel chemotherapeutic delivery strategy on March 25, 2022 at 17:30 KST.

Dr. Wenyin Shi, Co-Director of the Brain Tumor Center of the Sidney Kimmel Cancer Center, will present data from the SPARE trial: Scalp sparing radiation with concurrent temozolomide and TT Fields (200 kHz) for patients with newly diagnosed glioblastoma on March 26, 2022 at 18:00 KST.

In addition, 28 posters at WFNOS 2022 will feature research on TTFields.

TTFields is investigational for the treatment of newly diagnosed GBM when used together with pembrolizumab.

About 2-THE-TOP

The 2-THE-TOP trial is an investigator-initiated, phase 2 pilot trial designed to assess the safety and preliminary efficacy of Tumor Treating Fields (TTFields) together with pembrolizumab and temozolomide for the treatment of adult patients with newly diagnosed GBM. Patients enrolled in the trial underwent maximal tumor resection followed by standard chemoradiation. Following the completion of chemoradiation, patients began a course of monthly cycles of adjuvant temozolomide. Treatment with TTFields started at approximately the same time as the first cycle of adjuvant temozolomide. Pembrolizumab was introduced in the second cycle of treatment and subsequent cycles of pembrolizumab were administered every three weeks until first disease progression or unacceptable toxicities or 2 years, whichever comes first.

About EF-14

The EF-14 trial was a randomized, phase 3 pivotal trial which compared, post radiation, TTFields plus temozolomide versus temozolomide alone for the treatment of newly diagnosed GBM. Median progression-free survival, the primary endpoint, was 6.7 months for TTFields plus temozolomide versus 4 months for temozolomide alone. Median overall survival was 20.9 months for TTFields plus temozolomide versus 16 months for temozolomide alone.

About Tumor Treating Fields

Tumor Treating Fields, or TTFields, are electric fields that disrupt cancer cell division. Fundamental scientific research extends across more than two decades and, in all preclinical research to date, TTFields have demonstrated a consistent anti-mitotic effect. TTFields therapy is intended principally for use together with other standard-of-care cancer treatments. There is a growing body of evidence that supports TTFields’ broad applicability with certain other cancer therapies, including radiation therapy, certain chemotherapies and certain immunotherapies. In clinical research and commercial experience to date, TTFields therapy has exhibited no systemic toxicity, with mild to moderate skin irritation being the most common side effect. The TTFields global development program includes a network of preclinical collaborators and a broad range of clinical trials across all phases, including four phase 3 pivotal trials in a variety of tumor types. To date, more than 22,000 patients have been treated with TTFields therapy.

On March 24, 2022 Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing allogeneic cell therapies for unmet medical needs, reported that Brian M. Culley, the Company’s Chief Executive Officer, will be presenting at the 2022 Virtual Growth Conference, presented by Maxim Group LLC and hosted by M-Vest (Press release, Lineage Cell Therapeutics, MAR 24, 2022, View Source [SID1234610928]). Mr. Culley will be participating in an "Ophthalmology Panel" hosted by Jason McCarthy, Ph.D., Senior Managing Director, Biotechnology, on March 28th, 2022 at 10am ET / 7am PT . Mr. Culley will also provide a corporate overview which will be available to investors on demand, starting on Monday March 28th, 2022.

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The live panel and on-demand presentation will be available to registered users directly through the M-Vest platform: https://m-vest.com/events/2022-virtual-growth-conference. Registration is required for conference participation. An archived webcast of the corporate presentation will also be available on the Events and Presentations page of the Lineage website. Additional videos are available on the Media page of the Lineage website.