On May 12, 2022 Isofol Medical AB (publ), (Nasdaq Stockholm: ISOFOL), reported that the company’s interim report for January–March 2022 is now available on the company’s website, www.isofolmedical.com (Press release, Isofol Medical, MAY 12, 2022, View Source [SID1234614268]).

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First quarter, January–March 2022
● Net revenue amounted to TSEK 4,006 (5,215) and other revenue to TSEK 1 (0)
● The result for the period amounted to TSEK -47,874 (-42,662)
● Earnings per share amounted to SEK -0.30 (-0.51)
● Cash and cash equivalents on March 31 amounted to TSEK 332,035 (77,524)

Significant events during the first quarter 2022
● Jenny Sundqvist assumed her role as Chief Commercial Officer on January 1, 2022.

Significant events after the event of the period
● Isofol’s Nomination Committee proposes the election of Jan Törnell as new Chairman of the Board at the Annual General Meeting on May 19, 2022.
● On April 22, Isofol announced that the process of analyzing study data from the AGENT study has begun.

CEO´s comment:
"During the first quarter, Isofol performed many crucial and important activities to lay the foundation for the presentation of the forthcoming study results in the AGENT study. Having now passed the cut-off point that enables the start of the data analysis process, we see several milestones ahead, presentation of top-line data and later also final data", says CEO Ulf Jungnelius.

Audiocast, May 12, at 11:00 a.m. CEST
In conjunction with the publication of the interim report for the first quarter of 2022, Isofol invites investors, analysts, and media to an audiocast on May 12, 2022 at 11:00 a.m. CEST. The presentation will be held by Isofol´s CEO Ulf Jungnelius and CFO Gustaf Albèrt, who will present and comment the report, followed by a Q&A-session. The presentation will be held in English.

The information was submitted for publication, through the agency of the contact person set out above, at 08:00 CEST, on May 12, 2022.

About arfolitixorin
Arfolitixorin is Isofol’s proprietary drug candidate being developed to increase the efficacy of standard of care chemotherapy for advanced colorectal cancer. The drug candidate is currently being studied in a global pivotal Phase III study, AGENT. As the key active metabolite of the widely used folate-based drugs, arfolitixorin can potentially benefit more patients with advanced colorectal cancer, as it does not require complicated metabolic activation to become effective.

On May 12, 2022 Crown Bioscience and Medical & Biological Laboratories (MBL), JSR Life Sciences companies, reported the formation of a joint venture, to further expand the provision of Crown Bioscience’s preclinical services to Japanese customers (Press release, Crown Bioscience, MAY 12, 2022, View Source [SID1234614267]).

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The new entity named "Crown Bioscience & MBL", is a long-term strategic partnership that is expected to accelerate growth for both companies. The initial focus is to provide preclinical and translational services to expand Crown Bioscience’s offerings in Japan. The agreement will enhance Crown Bioscience’s current distributor model and establish a local presence to ensure premium service delivery in Japan.

Based in Tokyo, Crown Bioscience & MBL will establish a local team led by an experienced General Manager, Hiroki Itou, Executive Officer of MBL and General Manager, Diagnostic & Research Reagents Department at JSR.

The new company will leverage each organisations’ respective areas of excellence and expertise, combining Crown Bioscience’s world-class preclinical and translational service capabilities with MBL’s deep knowledge and experience of the Japanese pharmaceutical market. The company, established in April 2022, is expected to initiate services from September 2022.

Commenting on the establishment of the new company, Armin Spura PhD, CEO of Crown Bioscience, noted that the agreement will extend and deepen the current partnership with MBL. He said: "Japan will play a significant part in Crown Bioscience and MBL’s long-term strategic vision. Our new company has been created to better serve the evolving needs of the Japanese biopharmaceutical community, and to serve our Japanese customers more effectively. I am excited to further develop our synergies with MBL – a trusted partner in the Japanese life sciences sector."

Hiroki Itou, President of Crown Bioscience & MBL commented: "Our two companies share a deep respect and identical values in the way we conduct business. I am confident that together we will be able to provide a unique and innovative portfolio of services that will accelerate drug discovery and development in Japan."

On May 12, 2022 Curium reported confirmed no supply challenges of 177Lu-PSMA-I&T for the Phase 3 ECLIPSE clinical trial (NCT05204927), evaluating Lutetium 177Lu-PSMA-I&T treatment compared to the standard of care hormone therapy in men with metastatic Castration-Resistant Prostate Cancer (mCRPC) (Press release, Curium, MAY 12, 2022, View Source [SID1234614266]). Curium continues to provide clinical trial supply, and enroll patients in the ECLIPSE clinical trial with no disruptions.

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"Earlier this month we announced significant progress in our ECLIPSE clinical trial. We are enrolling eligible patients into our study of 177Lu-PSMA-I&T without disruption, which is a testament to our surety of supply. Reliability is a core competency for Curium and is fundamental to fulfilling our purpose of redefining the experience of cancer through our trusted legacy in nuclear medicine," said Renaud Dehareng, Curium’s Group CEO.

"We are thrilled to be able to reliably support our patients, investigators and clinical trial sites," said Sakir Mutevelic, MD, Curium’s Chief Medical Officer. "We remain committed to patients with metastatic castration-resistant prostate cancer."

For more information about the ECLIPSE Trial, visit Curium’s Clinical Trial website View Source or contact Curium’s Clinical Trial team directly at [email protected] with questions or to locate a clinical trial site near you.

On May 12, 2022 Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, reported its first quarter 2022 results (Press release, Targovax, MAY 12, 2022, View Source [SID1234614265]). Members of Targovax’s executive management team will give an online presentation to investors, analysts and the press at 10:00 CET today (details below).

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1Q 2022 HIGHLIGHTS
Business Development
Announced two key collaboration agreements with Agenus:

Free drug supply of two checkpoint inhibitors for ONCOS-102 combination therapy in the upcoming phase 2 melanoma trial
Inclusion of the adjuvant QS-21 STIMULONTM as an immune-stimulatory component of the TG mutant KRAS cancer vaccine
R&D
Announced that Oslo University Hospital will sponsor a study to test the TG01 cancer vaccine in RAS mutant multiple myeloma patients
Announced a research collaboration with Prof Michael Uhlin at Karolinska Institutet in Stockholm for development and characterization of NextGen circular RNA ONCOS viruses
Organization
Appointed circular RNA co-discoverer and pioneer Dr Thomas B Hansen as VP of Research to lead the circular RNA pipeline program
Strengthened the management team with the appointment of industry veteran Dr Lubor Gaal as Chief Financial Officer
Appointed Dr Raphael Clynes and Mr Thomas Falck as new members of the Board of Directors

On May 12, 2022 Kuraray Co., Ltd. reported (Press release, Kuraray, MAY 12, 2022, https://pdf.irpocket.com/C3405/wigp/TW1Q/plJB.pdf [SID1234614264])

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1. Consolidated Financial Results for the First Quarter of the Fiscal Year Ending December 31, 2022 (January 1, 2022 to March 31, 2022)
(1) Consolidated Operating Results (Percentage changes displayed for net sales, operating income, ordinary income and net income attributable to owners of the parent are comparisons with the corresponding period of the previous fiscal year.)
(2) Consolidated Financial Position

2. Dividends
3. Forecasts of Consolidated Financial Results for the Fiscal Year Ending December 31, 2022 (January 1, 2022 to December 31, 2022) (Percentage changes displayed for net sales, operating income, ordinary income and net income attributable to owners of the parent are comparisons with the corresponding period of the previous fiscal year.)