On May 6, 2022 Cytovia Therapeutics, LLC ("Cytovia Therapeutics"), a global biotechnology company focused on harnessing the power of natural killer (NK) cells to fight cancer through multispecific antibodies and stem cell engineering, reported that it will be presenting at the AACR (Free AACR Whitepaper) Special Conference on Advances in the Pathogenesis and Molecular Therapies of Liver Cancer, to be held from May 5-8, 2022, at the Westin Copley Place in Boston, Massachusetts (Press release, Cytovia Therapeutics, MAY 6, 2022, View Source [SID1234613804]). The conference is an in-person event and will not live-stream content, but Cytovia Therapeutics’s short poster video will be available for on-demand viewing by conference registrants after the conference and Cytovia Therapeutics’s poster will be available on its website under the "Resources" section.

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Details of Cytovia’s poster presentation:
Abstract title: Preclinical activity of glypican-3 (GPC3) and NKp46 directed FLEX-NK engager antibody (CYT-303) in combination with iPSC derived natural killer cells (iNKs) or peripheral blood (PB) NK cells in hepatocellular carcinoma (HCC)

Session: Poster Session/Reception
Session Date and Start Time: Friday, May 6, 5:30-7:30 p.m.

Conclusions from the poster:

The FLEX-NKTM multifunctional engager antibody CYT-303 directed against NKp46 and GPC3 demonstrated potent single agent anti-tumor activity:
potent NK cell cytotoxicity against HCC tumor cells accompanied by cytokine production in an in vitro model indicative of NK cell engagement and activation
HCC tumor growth inhibition in an in vivo model
Favorable cytokine release and immune cell subset safety profile
iNK cells expressed a favorable combination of multiple activation and few inhibitory receptors that facilitated potent cytolytic activity against HCC tumors
The combination of the FLEX-NKTM and iNK cells demonstrated greater in vitro and in vivo anti-tumor activity in HCC tumor models than iNK cells alone
The preclinical proof of concept studies with CYT-303 alone or in combination with iNK cells in HCC warrant clinical development

On May 6, 2022 Tempus, a leader in artificial intelligence and precision medicine, reported a multi-year agreement with the United States Department of Veterans Affairs (VA) National Precision Oncology Program (NPOP) designed to expand access to Tempus’ portfolio of next-generation sequencing offerings to support physicians in delivering personalized treatment approaches for their patients with cancer (Press release, Tempus, MAY 6, 2022, View Source [SID1234613803]). The Veterans Health Administration is the largest integrated health system in the U.S., providing care to more than nine million Veterans annually.

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The NPOP is leveraging Tempus’ broad range of comprehensive molecular profiling capabilities in an effort to improve patient outcomes with precision medicine. As part of the collaboration, providers across the VA’s 171 Medical Centers can leverage Tempus’ next-generation sequencing tests, including its solid tumor/normal assay and liquid biopsy assay. In the event of insufficient tumor tissue, Tempus offers a conversion option to a blood-based liquid biopsy test which seamlessly delivers genomic results without a delay to the clinician or the patient.

"Our AI-enabled tests combine high-quality and comprehensive genomic data with clinical data for each patient being sequenced, which allows physicians to make truly personalized decisions as they seek the optimal therapy for their patients," said Eric Lefkofsky, Founder and CEO of Tempus. "We look forward to supporting the VA as they expand access to precision medicine solutions in oncology care to those who have served our country and deserve the very best care we have to offer."

On May 6, 2022 InterVenn Biosciences, the leader in applied glycoproteomics, reported that it will present new clinical data detailing the success of its novel approach to liquid biopsy testing in multiple cancer indications at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2022 Annual Meeting (Press release, InterVenn Biosciences, MAY 6, 2022, View Source [SID1234613802]). The meeting will take place from June 3 to June 7 at McCormick Place in Chicago.

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InterVenn will present two posters and five online publications highlighting data that demonstrate clinically relevant applications of its glycoproteomics-based biomarker signatures in a variety of cancers, including malignant melanoma, ovarian cancer, colorectal cancer, non-small-cell lung carcinoma, and bone and soft tissue sarcoma.

"We look forward to sharing our data at ASCO (Free ASCO Whitepaper) 2022 further validating the power of InterVenn’s pioneering glycoproteomic biomarker signatures to transform clinical care in cancer," said InterVenn CEO Aldo Carrascoso. "As a mission-driven company, InterVenn is building a robust pipeline of accessible, clinically validated and powerful tests, with the aim of detecting cancer earlier, treating it more effectively, and saving lives."

The InterVenn approach addresses many of the common challenges associated with liquid biopsy analysis by industrializing the process of glycoproteomics-based blood testing at high accuracy with fast turnaround times. Unlike other non-invasive methods, it does not depend on detecting material shed by tumors, and therefore allows the detection of very early-stage, potentially curable tumors that are commonly missed by other technologies. It also requires a significantly lower blood sample volume than most other analytical platforms.

InterVenn Presentations at ASCO (Free ASCO Whitepaper) 2022

Poster Presentations:

Title: "Serum glycoproteomic signatures predict overall survival in bone and soft tissue sarcoma patients treated with immune checkpoint inhibitor therapy"
Presenter: D. Serie, C. Pickering, R. Rice, M. Wong, H. Huang, M. Kansara, DM. Thomas, and K. Lindpaintner

Title: "Glycoproteomics as a powerful liquid biopsy-based predictor of checkpoint-inhibitor treatment benefit in metastatic malignant melanoma"
Presenter: A. Mitchell, C. Pickering, G. Xu, K. Vigal, B. Axenfeld, R. Rice, X. Cong, D. Frederick, W. A. Michaud, G. Boland, D. Serie, and K. Lindpaintner

Online Publications:

Title: "Glycoproteomics as a powerful liquid biopsy based screening tool for NSCLC"
Author: C. Pickering, G. Xu, R. Rice, A. Castellanos, R. Bhadra, L. Brcic, J. Lindenmann, F.M. Smolle-Juettner, K. Lindpaintner, D. Serie, and A. Mitchell

Title: "Clinicians’ perspectives on use of immune checkpoint inhibitors and related biomarkers for solid tumors"
Author: K. Moser, M. Soto, D. Geba, P. Allen, and K. Lindpaintner

Title: "Identifying potential glycoproteomic biomarkers for diagnosis of colorectal cancer"
Author: K. Desai, G. Xu, R. Rice, A. Castellanos, D. Serie, A. Mitchell, and K. Lindpaintner

Title: "Liquid-biopsy derived glycoproteomic profiling as a novel means for non-invasive diagnosis of ovarian cancer"
Author: C. Pickering, P. Aiyetan, G. Xu, R. Rice, P. Ramachandran, K. Moser, D. Serie, and K. Lindpaintner

Title: "Predicting Breast Cancer in Women using Liquid Biopsy-Derived Glycoproteomic Marker"
Author: A. Mitchell, A. Srinivasan, G. Xu, R. Rice, A. Castellanos, R. Bhadra, D. Serie, X. Cong, and K. Lindpaintner

On May 6, 2022 Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), reported that Feng Tian, Ph.D., Chairman of the Board, President and CEO of Ambrx, will present at two upcoming investor conferences in May (Press release, Ambrx, MAY 6, 2022, View Source [SID1234613801]).

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Bank of America 2022 Healthcare Conference. Dr. Tian will participate in an analyst led fireside chat on Wednesday, May 11 at 12:00 PM Pacific Time / 3:00 PM Eastern Time.

H.C. Wainwright Global Investment Conference. Dr. Tian will conduct a pre-recorded presentation that will be available on-demand on Tuesday, May 24 at 4:00 AM Pacific Time / 7:00 AM Eastern Time.

Interested parties can access the live and pre-recorded webcasts for these conferences from the Investor Relations section of the company’s website at www.Ambrx.com. The webcast replays will be available after the conclusion of the respective presentations for approximately 90 days.

On May 6, 2022 Palisade Bio, Inc. (Nasdaq: PALI) (the "Company" or "Palisade Bio"), a clinical-stage biopharmaceutical company advancing therapies for acute and chronic gastrointestinal complications, reported that it has entered into definitive agreements with several institutional and accredited investors for the purchase and sale in a registered direct offering of 3,646,690 shares of its common stock, at a purchase price of $0.55 per share (Press release, Seneca Biopharma, MAY 6, 2022, View Source [SID1234613792]).

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Ladenburg Thalmann & Co. Inc. is acting as the exclusive placement agent for the offering.

The closings of the sale of the securities in the financing is expected to occur on or about May 10, 2022, subject to the satisfaction of customary closing conditions. Palisade Bio intends to use the net proceeds from the financing for working capital and general corporate purposes, including the development of the Company’s lead product candidate LB1148.

The Company also agreed to issue to the investors in a concurrent private placement, unregistered warrants to purchase up to an aggregate of 3,646,690 shares of its common stock. The warrants have an exercise price of $0.7105 per share of common stock, will be exercisable 6 months after the date of issuance, and will expire five and a half years following the initial issuance date.

The shares of common stock (but not the warrants or the shares of common stock underlying such warrants) offered in the registered direct offering are being offered and sold by the Company pursuant to a "shelf" registration statement on Form S-3 (Registration No. 333-263705), including a base prospectus, previously filed with and declared effective by the Securities and Exchange Commission ("SEC") on April 26, 2022. The offering of the shares of common stock in the registered direct transaction are being made only by means of a prospectus supplement that forms a part of the registration statement. A final prospectus supplement and an accompanying base prospectus relating to the registered direct offering will be filed with the SEC and will be available on the SEC’s website located at View Source Electronic copies of the prospectus supplement and accompanying base prospectus may also be obtained, when available, by contacting Ladenburg Thalmann & Co. Inc. at Attn: Prospectus Department, 640 Fifth Avenue, 4th Floor, New York, NY 10019 or by e-mail at [email protected]..

The warrants (and the shares of common stock underlying such warrants) are being offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act") and/or Regulation D promulgated thereunder, and such securities have not been registered under the Act or applicable state securities laws. Accordingly, such securities may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Act and such applicable state securities laws. Palisade Bio has agreed to file a registration statement with the SEC registering the resale of the shares of common stock issuable upon the exercise of the warrants.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.