On June 6, 2022 Boundless Bio, a next-generation precision oncology company developing innovative therapeutics directed against extrachromosomal DNA (ecDNA) in oncogene amplified cancers, reported that Chief Executive Officer, Zachary Hornby, will present at the 2022 Jefferies Healthcare Conference, which will take place in New York City (Press release, Boundless Bio, JUN 6, 2022, View Source [SID1234615651]). Presentation details are as follows:

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Date: Thursday, June 9, 2022
Time: 10:30 AM ET
Location: New York Marriott Marquis

On June 6, 2022 TwinStrand Biosciences, Inc., the pioneer in duplex sequencing technology, reported that the company will present several data sets as part of its sponsorship and participation in the annual Advances in Genome Biology and Technology conference in Orlando on June 6-9, 2022 (Press release, TwinStrand Biosciences, JUN 6, 2022, View Source [SID1234615650]). The studies will highlight advances in TwinStrand’s innovative technology and share recent research that demonstrates the power of duplex sequencing for some of the most demanding applications in clinical and foundational research.

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"At TwinStrand, we continue to make progress and see the impact of our technology in important areas like hematology-oncology, genetic toxicology, and cellular therapies," said Jesse Salk, M.D., Ph.D., TwinStrand’s Cofounder, and CEO. "We are pleased to share this progress with the AGBT community and look forward to forming new collaborations that leverage our highly sensitive and specific Duplex Sequencing technology which has consistently demonstrated its potential as a critical decision support tool in medicine, public health, and other fields of science where high-resolution insights are most impactful."

TwinStrand DuplexSeq AML-29 Minimal Residual Disease (MRD) Assays offer high-sensitivity detection of ultra-low frequency mutations in acute myeloid leukemia (AML) cases. The 29-gene panel covers loci that are mutated in up to 95% of adult AML patients and is several orders of magnitude more sensitive and specific than other next-generation sequencing-based (NGS) MRD assays. TwinStrand is a member of the Foundation for the National Institutes of Health Biomarkers Consortium, which recently launched a program to validate and standardize methods of detecting and quantifying MRD in AML patients.

TwinStrand DuplexSeq Mutagenesis Assays offer a novel NGS-based approach to mutational research that detects, quantifies, and characterizes genome mutagenesis. It is the first NGS technology able to directly measure ultra-rare mutations caused by chemical carcinogens, without requiring biological selection and is applicable in vitro and in vivo. The final output is comprehensive data on induced mutations including frequency, simple spectrum, and trinucleotide signatures. TwinStrand is collaborating with the Health and Environmental Sciences Institute (HESI), the UK branch of the European Environmental Mutagenesis Society (UKEMS), and the US National Institutes of Standards (NIST) to showcase the value of error-corrected NGS for various preclinical research and regulatory applications.

AGBT attendees can learn more about TwinStrand technology in the Escambia suite. The company will share details from its pioneering work and partnerships in the field of genetic toxicology, which has significant implications for future regulatory mutagenicity and carcinogenicity testing. Other data sets will showcase recent applications of TwinStrand DuplexSeq products in acute myeloid leukemia and allogeneic cell therapy, including:

Ultra-Sensitive Duplex Sequencing for Quantifying Multi-Individual Cell Therapy Sub-Population Fractions
Authors from TwinStrand Biosciences and Deverra Therapeutics
Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia
Authors from TwinStrand Biosciences, Fred Hutchinson Cancer Research Center, National Heart, Lung, and Blood Institute – National Institutes of Health, and Children’s Hospital Los Angeles
Duplex Sequencing Reveals Ubiquitous Clonal Hematopoiesis and Complex Donor-Recipient Clonal Dynamics Following Hematopoietic Stem Cell Transplant
Authors from TwinStrand Biosciences and Fred Hutchinson Cancer Research Center
Longitudinal Monitoring of Pediatric Acute Myeloid Leukemia Using Duplex Sequencing of Patient-Specific Panels Reveals Ultra-Low Frequency MRD that Marks Persistent Carcinogenesis and Complex Clonal Evolution
Authors from TwinStrand Biosciences, Fred Hutchinson Cancer Research Center, and University of California San Francisco

On June 6, 2022 Thermo Fisher Scientific Inc. (NYSE:TMO), the world leader in serving science, is showcasing new instruments, workflows, software and industry collaborations that enable customers to generate new analytical insights and accelerate next generation vaccine and therapy development (Press release, Thermo Fisher Scientific, JUN 6, 2022, View Source [SID1234615649]). The company will showcase these innovations during the 70th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, being held June 5-9, 2022, in the Minneapolis Convention Center, Minneapolis.

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"Our newest innovations are focused on improving each of the critical steps in an end-to-end mass spectrometry workflow," said John Lesica, president, chromatography and mass spectrometry, Thermo Fisher Scientific. "New instruments, consumables, workflows and software solutions enable leading-edge biological research that spans the molecular spectrum—from targeted and small molecule quantitation and advancements in high-throughput quantitative proteomics and bio-molecular characterization to a revolution in intuitive, AI-driven software."

Enabling Next Generation Therapies

To improve material quantitation and accelerate biopharma development, Thermo Fisher has added a new Thermo Scientific Direct Mass Technology mode for its Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometers that lets manufacturers analyze the characteristics of biotherapeutics in greater detail throughout development. For proteomics researchers, the Thermo Scientific AccelerOme Automated Sample Preparation Platform improves reproducibility in sample prep, a longstanding bottleneck preventing wider use in biomarker discovery for disease detection and research into new therapies.

A new Thermo Scientific µPAC Neo HPLC Column improves column-to-column reproducibility within proteomics and biopharmaceutical research applications as part of an end-to-end liquid chromatography-mass spectrometry (LC-MS) workflow. This further simplifies complex bottom-up proteomics analyses, enabling wider use in discovery and detection of cancer and other disease biomarkers and in development of new therapies and vaccines ranging from COVID to cancer and rare diseases.

Unlocking Deeper Analytical Insights

The new cloud-based Thermo Scientific Ardia platform integrates data across multiple chromatography and mass spectrometry instruments, letting biopharmaceutical and proteomics scientists share previously siloed data, simplifying analyses and unlocking deeper insights into new diagnostics and therapies that could reach the point of care sooner.

New Thermo Scientific BioPharma Finder 5.1 software uses advanced algorithms to improve biotherapeutic characterization, an increasing priority as industry and regulators build stricter quality controls into the production of complex new biotherapies and vaccines.

For proteomic scientists, Thermo Scientific Proteome Discoverer 3.0 software interprets data from Thermo Scientific Orbitrap mass spectrometers and applies artificial intelligence (AI), giving researchers a faster method to identify and analyze billions of possible protein interactions in humans, insights that accelerate discovery and development of next-generation drugs and vaccines.

Lastly, for forensic toxicologists, clinical research toxicologists, employee drug testing facilities and wellness organizations, expanding the Thermo Scientific Tox Explorer Collection onto the Thermo Scientific Orbitrap Exploris Mass Spectrometer platform, provides an all-in-one LC-MS toxicology solution to solve complex analytical challenges and increase laboratory productivity.

Cross Industry Collaboration

Thermo Fisher has entered a relationship with TransMIT GmbH Center for Mass Spectrometric Developments to promote a mass spectrometry imaging (MSI) platform for spatial multi-omics applications in pharmaceutical and clinical laboratories. The Thermo Scientific Orbitrap MS instrumentation, coupled with TransMIT’s AP-SMALDI5 AF Ion Source, enables higher-resolution spatial distribution mapping of cancer and other complex tissues to improve disease detection.

On June 6, 2022 Eureka Therapeutics, Inc., a clinical-stage biotechnology company developing novel T cell therapies to treat solid tumors, reported the publication of a preclinical study in blood entitled "A TCR Mimic CAR T Cell Specific for NDC80 Is Broadly Reactive With Solid Tumors and Hematological Malignancies" (Press release, Eureka Therapeutics, JUN 6, 2022, View Source [SID1234615648]). The study was led by Dr. Cheng Liu, President & Chief Executive Officer of Eureka and Dr. Martin Klatt and Dr. David Scheinberg of Memorial Sloan Kettering Cancer Center (MSK).

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Chimeric antigen receptor (CAR) T cells represent a novel class of FDA-approved drugs with high efficacy against refractory B cell-derived malignancies. However, target identification and selection for CAR T cell therapy remains challenging as most cell surface proteins are not cancer-specific and therefore often not adaptable for CAR T cell therapy. In contrast, many intracellular proteins are highly tumor-specific and targetable after being presented on the cell surface by human leukocyte antigen (HLA) complexes in the form of peptide-MHC complexes. T cell receptor mimic (TCRm) antibodies can recognize peptide-MHC complexes similarly to TCRs, but with the versatility and applicability of an antibody.

In collaboration with MSK, Eureka scientists used its E-ALPHA platform to identify TCRm antibodies that target the NDC80-derived complex. NDC80 is an intracellular protein over-expressed in multiple tumor types such as ALL, AML, lymphoma, melanoma, mesothelioma, pancreatic and thyroid cancer. In the study, anti-NDC80 TCRm-redirected T cells demonstrated high specificity in recognizing and killing multiple cancer cell lines. Moreover, no toxicities to healthy leukocytes and hematopoietic stem cells were observed.

"TCR mimic antibodies can unlock the potential of T-cell therapies by targeting intracellular proteins that are presently not druggable by conventional antibodies or conventional CAR-T cells that target cell surface proteins," said Dr. Cheng Liu, Founder and CEO, Eureka Therapeutics. "We are excited by the study and look forward to seeing the expanded use of TCR mimic antibodies in other cancer types."

On June 6, 2022 Bruker Corporation (Nasdaq: BRKR) reported key innovations for spatial multiomics of tissue and tumor microenvironments (TME) (Press release, Bruker, JUN 6, 2022, View Source [SID1234615647]). Following Bruker’s strategic partnership with AmberGen1, key enhancements are introduced for MALDI HiPLEX-IHC mass spectrometry imaging.

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MALDI HiPLEX-IHC represents a breakthrough in multiomics imaging by combining targeted protein expression spatial profiling with unbiased small molecule MALDI Imaging to co-localize proteins and small molecules such as glycans, lipids, metabolites, or xenobiotics. Using AmberGen’s MiralysTM antibody-based photocleavable peptide mass tags, highly multiplexed IHC staining and photocleavage of peptide markers fit seamlessly into Bruker’s IntelliSlide-based automated workflows for MALDI imaging.

Novel multiomic imaging enhances spatial high-plex protein imaging with the ability to elucidate metabolic processes in the same tissue section. In addition to mapping tens to over one hundred targeted proteins with high-plex peptide tags, MALDI HiPLEX-IHC can track signaling pathways such as glycosylation, observe lipid spatial profiles for tumor microenvironment segmentation, or simultaneously observe how drugs affect both protein and metabolic states.

Dr. Peggi Angel, Professor of Cell and Molecular Pharmacology and Experimental Therapeutics at the Medical University of South Carolina commented: "From the perspective of a lab heavily invested in cellular signaling processes in cancer biology, MALDI HiPLEX-IHC is a game changer allowing integration of mass spectrometry imaging with cell biology. We will be using this technology for multiomic N-glycan and collagen imaging studies to understand aggressive breast cancers. I expect that researchers investigating the tissue microenvironment will quickly adopt this unique spatial multiomics technology."

Bruker also announced its microGRID module for smartbeam 3D MALDI sources for timsTOF fleX systems. The microGRID improves the MALDI stage to sub-micron precision to correct laser positioning on tissue surfaces down to 5 micrometers (µm), virtually eliminating any visual artifacts or artifacts in co-registration of MALDI images with optical microscopy. As correction is effective for entire pathology slides, microGRID leverages a large field-of-view for MALDI HiPLEX-IHC protein expression profiling.

Dr. Ron Heeren, Distinguished Professor and Limburg co-chair of the Maastricht Multimodal Molecular Imaging (M4I) Institute, added: "At M4I, we develop workflows and techniques to contextualize the role of individual cells in disease, and determine how interactions between cells affects cellular states locally and across long distances."

Dr. Heeren continued: "Since we work closely with pathologists and cancer researchers who are used to microscopes, we cannot afford artifacts in our mass spectrometry images, and need large fields-of-view. Bruker’s microGRID achieves this effortlessly without limiting the area of the slide we can process for multiomic, multimodal images of diseased and homeostatic pathology."

Bruker also demonstrated key updates for MALDI Imaging data analysis using SCiLSTM Lab 2023a, including microGRID support and improvements in handling CCS (collisional cross section)-enabled imaging datasets acquired with timsTOF technology. SCiLSTM Lab 2023a introduces the novel 4D Feature-Finder for visualizing CCS-resolved features in intuitive mass-mobility diagrams. In addition, images produced from multimodal datasets were demonstrated with MALDI HiPLEX-IHC protein expression spatial profiling. This allows SCiLS Lab to leverage its auto-segmentation and statistical profiling tools using images that overlay protein and small molecule localization on the same tissue section.