On September 7, 2022 Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of injectable biologics to selectively engage and modulate tumor-specific T cells directly within the patient’s body, reported members of their management and scientific teams will participate in two scientific conferences this September, The Promise of Interleukin-2 Therapy taking place September 14-17 in Paris, France and the Next Generation Protein Therapeutics Summit, held in Boston, Massachusetts and virtually on September 28-30 (Press release, Cue Biopharma, SEP 7, 2022, View Source [SID1234619179]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Presentation Details
The Promise of IL-2 Therapy
Location: Centre international de Conférence Sorbonne Université, Paris, France
Presentation title: Leveraging the Immuno-STAT platform to enhance anti-tumor immunity by selectively delivering IL-2 to tumor-specific T cells
Presenter: Matteo Levisetti, M.D., senior vice president, Clinical Development, Cue Biopharma
Session: Session IX – IL-2 in Cancer Therapy
Date and time: September 17, 2022, 9:00 am CET
Dr. Levisetti will present an overview of Cue Biopharma’s Immuno-STAT (Selective Targeting and Alteration of T cells) platform including the interleukin 2 (IL-2)-based CUE-100 series of biologics designed to enable selective targeting of IL-2 to tumor-specific T cells. The presentation will highlight data from clinical trials evaluating CUE-101, the company’s lead clinical candidate from the CUE-100 series, in patients with human papilloma virus positive recurrent/metastatic head and neck squamous cell carcinoma (HPV+ R/M HNSCC) as a monotherapy and in combination with pembrolizumab. Dr. Levisetti will also discuss the company’s second clinical candidate, CUE-102, currently in evaluation in a Phase 1 trial for patients with Wilms’ Tumor 1 (WT1)-positive cancers as well as other platform developments that support versatility for the potential treatment of several diverse cancers.
Presentation title: CUE-401: a novel IL-2/TGF-beta fusion protein for induction and expansion of regulatory T cells
Presenter: Steven Quayle, Ph.D., vice president Translational Pharmacology, Translational Medicine, Cue Biopharma
Session: Session X – Novel IL-2s and Combination Therapies
Date and time: September 17, 2022, 11:30 am CET
Dr. Quayle will provide an overview on the Company’s lead CUE-400 series drug product candidate CUE-401, a novel bispecific molecule designed for differentiation and expansion of induced regulatory T cells (iTregs). Dr. Quayle will discuss preclinical data supporting CUE-401’s mechanism of action and potential opportunity for the treatment of patients with autoimmune and graft-versus-host disease. Cue Biopharma plans to advance the CUE-400 series programs through strategic partnerships.
Presentation Details
Next Generation Protein Therapeutics Summit
Location: Boston Convention and Exhibition Center & virtual. The event will be simultaneously live streamed: https://informaconnect.com/next-gen-protein/
Presentation title: Immuno-STATs: TCR-selective engagers and activators of anti-tumor T cells
Presenter: Anish Suri, President and chief scientific officer, Cue Biopharma
Session: T Cell Engager Design and Challenges
Date and time: September 28, 2022, 4:30 pm ET
Dr. Suri will present an overview of Cue Biopharma’s Immuno-STAT platform and biologics designed to present tumor-specific proteins to T cell receptors (TCR) of the target tumor-specific T cells, to modulate that T cell repertoire for the anti-cancer response, as well as clinical data demonstrating the single-agent anti-tumor activity of CUE-101, the Company’s first IL-2 based clinical candidate, in late-stage head and neck cancer patients.
About Immuno-STAT
The company’s Immuno-STAT (Selective Targeting and Alteration of T cells) biologics are designed for targeted modulation of disease-associated T cells in the areas of immuno-oncology and autoimmune disease. Each of our biologic drugs is designed using our proprietary scaffold comprising: 1) a pMHC to provide selectivity through interaction with the T cell receptor (TCR), and 2) a unique co-stimulatory signaling molecule to modulate the activity of the target T cells. The simultaneous engagement of co-regulatory molecules and pMHC binding mimics the signals delivered by antigen presenting cells (APCs) to T cells during a natural immune response. This design enables Immuno-STAT biologics to engage with the T cell population of interest, resulting in selective T cell modulation. Because our drug candidates are delivered directly in the patient’s body (in vivo), they are fundamentally different from other T cell therapeutic approaches that require the patients’ T cells to be extracted, modified outside the body (ex vivo), and reinfused.