On September 21, 2022 AVEO Oncology (Nasdaq: AVEO), a commercial stage, oncology-focused biopharmaceutical company committed to delivering medicines that provide a better life for patients with cancer, reported that Michael Bailey, president and chief executive officer, will participate in a panel discussion at the Cantor Fitzgerald Oncology & HemOnc Conference (Press release, AVEO, SEP 21, 2022, View Source [SID1234621291]). The panel titled "Building Combinations: What are the Novel Ideas?" will be held on Wednesday, September 28th, at 10:40 a.m. eastern time.

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If you are interested in arranging a 1×1 meeting at the conference, please contact your Cantor representative. For more details, please see the Calendar of Events section of AVEO Oncology’s corporate website.

On September 21, 2022 ALX Oncology Holdings Inc., ("ALX Oncology") (Nasdaq: ALXO) a clinical-stage immuno-oncology company developing therapies that block the CD47 checkpoint pathway, reported that Jaume Pons, Ph.D., Founder, President and Chief Executive Officer, will participate in a panel and investor meetings at the Cantor Oncology, Hematology & HemeOnc Conference on Wednesday, September 28 in New York (Press release, ALX Oncology, SEP 21, 2022, View Source [SID1234621290]).

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Format: Moderated panel with analysts, Li Watsek & Brandon Folkes
Panel: "Building Combinations: What are the Novel Ideas?"
Date: Wednesday, September 28
Time: 10:40 AM Eastern Time
Location: New York, NY

Dr. Pons and Mr. Peter Garcia, CFO of ALX Oncology, will be hosting one-on-one meetings during the conference. To schedule a one-on-one meeting with the ALX Oncology management team, please contact your Cantor conference representative.

On September 21, 2022 Helsinn Group ("Helsinn"), a fully integrated, global biopharma company with a diversified pipeline of innovative oncology assets, reported that two scientific abstracts have been accepted for oral presentation at the upcoming EORTC CLTG (European Organisation for Research and Treatment of Cancer Cutaneous Lymphoma Tumors Group) Annual Meeting 2022, taking place in Madrid, Spain from the 22-24 September (Press release, Helsinn, SEP 21, 2022, View Source [SID1234619715]).

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Details on the presentations are below:

Presentations:

Title: A Post-hoc Analysis of Clinical Trial Data Shows that Prior Phototherapy Does Not Affect Response to Chlormethine Gel in Patients with Mycosis Fungoides

Authors: Chalid Assaf, Christiane Querfeld, Marta Scandurra, Marco Turini, Julia J. Scarisbrick

Date/Time: 23 September, 6:36pm CET

Presenter: Chalid Assaf, Prof. Dr. med., Chief Physician of the Clinic for Dermatology and Venerology, Helios Klinikum Krefeld, Germany

Title: Combination Therapy with Chlormethine Gel and Narrow-Band Ultraviolet B for Patients with Mycosis Fungoides: a Case Series

Authors: Laura Gleason, Daniel Joffe, Neda Nikbakht MD, PhD

Date/Time: 23 September, 5:12pm CET

Presenter: Laura Gleason, MD, Thomas Jefferson University, Department of Dermatology and Cutaneous Biology, Philadelphia, US

During the conference Helsinn will also be sponsoring a satellite symposium which will focus on chlormethine’s mechanism of action. The symposium, entitled "A multi-level analysis of chlormethine: from skin cells to clinical cases", will involve experts in the field of mycosis fungoides, including Prof. Pablo Ortiz-Romero, Head of Dermatology at University Hospital 12 de Octubre in Madrid, Spain and Prof. Emmanuella Guenova, Dermatologist at the Lausanne University Hospital, Switzerland and one of the leading researchers of the chlormethine molecule.

Satellite symposium

Title: A multi-level analysis of chlormethine: from skin cells to clinical cases

Date/Time: Thursday 22 September/1:30-2:30pm CET

Presenters: Emmanuella Guenova and Pablo Ortiz-Romero

Dr. Silvia Sebastiani, Group Head of Medical Affairs, commented: "It’s fantastic to see the growing body of data emerging from in vitro, clinical and case studies of LEDAGA/VALCHLOR for the treatment of this rare skin lymphoma. We’re pleased to be taking part in EORTC CLTG, sharing our own findings, as well as hearing the latest insights from across the cutaneous lymphoma research landscape. We remain committed to support the global MF-CTCL patient population."

Prof. Pablo Ortiz-Romero Head of Dermatology at University Hospital 12 de Octubre, added: "There is currently no cure for patients living with MF-CTCL and treatment goals are mainly aimed at reducing the abnormal appearance of the skin and to control any itching or other symptoms. I am delighted to Chair the Helsinn satellite symposium where emerging new data regarding chlormethine’s mode of action will be discussed, as well as interesting insights from Professor Guenova‘s clinical experience. The latest research further delineates the mechanism of LEDAGA/VALCHLOR in the treatment of this rare skin cancer."

Chlormethine gel 0.016%, also known as mechlorethamine gel, is approved in multiple countries, including the EU and US, and is marketed under the trade names LEDAGA and VALCHLOR. The authorized use for each country varies based on the design of the registrational trial and the individual health authority requirements. For more details, please refer to the approved product information for each respective jurisdiction.

On September 20, 2022 GenScript USA Inc., the world’s leading life-science research tools and services provider and Avectas, reported a cell engineering technology leader, are partnering to develop an improved non-viral cell therapy manufacturing process (Press release, Avectas, SEP 20, 2022, View Source [SID1234626218]). The two companies share a goal of providing their customers with potent, new methods for developing cell therapies that offer an improved safety profile over viral and non-viral vector techniques.

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By combining Avectas’ cell engineering technology and know-how with GenScript’s expertise in synthetic long oligo production, the partnership aims to demonstrate a novel and efficient solution for cell therapy manufacturing and to improve editing efficiency and cell viability over traditional delivery methods.

CRISPR-based non-viral gene editing methods have gained popularity among research teams following concerns about the FDA’s recent draft guidance on the use of viruses for gene and cell therapy. GenScript is collaborating with both academic and industry partners in the development of CRISPR non-viral gene editing to enable next-generation gene- and cell-therapy R&D projects.

Intracellular delivery is integral to the generation of engineered ex vivo cell-based therapies, including genome editing approaches. But the limitations of current delivery modalities, both viral and non-viral, led Avectas to develop the non-viral solupore cell engineering technology, which enables efficient delivery of cargoes into cells for the development of next-generation therapies.

The research teams will apply solupore technology to permeabilize the target cell membrane so that engineered cargoes can be delivered while retaining very high levels of cell viability and functionality. GenCRISPR synthetic sgRNA and Cas9 protein are then complexed into a ribonucleic protein that is co-delivered with GenExact ssDNA HDR templates into the cell nucleus.

"GenScript is excited to partner with Avectas as part of our program to develop novel RNP and oligo delivery systems for non-viral cell engineering," said Ray Chen, PhD, president of GenScript USA Life Science Group. "We expect this method will provide our customers with more complete solutions for efficient gene editing using our GenCRISPR sgRNA and ss/dsDNA HDR templates."

"Avectas is delighted to partner with GenScript to combine its innovative editing tools together with our solupore delivery platform," said Michael Maguire, PhD, CEO of Avectas. "This will enable the development of next-generation cell therapies differentiated by the quality of the modified cells, which retain high viability, functionality, and post-process proliferation."

On September 20, 2022 Basilea Pharmaceutica Ltd, a commercial-stage biopharmaceutical company committed to meeting the needs of patients with severe bacterial and fungal infections, reported that it has entered into an asset purchase agreement and a sub-license agreement with SillaJen, Inc. for Basilea’s novel kinase inhibitor, BAL0891, a potential first-in-class mitotic checkpoint inhibitor, that drives aberrant tumor cell division leading to tumor cell death (Press release, Basilea Pharmaceutica, SEP 20, 2022, View Source [SID1234625345]).

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Basilea in-licensed BAL0891 in 2018 from the Dutch precision medicine company NTRC. Under the asset purchase agreement Basilea is selling its intellectual property rights generated under the license and collaboration agreement with NTRC. In addition, Basilea is sub-licensing its rights and obligations under the license and collaboration agreement with NTRC to SillaJen.

Adesh Kaul, Chief Financial Officer of Basilea, said: "We are pleased to have found in SillaJen an experienced oncology partner for the further development of BAL0891. This transaction marks an important step on our path to be a focused anti-infectives company. We are proud to have advanced BAL0891 through preclinical development to the start of clinical studies. The unique inhibition profile of BAL0891, targeting both TTK and PLK1 kinases, differentiates the compound and offers the potential for development in multiple cancers. Through the structure of the transaction we continue to participate in the long-term value creation potential of this promising program."

Jaegyeong Kim, MD, CEO at SillaJen, Inc. stated: "We are excited to acquire the rights to BAL0891. This agreement for a first-in-class anti-cancer drug, demonstrates our commitment to enhance lives of patients suffering from advanced solid tumors. In addition to our leading pipeline of Pexa-Vec, and the next generation SJ-600 series of oncolytic virus modalities, we are committed to advance and further develop medicines that will address the greatest unmet needs in cancer treatment. We hope to successfully deliver these products and help alleviate the burden of cancer patients worldwide."

Under the terms of the agreement, Basilea will receive upfront and near-term milestone payments of USD 14 million. Basilea is also eligible to receive further payments of up to approximately USD 320 million upon the achievement of predefined development, regulatory and sales milestones and tiered royalties on net sales starting in the single digit range going up to double-digits. Basilea remains responsible for making milestone and royalty payments to NTRC according to the license and collaboration agreement with NTRC.

In February this year Basilea announced its intention to focus on becoming a leading anti-infectives company and therefore to separate its oncology assets. Basilea has already made significant progress in the implementation of the new strategy and expects no material expenses related to oncology activities beyond 2022. Basilea is on track to achieve sustainable profitability from 2023.

Basilea updates its full-year 2022 financial guidance. It expects higher total revenues of CHF 116 to 122 million (previously CHF 106 to 112 million), an improved operating result of CHF -10 to -15 million (previously CHF -20 to -25 million) and improved cash flow from operating activities of CHF 0 to -5 million (previously CHF -10 to -15 million).

About SillaJen, Inc.

SillaJen, Inc. (KOSDAQ:215600) is one of the leading biotech companies in the development of oncolytic vaccinia immunotherapy. It is headquartered in Seoul, South Korea, with research center and satellite offices in Busan, South Korea and San Francisco, CA. SillaJen, Inc. is conducting Phase 2 trials for the treatment of renal cell carcinoma with the company’s lead pipeline, Pexa-Vec. The company is also developing intravenous injectable oncolytic vaccinia virus pipelines (SJ-600 series) to be more applicable and efficacious against various tumors. Additional information about SillaJen, Inc. is available at www.sillajen.com.

About BAL0891

BAL0891 is a first-in-class mitotic checkpoint inhibitor that pushes cells through mitosis without adequate time for correct chromosome segregation. This results in aberrant tumor cell division leading to tumor cell death. The compound is a unique dual inhibitor of threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1). Both kinases collaborate in activating the mitotic spindle assembly checkpoint (SAC), a cell division mechanism regulating correct chromosome alignment and segregation. The dual action of BAL0891 leads to a rapid disruption of the SAC driving cells through mitosis before the chromosomes are properly aligned, leading to premature cell division and tumor cell death. BAL0891 has shown anti-proliferative activity across diverse tumor cell lines in vitro and single agent efficacy in in-vivo models of solid human cancers. BAL0891 was in-licensed from NTRC in 2018.