On September 19, 2022 Regen BioPharma, Inc. (OTC PINK: RGBP) and (OTC PINK: RGBPP) reported that filing of a provisional patent application with the USPTO entitled "Dual Checkpoint Inhibitor Aptamer Based Therapeutics" (Press release, Regen BioPharma, SEP 19, 2022, View Source [SID1234619675]). The application covers novel compositions of matter capable of acting as conventional checkpoint inhibitor drugs while simultaneously silencing genes which regulate T cells and cancer cells such as NR2F6 and Survivin. The Company believes that this platform technology is the first combination of an immunotherapy and a gene silencing agent in a single drug.

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Aptamers are short DNA or RNA sequences which can function as antibodies – they recognize specific proteins and bind to them. This new technology takes advantage of the fact that the Company can put its proprietary RNA or DNA sequences which code for inhibitory RNAs on one end of an aptamer while using the other end of the aptamer to bind to, and thus inhibit, a traditional immune checkpoint such as PD-1. Once the aptamer is internalized into the cell, the proprietary DNA or RNA sequence is converted to an inhibitory RNA which targets other genes involved in T cell function or cancer growth leading to a two-pronged approach to T cell activation or cancer-killing.

"Our Company has been working on RNA therapeutics for several years, including being granted a U.S. patent for survivin-based RNA vaccines, as well as gene silencing of NR2F6," said Dr. David Koos, CEO and Chairman of the Company. "We believe the merger of this technology with checkpoint inhibitors, and the resulting platform technology, will result in development of numerous potent therapeutic candidates."

On September 19, 2022 IDEAYA Biosciences, Inc. ( Nasdaq:IDYA) reported the closing of its underwritten public offering of 8,761,905 shares of its common stock at a public offering price of $10.50 per share, before underwriting discounts and commissions, including the exercise in full by the underwriters of their option to purchase up to an additional 1,142,857 shares of common stock in the offering (Press release, Ideaya Biosciences, SEP 19, 2022, View Source [SID1234619674]). The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by IDEAYA, were approximately $92.0 million.

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J.P. Morgan, Jefferies, Citigroup and Guggenheim Securities acted as joint book-running managers for the offering. Wedbush PacGrow acted as lead manager for the offering.

The public offering was made by IDEAYA pursuant to a shelf registration statement on Form S-3 that was previously filed with and declared effective by the U.S. Securities and Exchange Commission, or the SEC. The offering was made only by means of a written prospectus and prospectus supplement that form a part of the registration statement. A final prospectus supplement and accompanying prospectus relating to the offering has been filed with the SEC and is available on the SEC’s website at View Source Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may also be obtained by request from: J.P. Morgan, by mail at J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at 866-803-9204, or by email at [email protected]; Jefferies, by mail at Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, or by telephone at 877-547-6340 or 877-821-7388, or by email at [email protected]; Citigroup, by mail at Citigroup Global Markets Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at 1-800-831-9146; or Guggenheim Securities, by mail at Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, New York, NY 10017, or by telephone at (212) 518-5548 or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On September 19, 2022 SHINE Technologies, a next-generation fusion technology company, and Radiopharm Theranostics (ASX:RAD), a developer of a world-class platform of radiopharmaceutical products for both diagnostic and therapeutic uses, reported that they have entered into a clinical supply agreement (Press release, Radiopharm Theranostics, SEP 19, 2022, View Source [SID1234619672]). SHINE will supply Radiopharm with isotope non-carrier-added lutetium-177 (Lu-177).

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The isotope will be used by Radiopharm in the development of its clinical pipeline of diagnostic and therapeutic radiopharmaceutical products. Lu-177 is an important isotope utilized in multiple programs across Radiopharm’s portfolio.

Nearly everyone has been affected by cancer. SHINE’s efforts are about prolonging lives of those affected most directly.

"One way or another, nearly everyone has been affected by cancer. SHINE’s efforts in lutetium-177 are all about prolonging the lives of those affected most directly," said Chris Vessell, general manager of SHINE’s Therapeutics Division. "We are excited that our isotopes will play a critical role in Radiopharm Theranostics’ programs that aim to revolutionize cancer treatment."

SHINE, an emerging leader in the production of this medical radioisotope, intends to be the industry’s only vertically integrated producer of Lu-177, aiming to provide a reliable and scalable supply independent of current supply-chain restraints."

"Ensuring supply of key isotopes continues to be a priority for our team, allowing us to accelerate our clinical programs unimpeded," said Riccardo Canevari, CEO and managing director of Radiopharm Theranostics. "Lutetium-177 is required for three of our more advanced assets and this clinical supply agreement with SHINE, an experienced player in nuclear technology, is another important step in de-risking our business plan."

On September 19, 2022 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported that the 2nd Annual VISTA Symposium will take place virtually on September 23, 9:00am-1:00pm ET (Press release, Curis, SEP 19, 2022, View Source [SID1234619671]).

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The event will be hosted by Randolph Noelle, Ph.D., Active Emeritus Professor of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth. Global leaders in immuno-oncology will gather at the Symposium to discuss the VISTA checkpoint, its role in cancer, and the latest VISTA research and therapeutic development.

"Curis is pleased to continue its sponsorship of the Annual VISTA Symposium," said James Dentzer, President and Chief Executive Officer of Curis. "As the global leader in VISTA development, we are honored to provide a forum for discussing the progress we’re seeing with CI-8993, our own VISTA program, as well as programs from other companies and academic labs, as we collectively advance the forefront of VISTA research and development for the benefit of patients living with cancer."

The virtual event features agenda topics including:

VISTA Biology
Biology Overview
VISTA ligands and counterreceptors
Role of VISTA in Tumor Immune Evasion
VISTA Targeting
The PK/PD complexities of target mediated disposition
PET Imaging of VISTA targeting
Clinical Opportunities and Questions
Biomarkers, pathways and tumor subsets
Anti-VISTA antibody in combination with radiation therapy
Translational immunology in cutaneous malignancies
Anti-VISTA Therapeutic Strategies
To learn more about the symposium and register to attend, please visit https://bit.ly/VISTA22.

On September 19, 2022 Moffitt Cancer Center, one of the nation’s leading cancer care and research institutions, and Deerfield Management, a health care investment firm, reported a major translational research alliance to accelerate the development of new therapeutics to treat cancer (Press release, Moffitt Cancer Ctr, SEP 19, 2022, View Source [SID1234619670]). Through a newly launched company called Bayfield Therapeutics LLC, Deerfield has committed up to $130 million over the next 10 years to this new collaboration.

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"This partnership is a strong representation of what we aim to achieve at Deerfield to help shape the future of health care," said James E. Flynn, managing partner at Deerfield Management. "Alongside the impressive team at Moffitt, we’ll have the opportunity to combine our financial, operational and development expertise with their existing pipeline, offering a flexible approach and access to additional resources that will ideally bring several new and improved therapeutic solutions to patients battling cancer."

"This new research collaboration will help build upon Moffitt’s stellar reputation of translating our research from the bench to the bedside. Through Bayfield Therapeutics we aim to accelerate the rate at which we are translating these discoveries, into potentially lifesaving therapies for cancer patients," said John Cleveland, Ph.D., executive vice president and center director of Moffitt. "Together, we hope to make a lasting impact on cancer care, improving outcomes for patients in our community and beyond."

Bayfield Therapeutics, LLC is a private company wholly owned by affiliates of Deerfield Management. Its goal is to fund projects that have uncovered novel therapeutics that have the potential to cure life-altering diseases. This collaboration will build upon the robust drug pipeline already established by scientists at Moffitt.

"We are very excited to partner with Deerfield in this effort to advance novel cancer drugs toward the clinic. Moffitt has a strong and innovative basic and pre-clinical drug discovery pipeline with deep expertise in state-of-the-art technologies," said Derek Duckett, Ph.D., chair of the Drug Discovery Department at Moffitt. "With the operational support from Deerfield, we are confident that this new collaboration will accelerate the development of our unique and promising molecules to achieve Investigational New Drug readiness."

As part of the alliance, Deerfield will provide development expertise to help shepherd potential cutting-edge treatments to cancer patients.

Starting this fall, researchers at Moffitt will have the opportunity to submit proposals to Deerfield for review. Each selected project will receive resources and expertise to support the progression from the discovery research phase to clinical testing. Selected proposals will also have eligibility for additional capital investments to create spinoff companies.