On October 18, 2022 Kureha Corporation reported that it has resolved at the meeting of the Board of Directors today to pay the following dividend to shareholders held in record as of September 30, 2022 (Press release, Kureha Corporation, OCT 18, 2022, View Source [SID1234622107]).

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1. Details of dividend payment
2. Reasons

Kureha’s basic policy regarding dividend distribution is to pay a steady dividend to shareholders over a long period of time, while strengthening the company’s financial structure to sustain long-term growth and future business development. From this standpoint, Kureha has determined to pay 125 yen per share for the FY2022 interim dividend, which is consistent with its most recent forecast.

On October 18, 2022 Iterion Therapeutics, Inc., a venture-backed, clinical-stage biotechnology company developing novel cancer therapeutics, reported that results from a preclinical murine study of tegavivint in beta-catenin activated hepatocellular carcinoma (HCC) will be featured in a poster presentation and discussion session at the 34th European Organisation for Research and Treatment of Cancer (EORTC), National Cancer Institute (NCI), and American Association for Cancer Research (AACR) (Free AACR Whitepaper) Symposium (ENA 2022). ENA 2022 is being held October 26-28, 2022, in Barcelona, Spain (Press release, Iterion Therapeutics, OCT 18, 2022, View Source [SID1234622106]).

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Tegavivint is a potent and selective first-in-class small molecule inhibitor of Transducin Beta-like Protein One (TBL1), a novel downstream co-factor in the Wnt/beta-catenin signaling pathway. Increased expression of beta-catenin and TBL1 are associated with metastasis and poor prognosis in a broad range of tumor types, including HCC. Up to 50% of HCC patients have tumors driven by activating beta-catenin and canonical Wnt pathway mutations. Tegavivint targets TBL1 and prevents TBL1/beta-catenin complex formation, specifically inhibiting nuclear beta-catenin’s oncogenic transcriptional activity without disrupting key cell membrane functions that are linked to toxicity common to other drugs in this pathway.

The poster presentation, entitled, "The TBL1 inhibitor, Tegavivint, suppresses tumour growth and enhances T-cell infiltration in preclinical murine β-Catenin mutant hepatocellular carcinoma," will be presented on Wednesday, October 26, 2022, between 12:00-20:00 CET, during the Molecular Targeted Agents 1 session (poster board number PB043; abstract number 53) by Thomas Drake, M.B.Ch.B., B.Med.Sci, principal investigator of the study from the Cancer Research UK Beatson Institute. The poster reports on research studying the therapeutic potential for tegavivint in a genetically engineered C57BL/6J mouse model (GEMM) of beta- cateninexon3 mutant HCC (reference) in both early and late-stage disease. The results include evidence for direct anti-tumor activity and immunomodulatory effects on the ‘cold’ immune microenvironment.

The study found that inhibition of TBL1 in early-stage disease significantly reduced the number of tumor-initiating clones compared with vehicle controls. Treatment of established beta-cateninexon3 activated tumors with tegavivint inhibited tumor growth and resulted in a reduced tumor burden compared with vehicle controls. Additionally, in mice with established tumors, tegavivint treatment increased CD3+ T-lymphocyte tumor infiltration, with prominent increases in intratumoral CD8+ T-cells. Importantly, no off-target effects were observed in intestinal tissue, which is dependent on canonical Wnt signaling to maintain tissue homeostasis.

"Hepatocellular cancer is the third leading cause of death worldwide with approximately half of all patients harboring a Wnt/beta-catenin mutation that is correlated with poor prognosis and resistance to checkpoint inhibitor therapy," said Rahul Aras, Ph.D., CEO of Iterion. "The research presented at ENA 2022 suggests that tegavivint’s ability to inhibit TBL1 and thereby nuclear beta-catenin’s oncogenic activity has the potential to reduce tumor growth and activate an immune response in previously ‘cold’ HCC tumors. These data add to a growing body of literature suggesting nuclear beta-catenin inhibition may be beneficial in treatment of HCC and Iterion is now planning to initiate a company-sponsored clinical trial investigating the potential for tegavivint in this patient population."

On October 18, 2022 IntegraGen (FR0010908723 – ALINT – Eligible PEA PME), IntegraGen, a company specializing in the decryption of the human genome, which carries out interpretable genomic analyzes for academic and private laboratories and develops diagnostic tools in oncology and part of OncoDNA Group, reported its half results for the period ending June 30, 2022 (Press release, Integragen, OCT 18, 2022, View Source [SID1234622105]). The interim accounts were approved by the company’s Board of Directors which met on October 14th, 2022.

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Bernard Courtieu, CEO IntegraGen, said: « After two years strongly impacted by the pandemic and, in particular, a difficult year 2021 in all respects, 2022 should mark a form of return to normal. However, the economic context has been made difficult due to inflation, which has an impact on the purchases of reagents and energy, in an overall economic context that is, to say the least, uncertain. However, IntegraGen’s financial results in the first half of 2022 are again clearly improving both in terms of turnover and operating profit. This is explained in particular by the increase in the activities of the external platforms operated by IntegraGen, as well as by that of the genomic services carried out in our laboratory in Évry. The commercial synergies with the OncoDNA Group are beginning to generate growth with new customers identified by the Group, and confirm the interest of this operation. We would like to thank all our customers who have remained loyal to us during the pandemic period and also, above all, all the laboratory and development employees who, through their dedication, have enabled IntegraGen to successfully pursue its development while contributing to the projects of the researchers as well as clinicians and, ultimately, to improving patient care. »

Revenues for the first half of 2022 amounted to €6,764k, up 35% compared to the first half of 2021. Excluding the recharge of personnel costs to the parent company (€351K), revenue was €6,413k, representing a growth of 33%. This dynamic reflects the strong recovery in general economic activity during the period, compared with H1 2021, where the first quarter was significantly impacted by the pandemic. The recovery is visible in all business segments.

Operating income amounted to €6,933k compared to €5,138k in the first half of 2021 after taking into account transfers of charges and reversals of depreciation and provisions as well as subsidies.

Operating expenses amounted to €7,127k, up by 28% compared to the first half of 2021. This change is explained by various factors including the increase in production costs, in particular under the effect of the inflation, higher sales and marketing expenses and higher payroll costs. At the end of June 2022, the company had 57 employees. This increase also illustrates the investments in Quality within the framework of the certifications of the Évry laboratory.

Operating income before tax, amortization and depreciation (EBITDA) represents a limited loss of €79K compared to -€447k in the first half of 2021, thanks to the business growth.

After taking into account the financial and exceptional results, the net result shows a loss of -€141k compared to -€411k in the first half of 2021.

The available cash amounts to €4,489k at the end of June 2021 or a variation of -€292k compared to the situation as of 31 December 2021. This moderate change is in line with the previous period. The cash position includes a State Guaranteed Loan (PGE) of €1,763k obtained last year in the context of the Covid-19 pandemic. The reimbursement over a period of 5 years has started in June this year

OUTLOOK 2022: CONTINUED GROWTH EXPECTED

IntegraGen intends to pursue revenue growth in 2022 based on the order book to be delivered and the positive trend observed in the market with academic and private clients.

The completed integration within the OncoDNA group confirms IntegraGen’s commercial development perspectives outside of France.

The available cash will finance operational and investment needs.

On October 18, 2022 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) reported that the company will report its third quarter 2022 financial results Tuesday, November 1, 2022 (Press release, BioCryst Pharmaceuticals, OCT 18, 2022, View Source [SID1234622104]).

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BioCryst management will host a conference call and webcast at 8:30 a.m. ET that day to discuss the financial results and provide a corporate update.

The live call may be accessed by dialing 866-374-5140 for domestic callers and 404-400-0571 for international callers and using conference ID 28663801#. A live webcast of the call and any slides will be available online at the investors section of the company website at www.biocryst.com. A replay of the call will be available on the company website.

On October 18, 2022 Acorda Therapeutics, Inc. (Nasdaq: ACOR) reported that it will not use its common stock to make the approximately $6.2 million interest payment due on December 1, 2022, as provided for under its Convertible Senior Secured Notes Indenture (Press release, Acorda Therapeutics, OCT 18, 2022, View Source [SID1234622103]).

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Under the terms of the agreement with bondholders, Acorda may elect to pay interest in cash or shares of the Company’s common stock. Not paying in shares of common stock will ensure that there will be no dilution to shareholders.