On October 5, 2022 Beyond Cancer, Ltd., an affiliate of Beyond Air, Inc. (NASDAQ: XAIR) that is focused on developing ultra-high concentration nitric oxide (UNO) for the treatment of solid tumors, reported that the Company will present data at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting 2022, which is scheduled to be held November 8-12, at the Boston Convention & Exhibition Center in Boston, Massachusetts (Press release, Beyond Cancer, OCT 5, 2022, View Source [SID1234621729]).

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Details of the Company’s presentation are as follows:

Title: Intratumoral Administration of High-Concentration Nitric Oxide and Anti PD-1 Treatment Leads to Higher Tumor Regression Rates and Prolonged Survival in CT26 Tumor-Bearing Mice
Location: Boston Convention & Exhibition Center, Exhibit Hall C, Abstract 819
Date: Thursday Nov 10, 2022 from 9 a.m.-9 p.m. EST
Participant: Hila Confino, Ph.D; Chief Scientific Officer, Beyond Cancer, Ltd.

About Nitric Oxide (NO)

Nitric Oxide (NO) is a powerful molecule, naturally synthesized in the human body, proven to play a critical role in a broad array of biological functions. Currently, exogenous inhaled NO is used in adult respiratory distress syndrome, post certain cardiac surgeries, and persistent pulmonary hypertension of the newborn to treat hypoxemia. Additionally, NO is believed to play a key role in the innate and adaptive immune system response and in vitro studies suggest that NO possesses broad-spectrum antimicrobial activity and anticancer properties.

On October 5, 2022 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of therapeutics designed to activate the immune response to cancers and infections, reported the Company will present new data on its growing portfolio of clinical-stage immuno-oncology programs at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, to be held November 8-12 in Boston, MA and virtually (Press release, Agenus, OCT 5, 2022, View Source [SID1234621728]).

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New data on multiple expansion cohorts from the Phase 1 study of botensilimab (a multifunctional Fc-enhanced anti-CTLA-4) in cold (immunotherapy-resistant) tumors will be presented at an oral plenary session on novel immunotherapies on Saturday, November 12th at 10:50am ET. Three additional presentations will include new data on the mechanisms underpinning botensilimab’s differentiated and enhanced anti-tumor immunity and provide an overview of the Phase 2 trial in progress of AGEN1423, an anti-CD73-TGFβ-trap bifunctional antibody in combination with balstilimab (anti-PD-1) in advanced pancreatic cancer.

Separately, Agenus announced today that Dhan Chand, PhD, Head of Drug Discovery at Agenus was selected to present on the topic of enhanced CTLA-4 blockade at the SITC (Free SITC Whitepaper) Targets for Cancer IO Deep Dive Series on Wednesday, October 5, from 2:00 pm – 4:00 pm ET. To register for the webinar, please visit the Educational and Scientific Programs section of the SITC (Free SITC Whitepaper) website. Dr. Chand’s selection to participate through a highly competitive process underscores his leadership and highlights the focus on botensilimab, as well as the field’s appreciation for the important role CTLA-4 plays in anti-tumor immunity and the scientific contributions and understanding advanced by the team at Agenus.

Presentation Details:

Abstract Title: Botensilimab, a Novel Innate/Adaptive Immune Activator, plus or minus Balstilimab (Anti-PD-1) in "Cold" and I-O Refractory Metastatic Solid Tumors (NCT03860272)
Abstract Number: 778
Presenting Author: Breelyn Wilky, MD, Director of Sarcoma Medical Oncology, Deputy Associate Director for Clinical Research, University of Colorado Medicine
Details: Session 302: Thomas Waldmann Memorial Plenary Session: New Immunotherapies, 11/12/2022, 9:55am – 11:25am ET

Abstract Title: Botensilimab, an Fc-enhanced CTLA-4 Antibody, Enhances Innate and Adaptive Immune Activation to Promote Superior Anti-Tumor Immunity in "Cold" and I-O Refractory Tumors
Abstract Number: 470
Presenting Author: Daniel Levey, PhD, Senior Director Vaccine Research, Agenus
Details: Poster Hall, 11/10/2022 – 11/11/2022, 9:00am – 9:00pm ET

Abstract Title: Botensilimab Modulates Innate and Adaptive Gene Expression Programs Resulting in Superior Immune Stimulation Relative to a First-Generation Anti-CTLA-4 Antibody
Abstract Number: 941
Presenting Authors: Shanmugarajan Krishnan, PhD, Vision Scientist II, Agenus; Jacky Chow, PhD, Senior Scientist, Agenus
Details: Poster Hall, 11/10/2022 – 11/11/2022, 9:00am – 9:00pm ET

Abstract Title: Phase 2 trial of AGEN1423, an Anti-CD73-TGFβ-Trap Bifunctional Antibody, in Combination with Balstilimab, with or without Chemotherapy in Subjects with Advanced Pancreatic Cancer
Abstract Number: 651
Presenting Author: Bruno Bockorny, MD, Assistant Professor, Medicine, Harvard Medical School
Details: Poster Hall, 11/10/2022 – 11/11/2022, 9:00am – 9:00pm ET

Complete abstracts will be released on Monday, November 7, 2022 at 8:00am ET. Updated data presented at the conference will be available to view in the Publications section of the Agenus website (View Source) following the SITC (Free SITC Whitepaper) Annual Meeting.

On October 5, 2022 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") and machine learning ("M.L.") platform to transform the cost, pace, and timeline of oncology drug discovery and development, reported that Lantern management will be presenting at two upcoming investor conferences (Press release, Lantern Pharma, OCT 5, 2022, View Source [SID1234621727]):

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MicroCap Rodeo Presents: Windy City Roundup in Chicago, IL on Wednesday, October 12 at 10:00 a.m. CT. CEO & President Panna Sharma will present.
Webcast Link: View Source
Registration Link: View Source
ThinkEquity Conference in New York, NY on Wednesday, October 26 at 10:30 a.m. ET. CEO & President Panna Sharma and CFO David Margrave will present.
Webcast Link: View Source
Registration Link: View Source

On October 5, 2022 Targovax ASA (OSE: TRVX), a clinical-stage immuno-oncology company developing immune activators to target solid tumors, reported that the SITC (Free SITC Whitepaper) abstract review committee has selected the ONCOS-102 phase 1b study in PD-1 resistant advanced melanoma for oral presentation at the annual meeting to be held in November in Boston (Press release, Targovax, OCT 5, 2022, View Source [SID1234621726]).

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PD-1 checkpoint inhibitor (CPI) resistant advanced melanoma is a major unmet medical need affecting up to 25,000 patients per year in the major markets. The diagnosis is associated with a poor prognosis and there are currently no approved treatment options available.

In an earlier topline data release from this Phase 1b study, Targovax reported an encouraging objective response rate (ORR) of 35% for the combination of ONCOS-102 and the PD-1 CPI Keytruda. At the SITC (Free SITC Whitepaper) conference, further translational biomarker analyses and the impact of dosing regimen on systemic activity and immune responses will be presented.

Title of the abstract, to be presented both orally and as a poster:

Presenter: Dr. Alexander Shoushtari, Principal Investigator, Memorial Sloan Kettering Cancer Center, NYC
Title: Repeat dosing of oncolytic adenovirus ONCOS-102 is associated with enhanced and persistent immune responses and improved systemic activity in anti-PD-1 resistant/refractory (r/r) melanoma
Date: 10 November, 2022
Time: 7pm ET
Dr. Lone Ottesen, Chief Medical Officer of Targovax ASA, said: "It is a great honor to have our study selected for an oral presentation at the SITC (Free SITC Whitepaper) annual meeting, which is considered the most prestigious scientific forum in cancer immunotherapy. The podium presentation will be given by principal investigator Dr. Alexander Shoushtari from the Memorial Sloan Kettering Cancer Center in New York, and provides an excellent opportunity to showcase the strong ONCOS-102 melanoma data package to a broad, international audience of academic leaders".

On October 5, 2022 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), an immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer, reported it will present two posters at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, being held in Boston, MA from November 8 – 12, 2022 (Press release, Sensei Biotherapeutics, OCT 5, 2022, View Source [SID1234621725]).

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Presentation Details:

Title: Functional characterization of the inhibitory activity and identification of novel T-cell receptors for the tumor-associated macrophage receptor VSIG4
Presentation Type: Poster
Abstract Number: 485
Date and Time: Thursday, November 10, 2022 at 9:00 a.m. ET – 9:00 p.m. ET
Location: Boston Convention and Exhibition Center

Title: SNS-101, a highly pH-selective VISTA:PSGL-1 inhibitory antibody, potentiates anti-PD-1 sensitivity, expands memory T-cells and enhances tumor infiltration of CD8 T-cells
Presentation Type: Poster
Abstract Number: 856
Date and Time: Friday, November 11, 2022 at 9:00 a.m. ET – 9:00 p.m. ET
Location: Boston Convention and Exhibition Center