On October 1, 2022 Takura’s affiliate CuraCell reported the company signes collaboration agreement with Zellwerk-Berlin, a Specialized Contract Development & Manufacturing Organization (CDMO) with engagements in Tumor Infiltrating Lymphocytes (TIL), Natural Killer (NK) cells and Mesenchymal Stromal Cells (MSC), an affiliate of Hiper Group. CuraCell acquires intellectual property rights from Zellwerk Berlin associated with CuraCell’s TIL product, CC-38.

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CC-38 has been used in patient named treatments in Germany demonstrating promising clinical results. The two companies will now join forces in optimizing and validating CC-38 for upcoming clinical trials. Through the collaboration CuraCell gets access to process engineering capabilities of Zellwerk Berlin’s R&D team and secures manufacturing capacity for its first clinical phase.

(Press release, CuraCell, OCT 1, 2022, View Source [SID1234661184])

On October 1, 2022 Angiex, developer of Nuclear-Delivered Antibody-Drug Conjugate (ND-ADC) therapies for solid cancers, reported that it has appointed Jason Sager, MD, as Chief Medical Officer (CMO) (Press release, Angiex, OCT 1, 2022, View Source [SID1234621831]).

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Following a 12-year career as a practicing pediatric oncologist, Dr. Sager gained extensive oncology drug development experience at Genentech, Novartis, Sanofi and Ikena Oncology where he led the early clinical development of many important therapeutics. His résumé includes 14 INDs. Over the past 18 months, he led the design of the clinical program for Angiex’s lead drug, AGX101.

Angiex CEO, Marty J. Duvall said, "The addition of Jason to our executive team is a critical step in the growth of our company. His extensive know-how and drug development network will help accelerate our company forward."

"I am highly motivated to join Angiex. The company has a deep scientific foundation in angiogenesis, vascular biology, and antibody-drug conjugate chemistry. I am driven to translate that into a meaningful benefit for cancer patients," said Dr. Sager.

Iain Dukes, executive chairman of Angiex and venture partner of Orbimed Advisors, said, "Adding Jason to the executive team marks another important milestone in the building of Angiex. Angiex’s ND-ADC technology holds great promise for the treatment of solid cancers and deserves a world-class team to drive it forward."