Myovant Sciences Cancels Second Quarter Earnings Conference Call

On October 24, 2022 Myovant Sciences (NYSE: MYOV) ("Myovant") reported the cancellation of its earnings conference call for the quarter ended September 30, 2022 that had originally been scheduled for October 26, 2022 at 5:00 p.m. Eastern Time (Press release, Myovant Sciences, OCT 24, 2022, https://investors.myovant.com/news-releases/news-release-details/myovant-sciences-cancels-second-quarter-earnings-conference-call [SID1234622332]). The call is being cancelled due to the announcement of the pending merger with Sumitovant Biopharma Ltd.

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OmniAb Business Combination Approved by APAC Shareholders

On October 24, 2022 Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) reported the business combination (Business Combination) of Avista Public Acquisition Corp. II (APAC) (NASDAQ: AHPA) and OmniAb, Inc. (OmniAb), was approved by APAC shareholders in a vote held this morning, with 96% of the shares represented in person, virtually or by proxy voting in favor of the combination (Press release, Ligand, OCT 24, 2022, View Source [SID1234622331]). Based on actual redemptions and estimated expenses, OmniAb expects to have approximately $95 million of net cash upon the closing of the Business Combination (Closing). Prior to the Business Combination, APAC will domesticate in Delaware and change its name to OmniAb, Inc. (New OmniAb).

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The spin-off of OmniAb from Ligand remains on track with an expected closing on November 1, 2022, subject to the satisfaction or waiver of closing conditions for the Business Combination. The record date (Record Date) for the dividend of shares of common stock of OmniAb to be distributed to Ligand shareholders (Distribution) is October 26, 2022, and the Distribution is expected to be made on November 1, 2022 immediately prior to the Business Combination, subject to the satisfaction or waiver of closing conditions.

Ligand shareholders as of the close of business on the Record Date will receive shares of OmniAb common stock on a pro rata basis representing 100% of Ligand’s interest in OmniAb. Immediately following the Distribution of OmniAb shares, OmniAb will merge (Merger) with APAC’s wholly-owned subsidiary and be the surviving company. Pursuant to the Merger, all shares of OmniAb common stock will be automatically exchanged for shares of New OmniAb on a pro rata basis according to a base exchange ratio (Base Exchange Ratio) calculated immediately prior to Closing using a formula set forth in the merger agreement (Merger Agreement) among Ligand, OmniAb, APAC and a subsidiary of APAC. The Base Exchange Ratio is based on the number of shares of OmniAb common stock outstanding immediately prior to Closing calculated using the treasury stock method with the number of equity awards being allocated to OmniAb in the Distribution calculated based on the relative trading values of Ligand common stock in the "regular way" and "ex-distribution" markets during the five-trading-day period prior to the Closing.

Based on an illustrative record date of June 30, 2022, the Ligand stock price as of such date and an estimated Base Exchange Ratio, Ligand shareholders would receive approximately 4.9 shares of New OmniAb common stock for each share of Ligand common stock.

In addition, as part of the exchange, Ligand shareholders as of the Record Date will receive earnout shares of New OmniAb common stock (Earnout Shares) on a pro rata basis according to an earnout exchange ratio (Earnout Exchange Ratio) calculated immediately prior to the Closing using a formula set forth in the Merger Agreement. Based on an illustrative record date of June 30, 2022, the Ligand stock price as of such date and an estimated Earnout Exchange Ratio, Ligand shareholders would receive approximately 0.75 Earnout Shares for each share of Ligand common stock. The Earnout Shares will vest based upon the achievement of certain volume-weighted average trading prices (VWAP) for shares of New OmniAb for any 20 trading days over a consecutive 30 trading-day period during the five-year period following the Closing. The Earnout Shares will vest (i) with respect to fifty percent of such Earnout Shares, upon achievement of a VWAP of $12.50 per share of New OmniAb common stock or upon the occurrence of a change of control transaction that will result in the holders of New OmniAb common stock receiving a price per share in excess of $12.50, and (ii) with respect to the remaining fifty percent of the Earnout Shares, upon achievement of a VWAP of $15.00 per share of New OmniAb common stock or upon the occurrence of a change of control transaction that will result in the holders of New OmniAb common stock receiving a price per share in excess of $15.00. After the Earnout Shares are distributed to stockholders pursuant to the Distribution, the Earnout Shares will not be transferrable until the vesting condition for the applicable tranche of Earnout Shares has been achieved.

The actual number of shares of New OmniAb common stock and Earnout Shares that each Ligand shareholder will receive with respect to each share of OmniAb common stock will be calculated on the closing date and may differ from these estimates. No fractional shares of New OmniAb common stock will be issued in the merger, and instead Ligand shareholders will receive cash in lieu of any fractional share (other than with respect to Earnout Shares, which will be rounded down to the nearest share).

Ligand shareholders do not need to take any action to receive their pro rata consideration in the Business Combination. Their OmniAb shares received upon Distribution of the dividend will automatically be exchanged for New OmniAb common stock and Earnout Shares in the Merger on the closing date of the Business Combination. Following the Closing, Ligand shareholders will continue to hold, along with their new shares of New OmniAb common stock and Earnout Shares, the same number of shares of Ligand common stock that they held immediately prior to the Closing. After the Closing, investors should expect that Ligand’s share price will adjust to reflect the transfer of the OmniAb business to New OmniAb.

In connection with the Business Combination, OmniAb and APAC filed registration statements with the Securities and Exchange Commission (SEC), described below under "Important Information and Where to Find It." On September 30, 2022, the SEC declared both registration statements effective. The registration statements contain further information regarding the spin-off and Business Combination, including the conditions to completion of the Business Combination, estimated transaction and other expenses and additional details regarding the calculation of the applicable exchange ratios described above.

Factors that May Affect the Dividend and Spin-Off

The dividend is conditioned upon, and the spin-off and Business Combination are subject to, the satisfaction or waiver of closing conditions for the Business Combination. If certain closing conditions are not satisfied or waived in advance of the expected closing date, Ligand may elect to change the record date for the dividend to a later date or to not proceed with the dividend or the spin-off.

Two-Way Trading to Begin for Ligand on the Nasdaq Global Market (Nasdaq)

Beginning on or around the trading day prior to the Record Date and continuing through the close of trading on the closing date of the Business Combination, there will be two markets in Ligand common stock on Nasdaq: a "regular way" market and an "ex-distribution" market. During this period of two-way trading in Ligand common stock, there will also be a market on Nasdaq for New OmniAb common stock on a "when issued" basis.

The trading options that will be available during the two-way trading period are:

Ligand Regular Way Trading

If, during the period of two-way trading, a Ligand shareholder sells a share of Ligand common stock in the regular way market under Ligand’s Nasdaq symbol, "LGND," the shareholder will be selling both the share of Ligand common stock and the right to receive the Distribution of OmniAb common stock (which will be exchanged for shares of New OmniAb common stock and Earnout Shares in the transaction). On the trading day after the Closing, shares of Ligand common stock will commence trading without the right to receive the Distribution. At that time, the Earnout Shares will not be tradable and will remain non-transferrable until the vesting condition for the applicable tranche of Earnout Shares has been achieved.

Ligand Ex-distribution Trading

If, during the period of two-way trading, a Ligand shareholder sells a share of Ligand common stock in the ex-distribution market under the temporary Nasdaq symbol "LGNDV," the Ligand shareholder will be selling only a share of Ligand common stock and will retain the right to receive the Distribution of OmniAb common stock (which will be exchanged for shares of New OmniAb common stock and Earnout Shares in the transaction).

New OmniAb When-issued Trading

During the two-way trading period, there will also be a market in shares of New OmniAb common stock on a when-issued basis under the temporary Nasdaq symbol "OABIV."

Trades under the symbols "OABIV" and "LGNDV" will settle after the closing date of the Business Combination. If the transaction is not completed, all trades made under these temporary symbols will be cancelled.

In all cases, investors should consult with their financial and tax advisors regarding the specific implications of selling shares of their Ligand common stock or the right to receive shares of New OmniAb common stock and Earnout Shares on or before the closing date of the Business Combination.

TechsoMed Announces Completion of Full Enrollment in Pivotal U.S trial Evaluating its BioTraceIO Software for Liver Ablation Outcomes Assessment in Liver Cancer Patients

On October 24, 2022 TechsoMed, the developer of first of its kind AI Algorithm powered tissue viability imaging technology, reported it has successfully completed patient enrollment in U.S. Pivotal trial designed to demonstrate the safety and effectiveness of its flagship product, BioTraceIO, in providing valuable visualization and quantitative insights on procedure outcome in liver cancer patients undergoing ultrasound guided percutaneous ablation procedures (Press release, TechsoMed, OCT 24, 2022, View Source [SID1234622328]).

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With its algorithm powered technology, the BioTraceIO software system is the first to provide visualization of the ablated area based on standard real-time ultrasound imaging intended to support interventional radiologists performing tumor ablation with valuable procedure outcomes assessment.

"Intraprocedural limited visibility of the area being treated is a true challenge we are facing when performing percutaneous ablation procedures. I believe this hinders the adoption of thermal ablation for treating liver tumors, and I am pleased that new technologies are addressing this challenge," said Dr. Sadeer Alzubaidi, an interventional radiologist from Mayo Clinic Arizona, principal investigator at the trial. "The BioTraceIO enables us, the interventional radiologists, to utilize a standard ultrasound for an added layer of accurate visual and quantitative information of the ablation process. This, no doubt, can increase accuracy and contribute to better care for our patients".

"Ultrasound imaging is critical imaging modality in providing real-time insights during ablation procedures," adds Dr. Nami Azar, Professor of radiology and principal investigator at University Hospitals Cleveland Medical Center. "I am happy to participate in this study to introduce innovative ultrasound monitoring capabilities to the field of tumor ablation. The BioTraceIO solution has the potential to help to see more during the ablation process and to achieve improved procedure outcomes".

The pivotal trial primarily intended to demonstrate that the BioTraceIO Ablation Map generated based on ultrasound imaging during the procedure is effective at estimating the ablation zone as measured 24-hours post-procedure by CT scan, representing the true ablation area. The trial has enrolled 50 patients across 6 leading clinical sites in the U.S. including Mayo Clinic in Arizona and Minnesota, Stanford, Mass General Hospital, UH Cleveland and Houston Methodist Hospital.

"The completion of our first BioTraceIO pivotal trial is a great accomplishment that reflects a milestone in executing our vision of transforming Thermal Ablation from guess-work into precise, real-time feedback dependent treatment", said Yossi Abu, TechsoMed’s CEO. "The collaboration with such leading medical centers and physicians indicates the deep recognition of the interventional-radiology community in BioTrcaeIO potential to provide a much-needed clinical value in the liver ablation space".

Upon the study completion, TechsoMed plans to expand its clinical validation program in the U.S to validate its extended end-to-end BioTraceIO360 software solution designed to equip interventional radiologists with advanced patient-specific procedure modeling, planning capabilities and 3D post-procedure assessment.

Enosi Therapeutics to Present at the ENA 2022 Symposium on Molecular Targets and Cancer Therapeutics in Barcelona

On October 24, 2022 Enosi Therapeutics, a drug research and development company focused on providing industry-leading therapeutics for cancer and autoimmune diseases, reported that Enosi CEO and CSO, Dr. H. Michael Shepard, will be presenting the company’s preclinical work in a presentation titled "High affinity ligand traps derived from the EGFR and HER3 are efficacious in murine models of cancer and autoimmune disease" at the ENA 2022 Symposium being held in Barcelona October 26-28, 2022 (Press release, Enosi Therapeutics, OCT 24, 2022, View Source [SID1234622327]). ENA is a joint program of the National Cancer Institute, the American Association of Cancer Research and the European Organization for Research and Treatment of Cancer.

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ENA 2022 is a drug development and translational research meeting, focusing on presentations and discussions regarding preclinical and phase I studies, drawing some of the foremost experts in the field from around the world. The symposium enables in-depth scientific discussions on the latest drug developments and attracts academics, scientists, and pharmaceutical industry executives to discuss the latest innovations in drug research and development.

EN-2642 is an affinity matured EGFR-Fc: HER3:Fc ligand trap and binds 9 of the 11 growth factors which activate the HER family. These growth factors participate in the progression of many diseases, including solid cancers and rheumatoid arthritis, which are characterized by hyperproliferative cells, hypoxia, angiogenesis, and inflammation.

"This therapeutic strategy is unique because it does not depend upon antibodies binding the cell surface, resulting in total signaling blockade or antibody-mediated cellular toxicity, but rather on starving diseased cells which are dependent upon an excess of free growth factors. The problem with earlier "Pan-HER" approaches has been that in most cases the targeted receptors are not overexpressed and thus toxicity results to non-diseased tissues," said Dr. Shepard.

Enosi’s poster will be presented on the opening day of the conference, "Molecular Targeted Agents 1" on Wednesday, October 26, 2022.

Transcenta To Present First-In-Class TST003 Antibody Program at the 10th TEMTIA Meeting

On October 24, 2022 Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, reported that Transcenta is invited to participate the 10th TEMTIA meeting in Paris, France, November 7 to 10 and present preclinical data of TST003, Transcenta’s first-in-class, high affinity humanized monoclonal antibody targeting Gremlin1 (Press release, Transcenta, OCT 24, 2022, View Source [SID1234622326]).

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Details of the speech are as follows:

Topic:TST003, a first-in-class anti-Gremlin1 monoclonal antibody, blocks EMT and displays potent single agent anti-tumor activities in PDX models of multiple difficult-to-treat solid tumors
Date & Time: 9 November 2022, 3:30 pm-3:45 pm (Paris time)
Speaker: Dr. Xueming Qian, CEO, Transcenta

TEMTIA is an international meeting dedicated to the study of epithelial to mesenchymal transition (EMT). EMT process is triggered when epithelial cells loosen cohesiveness and adopt an individualized motile phenotype in link with the progressive loss of epithelial features. EMT was originally defined in the context of developmental stages and contributes to cancer progression and metastasis. EMT has shown to be an important mechanism for resistance to cancer therapies including checkpoint inhibitor immunotherapy.

About TST003

TST003 is a high affinity monoclonal antibody targeting Gremlin1, a member of TGFb superfamily. Gremlin1 protein is a highly conserved secreted protein and has shown to play important roles during development. Gremlin1 is highly upregulated in multiple solid tumors. Gremlin1 protein promotes epithelial mesenchymal transition. TST003 has shown promising single agent activities in patient-derived xenograft tumor models of multiple difficult-to-treat solid tumors resistant to checkpoint inhibitor including castration resistant prostate cancer and microsatellite stable colorectal cancer. TST003 also enhanced the anti-tumor activity of checkpoint inhibitor in syngeneic tumor model. TST003 has received FDA clearance for entering clinical testing in September, 2022.