On October 20, 2022 Cytokinetics, Incorporated (Nasdaq: CYTK) reported that it is scheduled to report third quarter results on November 3, 2022 at 4:00 PM Eastern Time (Press release, Cytokinetics, OCT 20, 2022, View Source,-October%2020%2C%202022&text=SOUTH%20SAN%20FRANCISCO%2C%20Calif.%2C,4%3A00%20PM%20Eastern%20Time. [SID1234622264]). Following the announcement, Cytokinetics’ senior management will host a conference call at 4:30 PM Eastern Time to discuss operational and financial results and the company’s outlook for the future.

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The conference call will be simultaneously webcast and can be accessed from the homepage and in the Investors & Media section of Cytokinetics’ website at www.cytokinetics.com. The live audio of the conference call can also be accessed by telephone by registering in advance at the following link: Cytokinetics Q3 2022 Earnings Conference Call. Upon registration, participants will receive a dial-in number and a unique passcode to access the call. An archived replay of the webcast will be available via Cytokinetics’ website for twelve months.

On October 20, 2022 Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive biomarkers, reported poster presentations to be made at upcoming medical meetings (Press release, Jounce Therapeutics, OCT 20, 2022, View Source [SID1234622254]). Two preclinical poster presentations will be made at the SITC (Free SITC Whitepaper) 2022 Annual Meeting being held in Boston, November 8-12. These will include preclinical data on the JTX-1484 program, which targets LILRB4, and a characterization of the expression and function of LILRB receptors on human immune cells in tumor and blood samples across different cancer types. Two clinical poster presentations will be made at the ESMO (Free ESMO Whitepaper)-IO 2022 Annual Congress being held in Geneva, December 7-9. The submitted abstract for the JTX-8064 INNATE trial contains Phase 1 data, including safety, PK, and tumor response data. Jounce continues to expect to report preliminary clinical data on at least 80 Phase 2 patients from the INNATE trial by end of year 2022. The submitted abstract for the vopratelimab/pimivalimab SELECT trial includes all data previously announced on clinical endpoints. Additional durability data for patients who remain on study will also be reported.

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SITC Poster Details:

Poster Title: Preclinical evaluation of JTX-1484, an anti-LILRB4 antagonist antibody, for re-programming of immunosuppressive myeloid cells
Presenter: Andre Cunha, Ph.D.
Abstract Number: 483
Location: Poster Hall located in Hall C
Date and Time: Thursday, November 10, 2022: 11:40 a.m.-1:10 p.m., 7:30 p.m.-9:00 p.m. ET

Poster Title: Overlapping and Distinct Patterns of LILRB Receptors Support Complementary Targeting Approach in Cancer
Presenter: Yasmin Hashambhoy-Ramsay, Ph.D.
Abstract Number: 945
Location: Poster Hall located in Hall C
Date and Time: Thursday, November 10, 2022: 11:40 a.m.-1:10 p.m., 7:30 p.m.-9:00 p.m. ET

The Poster Hall will be open from 9 a.m. to 9 p.m. on Thursday, November 10, 2022, and Friday, November 11, 2022.

ESMO-IO Poster Details:

Poster Title: Phase 1 Study of JTX-8064, a LILRB2 (ILT4) inhibitor, as monotherapy and combination with pimivalimab (pimi), a PD-1 inhibitor (PD-1i), in patients (pts) with advanced solid tumors.
Presenter: K. Papadopoulos (San Antonio, TX, United States of America)
Session Title and Location: Poster Display, Foyer ABC
Presentation Number: 172P
Date and Time: Thursday, December 8, 2022: 12:30 p.m.-1:15 p.m. CET

Poster Title: SELECT: A phase 2 randomized trial evaluating 2 doses of vopratelimab (V) + pimivalimab (P) vs P in TISvopra selected patients (pts)
Presenter: M. Gumus (Istanbul, Turkey)
Session Title and Location: Poster Display, Foyer ABC
Presentation Number: 181P
Date and Time: Thursday, December 8, 2022: 12:30 p.m.-1:15 p.m. CET

On October 20, 2022 Harbour BioMed ("HBM", HKEX: 02142) reported that, it has successfully completed the dosing of first patient in the global phase I trial of B7H4x4-1BB bispecific antibody HBM7008 in the United States (Press release, Harbour BioMed, OCT 20, 2022, View Source [SID1234622251]). This study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of HBM7008 in patients with solid tumors.

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HBM7008 is generated from Harbour BioMed’s unique and innovative HBICE platform, leveraging the advantages of the HCAb and H2L2 platforms. It targets Tumor-Associated Antigen (B7H4), mediated crosslinking T cell activation through 4-1BB. B7H4 is overexpressed on a variety of solid malignancies, including breast, ovarian, endometrial, and non-small cell lung cancers. With its crosslinking dependent specificity on tumors and potent immune modulation activity, HBM7008 has shown excellent safety profile with strong anti-tumor efficacy in the pre-clinical study, including completed response observed in the mouse tumor model.

"We are pleased to have completed the first patient dosing of B7H4x4-1BB in the U.S., marking another milestone to lead next-gen immuno-oncology therapeutics innovation in global market. Following our global innovation and development strategy, Harbour BioMed will advance the global clinical development project of HBM7008 at full speed to provide a novel, effective and safe treatment for patients." said Dr. Jingsong Wang, Founder, Chairman and CEO of Harbour BioMed.

About HBM7008

HBM7008 is a bispecific antibody targeting Tumor Associated Antigen B7H4x4-1BB that not only displays high potency in the T cell co-stimulation and tumor growth inhibition, and potentially may also translate to better safety due to its strict dependency of TAA-mediated crosslinking T cell activation. HBM7008 is one of the fully human bispecific antibodies developed from the HBICE platform of the Company. It is the only bispecific antibody against these two targets globally. Its unique specificity on tumors and immune modulation activity makes it a promising therapeutic in PD-L1 negative or PD-1/PD-L1 resistant patients. It also has the potential to avoid 4-1BB liver toxicity risk observed in other products with the benefit of its innovative biology mechanisms and bispecific design.

On October 20, 2022 Asymchem (stock code: 002821.SZ), a leading global contract development and manufacturing service provider, and AUM Biosciences (AUM), a global clinical stage biotech company, focused on discovering, acquiring and developing next generation targeted oncology therapeutics, reported the completion of their first GMP production campaign of AUM601 (Press release, AUM BioSciences, OCT 20, 2022, View Source [SID1234622250]).

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Earlier this year, Asymchem and AUM Biosciences announced the two companies would collaborate on process development and clinical and commercial production of AUM 601, a highly selective oral small molecule inhibitor of the tropomyosin receptor kinase (TRK) for treating rare cancers.

The partnership resulted in 10 kg GMP bulk drug substance of AUM 601, which will be used to supply Phase II clinical trials. AUM 601 has shown potent in vitro and in vivo anti-tumor activities against tumors harboring NTRK fusion.

"Through our collaboration with Asymchem, we were able to develop a more robust manufacturing process for AUM 601 by utilizing affordable and safe reagents that enabled us to improve yield and quality. The promising data further justifies the advancement of AUM601 into Phase II clinical trials," said Vishal Doshi CEO, AUM Biosciences. "Asymchem surpassed our expectations and incorporated innovative ideas and development into the process, allowing us to further our work in transforming the oncology therapeutics market, and addressing unmet needs of patients."

The successful outcome of this collaboration is a testament to both Asymchem’s and AUM’s commitment to quality and excellence in drug development. "With Asymchem’s world-class CDMO service and AUM’s cutting-edge cancer research, together, we are poised to make a significant difference in the lives of cancer patients worldwide," added Elut Hsu, President of Asymchem, Inc.

On October 20, 2022 Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, reported it will report third quarter 2022 financial results on Thursday, November 3, 2022 (Press release, Karyopharm, OCT 20, 2022, View Source [SID1234622249]). Karyopharm’s management team will host a conference call and audio webcast at 4:30 p.m. ET on Thursday, November 3, 2022, to discuss the financial results and other company updates.

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To access the conference call, please dial (888) 349-0102 (local) or (412) 902-4299 (international) at least 10 minutes prior to the start time and ask to be joined into the Karyopharm Therapeutics call. A live audio webcast of the call, along with accompanying slides, will be available under "Events & Presentations" in the Investor section of the Company’s website, View Source An archived webcast will be available on the Company’s website approximately two hours after the event.