Dynavax to Report Third Quarter Financial Results and Host Conference Call on November 3, 2022

On October 20, 2022 Dynavax Technologies Corporation (Nasdaq: DVAX), a commercial stage biopharmaceutical company developing and commercializing innovative vaccines, reported that it will report third quarter financial results on Thursday, November 3, 2022, after the U.S. financial markets close (Press release, Dynavax Technologies, OCT 20, 2022, View Source [SID1234622223]).

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Dynavax will host a conference call and live audio webcast on Thursday, November 3, 2022, at 4:30 p.m. (ET)/1:30 p.m. (PT).

The live audio webcast may be accessed through the "Events & Presentations" page on the "Investors" section of the Company’s website at View Source A replay of the webcast will be available for 30 days following the live event.

To dial into the call, participants will need to register for the call using the caller registration link. It is recommended that participants dial into the conference call or log into the webcast approximately 10 minutes prior to the call.

Entry into a Material Definitive Agreement

On October 20, 2022 Thermo Fisher Scientific Inc. (the "Company") reported that issued ¥22,300,000,000 aggregate principal amount of the Company’s 0.853% Senior Notes due 2025 (the "2025 Notes"), ¥28,900,000,000 aggregate principal amount of the Company’s 1.054% Senior Notes due 2027 (the "2027 Notes"), ¥4,700,000,000 aggregate principal amount of the Company’s 1.279% Senior Notes due 2029 (the "2029 Notes"), ¥6,300,000,000 aggregate principal amount of the Company’s 1.490% Senior Notes due 2032 (the "2032 Notes"), ¥14,600,000,000 aggregate principal amount of the Company’s 2.069% Senior Notes due 2042 (the "2042 Notes") and ¥33,300,000,000 aggregate principal amount of the Company’s 2.382% Senior Notes due 2052 (the "2052 Notes" and, together with the 2025 Notes, the 2027 Notes, the 2029 Notes, the 2032 Notes and the 2042 Notes, the "Notes") in a public offering (the "Offering") pursuant to a registration statement on Form S-3 (File No. 333-263034) and a preliminary prospectus supplement and prospectus supplement related to the offering of the Notes, each as previously filed with the Securities and Exchange Commission (the "SEC") (Filing, 8-K, Thermo Fisher Scientific, OCT 20, 2022, View Source [SID1234622222]).

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The Notes were issued under an indenture, dated as of November 20, 2009 (the "Base Indenture"), and the Twenty-Fourth Supplemental Indenture, dated as of October 20, 2022 (the "Supplemental Indenture" and, together with the Base Indenture, the "Indenture"), between the Company, as issuer, and The Bank of New York Mellon Trust Company, N.A., as trustee.

The 2025 Notes will mature on October 20, 2025, the 2027 Notes will mature on October 20, 2027, the 2029 Notes will mature on October 19, 2029, the 2032 Notes will mature on October 20, 2032, the 2042 Notes will mature on October 20, 2042 and the 2052 Notes will mature on October 18, 2052. Interest on the Notes will be paid semi-annually in arrears on April 20 and October 20 of each year, commencing on April 20, 2023.

Upon the occurrence of a change of control (as defined in the Indenture) of the Company and a contemporaneous downgrade of the Notes below an investment grade rating by at least two of Moody’s Investors Service, Inc., S&P Global Ratings, a division of S&P Global, Inc., and Fitch Ratings, Limited, the Company will, in certain circumstances, be required to make an offer to purchase the Notes at a price equal to 101% of the principal amount of the Notes, plus any accrued and unpaid interest to, but excluding, the date of repurchase.

The Notes are general unsecured obligations of the Company. The Notes rank equally in right of payment with existing and any future unsecured and unsubordinated indebtedness of the Company and rank senior in right of payment to any existing and future indebtedness of the Company that is subordinated to the Notes. The Notes are also effectively subordinated to any existing and future secured indebtedness of the Company to the extent of the assets securing such indebtedness, and are structurally subordinated to all existing and any future indebtedness and any other liabilities of its subsidiaries.

The Indenture contains limited affirmative and negative covenants of the Company. The negative covenants restrict the ability of the Company and its subsidiaries to incur debt secured by liens on Principal Properties (as defined in the Indenture) or on shares of stock of the Company’s Principal Subsidiaries (as defined in the Indenture) and engage in sale and lease-back transactions with respect to any Principal Property. The Indenture also limits the ability of the Company to merge or consolidate or sell all or substantially all of its assets.

Upon the occurrence of an event of default under the Indenture, which includes payment defaults, defaults in the performance of affirmative and negative covenants, bankruptcy and insolvency related defaults and failure to pay certain indebtedness, the obligations of the Company under the Notes may be accelerated, in which case the entire principal amount of the Notes would be immediately due and payable.
Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Company, has issued an opinion to the Company, dated October 20, 2022, regarding the Notes. A copy of this opinion is filed as Exhibit 5.1 hereto.

The foregoing description is qualified in its entirety by reference to the full text of the Base Indenture and the Supplemental Indenture, which are filed with this report as Exhibits 4.1 and 4.2 hereto, respectively. Each of the foregoing documents is incorporated herein by reference.

Item 8.01. Other Events.

The sale of the Notes was made pursuant to the terms of an Underwriting Agreement, which the Company entered into on October 14, 2022 (the "Underwriting Agreement"), with Citigroup Global Markets Limited, Mizuho Securities USA LLC, MUFG Securities EMEA plc and SMBC Nikko Securities America, Inc., as the several underwriters.

The Company expects that the net proceeds from the sale of the Notes will be approximately ¥109.1 billion, after deducting underwriting discounts and estimated offering expenses. The Company intends to use the net proceeds of the Offering for general corporate purposes, which may include the acquisition of companies or businesses, repayment and refinancing of debt, working capital and capital expenditures or the repurchase of its outstanding equity securities or the Company may temporarily invest the net proceeds in short-term, liquid investments until they are used for their ultimate purpose.

ImmunoGen Announces Conference Call to Discuss Its Third Quarter 2022 Operating Results

On October 20, 2022 ImmunoGen Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that the Company will host a conference call at 8:00 a.m. ET on Friday, November 4, 2022 to discuss its third quarter 2022 operating results (Press release, ImmunoGen, OCT 20, 2022, View Source [SID1234622221]). Management will also provide a brief update on the business.

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CONFERENCE CALL INFORMATION
To access the live call by phone, please register here. A dial-in and unique PIN will be provided to join the call. The call may also be accessed through the Investors and Media section of the Company’s website, www.immunogen.com. Following the call, a replay will be available at the same location.

Biotech Startup Orionis Gets $55 Million for Cancer Trials

On October 20, 2022 Orionis Biosciences LLC, one of several companies seeking to extend cancer immunotherapy to more patients, reported that it has raised $55 million in new venture capital to launch its initial clinical trials (Press release, Orionis Biosciences, OCT 20, 2022, View Source [SID1234622220]).

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Cancers can suppress the immune system, so startups are seeking treatments designed to overcome this suppression. Waltham, Mass.-based Orionis is developing drugs designed to spark activity in various types of immune cells.

Kite And Refuge Biotechnologies Announce Exclusive License Agreement For Investigational Gene Expression Platform For Blood Cancers

On October 20, 2022 Kite, a Gilead Company (Nasdaq: GILD) and Refuge Biotechnologies, Inc. ("Refuge"), reported that Kite has entered into an exclusive, worldwide license agreement with Refuge, a synthetic biology company for cancer immunotherapy, for exclusive rights to utilize Refuge’s proprietary gene expression platform to develop potential treatments for blood cancers (Press release, Kite Pharma, OCT 20, 2022, View Source [SID1234622219]).

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Refuge’s proprietary platform is a synthetic biology system that utilizes an expression modulation strategy to repress or activate transcription of target genes. Early pre-clinical data suggest a potential for this highly modular platform to regulate target antigen-dependent gene expression as a means to improve upon both the efficacy and safety of first-generation CAR T-cell therapies. Kite will have an exclusive license to Refuge’s intellectual property portfolio for use in blood cancers, as well as a library of synthetic gene expression programs for these indications. Refuge will retain all rights and programs related to solid tumor indications.

"First-generation autologous CAR T-cell therapies have dramatically changed outcomes for people with certain blood cancers yet more work needs to be done to reach additional patients. As the global CAR T-cell therapy leader, Kite is working on the next generation of cell therapies with the goal to improve upon the great results we have today so more patients can benefit," said Francesco Marincola, MD, Global Head of Cell Therapy Research, Kite. "Through this exclusive license agreement with Refuge’s platform, coupled with our unique in-house research capabilities, we aim to create a new generation of CAR T-cell products to induce long-term remissions for more patients."

"As a leader in the advancement of cell therapy from research to life-changing therapeutics, Kite is an ideal partner for Refuge as we seek to further evaluate the promise of Refuge’s proprietary platform," said Jing Zhao, Chief Business Officer, Refuge. "We look forward to collaborating closely with Kite in this area, while continuing to advance our internal therapeutic research and programs focused on solid tumors."

Under the terms of the agreement, Kite will be responsible for all costs and activities related to research, development, manufacturing and commercialization. Kite will also make an upfront payment to Refuge and Refuge will be eligible to receive potential performance-based regulatory milestone payments.