Biocept to Present at the LD Micro Main Event XV

On October 19, 2022 Biocept, Inc. (Nasdaq: BIOC), a leading provider of molecular diagnostic assays, products and services, reported that management will present at the LD Micro Main Event XV on Wednesday, October 26 at 2:30 p.m. Pacific time (5:30 p.m. Eastern time) (Press release, Biocept, OCT 19, 2022, View Source [SID1234622196]). The conference is being held at the Luxe Sunset Boulevard Hotel in Los Angeles.

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A webcast of the presentation will be live and archived on the Events and Presentation section of the company website.

Blue Earth Diagnostics Highlights Presentations on Axumin® (Fluciclovine F 18) and Investigational 18F-rhPSMA-7.3 in Biochemically Recurrent Prostate Cancer at Upcoming ASTRO Annual Meeting

On October 19, 2022 Blue Earth Diagnostics, a Bracco company and recognized leader in the development and commercialization of innovative PET radiopharmaceuticals, reported presentations on Axumin (fluciclovine F 18) and investigational 18F-rhPSMA-7.3 at the upcoming American Society for Radiation Oncology (ASTRO) 2022 Annual Meeting, to be held in San Antonio, Texas, from October 23 to 26, 2022 (Press release, Blue Earth Diagnostics, OCT 19, 2022, View Source [SID1234622195]). Details of selected oral and moderated poster presentations are listed below.

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An oral presentation on the investigational radiohybrid Prostate-Specific Membrane Antigen (rhPSMA) compound, 18F-rhPSMA-7.3, is being made at the conference. It includes additional results from the Company’s Phase 3 SPOTLIGHT study (NCT04186845) evaluating the impact of clinical factors on the detection rate of 18F-rhPSMA-7.3 PET imaging in men with suspected prostate cancer recurrence based on elevated PSA following prior therapy. Presentations on studies of Axumin (fluciclovine F 18) include interim analyses from a randomized trial of 18F-fluciclovine and 68Ga-PSMA PET/CT in post-prostatectomy radiotherapy, experience on the prognostic utility of 18F-fluciclovine PET after salvage radiotherapy, and timing and patterns of potentially salvageable recurrences after SBRT for localized prostate cancer. Additionally, the Company will host an Industry-Expert Theater event, "Emerging Data on the Impact of Axumin (fluciclovine F 18) PET Imaging on Radiotherapy Decisions." Details of selected oral and poster presentations by Blue Earth Diagnostics and its collaborators are listed below.

NOTE: Axumin (fluciclovine F 18) injection is FDA-approved for PET imaging in men with suspected prostate cancer recurrence based on elevated blood prostate-specific antigen (PSA) levels following prior treatment. Currently, 18F-rhPSMA-7.3 is investigational and has not received regulatory approval.

Blue Earth Diagnostics invites participants at the 2022 ASTRO Annual Meeting to attend the presentations above and visit the company at Exhibit Booth 4142. Blue Earth Diagnostics is hosting an Industry-Expert Theater event, "Emerging Data on the Impact of Axumin (fluciclovine F 18) PET Imaging on Radiotherapy Decisions," with invited speaker Dr. Edward Obedian, MD, Radiation Oncologist, St. Francis Hospital, Long Island, NY. The event will be held on Sunday, October 23, 2022, from 11:00 AM to 12:00 PM CT, in Room 216, Meeting Level, Henry B. Gonzalez Convention Center. For full session details and scientific presentation listings, please see the ASTRO online program here.

Indication and Important Safety Information About Axumin

INDICATION

Axumin (fluciclovine F 18) injection is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.

IMPORTANT SAFETY INFORMATION

Image interpretation errors can occur with Axumin PET imaging. A negative image does not rule out recurrent prostate cancer and a positive image does not confirm its presence. The performance of Axumin seems to be affected by PSA levels. Axumin uptake may occur with other cancers and benign prostatic hypertrophy in primary prostate cancer. Clinical correlation, which may include histopathological evaluation, is recommended.
Hypersensitivity reactions, including anaphylaxis, may occur in patients who receive Axumin. Emergency resuscitation equipment and personnel should be immediately available.
Axumin use contributes to a patient’s overall long-term cumulative radiation exposure, which is associated with an increased risk of cancer. Safe handling practices should be used to minimize radiation exposure to the patient and health care providers.
Adverse reactions were reported in ≤ 1% of subjects during clinical studies with Axumin. The most common adverse reactions were injection site pain, injection site erythema and dysgeusia.
To report suspected adverse reactions to Axumin, call 1-855-AXUMIN1 (1-855-298-6461) or contact FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Aqemia Raises €30M to Scale its Deep Physics and AI Enabled Drug Discovery Pipeline

On October 19, 2022 Aqemia reported that it raises €30 million in a Series A funding round led by Eurazeo and Bpifrance through its Large Venture fund, with the participation of Elaia its historic investor (Press release, Aqemia, OCT 19, 2022, View Source [SID1234622194]). This financing will further support Aqemia’s core mission: to massively scale drug discovery, through a first-in-class technological platform combining quantum-inspired physics and machine learning.

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In three years, Aqemia has grown from a spin-off of Ecole Normale Superieure to an A-team of 50 people at the crossroads of Chemistry and Artificial Intelligence, and has built its innovation engine – Aqemia’s Launchpad.

The Launchpad has proven successful in several disclosed and undisclosed collaborations worth up to millions of euros with leading pharmaceutical companies such as Sanofi, Janssen and Servier.

This unique technology has already resulted in the launch of a proprietary pipeline of several drug discovery projects, which now range from in vitro to in vivo phases, especially in oncology and immuno-oncology.

"After repeated successes in generating very efficiently innovative new chemical matter in collaboration with large pharmaceutical companies around the world, we are now excited to leverage this fundraising to accelerate towards Aqemia’s mission: build a massive pipeline of wholly-owned drug discovery projects.", said Maximilien Levesque, Co-founder and CEO of Aqemia.

Unlike AI-based platforms that need experimental data to train on, Aqemia addresses drug discovery projects from their earliest stage by generating its own data using unique quantum physics algorithms derived from 12 years of research at univ. Cambridge and Oxford (UK), and École Normale Supérieure and CNRS.

"The unprecedented pace – a whopping 10,000x faster while maintaining costs – and accuracy of our deep physics algorithms, adding up to our generative AI, creates a unique combination that permits to generate innovative new drug candidates more quickly, and scale drug discovery projects as technology projects." continued Emmanuelle Martiano, Co-Founder & COO of Aqemia. "We are continuously recruiting to address our next technology and drug discovery challenges", she added.

Aqemia’s ambition is to optimize and accelerate early drug discovery projects on a massive scale in order to uncover dozens of proprietary new drug candidates. Those candidates will fuel a diversified therapeutic pipeline across a variety of targets and indications that Aqemia intends to advance into clinical trials alone through a constellation of Biotech spin-offs or with partners as the case may be.

"We are thrilled to welcome Eurazeo and Bpifrance’s Large Venture fund onboard, as they are known for investing in the finest French scale-ups, and to receive again backing from Elaia, the first French Deeptech VC investor" said Maximilien.

When asked about this investment, Antoine Zins, Investment Director at Eurazeo, stated:

"I strongly believe that Aqemia has unparalleled power to shift the drug discovery paradigm. They have not only solved the missing data paradox in the discovery process with deep physics and AI, they can also generate leads at a faster pace than any discovery platform before them. We are very excited to be part of the adventure by their side".

Laurent Higueret, Senior Investment Director at Bpifrance’s Large Venture fund, added:

"Early drug discovery is a long, costly and cumbersome process with often unsatisfactory outcomes for sponsors and ultimately patients. Aqemia’s ambition is to change all that by bringing together deep physics and AI into a powerful computational engine that has the potential to generate promising new development candidates at scale. Through this investment, we are thrilled to be part of this exciting journey and further expand Bpifrance portfolio in deeptech and AI."

Blueprint Medicines to Host Investor Day and Announce Third Quarter 2022 Financial Results on November 1, 2022

On October 19, 2022 Blueprint Medicines Corporation (Nasdaq: BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, reported that it will host an Investor Day for analysts and investors on Tuesday, November 1, 2022 beginning at 8:30 a.m. ET in New York City (Press release, Blueprint Medicines, OCT 19, 2022, View Source [SID1234622193]). In addition, the company will report its third quarter 2022 financial results on Tuesday, November 1, 2022.

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The Investor Day will feature presentations by Blueprint Medicines’ management team, which will review the company’s plans to leverage the knowledge, skills and infrastructure of its fully integrated business to bring the promise of precision medicine to patients on a more expansive scale. In addition, the Investor Day will feature a panel discussion with key opinion leaders in the fields of mastocytosis, allergy and immunology.

A live webcast of the event will be available under "Events and Presentations" in the Investors & Media section of Blueprint Medicines’ website at View Source A replay of the webcast will be archived on Blueprint Medicines’ website for 90 days following the event.

Pharmaxis announces positive interim data from myelofibrosis Phase 2 cancer trial

On October 19, 2022 Clinical stage drug development company Pharmaxis (ASX: PXS) reported that it has concluded an interim analysis of data from 6 patients who have completed 6 months’ treatment with PXS-5505 in its open label phase 2 clinical trial in patients with the bone marrow cancer myelofibrosis (Press release, Pharmaxis, OCT 19, 2022, View Source;utm_campaign=Pharmaxis%20Releases%20Promising%20Interim%20Data%20from%20Skin%20Scarring%20Study&utm_content=Pharmaxis%20Releases%20Promising%20Interim%20Data%20from%20Skin%20Scarring%20Study+CID_e06885616dc6e57f4d0378eea23abf49&utm_source=Campaign%20Monitor&utm_term=View%20Full%20Media%20Release [SID1234622192]).

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The phase 2 trial known as MF-101 was cleared by the FDA under the Investigational New Drug (IND) scheme and aims to demonstrate that PXS-5505, the lead asset in Pharmaxis’ drug discovery pipeline, is safe and effective as a monotherapy in myelofibrosis patients who are intolerant, unresponsive or ineligible for treatment with approved JAK inhibitor drugs. These patients have very limited treatment options and a life expectancy of approximately 1 year.

A total of 15 patients have been enrolled in the cohort expansion phase of the study with 6 patients having completed 24 weeks of treatment. Four patients have dropped out of the study due to a lack of clinical response.

PXS-5505 has been well tolerated with no serious treatment related adverse events reported.
2/6 patients had clinically important improvement in symptoms.
5/6 patients had either stable or improved bone marrow fibrosis scores of ≥1 grade.
5/6 have stable or improved platelet and/or haemoglobin scores
No reductions were seen in spleen volume
Dr Gabriela Hobbs MD, Assistant Professor, Medicine, Harvard Medical School & Clinical Director, Leukemia Service, Massachusetts General Hospital said, "PXS-5505 continues to be very well tolerated in the clinic with no severe treatment related adverse events reported. Though still early in the dose expansion phase of the study, PXS-5505 appears to be stabilising and in some cases, improving the hemoglobin and platelet counts, which has also been associated with symptom improvements in those patients that were treated to 24 weeks.

"This is encouraging given the poor prognosis seen after ruxolitinib discontinuation with a median overall survival of only 11-14 months, typical of this study population. These results support further clinical investigation of PXS-5505 in myelofibrosis."