On November 3, 2022 Electra Therapeutics, Inc., a clinical stage biotechnology company developing antibody therapies that target signal regulatory proteins (SIRP), reported that the company will present three posters related to the company’s lead drug candidate, ELA026, at the American Society of Hematology (ASH) (Free ASH Whitepaper) annual meeting being held in New Orleans, Louisiana, December 10-13, 2022 (Press release, Electra Therapeutics, NOV 3, 2022, View Source [SID1234622912]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

With ELA026, Electra is taking a first-in-class approach to targeting SIRP to enable precise depletion of pathological immune cells. ELA026 is currently in Phase 1 clinical studies, including a Phase 1b trial in patients with secondary hemophagocytic lymphohistiocytosis (sHLH), a life-threatening inflammatory disease.

Details of the poster presentations are as follows:

Title: Characterization of ELA026, a clinical-stage monoclonal antibody that rapidly and potently depletes myeloid cells and T lymphocytes
Presenter: Sandip Panicker, PhD, Chief Scientific Officer, Electra Therapeutics
Session Date and Time: Monday, December 12, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 3722

Title: Trial in progress: A phase 1b study of ELA026 in patients with secondary hemophagocytic lymphohistiocytosis (sHLH)
Presenter: Gary Patou, MD, Chief Medical Officer, Electra Therapeutics
Session Date and Time: Monday, December 12, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 3730

Title: Identification and characterization of a retrospective cohort of secondary hemophagocytic lymphohistiocytosis (sHLH) patients in the US
Presenter: Catherine Broome, MD, Medstar Georgetown University Hospital
Session Date and Time: Sunday, December 11, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 2415

About Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory condition for which there is no approved treatment. sHLH can be triggered by cancer, immunotherapy, infection, or an autoimmune disease. Once triggered, sHLH requires immediate intervention. Without treatment, it can rapidly progress from symptoms such as persistent fever, hepatomegaly and/or splenomegaly, and cytopenias, to multi-organ failure and death. Even with the current use of off-label treatments that have toxicity challenges and limited efficacy, sHLH remains fatal in approximately 60% of adults within 3.5 years.

On November 3, 2022 Artiva Biotherapeutics, Inc., a clinical stage company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer (NK) cell-based therapies that are safe and accessible to cancer patients, reported the presentation of preclinical efficacy data combining anti-CD38 antibodies with AB-101, the Company’s clinical-stage ADCC-enhancer product candidate, in multiple myeloma models (Press release, Artiva Biotherapeutics, NOV 3, 2022, View Source [SID1234622911]). The data will be presented at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) (ASH 2022) Annual Meeting & Exposition taking place December 10-13, in New Orleans.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"These data provide additional support for the versatility of AB-101 as a highly scaled, off-the-shelf, ADCC-enhancing NK cell product candidate for therapeutic use in combination with monoclonal antibodies and NK cell engagers," said Peter Flynn, Ph.D., cofounder and Chief Operating Officer of Artiva. "Specifically, these data support the use of our platform in combination with anti-CD38 antibodies such as DARZALEX and SARCLISA, without the requirement for engineering or editing of our NK cells."

The data to be presented highlight the naturally low expression of CD38 and high and consistent expression of CD16 on AB-101, enabling its use with anti-CD38 antibodies for enhanced ADCC activity without the requirement for CD38 editing. AB-101 resistance to daratumumab-induced fratricide and glucocorticoid inhibition will be presented as well as preclinical in vitro activity and in vivo efficacy of the AB-101 combination with anti-CD38 antibodies.

Details of the presentation are as follows:

Title: Pre-Clinical Efficacy of AB-101, an Allogeneic Cord-Blood Derived Natural Killer (NK) Cell Therapeutic Candidate, in Combination with Anti-CD38 Antibodies in Models of Multiple Myeloma

About AB-101

AB-101 is a cord blood-derived, allogeneic, cryopreserved, ADCC-enhancing NK cell therapy candidate for use in combination with monoclonal antibodies or innate-cell engagers. Artiva selects cord blood units with the high affinity variant of the receptor CD16 and a KIR-B haplotype for enhanced product activity. Artiva can generate thousands of doses of pure, cryopreserved, infusion-ready NK cells from a single umbilical cord blood unit while retaining the high and consistent expression of CD16 without the need for engineering. Artiva is conducting a Phase 1/2 multicenter clinical trial (ClinicalTrials.gov Identifier: NCT04673617) to assess the safety and clinical activity of AB-101 alone and in combination with the anti-CD20 monoclonal antibody, rituximab, in patients with relapsed or refractory B-cell-non-Hodgkin lymphoma (NHL) who have progressed beyond two or more prior lines of therapy.

On November 3, 2022 Sutro Biopharma, Inc. (Sutro or the Company) (NASDAQ: STRO), a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs), reported that data from the Company’s compassionate use program on anti-leukemic activity of STRO-002, a novel folate receptor-α (FR-α) targeting ADC, in infants and children with relapsed/refractory CBF2AT3-GLIS2 acute myeloid leukemia (AML) will be reviewed in an oral presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition (ASH) (Free ASH Whitepaper) (Press release, Sutro Biopharma, NOV 3, 2022, View Source [SID1234622909]). The meeting will take place December 10 – 13, 2022 in New Orleans, LA.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Soheil Meshinchi, M.D., Ph.D., Principal Investigator for the compassionate use program with STRO-002 in relapsed/refractory CBF2AT3-GLIS2 AML, will deliver the oral presentation at 10:45 a.m. CST on December 10, 2022. Dr. Meshinchi is Professor, Clinical Research Division, at Fred Hutchinson Cancer Research Center and Professor, Division of Pediatric Hematology-Oncology, at the University of Washington School of Medicine.

"As a patient-driven company, we at Sutro are extremely pleased that STRO-002— which we are presently developing in ovarian cancer—had a profound effect in a pediatric patient group with a rare form of AML, for which treatment options are limited," said Bill Newell, Sutro’s Chief Executive Officer. "Among the highlights from our compassionate use program, there were a number of complete responses, which is particularly encouraging considering these patients are typically refractory to standard-of-care. We look forward to an oral presentation of the full data set at ASH (Free ASH Whitepaper) in December."

Oral Presentation Details:

Abstract Title: Anti-Leukemic Activity of STRO-002 a Novel Folate Receptor-α (FR-α)-Targeting ADC in Relapsed/Refractory CBF2AT3-GLIS2 AML
Session: Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Relapsed/Refractory AMLS Session
Date: Saturday, December 10, 2022
Session Time: 9:30 a.m. – 11:00 a.m. CST
Presentation Time: 10:45 a.m. CST

The accepted ASH (Free ASH Whitepaper) abstract will be made available today on the congress platform here, and a whitepaper with details about this rare indication and Sutro’s compassionate use program is now available on the Company’s website here. Following the conference, the presentation materials will be available in the "Clinical/Scientific Presentation and Publication Highlights" section of Sutro Biopharma’s website at www.sutrobio.com.

On November 3, 2022 Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for patients with cancer, reported that fourteen presentations for the Company’s induced pluripotent stem cell (iPSC) product platform were accepted for presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition being held in New Orleans, Louisiana, or virtually, December 10-13, 2022 (Press release, Fate Therapeutics, NOV 3, 2022, View Source [SID1234622908]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The presentations include initial Phase 1 clinical data for FT576, the Company’s multiplexed-engineered, iPSC-derived CAR NK cell product candidate targeting BCMA for multiple myeloma, and for FT819, the Company’s iPSC-derived CAR T-cell product candidate targeting CD19 for B-cell lymphoma. In addition, the Company will jointly present with its collaboration partner Janssen preclinical data for FT555, a multiplexed-engineered, iPSC-derived CAR NK cell product candidate targeting GPRC5D, a tumor-associated orphan G-protein-coupled receptor found to be highly expressed on myeloma cells. In May, Janssen exercised its commercial option to FT555, and the companies are conducting IND-enabling activities to support first-in-human clinical investigation of FT555 for the treatment of multiple myeloma as monotherapy and in combination with the CD38-targeted monoclonal antibody daratumumab.

The Company will also highlight multiple novel strategies to eliminate the need for patient conditioning for off-the-shelf cell therapy. These strategies include arming iPSC-derived effector cells with an alloimmune defense receptor (ADR), which targets 41BB-expressing alloreactive host immune cells to promote expansion, persistence, and anti-tumor activity; the combined genetic ablation of the adhesion molecules CD54 and CD58, which reduces immune synapse formation resulting in host immune cell evasion; and the genetic ablation of CD38 in combination with CD38-targeted monoclonal antibody therapy, which uniquely targets and depletes CD38-expressing activated host immune cells. Details of the ASH (Free ASH Whitepaper) presentations are as follows:

Clinical Programs

Interim Phase I Clinical Data of FT819-101, a Study of the First-Ever, Off-the-Shelf, iPSC-Derived TCR-Less CD19 CAR T-Cell Therapy for Patients with Relapsed / Refractory B-Cell Malignancies
Publication Number: 2000
Session Name: 704. Cellular Immunotherapies: Early Phase and Investigational Therapies: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
Interim Phase I Clinical Data of FT576 As Monotherapy and in Combination with Daratumumab in Subjects with Relapsed / Refractory Multiple Myeloma
Publication Number: 2004
Session Name: 704. Cellular Immunotherapies: Early Phase and Investigational Therapies: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
A Phase I Study of FT538, an Off-the-Shelf, Multiplexed-Engineered, iPSC-Derived NK Cell Therapy in Combination with Daratumumab in Relapsed / Refractory Multiple Myeloma
Publication Number: 4639
Session Name: 704. Cellular Immunotherapies: Early Phase and Investigational Therapies: Poster III
Presentation Date / Time: Monday, December 12, 2022, 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
Preclinical Programs

FT555: Off-the-Shelf CAR-NK Cell Therapy Co-Targeting GPRC5D and CD38 for the Treatment of Multiple Myeloma
Publication Number: 1992
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
A Novel Dual-Antigen Targeting Approach Enables Off-the-Shelf CAR NK Cells to Effectively Recognize and Eliminate the Heterogenous Population Associated with AML
Publication Number: 4623
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster III
Presentation Date / Time: Monday, December 12, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
iPSC Product Platform

Alloimmune Defense Receptor Harnesses Host Immune Cell Activation to Potentiate Functional Persistence and Anti-Tumor Activity of Off-the-Shelf, Cell-Based Cancer Therapy
Publication Number: 1986
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
Combined Genetic Ablation of CD54 and CD58 in CAR Engineered Cytotoxic Lymphocytes Effectively Averts Allogeneic Immune Cell Rejection
Publication Number: 481
Session Name: 703. Cellular Immunotherapies: Basic and Translational IV
Presentation Date / Time: Sunday, December 11, 2022; 9:30 AM
Room: Ernest N. Morial Convention Center, 388-390
iPSC-Derived CD38-Null NK Cells in Combination with CD38-Targeted Antibody: A Dual Therapeutic Strategy to Enable ADCC and Eliminate Host Immune Cells in Multiple Myeloma
Publication Number: 3288
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster II
Presentation Date / Time: Sunday, December 11, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
A CD3 Fusion Receptor (CD3-FR) Uniquely Enables Compatibility of Allogeneic CAR-T and -NK Cells with T Cell Engagers to Enhance Antitumor Function and Limit Antigen Escape
Publication Number: 3308
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster II
Presentation Date / Time: Sunday, December 11, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity
Publication Number: 4605
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster III
Presentation Date / Time: Monday, December 12, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
The Development of Allogeneic Tips-Derived TCR- CAR+ CD8αβ T Cells
Publication Number: 4624
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster III
Presentation Date / Time: Monday, December 12, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D
Characterization of Engineered Macrophages and Other Myeloid Cells Differentiated from CD34+ Hematopoietic Progenitor Cells Derived from Pluripotent Stem Cells
Publication Number: 1218
Session Name: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
High-Density Cryopreservation of Off-the-Shelf CAR-NK Cells Facilitates On-demand Treatment Access
Publication Number: 2045
Session Name: 711. Cell Collection and Processing: Poster I
Presentation Date / Time: Saturday, December 10, 2022; 5:30 PM
Room: Ernest N. Morial Convention Center, Hall D
CD82 Is Sufficient to Uniquely Identify Pluripotent Stem Cell-Derived Hemogenic Endothelium with the Hematopoietic Lineage Potency to Give Rise to Bona Fide Lymphocytes
Publication Number: 2532
Session Name: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Poster II
Presentation Date / Time: Sunday, December 11, 2022; 6:00 PM
Room: Ernest N. Morial Convention Center, Hall D

On November 3, 2022 GlycoMimetics, Inc. (Nasdaq: GLYC), a late clinical-stage biotechnology company discovering and developing glycobiology-based therapies for cancers and inflammatory diseases, reported that data from two investigator-sponsored trials studying uproleselan in patients with acute myeloid leukemia (AML) have been accepted for poster presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting (Press release, GlycoMimetics, NOV 3, 2022, View Source [SID1234622907]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We are excited to share initial results from these two investigator-sponsored trials of uproleselan regarding safety and preliminary efficacy in frontline unfit and treated secondary AML populations not previously studied with this novel investigational agent," said Edwin Rock, M.D., Ph.D., Chief Medical Officer. "These presentations provide the first uproleselan clinical data generated outside of company-sponsored studies. We thank these investigators and patients for their efforts and consent, respectively, to help us learn how adding uproleselan to existing therapies may benefit people with heterogeneous forms of AML."

Details on GlycoMimetics posters at the ASH (Free ASH Whitepaper) Meeting are as follows (all times CT):

Publication Number: 1448
Title: Uproleselan Added to Cladribine Plus Low Dose Cytarabine (LDAC) in Patients with Treated Secondary Acute Myeloid Leukemia (TS-AML)
Authors: Emmanuel Almanza-Huante, Hagop Kantarjian, Kelly Chien, Courtney Dinardo, Nicholas Short, Abhishek Maiti, Guillermo Montalban-Bravo, Naval Daver, Jitesh Kawedia, Kayleigh Bowie, Sherry Pierce, Farhad Ravandi, Marina Konopleva, Guillermo Garcia-Manero, Tapan M. Kadia
Session Name: 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster I
Session Date/ Presentation Time: Saturday, December 10, 2022, 5:30 PM – 7:30 PM
Location: Ernest N. Morial Convention Center, Hall D

Publication Number: 2764
Title: A Phase I Study of Uproleselan Combined with Azacitidine and Venetoclax for the Treatment of Older or Unfit Patients with Treatment Naïve Acute Myeloid Leukemia
Authors: Brian A Jonas, Jeanna L Welborn, Naseem S Esteghamat, Rasmus T Hoeg, Aaron S Rosenberg, Laura Molnar, Ashley Linh Dang-Chu, Susan L Stewart, Joseph M Tuscano
Session Name: 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster II
Session Date/Presentation Time: Sunday, December 11, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D

About Uproleselan

Discovered and developed by GlycoMimetics, uproleselan is an investigational, first-in-class, targeted inhibitor of E-selectin. Uproleselan (yoo’ pro le’se lan), currently in a comprehensive Phase 3 development program in AML, has received Breakthrough Therapy Designation from the U.S. Food and Drug Administration and from the Chinese National Medical Products Administration for the treatment of adult AML patients with relapsed or refractory disease. Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance within the bone marrow microenvironment.