On November 3, 2022 Imago BioSciences, Inc. ("Imago") (Nasdaq: IMGO), a clinical stage biopharmaceutical company discovering and developing new medicines for the treatment of myeloproliferative neoplasms (MPNs) and other bone marrow diseases, reported two abstracts have been accepted for oral presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition, to be held December 10-13, 2022 (Press release, Imago BioSciences, NOV 3, 2022, View Source [SID1234622915]).

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ASH 2022 Presentation Details:

Oral Presentation Title: "A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Essential Thrombocythemia (ET)"
Session Name: Myeloproliferative Syndromes: Clinical and Epidemiological: Novel Therapies and Surrogate Endpoints in ET and PV
Presentation Date/Time: Monday, December 12, 2022, at 11:45 AM ET
Location: Ernest N. Morial Convention Center, 217-219
Presenting Author: Harinder Gill, Queen Mary Hospital University of Hong Kong

Poster Presentation Title: "A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Advanced Myelofibrosis (MF): Updated Results and Genomic Analyses"
Session Name: Myeloproliferative Syndromes: Clinical and Epidemiological: Poster III
Presentation Date/Time: Monday, December 12, 2022, at 7:00 PM ET
Location: Ernest N. Morial Convention Center, Hall D
Presenting Author: Kristen Pettit, University of Michigan

On November 3, 2022 Caribou Biosciences, Inc. (Nasdaq: CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, reported that a trial-in-progress abstract for the Company’s ongoing ANTLER Phase 1 clinical trial evaluating CB-010 for relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL) has been accepted as a poster presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, being held in New Orleans, Louisiana, December 10-13, 2022 (Press release, Caribou Biosciences, NOV 3, 2022, View Source [SID1234622914]).

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The poster will provide details on the ANTLER clinical trial design and objectives. Details of the poster presentation are as follows:

Title: A First-in-Human Phase 1, Multicenter, Open-Label Study of CB-010, a Next-Generation CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy with a PD-1 Knockout, in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER Study)
Presenter: Susan O’Brien, M.D., professor, Division of Hematology/Oncology and associate director for clinical science, Chao Family Comprehensive Cancer Center, University of California, Irvine, CA
Session Name: 626. Aggressive Lymphomas: Prospective Therapeutic Trials: Poster III
Session Date: Monday, December 12, 2022
Presentation Time: 6:00 pm – 8:00 pm CST
Location: Ernest N. Morial Convention Center, Hall D
Abstract number: 4257

The poster presentation will be available for registered attendees on the ASH (Free ASH Whitepaper) website and on Caribou’s website (View Source) Monday, December 12, 2022 at 9:00 am CT.

About CB-010
CB-010 is the lead product candidate from Caribou’s allogeneic CAR-T cell therapy platform and is being evaluated in patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL) in the ongoing ANTLER Phase 1 trial. CB-010 is an allogeneic anti-CD19 CAR-T cell therapy engineered using Cas9 CRISPR hybrid RNA-DNA (chRDNA) technology to insert a CD19-specific CAR into the TRAC gene and knock out PD-1 to boost the persistence of antitumor activity. CB-010 is the first allogeneic CAR-T cell therapy in the clinic with a PD-1 knockout. Additional information on the ANTLER trial can be found at View Source using identifier NCT04637763.

About Caribou’s Novel Next-Generation CRISPR Platform
CRISPR genome editing uses easily designed, modular biological tools to make DNA changes in living cells. There are two basic components of Class 2 CRISPR systems: the nuclease protein that cuts DNA and the RNA molecule(s) that guide the nuclease to generate a site-specific, double-stranded break, leading to an edit at the targeted genomic site. CRISPR systems are capable of editing unintended genomic sites, known as off-target editing, which may lead to harmful effects on cellular function and phenotype. In response to this challenge, Caribou has developed CRISPR hybrid RNA-DNA guides (chRDNAs; pronounced "chardonnays") that direct substantially more precise genome editing compared to all-RNA guides. Caribou is deploying the power of its Cas12a chRDNA technology to
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carry out high efficiency multiple edits, including multiplex gene insertions, to develop CRISPR-edited therapies.

On November 3, 2022 ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, reported a preclinical poster presentation on ORIC-533 at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting to be held December 10-13, 2022, in New Orleans, LA (Press release, ORIC Pharmaceuticals, NOV 3, 2022, View Source [SID1234622913]).

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ORIC-533 continues to demonstrate a best-in-class CD73 inhibitor profile in preclinical analyses.
In autologous ex vivo assays using bone marrow aspirates from patients with relapsed refractory multiple myeloma, ORIC-533 overcame immune suppression and triggered significant lysis of multiple myeloma cells across all dose levels tested and in a dose-responsive manner.
Lysis of multiple myeloma cells in autologous relapsed refractory multiple myeloma assays correlated with significantly reduced CD73 activity, providing the mechanistic link between ORIC-533 and reduced adenosine production.
Together these data confirm that CD73 inhibition with ORIC-533 can potently reduce adenosine generation, overcome immune suppression and restore lysis of multiple myeloma cells as a single agent and therefore holds potential as a treatment for patients with multiple myeloma.
Full abstracts are available for online viewing via the ASH (Free ASH Whitepaper) Annual Meeting website at www.hematology.org/meetings/annual-meeting.

About ORIC-533

ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy and immunotherapy-based treatment regimens. ORIC-533 has demonstrated greater potency in preclinical studies compared to an antibody approach, as well as other small molecule inhibitors of CD73 and adenosine receptor antagonists. Preclinical data demonstrated that ORIC-533 binds CD73 with high affinity and effectively blocks adenosine-driven immunosuppression in a high AMP environment, reflective of AMP levels observed in tumors. In preclinical studies, nanomolar concentrations of ORIC-533 efficiently rescued cytotoxic T-cell function in the presence of high AMP concentrations, as well as in ex vivo bone marrow aspirates from relapsed or refractory multiple myeloma patients. A Phase 1b trial with ORIC-533 as a single agent in multiple myeloma is enrolling patients, and the company expects to report initial Phase 1b data from this trial in the first half of 2023.

On November 3, 2022 Electra Therapeutics, Inc., a clinical stage biotechnology company developing antibody therapies that target signal regulatory proteins (SIRP), reported that the company will present three posters related to the company’s lead drug candidate, ELA026, at the American Society of Hematology (ASH) (Free ASH Whitepaper) annual meeting being held in New Orleans, Louisiana, December 10-13, 2022 (Press release, Electra Therapeutics, NOV 3, 2022, View Source [SID1234622912]).

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With ELA026, Electra is taking a first-in-class approach to targeting SIRP to enable precise depletion of pathological immune cells. ELA026 is currently in Phase 1 clinical studies, including a Phase 1b trial in patients with secondary hemophagocytic lymphohistiocytosis (sHLH), a life-threatening inflammatory disease.

Details of the poster presentations are as follows:

Title: Characterization of ELA026, a clinical-stage monoclonal antibody that rapidly and potently depletes myeloid cells and T lymphocytes
Presenter: Sandip Panicker, PhD, Chief Scientific Officer, Electra Therapeutics
Session Date and Time: Monday, December 12, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 3722

Title: Trial in progress: A phase 1b study of ELA026 in patients with secondary hemophagocytic lymphohistiocytosis (sHLH)
Presenter: Gary Patou, MD, Chief Medical Officer, Electra Therapeutics
Session Date and Time: Monday, December 12, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 3730

Title: Identification and characterization of a retrospective cohort of secondary hemophagocytic lymphohistiocytosis (sHLH) patients in the US
Presenter: Catherine Broome, MD, Medstar Georgetown University Hospital
Session Date and Time: Sunday, December 11, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
Abstract Number: 2415

About Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory condition for which there is no approved treatment. sHLH can be triggered by cancer, immunotherapy, infection, or an autoimmune disease. Once triggered, sHLH requires immediate intervention. Without treatment, it can rapidly progress from symptoms such as persistent fever, hepatomegaly and/or splenomegaly, and cytopenias, to multi-organ failure and death. Even with the current use of off-label treatments that have toxicity challenges and limited efficacy, sHLH remains fatal in approximately 60% of adults within 3.5 years.

On November 3, 2022 Artiva Biotherapeutics, Inc., a clinical stage company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer (NK) cell-based therapies that are safe and accessible to cancer patients, reported the presentation of preclinical efficacy data combining anti-CD38 antibodies with AB-101, the Company’s clinical-stage ADCC-enhancer product candidate, in multiple myeloma models (Press release, Artiva Biotherapeutics, NOV 3, 2022, View Source [SID1234622911]). The data will be presented at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) (ASH 2022) Annual Meeting & Exposition taking place December 10-13, in New Orleans.

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"These data provide additional support for the versatility of AB-101 as a highly scaled, off-the-shelf, ADCC-enhancing NK cell product candidate for therapeutic use in combination with monoclonal antibodies and NK cell engagers," said Peter Flynn, Ph.D., cofounder and Chief Operating Officer of Artiva. "Specifically, these data support the use of our platform in combination with anti-CD38 antibodies such as DARZALEX and SARCLISA, without the requirement for engineering or editing of our NK cells."

The data to be presented highlight the naturally low expression of CD38 and high and consistent expression of CD16 on AB-101, enabling its use with anti-CD38 antibodies for enhanced ADCC activity without the requirement for CD38 editing. AB-101 resistance to daratumumab-induced fratricide and glucocorticoid inhibition will be presented as well as preclinical in vitro activity and in vivo efficacy of the AB-101 combination with anti-CD38 antibodies.

Details of the presentation are as follows:

Title: Pre-Clinical Efficacy of AB-101, an Allogeneic Cord-Blood Derived Natural Killer (NK) Cell Therapeutic Candidate, in Combination with Anti-CD38 Antibodies in Models of Multiple Myeloma

About AB-101

AB-101 is a cord blood-derived, allogeneic, cryopreserved, ADCC-enhancing NK cell therapy candidate for use in combination with monoclonal antibodies or innate-cell engagers. Artiva selects cord blood units with the high affinity variant of the receptor CD16 and a KIR-B haplotype for enhanced product activity. Artiva can generate thousands of doses of pure, cryopreserved, infusion-ready NK cells from a single umbilical cord blood unit while retaining the high and consistent expression of CD16 without the need for engineering. Artiva is conducting a Phase 1/2 multicenter clinical trial (ClinicalTrials.gov Identifier: NCT04673617) to assess the safety and clinical activity of AB-101 alone and in combination with the anti-CD20 monoclonal antibody, rituximab, in patients with relapsed or refractory B-cell-non-Hodgkin lymphoma (NHL) who have progressed beyond two or more prior lines of therapy.