On December 1, 2022 bioAffinity Technologies, Inc. (NASDAQ: BIAF; BIAFW), a biotechnology company addressing the need for noninvasive diagnosis of early-stage cancer and diseases of the lung and targeted cancer treatment, reported that David Elzi, Ph.D., bioAffinity Vice President of Research, will discuss his research into a possible mechanism by which the knock down of two genes kills cancer cells with little or no effect on normal cells at Cell Bio, a joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), in Washington, D.C., on Dec. 3-7, 2022. Dr. Elzi’s research supports the Company’s development of broad-spectrum cancer therapeutics.

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Dr. Elzi will present a poster titled "Reassessing Cobalamin Requirements in Cell Culture" on Monday, Dec. 5, 2022, from 12:15 p.m. to 1:45 p.m. EST at the Walter E. Reed Convention Center in Washington, D.C.

"bioAffinity’s research is important in better understanding the foundation of our therapeutic platforms as it examines one potential mechanism for how silencing the genes CD320 and LRP2 together kills cancer cells but leaves normal cells unharmed," Dr. Elzi said.

"We previously reported on the Company’s design and use of siRNAs to kill multiple cancers at the cellular level, including prostate, lung, breast, brain and skin cancers, without harm to normal cells," said bioAffinity President and CEO Maria Zannes. "We have reported on how to deliver the potential therapy. Dr. Elzi’s recent research that will be presented next week at Cell Bio looks at why it works."

Cell Bio 2022, the joint meeting of the ASCB and EMBO, will showcase a diverse global community of the brightest minds in cell biology in person, Dec. 3-7, 2022, in Washington, D.C. The unique meeting focuses on cell biology as the fundamental basis of biology as well as sessions on emerging interdisciplinary topics.

On December 1, 2022 Alentis Therapeutics, the Claudin-1 company, reported that Alberto Toso, Head of Oncology, will present a poster at the ESMO (Free ESMO Whitepaper) Immuno-Oncology Congress in Geneva, Switzerland (and virtually), from 7-9 December 2022 (Press release, Alentis Therapeutics, DEC 1, 2022, View Source [SID1234624656]).

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The poster, CLAUDIN-1 Targeting Antibodies in Solid Tumors: from ALE.C04 to CLAUDIN-1 Oncology Platform, presents evidence that non-junctional Claudin-1 is overexpressed in different solid tumors, drives T-cell exclusion and resistance to checkpoint inhibitors (CPI). Importantly, the use of non-junctional Claudin-1-targeting monoclonal antibody ALE.C04 restored T-cell infiltration and CPI efficacy in a pre-clinical mouse tumor model.

ALE.C04, Alentis’ lead oncology asset, is the first potential treatment to target CLDN1 to open up the mechanical barrier that characterizes immune-excluded CLDN1+ tumors, thus making the tumors vulnerable to treatment. Based on Alentis’ pre-clinical data, rationale and safety profile, the company plans a Phase 1b trial with ALE.C04 in combination with CPIs in solid tumors, expected to initiate in the second half of 2023.

In November 2022, Alentis published pre-clinical proof-of-concept data, showing Claudin-1 monoclonal antibodies as potential first in-class compounds for HCC, in The Journal of Hepatology: View Source

Poster presentation details are listed below:

Poster title: CLAUDIN-1 Targeting Antibodies in Solid Tumors: from ALE.C04 to CLAUDIN-1 Oncology Platform (Abstract #193P)

Presenter: Alberto Toso, Head of Oncology, Alentis Therapeutics

Authors: A. Toso 1 , G. Teixeira 1 , T. Zimmermann 1 , D. Schmitter 1 , M. Meyer 1 , M. Muller 2 , L. Mailly 2 , T. Baumert 2 , R. Iacone 1 1 Oncology, Alentis Therapeutics AG, Allschwil, Switzerland, 2 UMR_S1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France

Date: Thursday, 8th December 2022

Time: 12:30-13:15 CET

Location: Foyer ABC

Register to join the ESMO (Free ESMO Whitepaper) Immuno-Oncology Congress’ digital platform, here.

On December 1, 2022 Akari Therapeutics, Plc (Nasdaq: AKTX), a late-stage biotechnology company developing advanced therapies for autoimmune and inflammatory diseases, reported that the company will participate in the investor-focused Cantor Medical and Aesthetic Dermatology, Ophthalmology and Medtech/Diagnostic Conference taking place in Miami December 7-8, 2022 (Press release, Akari Therapeutics, DEC 1, 2022, View Source [SID1234624655]). Akari President and CEO Rachelle Jacques will take part in an ophthalmology panel on December 8 at 1:45 pm ET,Vision for the Future: Dry AMD, Other Greenfield Opportunities, and Late-Stage Stories to Shake Things Up. The Akari management team also will attend 1:1 investor meetings at the conference to discuss progress in the promising pre-clinical program that is investigating long-acting PAS-nomacopan in geographic atrophy (GA).

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On December 1, 2022 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company focused on the development of new solid tumor cancer therapies, reported that Robert E. Hoffman, President and CEO of Kintara, will be participating at the RHK Capital Disruptive Growth Conference in New York City (Press release, Kintara Therapeutics, DEC 1, 2022, View Source [SID1234624653]).

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The RHK Capital Disruptive Growth Conference will feature leading C-suite executives and senior management of up to 30 growth-oriented and disruptive companies to meet with seasoned institutional investors, accredited investors, representatives of family offices, market analysts and financial advisors, as well as broker-dealer wealth managers, and select RHK clients.

Kintara’s webcast will be held on December 5, 2022 at 2:40 pm ET.

To view Kintara’s webcast please access the following link:

View Source

On December 1, 2022 Kineta, Inc. ("Kineta" or the "Company"), a clinical-stage biotechnology company focused on developing next-generation immunotherapies to address cancer immune resistance, reported that the Company will present at the Antibody Engineering and Therapeutics Conference, the Antibody Society’s Annual Meeting, to be held in-person in San Diego, CA from December 4-8, 2022 (Press release, Kineta, DEC 1, 2022, View Source;utm_medium=rss&utm_campaign=kineta-to-participate-in-jmp-securities-hematology-and-oncology-summit [SID1234624652]). Thierry Guillaudeux, Ph.D., Kineta’s Chief Scientific Officer, will give an oral presentation on KVA12123 (formerly referred to as KVA12.1). KVA12123 is the Company’s VISTA blocking immunotherapy that is expected to initiate Phase 1 clinical trials in patients with advanced solid tumors in the fourth quarter of 2022.

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Presentation Details:

Title: KVA12123 (formerly referred to as KVA12.1), a VISTA Blocking Immunotherapy

Presenter: Thierry Guillaudeux, Ph.D.

Date / Time: December 7, 2022, at 8:45 A.M. Pacific Time

Session Type: Oral Presentation

A copy of the presentation will be available on the Kineta website under Publications after the conference on December 7, 2022: View Source