On June 21, 2022 Aethlon Medical, Inc. (Nasdaq: AEMD), a company developing medical technology to treat cancer and life-threatening infectious disease, reported that it will issue financial results for its fiscal year ended March 31, 2022, at 4:15 p.m. EST on Tuesday, June 28, 2022 (Press release, Aethlon Medical, JUN 21, 2022, https://www.prnewswire.com/news-releases/aethlon-medical-to-release-fiscal-year-end-financial-results-and-host-conference-call-on-june-28-2022-301571954.html [SID1234616145]).

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Management will host a conference call on Tuesday, June 28, 2022 at 4:30 p.m. EST to review financial results and recent corporate developments. Following management’s formal remarks, there will be a question and answer session.

Interested parties can register for the conference by navigating to View Source Please note that registered participants will receive their dial in number upon registration.

A replay of the call will be available approximately one hour after the end of the call through July 28, 2022. The replay can be accessed via Aethlon Medical’s website or by dialing 1-877-344-7529 (domestic) or 1-412-317-0088 (international) or Canada toll free at 1-855-669-9658. The replay conference ID number is 4234353.

On June 21, 2022 OncoHost, a global leader in next-generation precision oncology for improved personalized cancer therapy, reported a peer-reviewed article published in Journal for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) (JITC), a BMJ oncology journal (Press release, OncoHost, JUN 21, 2022, View Source [SID1234616144]). The study highlights the role of blood plasma proteomic profiling for assessing resistance in non-small cell lung cancer (NSCLC) patients being treated with immune checkpoint inhibitors (ICIs).

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Over the last decade, ICIs targeting the PD-1/PD-L1 axis have emerged as standard-of-care treatments for NSCLC. Although ICI therapy achieves impressive long-term survival in some, the overall response rate is modest, ranging from 20-30 percent in NSCLC patients. A significant proportion of patients display innate resistance to ICIs, and many of those who derive initial clinical benefit experience disease progression at a later stage. The mechanisms underlying innate and acquired resistance to ICIs are not yet fully understood.

The study, Longitudinal plasma proteomic profiling of non-small cell lung cancer patients undergoing immune checkpoint blockade, focuses on how ICI resistance can be predicted in NSCLC patients through proteomic profiling. The analysis was done using PROphet, OncoHost’s first-of-its-kind diagnostic platform that combines proteomic analysis with AI to predict patient response to immunotherapy and identify resistance associated processes.

"While ICIs have played a major role in revolutionizing cancer therapy, we are still lacking clear biomarkers to predict resistance in patients being treated with these modalities," said Dr. Michal Harel, Director of Science and Innovation at OncoHost. "In this study, we have analyzed the largest and deepest plasma proteome dataset for NSCLC patients receiving ICI-based treatment published so far, revealing a predictive signature for response to treatment comprised of two proteins and two clinical parameters using our AI-powered PROphet platform. In addition, using bioinformatic tools, we have identified 3 subtypes of patients based on their plasma proteome, each subtype with distinct clinical and functional characteristics. Altogether, these results have the power to create a paradigm shift in truly understanding and overcoming resistance to cancer by characterizing systemic proteomic changes along ICI-based therapy."

The paper was authored by a team of Israeli and international scientists and oncologists, including Dr. Michal Harel, Prof. Yuval Shaked, co-founder and Chief Scientific Advisor at OncoHost, and professor of cell biology and cancer science at the Technion – Israel Institute of Technology, and Prof. Adam Dicker, a leading radiation oncologist at Thomas Jefferson University and Chief Medical Officer at OncoHost. Additional key investigators included Dr. David Carbone, professor of internal medicine and director of the James Thoracic Center, Prof. Jair Bar, Deputy Director, Institute of Oncology at Sheba Medical Center, and Dr. Alona Zer, Head, Department of Medical Oncology at Rambam Health Care Campus.

"This paper highlights continued success in our clinical trial initiatives as we prepare for the upcoming U.S. launch of PROphet," said Dr. Ofer Sharon, CEO of OncoHost. "We are finally making significant headway in overcoming the long-standing issue in clinical oncology of patient resistance to treatment. The knowledge that PROphet can provide clinicians with is an industry game-changer, and we are excited to be playing a part in transforming cancer patient care. I am proud of our team and look forward to what lies ahead."

On June 21, 2022 Verismo Therapeutics, a recent University of Pennsylvania spin-out company behind the novel KIR-CAR platform technology for CAR T-cells, reported that Penn and Verismo entered into a Sponsored Research Agreement (SRA) (Press release, Verismo Therapeutics, JUN 21, 2022, View Source [SID1234616143]). Under the SRA, Verismo is funding additional KIR-CAR T-cell focused preclinical research programs at Penn to advance new potential treatment options for solid tumor indications. The research funded under the SRA is expected to be conducted over four years, from 2021 to 2025, in the Penn laboratories of Michael C. Milone, MD, PhD, an associate professor of Pathology and Laboratory Medicine, and Donald L. Siegel, MD, PhD, a professor of Pathology and Laboratory Medicine.

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Dr. Milone, with Dr. Carl June, is the co-inventor of the CTL019 CAR T product that became the first FDA-approved CAR T cell therapy, and he is the lead inventor of the KIR-CAR technology. Under the SRA, Dr. Milone and his lab are working to advance the KIR-CAR platform engineering and are performing key preclinical research for the purpose of enabling an IND for future clinical studies involving the KIR-CAR platform.

Dr. Siegel is a leading innovator in phage display technology. Under the SRA, Dr. Siegel and his lab are utilizing this technology to generate novel antibodies to cancer targets, which will expand Verismo’s product pipeline and potentially enable the treatment of additional tumor indications.

"Our ongoing collaboration with Penn brings us closer to our goal to treat solid tumors. Dr. Milone and Dr. Siegel have a clear vision of what scientific advances are needed to advance our progress and pipelines. I am hopeful that the collaboration between Penn and Verismo will accelerate the development of the KIR-CAR therapy and ultimately bring a new much needed treatment option to patients with solid tumors," said Dr. Bryan Kim, CEO of Verismo.

Editor’s Note: Drs. June, Milone, Siegel, and Penn are equity holders in Verismo. Penn has licensed certain Penn-owned intellectual property to Verismo and Drs. June, Milone, and Siegel, along with Penn, may receive financial benefits under the license in the future. Penn’s Perelman School of Medicine receives sponsored research funding from Verismo to support certain research and development programs at Penn.

On June 21, 2022 G42 Healthcare, an Abu Dhabi-based leading health tech company and subsidiary of G42, an artificial intelligence and cloud computing company located in Abu Dhabi reported that it has signed a letter of intent (LOI) with global biopharmaceutical company, AstraZeneca, in presence of the Department of Health – Abu Dhabi (DoH), the regulator of the healthcare sector in the emirate of Abu Dhabi aiming to expand their collaboration into the domains of diagnostics and clinical research, providing access to innovative solutions and treatments for patients in the United Arab Emirates and beyond (Press release, AstraZeneca, JUN 21, 2022, View Source [SID1234616142]).

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Left to right – Ghaleb Al Ahdab Government Affairs, Associate Director Gulf at AstraZeneca, Hicham Mirghani, Corporate Affairs Director GCC at AstraZeneca, Dr. Asma Al Mannaei, Executive Director, Research and Innovation Centre at DoH, Dr. Fahed Al Marzooqi, Chief Operating Officer at G42 Healthcare, Francesco Redivo Senior Director at G42 Healthcare
Left to right – Ghaleb Al Ahdab Government Affairs, Associate Director Gulf at AstraZeneca, Hicham Mirghani, Corporate Affairs Director GCC at AstraZeneca, Dr. Asma Al Mannaei, Executive Director, Research and Innovation Centre at DoH, Dr. Fahed Al Marzooqi, Chief Operating Officer at G42 Healthcare, Francesco Redivo Senior Director at G42 Healthcare
Witnessed by Dr. Asma Al Mannaei, Executive Director, Research and Innovation Centre at DoH, Hicham Mirghani, Corporate Affairs Director GCC at AstraZeneca and Dr. Fahed Al Marzooqi, Chief Operating Officer at G42 Healthcare, the agreement was signed by Ghaleb Al Ahdab Government Affairs, Associate Director Gulf at AstraZeneca, and Francesco Redivo Senior Director at G42 Healthcare during the BIO International Convention held in San Diego, California.

G42 Healthcare and AstraZeneca initially signed a Declaration of Collaboration in December 2021. This agreement further expands on their partnership to build local research capabilities, conduct RWE / clinical trials in UAE and localize Oncology biomarkers testing in UAE.

Ashish Koshy, CEO of G42 Healthcare, said, "We value collaboration and believe the strategic partnership with AstraZeneca will yield incredible growth for the healthcare ecosystem. We are proud to align ourselves with these organizations to generate new treatments and technologies to solidify the UAE’s place as a global hub for life sciences, medical tourism and innovation."

Hicham Mirghani, Corporate Affairs Director GCC, AstraZeneca said, "We are excited about expanding our existing partnership with G42 Healthcare to further advance the healthcare sector in the country and region. There is no doubt that innovation is key to healthcare advancements, and we are eagerly looking forward to collaboratively exploring greater possibilities in clinical research and diagnostics, enabling us to together create a more patient-centric healthcare offering in the UAE."

On June 21, 2022 Brand Institute reported that having worked with Adello Biologics (acquired by Kashiv Biosciences in 2019) in developing the brand name FYLNETRA (pegfilgrastim-pbbk), for an injection used to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia (Press release, Brand Institute, JUN 21, 2022, View Source [SID1234616141]). In addition to working on the brand name, Brand Institute also partnered with Adello Biologics in developing the suffix "pbbk" for the non-proprietary name for FYLNETRA, pegfilgrastim-pbbk.

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FYLNETRA was developed by Kashiv Biosciences in collaboration with Amneal Pharmaceuticals. FYLNETRA is the most recent pegfilgrastim biosimilar approved by the FDA.

"The entire Brand Institute and Drug Safety Institute team congratulates Kashiv Biosciences and Amneal Pharmaceuticals on the FDA approval for FYLNETRA," said Brand Institute’s Chairman and C.E.O., James L. Dettore.