Deciphera Pharmaceuticals, Inc. to Participate in Upcoming Investor Conferences

On June 2, 2022 Deciphera Pharmaceuticals, Inc. (NASDAQ: DCPH) reported that members of the management team will participate in fireside chats at the following investor conferences (Press release, Deciphera Pharmaceuticals, JUN 2, 2022, View Source [SID1234615406]):

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Jefferies Healthcare Conference on June 9, 2022 at 10:00 AM ET in New York, NY
JMP Securities Life Sciences Conference on June 15, 2022 at 10:00 AM ET in New York, NY
A live webcast of both events will be available on the "Events and Presentations" page in the "Investors" section of the Company’s website at View Source A replay of both webcasts will be archived on the Company’s website for 90 days following the presentation.

Immatics and Bristol Myers Squibb Expand Strategic Alliance to Develop Gamma Delta Allogeneic Cell Therapy Programs

On June 2, 2022 Immatics N.V. (NASDAQ: IMTX, "Immatics"), a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, and Bristol Myers Squibb (NYSE: BMY), reported that they have expanded their strategic alliance to pursue the development of multiple allogeneic off-the-shelf TCR-T and/or CAR-T programs (Press release, Bristol-Myers Squibb, JUN 2, 2022, View Source [SID1234615405]).

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Under this collaboration, Bristol Myers Squibb and Immatics will develop two programs owned by Bristol Myers Squibb and both companies have an option to develop up to four additional programs each. The programs will utilize Immatics’ proprietary gamma delta T cell-derived, allogeneic Adoptive Cell Therapy (ACT) platform, called ACTallo, and a suite of next-generation technologies developed by Bristol Myers Squibb.

Under the terms of this agreement, Immatics will receive an upfront payment of $60 million as well as up to $700 million per Bristol Myers Squibb program through development, regulatory and commercial milestone payments and tiered royalty payments of up to low double-digit percentages on net product sales. Immatics will be responsible for preclinical development of the initial two Bristol Myers Squibb-owned programs and will receive additional payment for certain activities that Immatics could perform at Bristol Myers Squibb’s request. Bristol Myers Squibb will assume responsibility for clinical development and commercialization activities of all Bristol Myers Squibb-owned programs thereafter.

In addition, Bristol Myers Squibb and Immatics will expand their 2019 collaboration agreement focused on autologous T cell receptor-based therapy (TCR-T), with the inclusion of one additional TCR target discovered by Immatics. As part of this expansion, Immatics will receive an upfront payment of $20 million and be eligible for milestone payments and royalties.

"The expansion of our collaboration with Bristol Myers Squibb significantly advances our allogeneic cell therapy development strategy," commented Harpreet Singh, Ph.D., Chief Executive Officer and Co-Founder of Immatics. "We welcome opening another chapter of our work with a trusted partner and the expertise and capabilities both companies provide in cell therapy development to create novel medicines for cancer patients."

"Today’s announcement represents an important part of our continued investment in next generation cell therapies that have the potential to provide transformative outcomes to patients with cancer," said Rupert Vessey, M.A., B.M., B.Ch., FRCP, D.Phil., Executive Vice President, Research & Early Development, Bristol Myers Squibb. "We are excited to expand our collaboration with Immatics that allows us to combine their novel off-the-shelf platforms with our industry-leading research and manufacturing expertise in cell therapy to develop new allogeneic cell therapy treatments to potentially help patients with solid tumor malignancies."

About ACTallo

ACTallo is Immatics’ proprietary allogeneic, off-the-shelf adoptive cell therapy platform based on gamma delta T cells sourced from healthy donors. Our manufacturing process is designed to create hundreds of doses from one single donor leukapheresis. Gamma delta T cells are abundant in the peripheral blood, show intrinsic anti-tumor activity, naturally infiltrate solid tumors and do not cause graft-vs-host disease – characteristics that make this cell type well suited for an allogeneic approach. The ACTallo process engineers gamma delta T cells with chimeric antigen receptors (CARs) or T cell receptors (TCRs), thus accessing cancer cell surface targets as well as intracellular proteins that are presented as peptides on the surface of the cancer cell. This enables the redirection of gamma delta T cells to cancer cell targets. ACTallo products will be available for patient treatment without the requirement for personalized manufacturing. Since these T cells originate from healthy individuals, they are not reliant on the potentially encumbered immune system of the cancer patient.

Arbutus to Participate in June Investor Conferences

On June 2, 2022 Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, reported that the Company will participate in the following upcoming investor conferences taking place in New York (Press release, Arbutus Biopharma, JUN 2, 2022, View Source [SID1234615404]):

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Jefferies Healthcare Conference (June 8 – 10, 2022)

Fireside Chat: 3:00 pm ET on Thursday, June 9, 2022
Presenters: Michael McElhaugh, Chief Business Officer; Dr. Gaston Picchio, Chief Development Officer; and David Hastings, Chief Financial Officer
JMP Securities Life Sciences Conference (June 15 – 16, 2022)

Fireside Chat: 9:00 am ET on Wednesday, June 15, 2022
Presenters: Michael McElhaugh, Chief Business Officer; Dr. Michael Sofia; Dr. Gaston Picchio, Chief Development Officer; and David Hastings, Chief Financial Officer
Live webcasts of the fireside chats can be accessed through the Investors section of Arbutus’ website at www.arbutusbio.com. An archived replay of the webcast will be available on the Arbutus website after the event.

05/12/2022?Medical & Biological Laboratories and Crown Bioscience Enter Joint Venture ~Providing Advanced Preclinical Services in Japan~

On June 2, 2022 JSR Corporation reported that Medical & Biological Laboratories (MBL) and Crown Bioscience, JSR Life Sciences companies, have formed a joint venture to further extend their preclinical services to Japanese customers (Press release, JSR, JUN 2, 2022, View Source [SID1234615399]). The new company named "Crown Bioscience & MBL", provides preclinical and translational services to biopharmaceutical customers in Japan. MBL is currently a distributor for Crown Bioscience and the establishment of the joint venture marks a significant milestone in the long-standing relationship between the two founding companies.

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The company, established in April 2022, is expected to start service operation from September 2022. For details, please refer to the announcements from Crown Bioscience.

Doma Raises RMB 950 Million Series A Financing to Incubate Innovative Life Sciences Companies

On June 1, 2022 Doma Biopharmaceutical reported the closing of a Series A financing round of RMB 950 million (Press release, Doma Biopharmaceutical, JUN 1, 2022, View Source [SID1234636146]). The investors included Biocytogen, China Life Private Equity Investment, PICC Capital, SDIC Venture Capital, Suzhou Industrial Park, Taiping Healthcare Fund, and CMB International. As the founding shareholders of Doma Pharmaceutical, the investors aspired to build the company into a China-based integrated incubator for sustained life sciences innovations by pooling cutting-edge technologies, outstanding talents, and longterm capital inputs.

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Doma was established in Suzhou BioBAY in September 2021 with a vision to develop innovative drugs and disruptive biotechnologies. The company has successfully incubated dynamic biotech companies with novel proprietary drug pipelines/biotechnologies, while giving birth to an industry cluster for innovative life sciences. That has been made possible by the company’s optimal integration of talents, technologies/products and capital on the shareholders’ robust open R&D service platform. As a fully integrated incubator for life science innovations, the company will empower incubatees with diverse.

"We are grateful to our founding shareholders for their contributions to the Series A financing, which has set the company in motion," said Dr. Huang Rui, Director and Chief Operating Officer of Doma. "The past decade has seen rapid progress in life sciences research in China and an increasing number of qualified and experienced high-caliber talents in the industry. That has given us the confidence to integrate science, industry, talent, and capital resources to build the company into a fully integrated incubation platform for life science innovations in China. On this platform, we will create a series of innovative and vibrant biotech companies that seek to address real clinical needs, identify market value, improve public health, and realize sustainable development by taking groundbreaking approaches. Going forward, Doma aims to incubate world-class companies based in China. That entails joint efforts with technology innovators, top talents, investors, and industrial partners to develop innovative target drugs, dual anti-ADC drugs, oncolytic viruses, cell therapies, pet drugs, diagnostic reagents, and AI products."

"We are honored to be a part in the co-investment for the establishment of Doma," said Dr. Shen Yuelei, Chairman of Biocytogen, one of the founding shareholders. "Biocytogen boasts world-leading technology platforms for gene editing, antibody drug discovery and screening, innovative animal model development, and clinical drug development, as well as the ability to develop new drugs throughout the process from early target validation to preclinical research and clinical development of pharmaceutical molecules. Besides, Biocytogen’s Project Integrum program and unique drug development platform will bolster Doma’s R&D capabilities, helping the company incubate more innovative and dynamic biotech.

"It is a trend inevitable for China to become a pharmaceutical powerhouse through rapid construction of a biopharma innovation incubator and a biopharma industry cluster with global influence, while platform companies have emerged as one of the key drivers to enhance the industrial capacity," said Jiang Li, Managing Director of China Life Private Equity Investment. "Doma is incubating new antibody drug companies with premier biopharma talents at home and abroad working on Biocytogen’s antibody drug development service platform and the unique Project Integrum platform. A bright future can be anticipated from its distinctive operating model that combines industrial incubation and drug pipeline development. We hope that our collaboration with Biocytogen and Doma will result in greater concentration and flow of advanced technologies, high-end talents, abundant capital, and other innovation factors, faster commercialization of scientific and technological findings, incubation of more new biotech companies, and globalization of local businesses. These outcomes will ultimately accelerate China’s bioeconomy growth and secure strategic advantages, while providing humanity with more innovative and effective pharmaceuticals."

"Life sciences is a subject that keeps exploring new ways to prolong life and cure illness, carrying the hopes and expectations of all mankind," said Shu Wanting, Managing Director of PICC Capital. "To embark on a novel industrial growth path, China must be an innovator rather than a follower, while being more patient and persistent along the way. We are very pleased to be one of the founding shareholders of Doma, standing ready to contribute to the company’s biotech industry cluster incubation by combining our extensive industry experience, top-tier talents, and long-term capital inputs with those of other shareholders. We hope that Doma will soon roll out a series of new products that will make a big difference in treating diseases and extending people’s lives.

Flagship Pioneering, a world-renowned biotech incubator, a biotech platform should be versatile within the same sector and able to quickly adapt successful R&D cases to succeeding R&D processes within the same sector. The more versatile a biotech platform is, the more functional and valuable it becomes. With its unique industry incubation system and Biocytogen’s Project Integrum resources, Doma has the potential to become an excellent biotech platform. We expect the company to become ‘China’s Flagship Pioneering’."