Labcorp Expands Access to Comprehensive Genomic Testing Through New Lung Cancer Program

On June 2, 2022 Labcorp (NYSE: LH), a leading global life sciences company, reported the important and growing role of precision medicine and is working to ensure more people have access to targeted and personalized treatments (Press release, LabCorp, JUN 2, 2022, View Source [SID1234615429]). As part of this effort, the company is announcing a new sponsored testing program aimed at helping advanced non-small cell lung (NSCLC) cancer patients and their physicians make informed treatment and care management decisions through comprehensive genomic insights.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The new program is sponsored by Eli Lilly and Company, a global health care leader dedicated to developing and delivering innovative new medicines to make a meaningful difference in the lives of cancer patients. The program will use Labcorp’s OmniSeq INSIGHTSM test, a pan-cancer, tissue-based sequencing test, to provide comprehensive genomic and immune profiling for cases that meet eligibility criteria. The program is designed to increase awareness of and provide enhanced access to more comprehensive testing options for eligible NSCLC patients in order to encompass all indicated guideline-directed genes and biomarkers.

"Comprehensive genomic and immune profiling allows for a much more extensive investigation into biomarkers that can lead to more effective treatment options, access to new clinical trials, and better patient outcomes," said Prasanth Reddy, M.D., MPH, senior vice president and oncology head at Labcorp. "With OmniSeq INSIGHT testing, people across the country living with lung cancer may be able to receive therapies or be informed of clinical trials that otherwise may not have been available because their specific biomarkers or gene mutations were not found in a single gene test. By equipping oncologists, health care systems and pharmaceutical developers with data-driven insights we are bringing the promise of precision medicine within reach for all."

Comprehensive genomic profiling (CGP) allows physicians to test for all actionable biomarkers that may be present in patients with NSCLC, rather than one or a few biomarkers that can be found using single gene testing. Comprehensive immune profiling tests for immune-related genes to provide novel, differentiating insights into the tumor microenvironment by testing for immune-related genes. These insights help identify potential immunotherapy eligibility. Test results from both genomic and immune profiling are used to help inform oncologists of the most appropriate targeted therapy for their patients.

"Comprehensive genomic profiling helps identify treatment options for patients to better inform targeted therapy selection," said Anthony (Nino) Sireci, M.D., vice president clinical biomarker and diagnostics development, Loxo Oncology at Lilly. "Our collaboration with Labcorp in their efforts to deliver OmniSeq INSIGHT tests to more patients further demonstrates the value of precision medicine and our commitment to making a difference."

Labcorp Oncology is committed to pioneering scientific breakthroughs that make a difference in cancer care through investments in innovative programs such as OmniSeq INSIGHT. OmniSeq INSIGHT is a pan-cancer, solid tumor test that combines two different treatment paradigms—genomic and immune profiling. The test enhances the characterization of the unique genomic biomarkers in a patient’s tumor enabling clinicians to make more informed decisions about personalized treatment approaches that can be more effective and may have fewer side effects, in addition to identifying clinical trials for which patients may be eligible.

ORIC Pharmaceuticals to Present at the Jefferies Healthcare Conference

On June 2, 2022 ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, reported that management will participate in a fireside chat at the Jefferies Healthcare Conference on Thursday, June 9, 2022, at 8:00 a.m. ET (Press release, ORIC Pharmaceuticals, JUN 2, 2022, View Source [SID1234615428]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live webcast of the fireside chat will be available through the investor section of the company’s website at www.oricpharma.com. A replay of the webcast will be available for 90 days following the event.

Supernus to Participate in the Jefferies Healthcare Conference

On June 2, 2022 Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, reported that Jack Khattar, President and CEO of Supernus Pharmaceuticals, will present at the Jefferies Healthcare Conference on Thursday, June 9, 2022, at 10:30 a.m. ET (Press release, Supernus, JUN 2, 2022, View Source [SID1234615426]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Investors interested in arranging a meeting with company management should contact the Jefferies conference coordinator. The conference will take place June 8-10, 2022 at the New York Marriott Marquis in New York City. A live audio webcast of the presentation can be accessed by visiting Events & Presentations in the Investor Relations section on the Company’s website at www.supernus.com. An archived replay of the webcast will be available for 60 days on the Company’s website following the conference.

CTI BioPharma to Present at Upcoming June Conferences

On June 2, 2022 CTI BioPharma Corp. (NASDAQ: CTIC) reported that management will provide a corporate overview at two upcoming investor conferences in New York City (Press release, CTI BioPharma, JUN 2, 2022, View Source [SID1234615425]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Presentation details:

Event: Jefferies Healthcare Conference
Date: Friday, June 10, 2022
Time: 10:00 a.m. ET

Event: JMP Securities Life Sciences Conference
Date: Wednesday, June 15, 2022
Time: 11:00 a.m. ET

Both presentations will be webcast live and available for replay from the Investors section of CTI BioPharma’s website at www.ctibiopharma.com.

NuCana Reports First Quarter 2022 Financial Results and Provides Business Update

On June 2, 2022 NuCana plc (NASDAQ: NCNA) reported that financial results for the first quarter ended March 31, 2022 and provided an update on its broad clinical program with its transformative ProTide therapeutics (Press release, Nucana BioPharmaceuticals, JUN 2, 2022, View Source [SID1234615424]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

As of March 31, 2022, NuCana had cash and cash equivalents of £52.6 million compared to £60.3 million as of December 31, 2021. NuCana continues to advance its various clinical programs and reported a net loss of £8.4 million for the quarter ended March 31, 2022, as compared to a net loss of £9.8 million for the quarter ended March 31, 2021. Basic and diluted loss per share was £0.16 for the quarter ended March 31, 2022, as compared to £0.19 per share for quarter ended March 31, 2021.

"We are excited about the optimized development plan we recently announced for NUC-3373 in colorectal cancer and have initiated the randomized Phase 2 study, NuTide:323, in second-line patients", said Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer. "We are also pleased to have initiated the NuTide:303 Phase 1b/2 study of NUC-3373 in combination with other agents, including PD-1 inhibitors, for the treatment of patients with solid tumors. In addition, we have enrolled the first patients into the Phase 2 part of the NuTide:701 study of NUC-7738. We look forward to providing numerous data updates throughout 2022 for both NUC-3373 and NUC-7738."

Mr. Griffith continued: "Positive data that we have previously announced for NUC-3373 and NUC-7738 have demonstrated our ProTides’ potential to provide cancer patients with more efficacious and safer treatment options. These data continue to demonstrate our ProTides’ encouraging anti-cancer activity and favorable safety profiles and pharmacokinetic properties."

Mr. Griffith concluded: "We have an anticipated cash runway which we expect will extend into 2025 and through many key milestones for both NUC-3373 and NUC-7738. We look forward to progressing towards our goal of significantly improving treatment options for patients with cancer."

Anticipated 2022 Milestones

NUC-3373 (a ProTide transformation of 5-FU)

In 2022, NuCana expects to:

Commence enrollment in the randomized, controlled Phase 2 (NuTide:323) study of NUC-3373 in combination with other agents for the second-line treatment of patients with colorectal cancer;
Commence enrollment in the Phase 1b/2 (NuTide:303) modular study of NUC-3373 in combination with other agents, including PD-1 inhibitors, in patients with solid tumors to identify additional indications for development;
Expand the Phase 1b/2 (NuTide:302) study of NUC-3373 in second-line colorectal cancer patients, and evaluate NUC-3373-based regimens in combination with bevacizumab;
Announce data from the Phase 1b/2 (NuTide:302) study of NUC-3373 combined with leucovorin, irinotecan and bevacizumab in patients with colorectal cancer; and
Announce data from the Phase 1b/2 (NuTide:303) modular study of NUC-3373 in combination with other agents in patients with solid tumors to identify additional indications for development.
NUC-7738 (a ProTide transformation of 3’-deoxyadenosine)

In 2022, NuCana expects to:

Announce data from the Phase 1 part of the NuTide:701 study of NUC-7738 in patients with solid tumors; and
Announce data from the Phase 2 part of the NuTide:701 study of NUC-7738 in patients with solid tumors.