On May 18, 2022 (GLOBE NEWSWIRE) — Instil Bio, Inc. ("Instil") (Nasdaq: TIL), a clinical-stage biopharmaceutical company focused on developing tumor infiltrating lymphocyte, or TIL, therapies for the treatment of patients with cancer, reported results of genomic and correlative analyses in a cohort of patients with metastatic melanoma treated with TILs manufactured by Instil (ORR of 67% in 14/21 patients) (Press release, Instil Bio, MAY 18, 2022, View Source [SID1234614790]). All TIL products were analyzed using T-cell receptor (TCR) sequencing, RNA and protein expression, and correlated with patient demographic and historical treatment data. Results will be presented at an oral presentation at the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 25th Annual Meeting.
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"We believe that TILs represent more than a potential therapy for patients, as they are also a platform to understand fundamental T cell biology," said Bronson Crouch, Chief Executive Officer of Instil Bio. "We are applying the recent advances in analytical technologies to deeply probe the function of TILs, and expect to generate insights that could be foundational for the development of anti-cancer therapies."
In the presentation, a correlation between tumor response and clonal expansion of TILs is shown, as well as an inverse correlation between tumor response and specific T cell populations in the product. Expression profiling and transcriptional network analysis points to "master regulator" genes which can be manipulated during TIL manufacturing to enhance TIL activity.
"This correlative analysis is one of the most informative looks to date at T-cell product attributes that impact patient outcomes and underscores the power of single cell analytic approaches to inform our product and process development strategies," said Mark Dudley, Ph.D., Chief Scientific Officer of Instil Bio. "We believe this is one of the first published single-cell analyses of TIL products provided to patients, and the identification of potential manipulations to enhance the efficacy of TILs exemplifies the sort of insights we hope to achieve using our cell therapy data analytics and computational platform."
Details of the oral presentation are as follows:
Title: Characterization of the Transcriptomic and T-Cell Receptor (TCR) Clonal Heterogeneity of Tumor-Infiltrating Lymphocyte (TIL) Therapy Infusion Products by Single-Cell Sequencing and Correlative Analyses with Clinical Efficacy in Patients with Advanced Cutaneous Melanoma
Session Type: Oral Abstract
Session Title: Cell-based Cancer Immunotherapies II
Location: Salon G
Date & Time: Wednesday May 18, 2022, 3:45 – 4:00 pm EDT
Abstract Number: 847
Full abstracts are available on the ASGCT (Free ASGCT Whitepaper) conference website View Source