On April 20, 2022 BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) reported that the company’s partner AbbVie has decided to terminate its collaboration with BioArctic regarding the portfolio of alpha-synuclein antibodies, including ABBV-0805 (Press release, AbbVie, APR 20, 2022, View Source [SID1234612604]).
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BioArctic and AbbVie have collaborated since 2016 regarding the research and development of BioArctic’s portfolio of alpha-synuclein antibodies for Parkinson’s disease and other potential indications. In 2019, a Phase 1 study of the lead asset, ABBV-0805, was initiated, and results from the study, presented at the International Congress of Parkinson’s Disease and Movement Disorders (MDS) in September 2021, supports a continuation into Phase 2 with once-monthly dosing.
"We are disappointed that AbbVie has taken this decision. All available data indicates that ABBV-0805 has uniquely high selectivity for the pathological forms of aggregated alpha-synuclein, as well as Phase 1 data supporting progression to Phase 2. We believe that ABBV-0805 has the potential to become a disease-modifying treatment for people with Parkinson’s disease and will now investigate options to continue the development of this asset," says Gunilla Osswald, BioArctic’s CEO.
This release discusses investigational uses of an agent in development and is not intended to convey conclusions about efficacy or safety. There is no guarantee that any investigational uses of such product will successfully complete clinical development or gain health authority approval.
This information is information that BioArctic AB (publ) is obliged to disclose pursuant to the EU Market Abuse Regulation. The information was released for public disclosure, through the agency of the contact persons above, on April 20, 2022, at 07:50 a.m. CET.
About ABBV-0805
ABBV-0805 is a monoclonal antibody drug candidate that is designed to selectively bind and eliminate aggregated forms of alpha-synuclein such as oligomers and protofibrils, which participates in neurodegenerative maladies including Parkinson’s disease. The goal is to develop a disease modifying treatment that stops or slows down the progression of Parkinson’s disease.
About the collaboration between BioArctic and AbbVie
BioArctic has been collaborating with AbbVie since 2016, when the two companies entered into a research agreement. AbbVie then obtained the right to acquire a license to develop and commercialize BioArctic’s portfolio of alpha-synuclein antibodies for Parkinson’s disease and other potential indications. In late 2018, AbbVie exercised this option. In 2019, a Phase 1 study of ABBV-0805 was initiated. Results from the study, presented in September 2021, support a continuation into Phase 2. AbbVie has been managing and funding the clinical development of ABBV-0805. The scope of the drug candidate ABBV-0805 may be broadened to include, for example, Lewy body dementia and multiple system atrophy.