On April 19, 2022 RenovoRx, Inc. ("RenovoRx" or the "Company") (Nasdaq: RNXT), a biopharmaceutical company and innovator in targeted cancer therapy, reported it will join the Pancreatic Cancer Action Network (PanCAN) as a Silver Sponsor of the organization’s PurpleStride Silicon Valley event to end pancreatic cancer (Press release, Renovorx, APR 19, 2022, View Source [SID1234612511]).

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In order to help improve patient outcomes, RenovoRx employees and their families have united to create Team RenovoRx with a goal to support PanCAN’s urgent mission to save lives. After two years of virtual fundraising events due to the ongoing pandemic, PurpleStride Silicon Valley 2022 will be back in person at Discovery Meadow in downtown San Jose, CA on Saturday, April 30.

"All of us at RenovoRx proudly support the PurpleStride walk, which improves pancreatic cancer awareness across the country," said Shaun Bagai, CEO of RenovoRx. "We’re continually energized by the people we meet in this important cause and are dedicated to advancing treatment options for patients impacted by pancreatic cancer."

For the first time ever, Silicon Valley’s PurpleStride walk is coordinated with nearly 60 other communities across the nation for one nationally synchronized PanCAN PurpleStride event. City-by-city, thousands of supporters will walk the nation in solidarity to raise national awareness and much-needed funds for pancreatic cancer. Funds raised through this nationwide movement fuel life-changing programs and services for pancreatic cancer patients and their families.

"By taking action locally, we have the opportunity to make a difference in the lives of pancreatic cancer patients nationwide," said Ariane Chappel, chair of PanCAN’s Silicon Valley affiliate. "We are grateful to RenovoRx’s commitment to raise vital funds and awareness to support the pancreatic cancer community through this important event."

Pancreatic cancer is the world’s deadliest cancer with a five-year survival rate of just 11 percent. In 2022, more than 62,000 Americans will be diagnosed with pancreatic cancer and nearly 50,000 will die from the disease, making it the third leading cause of cancer-related death in the U.S.

On April 19, 2022 AVM Biotechnology, a clinical-stage company developing AVM0703, a small molecule that mobilizes endogenous gamma delta TCR+ and invariant TCR+ bispecific Natural Killer T-like cells, reported that Founder and Chief Science Officer, Dr. Theresa Deisher, will provide an invited company presentation as well as a poster presentation at Life Science Innovation Northwest taking place April 20-21, at the Washington State Convention Center in Seattle (Press release, AVM Biotechnology, APR 19, 2022, View Source [SID1234612510]). The oral presentation will feature a discussion of AVM0703, the company’s lead asset, as well as a clinical update on the status of the WWRD Study: AVM0703 for the Treatment of Lymphoma and Leukemia (NCT04329728). Dr. Deisher’s presentation is scheduled for Wednesday, April 20th at 11:20 AM in the Oncology and Immunology Session.

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AVM0703 is a small molecule which triggers the production and release of endogenous bispecific gamma delta TCR+ and invariant TCR+ Natural Killer T-like cells (AVM-NKT). These naturally occurring amplified immune cells have unique properties and appear rapidly in the blood following a single dose of AVM0703 which can be administered in an infusion center. Preclinical data suggest even greater efficacy in conjunction with chemotherapy as well as potential in solid tumors and autoimmune disorders. AVM0703 offers advantages over existing oncology standard of care treatment as the AVM-NKT cells are induced in vivo and do not face the same challenges in manufacturing and supply as other cell therapies.

Dr. Deisher will provide a clinical update on the near completion of the safety portion of the company’s pivotal clinical trial in treating "no-option" Relapsed /Refractory Non-Hodgkin’s Lymphoma/Leukemia patients as well as startling results in a patient enrolled in the FDA-authorized Expanded Access or Compassionate Use Program. The drug has been generally well-tolerated with patients experiencing mild to moderate and self-limiting side effects.

The mission of AVM Biotechnology is to develop and deliver treatments which save lives and improve outcomes by unlocking the potential of the body’s own immune system. The company has raised nearly $25M to date with approximately 20% from non-dilutive funding. They have recently been awarded a $1.6M Phase II SBIR grant from the National Institute of Diabetes and Digestive Kidney Disease to study the reversal and prevention of Type 1 Diabetes and an Intent to Fund letter from the National Cancer Institute for an additional $2M Phase II SBIR grant to further the existing clinical trial. AVM will be requesting Breakthrough Therapy Designation, an expedited FDA review and accelerated approval in Non-Hodgkin’s Lymphoma (NHL) while simultaneously exploring the potential of AVM0703 in Type 1 Diabetes. Commercialization in NHL is planned for Q1 2024.

Life Science Innovation Northwest, the largest annual Life Science conference in the Pacific Northwest, brings together investors, public and private life science organizations, research institutions, scientists, entrepreneurs, and the global health community to discuss and feature some of the most compelling recent life science breakthroughs. Dr. Deisher is delighted to highlight the transformative work of AVM Biotechnology in this setting. To register, please visit Life Science Innovation Northwest 2022 | Life Science Washington.

On April 19, 2022 Immune-Onc Therapeutics, Inc. ("Immune-Onc"), a private, clinical-stage cancer immunotherapy company developing novel biotherapeutics targeting myeloid checkpoints, reported the Company will present at the virtual LILRB/ILT Symposium: A Deep Dive into Myeloid Checkpoint Therapeutics in Cancer on Tuesday, April 26, 2022, at 2:00 PM EDT, hosted by Raymond James biotech analysts (Press release, Immune-Onc Therapeutics, APR 19, 2022, View Source [SID1234612509]). Charlene Liao, Ph.D., chief executive officer of Immune-Onc and Paul Woodard, M.D., chief medical officer, will provide a corporate overview, including recent clinical development progress and anticipated milestones for 2022 and beyond. Dr. Chengcheng (Alec) Zhang, Professor of Physiology at UT Southwestern Medical Center and Scientific Founder of Immune-Onc, will give an expert presentation on the LILRB/ILT family of receptors as myeloid checkpoint targets in immuno-oncology at 2:30 PM EDT.

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"As a private company and a leader in LILRB/ILT family of myeloid checkpoint target validation and therapeutics development, we are pleased to be invited to the Raymond James LILRB/ILT Symposium," said Charlene Liao, Ph.D., chief executive officer of Immune-Onc. "Immune-Onc was founded on groundbreaking science that first illuminated the role of the previously unexplored LILRB family of myeloid checkpoints in cancer. This research has rapidly advanced a completely new field of study and class of cancer immunotherapy that goes beyond T cells to overcome immune resistance and the limitations of current treatment options. We look forward to sharing our pipeline progress on the same stage with our Scientific Founder Dr. Alec Zhang."

On April 19, 2022 Oncomatryx reported that it is embarking on a new phase in the development of its tumor microenvironment – targeted ADCs (Press release, Oncomatryx, APR 19, 2022, View Source [SID1234612508]).

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OMTX705, the Crown Jewel, has already proven high antitumor efficacy and unbeatable ADC safety in murine and non-human primate models. Phase I clinical trials in patients suffering metastatic solid tumors will be launched in Europe and USA in Q2 2022.

In order to fund OMTX705 Phase I clinical trials, Oncomatryx has raised 15 million euros. The capital increase was funded by current shareholders and by national and international family offices. These funds, together with Oncomatryx recurring revenues from its licensing agreements with international biopharmaceutical companies, will be used for the clinical development of additional ADCs of Oncomatryx tumour-microenvironment pipeline. The total investment for the three-year period 2022-2024 will be 50 million Euros.

In addition, Dr. Ignacio Garcia-Ribas has been appointed as Medical Director of Oncomatryx. Dr. Garcia-Ribas will lead the clinical development of OMTX705 and oversee the transition of molecules in the Oncomatryx pipeline from preclinical to clinical studies.

Dr. Garcia-Ribas is a medical oncologist with 17 years of experience in early-stage oncology drug development. Most recently he was Chief Medical Officer of the Swedish company Cantargia where he created and implemented the initial development plan for Nadunolimab in both Europe and USA. He previously worked at Takeda as global clinical lead on several Phase 1/2 programmes with a specific focus on immuno-oncology, and before that he was Senior Medical Director and a member of the Early Development Group of Sanofi’s Oncology Division where he was involved in the clinical development of small molecules and ADCs. Prior to that, he was part of the Early Development Unit at Eli Lilly, where he contributed to the development of several small molecules and antisense oligonucleotides. Dr. Garcia Ribas received his PhD in Medicine from the Richard Dimbleby Cancer Research Department/ICRF Unit at St. Thomas’ Hospital in London, which focused on cancer gene therapy.

On April 19, 2022 Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing first-in-class allogeneic gamma delta chimeric antigen receptor (CAR) T cell therapies for cancer, reported the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to its lead program ADI-001, an investigational therapy targeting CD20 for the potential treatment of relapsed or refractory B-cell Non-Hodgkin’s lymphoma (NHL) (Press release, Adicet Bio, APR 19, 2022, View Source [SID1234612507]).

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ADI-001 is currently being evaluated in an ongoing dose escalation Phase 1 study evaluating the safety and tolerability of ADI-001 for the potential treatment of NHL. The Fast Track Designation was granted based on ADI-001’s potential to address an unmet need within the adult NHL patient population.

"Fast Track Designation represents an important milestone in the clinical development of ADI-001," said Chen Schor, President and Chief Executive Officer of Adicet Bio. "We believe ADI-001 is unique in that it is designed to target malignant B cells by leveraging the innate and adaptive receptors found naturally on gamma delta T cells with the added benefit of an engineered anti CD20 CAR. We remain optimistic about the potential of our program and look forward to reporting additional data from the Phase 1 trial of ADI-001 in the first half of 2022."

Fast Track Designation is a process designed to facilitate the development and expedite the review of drugs intended to treat serious conditions and fill an unmet medical need.