On April 18, 2022 Beyond Air, Inc. (NASDAQ: XAIR), a clinical-stage medical device and biopharmaceutical company focused on developing inhaled nitric oxide (NO) for the treatment of patients with respiratory conditions, including serious lung infections and pulmonary hypertension and, through its affiliate Beyond Cancer, ultra-high concentration nitric oxide (UNO) for the treatment of solid tumors, reported that the Company is scheduled to present new data at three upcoming medical conferences (Presentation, Beyond Air, APR 18, 2022, View Source [SID1234612405]).

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The Pediatric Academic Societies 2022 Meeting (PAS 2022)
The Company is scheduled to present new long-term safety data for high concentration inhaled nitric oxide for the treatment of bronchiolitis at the PAS 2022 Meeting, which is scheduled to be held April 21-25 in Denver, Colorado. Details of the presentation are as follows:

Abstract Title: 1179165 – Long-term effects of inhaled nitric oxide in infants with bronchiolitis – a multi-center study
Session: Pulmonology – Oral Abstract
Date: Monday April 25, 2022 at 1:00 PM – 3:30 PM MST
Participant: Aviv Goldbart, M.D. Professor, Head of Department Pediatrics, Soroka University Medical Center; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2022)
The Company will present new data from the LungFit PRO pilot study of high-concentration nitric oxide in Community-Acquired Viral Pneumonia (CAVP) including COVID-19 at the upcoming 32nd ECCMID 2022, which is scheduled to be held April 23-26, 2022 in Lisbon, Portugal. Details of the oral poster presentation are as follows:

Abstract Title: 00400 – Treatment of COVID-19 with inhaled nitric oxide using a novel nitric oxide generator
Poster Session: 12e. Drug development and treatment modalities (incl. clinical trials)
Participant: Talya Wolak, M.D. Faculty of Medicine, Hebrew University of Jerusalem, Israel; The Internal Medicine Department D at Shaare Zedek Medical Center, Israel

American Thoracic Society International Conference 2022 (ATS 2022),
The Company will present new data from the LungFit GO pilot study of high concentration inhaled nitric oxide in NTM at the upcoming ATS 2022, which is scheduled to be held May 13-18, 2022 in San Francisco. Details of the oral poster presentation are as follows:

Title: (Under Embargo)
Session: C28 – LET’S TALK NTM
Date: May 17, 2022 9:30 AM – 11:00 AM PT
Participant: Dr. Rachel Thomson MBBS, PhD, FRACP; Professor at University of Queensland, School of Medicine

On April 18, 2022 Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a clinical stage biotechnology company developing the next generation of therapeutics based on its proprietary self-delivering RNAi (INTASYL) therapeutic platform, reported that in vivo data showing PH-762 administered locally clears untreated distal tumors, indicating a systemic immune response was selected for an encore presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Tumor Immune Microenvironment: A Holistic Approach Workshop, which is being held April 21st – 22nd in San Diego and virtually (Press release, Phio Pharmaceuticals, APR 18, 2022, View Source [SID1234612403]).

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Presentation Details are as follows:
Title: Locally administered immunotherapy self-delivering RNAi PH-762 results in abscopal clearance of untreated distal tumors, suggesting systemic immune response, in a murine hepatocarcinoma model
Presenter: Simon Fricker
Abstract Number: 019
Session Date and Time: April 21st from 5:20 p.m. – 6:20 p.m. PT
Location: Sheraton San Diego Hotel and Marina in San Diego

The poster will be made available on the "Investors – Events and Presentations" section of the Company’s website (click here).

On April 18, 2022 Navidea Biopharmaceuticals, Inc. (NYSE American: NAVB) ("Navidea" or the "Company"), a company focused on the development of precision immunodiagnostic agents and immunotherapeutics, reported the regulatory approval of Lymphoaim ("Lymphoseek" in the rest of the world; Tc99m tilmanocept) by the Central Drugs Standard Control Organisation, India (Press release, Navidea Biopharmaceuticals, APR 18, 2022, View Source [SID1234612402]).

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Tc99m tilmanocept is approved for imaging and intraoperative detection of sentinel lymph nodes draining a primary tumor in adult patients with breast cancer, melanoma, or localized squamous cell carcinoma of the oral cavity. External imaging and intraoperative evaluation may be performed using a gamma detection device. Tc99m tilmanocept is designed for the precise identification of lymph nodes that drain from a primary tumor, which have the highest probability of harboring cancer.

Sayre Therapeutics will lead Lymphoaim commercialization efforts in India through a previously announced exclusive license and distribution agreement with Navidea. Sayre Therapeutics specializes in innovative treatment and medical device commercialization in South Asia.

Dr. Michael Rosol, Chief Medical Officer for Navidea, said, "We are delighted that Lymphoaim has received regulatory approval in India and will be available to patients in need." Dr. Rosol continued, "This will also bring a new revenue stream to the Company to help us advance other pipeline products."

Mr. Shukrit Sudhir Chimote, Chief Executive Officer for Sayre, said, "Lymphoaim, a radioactive diagnostic agent, would benefit surgeons in guiding sentinel lymph node biopsies. This product fits well with Sayre’s mission of providing novel treatment solutions, and will certainly help boost our presence in the surgical oncology segment."

On April 18, 2022 Kinnate Biopharma Inc. (Nasdaq: KNTE) ("Kinnate"), a biopharmaceutical company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers, reported that the first patient has commenced treatment in its Phase 1 KN-4802 (NCT05242822) clinical trial evaluating its lead Fibroblast Growth Factor Receptor (FGFR) product candidate, KIN-3248 (Press release, Kinnate Biopharma, APR 18, 2022, View Source [SID1234612401]). KIN-3248 is a next-generation pan-FGFR inhibitor being developed for the treatment of intrahepatic cholangiocarcinoma (ICC) and urothelial carcinoma (UC), as well as other solid tumors.

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"With the dosing of the first patient in our Phase 1 trial of KIN-3248, we are excited to further advance the development of this next-generation therapy which we believe is unique among FGFR inhibitors and has the potential to offer a new targeted therapy option for cancer patients with FGFR-altered tumors," said Richard Williams, MBBS, PhD, Chief Medical Officer of Kinnate. "We are grateful for the contribution of all the participants in this multi-center trial and for the support of our clinical collaborators at each trial site."

KIN-3248 is an irreversible, small molecule pan-FGFR inhibitor that has been developed to address both primary FGFR2 and FGFR3 oncogenic alterations and those predicted to drive acquired resistance to current FGFR-targeted therapies, including gatekeeper, molecular brake, and activation loop mutations observed in cancers such as ICC and UC. In preclinical studies, KIN-3248 demonstrated inhibitory activity across a wide range of clinically relevant mutations that drive primary disease and acquired resistance to other FGFR inhibitors.

The KN-4802 clinical trial (NCT05242822) is a multi-center, open-label, two-part study of approximately 120 patients to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-3248 in adults with advanced tumors harboring FGFR2 and/or FGFR3 gene alterations. The dose escalation portion (Part A) of the trial will determine the recommended dose and schedule of KIN-3248 for further evaluation in patients with FGFR2 and/or FGFR3 gene alteration-driven cancers. The dose expansion phase (Part B) of the trial will assess the safety and efficacy of KIN-3248 at the recommended dose and schedule in FGFR inhibitor naïve and FGFR inhibitor pretreated patients with cancers driven by FGFR2 and/or FGFR3 gene alterations, including ICC, UC, and other selected adult solid tumors.

"Successfully treating ICC and UC patients with FGFR2 and/or FGFR3 gene alteration-driven cancers remains a significant unmet need in cancer care. KIN-3248 brings a unique approach to potentially address the shortcomings of existing therapies in specific patient populations with primary FGFR2 and/or FGFR3 oncogenic alterations, including those patients with gatekeeper, molecular brake, and activation loop mutations," said Benjamin Garmezy, MD, Assistant Director of Genitourinary Research for Sarah Cannon Research Institute at Tennessee Oncology. "We are proud to be the first site to treat a patient with KIN-3248 and look forward to working with Kinnate to continue enrollment in this important Phase 1 trial."

On April 18, 2022 Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, reported that its executive leaders will be providing an overview of the Company’s gene therapies for cancer and diabetes to investors and industry professionals at the following investor and industry conferences in April 2022 (Press release, Genprex, APR 18, 2022, View Source [SID1234612400]).

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Event: NobleCon 18

Conference Dates: April 19-21, 2022

Presentation Date: Wednesday, April 20

Presentation Time: 11:30 a.m. ET

Location: Hard Rock Guitar Hotel, Hollywood, FL – Seminole Ballroom B

Presenter: Ryan Confer, Chief Financial Officer

A high-definition, video webcast of the presentation will be available the following day on the Company’s website at www.genprex.com and as part of a complete catalog of presentations available at Noble Capital Markets’ Conference website: www.nobleconference.com and on Channelchek www.channelchek.com the investor portal created by Noble. The webcast will be archived on the company’s website, the NobleCon website and on Channelchek.com for a period of time following the event.

Event: Alliance for Regenerative Medicine’s Cell & Gene Meeting on the Mediterranean (Virtual)

Conference Dates: April 20-22, 2022

Virtual Presentation Date: Available on-demand within the virtual platform for all delegates to view starting April 20, 2022

Presenter: Mark Berger, Chief Medical Officer

This meeting will feature in-person and pre-recorded virtual presentations by leading public and private companies, highlighting technical and clinical achievements over the past 12 months in the areas of cell therapy, gene therapy, gene editing, tissue engineering and broader regenerative medicine technologies.