On April 11, 2022 Adcendo ApS ("Adcendo"), a biotech company focused on the development of breakthrough antibody-drug conjugates (ADCs) for the treatment of underserved cancers, reported that a poster presentation will be provided on data of uPARAP targeting Antibody-Drug Conjugates in osteosarcoma preclinical xenograft models at the ongoing American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, held in New Orleans from April 8-13, 2022 (Press release, ADCendo, APR 11, 2022, View Source [SID1234613272]).

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American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022
Presentation title: 2016 / 20 – Preclinical Evaluation of uPARAP (MRC2) Antibody-drug Conjugates (ADCE-003,010,011) in Osteosarcoma PDX Models
Session: Clinical Research Excluding Trials
Session Title: Paediatric Oncology: Clinical Investigation
Presenter: Yifei Wang
Authors: Yifei Wang, Wendong Zhang, Zhongting Zhang, Xiangjun Tian, Rossana N Lazcano Segura, Pooja Hingorani, Michael Roth, Jonathan Gill, Douglas Harrison, Zhaohui Xu, Jing Wang, Niels Behrendt, Christoffer F. Nielsen, Lars H. Engelholm, and Richard Gorlick
Date & Time: April 11th at 1:30 – 5.00 pm CDT

uPARAP is a cell-surface receptor, which is involved in collagen degradation and displays a differentiated expression profile between healthy tissue and cancer tissue, with several cancer types significantly overexpressing the receptor, including soft-tissue sarcoma, osteosarcoma, mesothelioma and glioblastoma multiforme (GBM). The preclinical study in Osteosarcoma PDX models presented at the 2022 AACR (Free AACR Whitepaper) meeting was carried out by researchers at the University of Texas MD Anderson Cancer Center.

Principal Investigator Richard Gorlick, M.D., Department Chair of the Department of Pediatrics Patient Care and Director of the Department of Pediatric Sarcoma Research Laboratory of The University of Texas MD Anderson Cancer Center, Houston, TX, said: "ADCs have shown robust clinical activity in several solid tumor cancers but, due to the lack of suitable targets, none are yet available for osteosarcoma. Osteosarcoma are the most common primary malignant bone tumors in children and young adults, where treatment has shown limited progress in the last few decades. We are encouraged by this data and look forward to further support the ongoing development of a uPARAP-targeting ADC in order to improve the outcome of our patients."

Niels Behrendt, Professor of the Finsen Laboratory, University of Copenhagen and Copenhagen University Hospital, and Scientific Co-founder of Adcendo, said: "After 25 years of research on the biology of uPARAP we are very encouraged by the promising activity data, suggesting that targeting uPARAP via ADCs could represent a novel therapeutic option for osteosarcoma patients and other underserved cancer indications."

On April 11, 2022 BerGenBio ASA (OSE:BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL inhibitors for severe unmet medical needs, reported the appointment of Cristina Oliva, MD as Chief Medical Officer (CMO), effective 25 April 2022 (Press release, BerGenBio, APR 11, 2022, View Source [SID1234612476]). Cristina joins the senior leadership team heading up clinical development of BerGenBio’s selective AXL inhibitor programs.

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Cristina is a Board-certified oncologist and brings over 20 years of senior clinical development experience across large pharmaceutical, biotechnology and Clinical Research Organizations (CROs). Most recently Cristina was Vice President, Oncology and Head of Oncology Centre of Excellence at IQVIA Ltd, where she led the development of decentralized trials and established and led the IQVIA Oncology Global Scientific Advisory Board. Prior to her role at IQVIA, Cristina held senior positions leading oncology development programs for Nordic Nanovector, Takeda Pharmaceuticals, GlaxoSmithKline and Eli Lilly.

Martin Olin, Chief Executive Officer of BerGenBio, commented: "I’m delighted to welcome Cristina as our new Chief Medical Officer. Cristina’s leadership experience within oncology drug development across big pharma, biotech and CRO environments will be instrumental in executing BerGenBio’s development strategy for our AXL inhibitor programs, including our most advanced program bemcentinib, currently in phase II trials."

On her appointment as Chief Medical Officer at BerGenBio, Cristina Oliva, MD, commented:"BerGenBio is on the frontier of developing novel, highly selective AXL inhibitors for the treatment of severe diseases such as oncology and respiratory infections. I’m very excited to join BerGenBio at this critical phase and look forward to working with the senior leadership team to help further advance its AXL inhibitor programs."

On April 11, 2022 Bio-Platform NewStem Ltd reported the filing of a pre-submission to the FDA for a De Novo Request and an in vitro diagnostic device (IVDD) for EMA for their NewStem Software Diagnostic Device (Press release, NewStem, APR 11, 2022, View Source [SID1234612062]). The announcement followed the company’s graduation from Illumina’s Accelerator 3rd funding cycle in March 2022.

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The NewStem Software Diagnostic Device (NSDD), a bioinformatics-based software medical device platform, provides oncologists with information regarding the presence of mutations in tumors, which may confer patient resistance to certain anti-cancer drugs. The information provided by NSDD, will aid oncologists when deciding which treatment regime to apply.

Cancer is the second leading cause of death globally. Despite efforts and achievements made in treating cancer over the past several decades, resistance to anti-cancer drugs continues to be a major problem in cancer therapies. Resistance is the leading cause of relapses in cancer and one of the significant causes of death due to the disease. Drug resistance (whether pre-existing or generated after therapy) is responsible for over 90% of deaths in cancer patients receiving traditional chemotherapeutics or novel targeted drugs treatments.

NewStem is a biotechnology company established as a bio-platform for genome wide screenings based on proprietary Haploid human Embryonic Stem Cells (HhESCs) technology. These cells can potentially change how we develop genetic based therapeutics and diagnostics, as they are superior to other cells used for whole genome screenings. NewStem is currently the only company worldwide to develop innovative practice-changing products based on this innovative and exclusive technology. The company is now raising funds to deepen its internal personnel capabilities and for further research and development.

"The technology, based on our proprietary haploid cells, has changes the dogma and enables what was formerly impossible", says Prof. Nissim Benvenisty. "NSDD will give oncologists a better understanding of the many variances that present challenges in the treatment of cancer and in the identification of drug-type resistance. That is unprecedented."

On April 11, 2022 AnPac Bio-Medical Science Co., Ltd. ("AnPac Bio," the "Company" or "we") (ANPC), a biotechnology company with operations in the United States and China focused on early cancer screening and detection, reported that on April 4, 2022, the Company and Hunan Weitou Technology Co., Ltd. ("new investor") have signed a legally binding equity investment totaling $15 Million which will be invested in five installments over the next 30 months (Press release, Anpac Bio, APR 11, 2022, View Source [SID1234612051]).

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Under the terms of the agreement, the new investor will invest $3 Million at the beginning of every 6 months. The first $3 Million, which is in the form of private equity investment, has a purchase price at $0.414 per share. It is expected that the first investment installment will be completed in April 2022.

Dr. Ai-Dong Chen, Chairman of the board and CEO of the Company, commented: "This long term equity investment is significant and important to the growth of our company. It also shows investors’ confidence in the prospects of our company and its leading-edge technology. We have a very strong innovation track record, significant intellectual property, including over 260 filed patent applications and 150 issued patents, the world’s largest cancer detection data base and sample size (in new generation cancer detection technology space) according to Frost & Sullivan, and a leading edge, novel cancer detection technology which is already saving lives on the weekly basis."

On April 11, 2022 BioNTech SE (Nasdaq: BNTX, "BioNTech") and Matinas BioPharma (NYSE AMER: MTNB, "Matinas"), a clinical-stage biopharmaceutical company focused on redefining the intracellular delivery of nucleic acids and small molecules with its lipid nanocrystal (LNC) platform technology, reported that they have entered into an exclusive research collaboration to evaluate the combination of mRNA formats and Matinas’ proprietary LNC platform technology (Press release, BioNTech, APR 11, 2022, View Source [SID1234612023]). The parties will closely collaborate on formulation, optimization, and in vitro testing.

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"We pioneered the treatment of the first patient in history with nano-sized lipid-encapsulated mRNA back in 2015, after years of extensive research. Accomplishing strong immune responses with low doses are crucial in the development of well-tolerated and highly effective vaccines. This can be achieved with the right technology that enables targeted vaccine delivery," said Ugur Sahin, M.D., Chief Executive Officer and Co-Founder of BioNTech. "Matinas’ LNC platform demonstrates encouraging capabilities for intracellular delivery, including the opportunity for oral delivery. We are excited to collaborate with this extraordinary team of experts."

"This collaboration with BioNTech is an important validation from a leading global biotech company with demonstrated expertise in the design, formulation, and delivery of mRNA," said Jerome D. Jabbour, Chief Executive Officer and Co-Founder of Matinas. "We are thrilled to partner with this world-class organization to further demonstrate the capabilities of our LNC platform, and potentially provide an opportunity for the oral administration of vaccines or other treatments. Intracellular delivery remains a significant challenge for many emerging therapies and the combination of oral bioavailability with non-immunogenic transfection could potentially benefit tens of millions of patients around the world."

Under the terms of the agreement, Matinas will receive an upfront access fee to work exclusively with BioNTech, as well as additional research funding from BioNTech. The parties have also commenced discussions on a license agreement for Matinas’ LNC platform technology.