Mission Therapeutics to Participate in SVB Leerink Biopharma Private Company Connect Event

On March 25, 2022 Mission Therapeutics ("Mission"), a drug discovery and development company focused on protein homeostasis by selectively inhibiting deubiquitylating enzymes (DUBs), reported that members of its management team, Dr Anker Lundemose, CEO, David Luther, CFO, Dr Suhail Nurbhai, CMO, and Dr Paul Thompson, CSO, will be attending the upcoming SVB Leerink Biopharma Private Company Connect Event (Press release, Mission Therapeutics, MAR 25, 2022, View Source [SID1234610958]).

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The event, which will take place virtually on 29-31 March, is intended to bring together private companies, institutional investors, and industry experts to discuss the trends and opportunities shaping the future of healthcare.

Companies and individuals interested in attending the conference should please contact SVB Leerink for more information.

Invitation to Roche’s First Quarter Sales 2022 Webinar

On March 25, 2022 Roche reported that it will publish its Sales Results for the 1st Quarter of 2022 prior to the opening of the Swiss Stock Exchange on Monday, 25 April 2022 (Press release, Hoffmann-La Roche, MAR 25, 2022, View Source [SID1234610957]).

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Scilex Holding Company, a majority-owned subsidiary of Sorrento Therapeutics, Inc., enters into a Non-Binding Term Sheet for a $5 Billion Committed Equity Financing Facility to be Effective in Connection with the Closing of the Merger with Vickers Vantage

On March 25, 2022 Scilex Holding Company ("Scilex"), a majority-owned subsidiary of Sorrento Therapeutics, Inc. (Nasdaq: SRNE, "Sorrento"), a commercial biopharmaceutical company focused on developing and commercializing non-opioid therapies for patients with acute and chronic pain, reported that it has entered into a non-binding term sheet with B. Riley Principal Capital, LLC ("BRPC"), a subsidiary of B. Riley Financial, Inc. (Nasdaq: RILY, together with its affiliates, "B. Riley") for a committed equity financing facility (the "Facility") under which it would be able to sell up to $5 billion of its registered common stock over a five-year period (Press release, Sorrento Therapeutics, MAR 25, 2022, View Source [SID1234610955]). The Facility would become effective in connection with the closing of the previously announced pending merger with Vickers Vantage Corp I ("Vickers"). Scilex would not be obligated to utilize any of the $5 billion facility and would be able to enter other financing transactions. No warrants will be issued in connection with the Facility.

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The term sheet contemplates that in connection with the closing of the merger with Vickers, Scilex would enter into definitive agreements with respect to the Facility. Scilex would be able to determine, in its sole discretion, the timing, dollar amount and floor price per share of each draw under the Facility, subject to certain conditions. Any resales of shares sold by Scilex to BRPC under the Facility will be made pursuant to a registration statement to be filed with the Securities and Exchange Commission (the "SEC") following the closing of the merger.

"We’re pleased to establish a relationship with B. Riley, a leader in providing capital markets access to clinical and commercial stage biopharmaceutical companies," commented Henry Ji, Ph.D., Scilex’s Executive Chairman and Chairman, CEO for Sorrento Therapeutics Inc. "We expect the Facility to enhance Scilex’s financial flexibility as we work to advance our drug development programs and business development initiatives."

"As we prepare to begin our registration and pre-commercialization plans of our recently successfully completed SP-102 (SEMDEXATM) Phase 3 clinical trial program, this Facility is an important addition to our menu of financing options. It will give us the ability to raise capital quickly, at a competitive cost, and the flexibility to issue shares in multiple tranches for a period of five years. We believe these advantages will be of significant benefit to Scilex and our shareholders as we continue to execute on our business plan," said Jaisim Shah, Chief Executive Officer of Scilex.

Scilex Holding Company and Vickers Vantage Corp. I (Nasdaq: VCKA) ("VCKA"), a special purpose acquisition company sponsored by Vickers Venture Fund VI Pte Ltd and Vickers Venture Fund VI (Plan) Pte Ltd, entered into a definitive business combination agreement ("BCA") on March 17, 2022. Upon the closing of the transaction, the combined company (the "Combined Company") will be renamed Scilex Holding Company, and its common stock is expected to be listed on Nasdaq under the ticker symbol "SCLX". The boards of directors of each of VCKA, Scilex and Sorrento have unanimously approved the proposed transaction. The closing of the transaction, which is expected to occur by the third quarter of 2022, is subject to the approval of VCKA’s shareholders and the satisfaction or waiver of certain other customary closing conditions.

A corporate presentation describing Scilex’s development plans can be found at www.scilexholding.com.

Formosa Pharmaceuticals And EirGenix Establish A Co-Development Alliance To Develop TSY-0110 / EG12043 (Ado-Trastuzumab Emtansine Biosimilar) For HER2-Positive Breast Cancer

On March 24, 2022 Formosa Pharmaceuticals reported the approval of a resolution by the boards of directors of both Formosa Pharmaceuticals and EirGenix, Inc. for the co-development of anticancer ADC, TSY-0110 (EG12043) (Press release, Formosa Pharmaceuticals, MAR 24, 2022, View Source [SID1234630879]). This agreement strengthens the existing relationship between both companies and fortifies TSY-0110’s clinical development pathway and subsequent licensing prospects.

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TSY-0110 is a biosimilar of the antibody-drug conjugate, Kadcyla, which combines Herceptin with the cytotoxic payload, mertansine, to achieve an enhanced antitumor effect with manageable safety profile. Kadcyla, developed by Roche Pharmaceuticals, was first approved by the US FDA in 2013 for the treatment of HER2-positive metastatic breast cancer (MBC) and later gained additional approval for early breast cancer (EBC) in 2019. Kadcyla is currently utilized as a single-agent 2nd-line treatment for breast cancer and is being tested in numerous clinical trials as a combination agent with other biologics and chemotherapeutics. Kadcyla’s global sales from 2021 is approximately USD $2.1 billion and annual sales are expected to remain strong.

Per the terms of the agreement, Formosa Pharmaceuticals will receive upfront and milestone payments for a total of USD $30 million from EirGenix in exchange for profit-sharing rights to TSY-0110. Additionally, EirGenix is named the exclusive supplier of its Herceptin biosimilar (EG12014) as the key intermediate toward the manufacturing of TSY-0110. EirGenix, who recently completed a USD $110 million cash capital increase and $175 million private placement, submitted Marketing Authorization (MAA) and Biologics Licensing (BLA) Applications to the EMA (EU) and FDA (US), respectively, for EG12014 with marketing partner, Sandoz AG, in December, 2021.

Formosa Pharmaceuticals’ chairman and founder, Dr. CY Cheng, said, "We are pleased to broaden our relationship with EirGenix for the development of HER2-related cancer therapies and leverage their proven clinical development expertise. We look forward to sharing the commercial benefits."

Release of Research Publication using Tribody Technology onto Cancer Immunotherapy from Chiome Bioscience in collaboration with Ceinge

On March 24, 2022 The publication is reported on a basis of the research using our Tribody technology (Press release, Chiome Bioscience, MAR 24, 2022, View Source [SID1234625712]). Tribody
tecnhology is one of our platform antibody engineering technologies that can generate multi-specific antibody applying for cancer immunotherapy. The research outcomes are published at International Journal of Molecular Sciences.

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This research is conducted in collaboration with Ceinge Biotecnologie Avanzate ("Ceinge"), a nonprofit consortium research organization in Italy. We constructed novel bi-specific tribodies targeting different molecules involved in immune checkpoints. The tribody exhibited the retained binding activity to each target, increased immuno-modulatory effect to induce lymphocyte activation, and enhanced in vitro cytotoxicity against tumor cells. Tribody format could also reduce the production costs. Also, the molecular size is well suited for both tumor penetration and an acceptable half-life. Tribody could offer useful therapeutic applications, particularly in monotherapy-resistant cancer patients.

Publication

T i t l e : Novel Bi-Specific Immuno-Modulatory Tribodies Potentiate T Cell Activation and
Increase Anti-Tumor Efficacy

Authors : Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto,
Rosa Rapuano Lembo, Lorenzo Manna, Koji Nakamura and Claudia De Lorenzo

Journal : International Journal of Molecular Sciences
View Source

About TribodyTM

The Tribody technology enables the generation of multi-specific antibody products. This unique technology overcomes the key shortcomings of conventional mono- as well as of currently developed bi-specific antibody formats. Tribody enables creation of unique antibody by building multi-binding sites that bind to different antigen or epitope, which differentiate from conventional antibody. It is expected to generate antibodies against targets that could not be made into pharmaceuticals, and to generate antibodies that can be released from the combination drugs therapy.