On November 21, 2022 Cardiff Oncology, Inc. (Nasdaq: CRDF), a clinical-stage biotechnology company leveraging PLK1 inhibition to develop novel therapies across a range of cancers, reported that company management will participate in fireside chats and 1×1 investor meetings at the 34th Annual Piper Sandler Healthcare Conference and the JMP Securities Hematology and Oncology Summit taking place on November 29 – December 1, 2022, and December 6 – 7, 2022, respectively (Press release, Cardiff Oncology, NOV 21, 2022, View Source [SID1234624362]).

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Details of the fireside chats can be found below.

34th Annual Piper Sandler Healthcare Conference

Date:

Tuesday, November 29, 2022

Time:

1:30 – 1:55 PM ET

Conference Location:

New York, NY

Webcast Link:

View Source

The JMP Securities Hematology and Oncology Summit

Date:

Wednesday, December 7, 2022

Time:

3:00 – 3:15 PM ET

Conference Location:

Virtual

Webcast Link:

Wecast Link

Replays of the fireside chats will be available by visiting the "Events" section of the Cardiff Oncology website and will be archived for 90 days.

On November 21, 2022 Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) reported that first patient has been dosed in a Phase II investigator-initiated study of TLX101 in combination with external beam radiation therapy (EBRT) in patients with recurrent high-grade gliomas (HGG), including glioblastoma multiforme (GBM) (Press release, Telix Pharmaceuticals, NOV 21, 2022, View Source [SID1234624361]).

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TLX101 (4-L-[131I] iodo-phenylalanine, or 131I-IPA) is one of Telix’s lead therapeutic clinical programs and has been granted orphan drug designation in the U.S. and Europe. TLX101 targets L-type amino acid transporter 1 (LAT-1), typically over-expressed in many malignant tumours, including HGG/GBM.

The IPAX-Linz study, which is being led by Professor Josef Pichler at Kepler University Hospital in Linz, Austria, builds on data generated in the IPAX-1 study. The final results of the IPAX-1 study, reported in September 2022, demonstrated a favourable safety profile and encouraging preliminary therapeutic effect.[1] IPAX-Linz will continue to study the benefit of TLX101 to patients in the second line (refractory) setting at this leading neuro-oncology site in Europe. Targeting recruitment of 10 patients, the goal of this study is to gather additional data on clinical utility.

IPAX-Linz will run concurrently with IPAX-2, which is evaluating TLX101 in combination with post-surgical standard of care comprised of EBRT and temozolomide in newly diagnosed (first line) GBM patients.

Prof. Josef Pichler, Kepler University Hospital, Austria, Principal Investigator in the IPAX-Linz study said, "Based on promising safety and early efficacy data for TLX101 in the IPAX-1 study, I am pleased to continue to explore this therapeutic modality in a larger patient cohort, where there are currently few effective treatment options. Preliminary results are only achieved thanks to close and optimal cooperation with our colleagues at Ordensklinikum Linz, Barmherzige Schwestern and we are grateful for their contribution to this trial."

Dr. Colin Hayward, Chief Medical Officer of Telix Pharmaceuticals added, "We are pleased to have commenced the IPAX-Linz study, which alongside IPAX-2 supports Telix’s goal to expedite the development of a potential new therapy in an aggressive cancer with poor prognosis. We would like to thank Prof. Josef Pichler and his clinical team at Kepler University Hospital, as well as the patients who will contribute to this important study."

On November 21, 2022, XOMA (US) LLC ("XOMA"), a wholly-owned subsidiary of XOMA Corporation (the "Company"), entered into an intellectual property acquisition agreement (the "Agreement") with ObsEva, SA, a Swiss biotech company ("ObsEva") (Press release, Xoma, NOV 21, 2022, View Source [SID1234624355]). Pursuant to the Agreement, XOMA has acquired all rights and title to ebopiprant, an investigational compound, previously licensed by ObsEva from Ares Trading SA ("Merck KGaA") pursuant to a certain license agreement dated June 10, 2015, held by ObsEva for $15 million, payable in cash at the closing, plus certain earn-out payments, based on some sales-based and non-sales milestones. XOMA has assumed the ebopiprant intellectual property estate and all license agreements, including a certain license agreement from ObsEva to Organon International GmbH dated July 26, 2021, related to the development and commercialization of ebopiprant (the "License Agreement"). XOMA is eligible to receive up to $475 million in development, regulatory, and sales-based milestone payments under the License Agreement. XOMA will pay to ObsEva a portion of the development and regulatory milestones, as well as certain sales milestones, up to $98 million. Upon commercialization, XOMA will receive royalties that range from low- to mid-teens from Organon and will make a mid-single-digit royalty payment to Merck KGaA.

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The Agreement contains certain covenants, representations and warranties regarding ObsEva’s rights and obligations with respect to the existing licenses, mutual indemnification provisions, and customary covenants and representations for a transaction of this nature.

The description of the Agreement contained herein does not purport to be complete and is qualified in its entirety by reference to such Agreement, a copy of which will be filed as an exhibit to the Company’s Annual Report on Form 10-K for the period ending December 31, 2022.

On November 21, 2022 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, reported that Dan Faga, interim chief executive officer of AnaptysBio, will represent the company in a fireside chat at the Piper Sandler 34th Annual Healthcare Conference on Tuesday November 29th, 2022, at 8:10 a.m. ET / 5:10 a.m. PT (Press release, AnaptysBio, NOV 21, 2022, View Source [SID1234624317]).

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A live audio webcast of the presentation will be available on the investor section of the AnaptysBio website at View Source A replay of the webcast will be available for 30 days following the event.

On November 21, 2022 Nona Biosciences, a wholly-owned subsidiary of HBM Holdings Limited committed to providing a total solution from "Idea to IND" ("I to ITM"), reported that it has entered into a collaboration agreement with Dragonfly Therapeutics based on Nona’s proprietary fully human heavy chain only antibody (HCAb) transgenic mice platform to discover and develop fully human heavy chain only antibodies for bispecific/multi-specific therapeutic antibody generation (Press release, Dragonfly Therapeutics, NOV 21, 2022, View Source [SID1234624315]).

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Through the collaboration, Nona Biosciences will provide Dragonfly Therapeutics with access to the HCAb technologies as well as antibody generation services for the targets designated by Dragonfly Therapeutics. Financial terms were not disclosed. The collaboration is Nona’s follows a recently announced license and collaboration agreement with Moderna for nucleic acid-based immunotherapies for select oncology targets.

Dr. Jingsong Wang, Founder, Chairman, and CEO of Harbour BioMed said: "The Dragonfly Therapeutics’ collaboration recognizes the potential of both our proprietary platform and antibody discovery capabilities. We believe that our HCAb technology together with our accumulated extensive experience in innovative biologics drug discovery will help our partners generate differentiated therapeutic molecules benefiting the patient worldwide."

About HCAb

HCAb’s patented technology generates novel "heavy chain only" antibodies, which are about half the size of a typical IgG. These antibodies carry IgG-like PK properties and Fc-domain functions without the need for additional engineering or humanization. Lack of light chain also minimizes the issue of light chain mispairing and heterodimerization. These characteristics enable the development of products with attributes not achievable by conventional antibody platforms. In addition, HCAb-derived multiple novel therapeutic antibody modalities, including single-domain antibodies, bi-, and multi-specifics, antibody-drug conjugates, CAR-Ts, or VH domain-derived diagnostic or therapeutic products, are also achievable using this platform.