Cyclacel Pharmaceuticals to Release Third Quarter 2022 Financial Results

On November 4, 2022 Cyclacel Pharmaceuticals, Inc. (NASDAQ: CYCC, NASDAQ: CYCCP; "Cyclacel" or the "Company"), a biopharmaceutical company developing innovative medicines based on cancer cell biology, will announce third quarter 2022 financial results on Wednesday, November 9, 2022 (Press release, Cyclacel, NOV 4, 2022, View Source [SID1234623134]). The company will host a conference call and live webcast at 4:30 p.m. Eastern Time on the same day.

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For the live and archived webcast, please visit the Corporate Presentations page on the Cyclacel website at www.cyclacel.com. The webcast will be archived for 90 days and the audio replay for 7 days.

REACTION BIOLOGY AND VYANT BIO ANNOUNCE CLOSING OF DEFINITIVE AGREEMENT TO ACQUIRE U.S. OPERATIONS OF VYANT BIO, INC. SUBSIDIARY

On November 4, 2022 Reaction Biology Corporation ("Reaction"), an industry-leading provider of drug discovery services, and Vyant Bio, Inc. ("Vyant Bio") (Nasdaq: VYNT), an innovative biotechnology company reinventing drug discovery for complex neurodevelopmental and neurodegenerative disorders, reported that the companies have closed on a definitive agreement for Reaction to acquire Vyant Bio’s subsidiary vivoPharm LLC, located in Hershey, Pennsylvania (Press release, Vyant Bio, NOV 4, 2022, View Source [SID1234623132]).

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Reaction will retain U.S. personnel from the acquired operations to establish its Hershey, Pennsylvania presence, which includes in vitro and in vivo capabilities. Through the acquisition, Reaction gains laboratory facilities, equipment, employees, cell lines and capabilities (in pharmacology, toxicology, pathology and bio analytics) that further expand the industry-leading suite of drug discovery services that Reaction provides for its biopharmaceutical customers. The purchase price for this transaction is $5.5 million in an upfront cash payment, subject to customary adjustments for working capital, closing cash, indebtedness and transaction expenses. After these closing adjustments were reflected, $5.5 million was paid at closing. Vyant Bio expects to net approximately $4.4 million in cash after tax and transaction related expenses, as well as incur $0.6 million in exit costs associated with this transaction.

"vivoPharm’s U.S. operations are highly complementary to Reaction’s existing suite of drug discovery CRO services, enabling us to build upon our legacy of excellent science and customer-centric innovation," said John H. Johnson, Chief Executive Officer of Reaction Biology. "This investment in talent, infrastructure and resources is an important step in our roadmap for fully realizing Reaction’s potential as a provider of solutions for discovery and development of new drug candidates."

"This transaction provides non-dilutive capital and enables Vyant Bio to further concentrate our efforts to more rapidly advance our therapeutic pipeline in genetic CNS disorders," said Jay Roberts, President and Chief Executive Office of Vyant Bio. "Reaction is an ideal partner to leverage vivoPharm’s preclinical oncology and immuno-oncology drug discovery services, including one of the broadest collections of syngeneic tumor models, well-characterized tumor cell lines and highly qualified technicians using our state-of-the art laboratories."

White & Case LLP served as Reaction’s legal counsel. Lowenstein Sandler LLP served as Vyant Bio’s legal counsel. Colliers Securities LLC and Lake Street Capital Markets LLC acted as financial advisors to Vyant Bio in the transaction.

OMEROS CORPORATION ANNOUNCES UPCOMING PRESENTATIONS AT ASH ANNUAL MEETING

On November 4, 2022 Omeros Corporation (Nasdaq: OMER) reported that two presentations pertaining to Omeros’ investigational complement inhibitors will be featured at the upcoming 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, which will be held from December 10-13, 2022 in New Orleans (Press release, Omeros, NOV 4, 2022, View Source [SID1234623130]). The following abstracts were published today and are now available on the ASH (Free ASH Whitepaper) website at www.hematology.org:

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Alternative Pathway MASP-3 Inhibitor OMS906 in a Phase 1 Study of Healthy Subjects (Abstract #2570)
Session Name: 508. Bone Marrow Failure: Acquired: Poster II
Date: Sunday, December 11, 2022
Presentation Time: 6:00 p.m. – 8:00 p.m. ET
Location: Ernest N. Morial Convention Center, Hall D

Trial in Progress: An Open-Label, Multi-Center Phase 2 Study Evaluating Efficacy and Safety of the MASP-2 Inhibitor Narsoplimab in Pediatric Patients with High-Risk Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (HSCT-TMA) (Abstract #3808)
Session Name: 331. Thrombotic Microangiopathies/Thrombocytopenias and COVID-19-related Thrombotic/Vascular Disorders: Clinical and Epidemiological: Poster III
Date: Monday, December 12, 2022
Presentation Time: 6:00 p.m. – 8:00 p.m. ET
Location: Ernest N. Morial Convention Center, Hall D

Following presentation at the meeting, the posters will be available on Omeros’ website at www.omeros.com

Oncternal Therapeutics to Present Updated Interim Phase 1/2 Data for Zilovertamab in Combination with Ibrutinib in an Oral Session at ASH 2022

On November 4, 2022 Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, reported that interim clinical data from the ongoing Phase 1/2 Study CIRM-0001 will be presented in an Oral Session at the American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition taking place on December 10-13, 2022, in New Orleans, Louisiana (Press release, Oncternal Therapeutics, NOV 4, 2022, View Source [SID1234623129]). In the CIRM-0001 study, zilovertamab, an investigational anti-ROR1 monoclonal antibody, is being evaluated in combination with ibrutinib in patients with mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL) and in a recently opened cohort for patients with marginal zone lymphoma (MZL). The clinical trial is being conducted in collaboration with the University of California San Diego (UC San Diego) and has been partially funded by the California Institute for Regenerative Medicine (CIRM).

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The interim clinical data has been accepted for an oral presentation during the Mantle Cell, Follicular, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological III session on Saturday, December 10, 2022 as part of the ASH (Free ASH Whitepaper) 2022 Annual Meeting. ASH (Free ASH Whitepaper) abstracts were released today, and more recent data updates will be available at the time of the presentation.

Poster Title: Phase 1/2 Study of Zilovertamab and Ibrutinib in Mantle Cell Lymphoma (MCL), Chronic Lymphocytic Leukemia (CLL), or Marginal Zone Lymphoma (MZL)
Publication Number: 232
Session Name: Mantle Cell, Follicular, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological III
Room: Ernest N. Morial Convention Center, New Orleans Theater C
Presenter: Hun Ju Lee, MD, Department of Lymphoma & Myeloma at the University of Texas MD Anderson Cancer Center
Session Date and Time: December 10, 2022 from 2:00-3:30 pm CST; CIRM-0001 presentation being held at 2:45 pm CST

corporate presentation

On November 4, 2022 Rain Therapeutics Inc. (the "Company") Presented an updated corporate presentation (Presentation, Rain Therapeutics, NOV 4, 2022, View Source [SID1234623116]).

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